AphasiaNCT05512884
Speeded Anomia Treatment in Chronic Post-stroke Aphasia
A study testing Speeded anomia therapy in people with Aphasia, run by University of Cambridge at 1 site in United Kingdom.
Trial summary
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Aphasia
- What is being tested?
- Speeded anomia therapy
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 15 Jan 2023to 1 Sep 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Native English speakers
- Age 18 years or above
- Stroke (any type) greater than 12 months post onset
- No history of neurological disorders / psychiatric disorders
- Normal or corrected-to-normal hearing \& vision
- Able to give informed consent
Show all 9Show fewer
- Currently not receiving Speech \& Language therapy
- Minimal repetition skills (>40% on an immediate word repetition test)
- Evidence of naming difficulties (<90% in Boston Naming Test - Goodglass et al., 1983)
Who cannot join
- Non-native English speakers
- Less than 18 years old
- Stroke less than 12 months post onset
- History of neurological disorders / psychiatric disorders
- Uncorrected hearing \& vision
- Unable to give informed consent
Show all 9Show fewer
- Currently receiving Speech \& Language therapy
- Insufficient repetition skills (<40% on an immediate word repetition test)
- Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site, 1 recruiting
- Recruiting
MRC Cognition & Brain Sciences Unit
Cambridge, CB2 7EF
Eleni Zevgolatakou, MSc, 07724386296, elena.zevgolatakou@mrc-cbu.cam.ac.uk
About this study
Official title: Testing the Effect of Speeded Anomia Therapy in Patients With Chronic Post-stroke Aphasia: a Cross-over Randomized Controlled Trial
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).
Read the detailed description
The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production.
This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).
- Conditions
- Aphasia
- Being tested
- Speeded anomia therapy
- Keywords
- Anomia, Speech Disorders, Language Disorders, Communication Disorders
- Medical subject headings
- Aphasia, Anomia, Speech Disorders, Language Disorders, Communication Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Speeded anomia therapyBehavioural
The speeded anomia therapy was introduced as RISP (Repeated, Increasingly Speeded Production) by Conroy et al. (2018). Participants are asked to name the picture presented to them before an auditory stimulus ('beep' sound) at the end of item presentation. In each session the allotted response time is gradually reduced. After an incorrect response, participants are asked to repeat the word three times.
| Study group | Role | What they receive |
|---|---|---|
| Speeded anomia therapy | Experimental | 21h of anomia therapy Receives: Behavioral: Speeded anomia therapy |
| Standard care | No intervention | Participants' typical daily routine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Speeded anomia therapy effect in reaction time
Change in reaction time in single-item picture naming
Measured: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Speeded anomia therapy effect in accuracy
Change in accuracy in single-item picture naming
Measured: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Generalisation to connected speech
Change in word retrieval in composite picture description. Participants will be asked to describe composite pictures (from the "Where's Waldo/Wally?" publications).
Measured: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Secondary outcomes (1)
Generalisation to story-telling connected speech
Change in narrative speech production. Participants will be asked to narrate the Cinderella story. A checklist with some of the most frequently used nouns (data obtained from AphasiaBank database) will be used.
Measured: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Aug 2022
- Study start15 Jan 2023 (estimated)
- Primary completion1 Sep 2023 (estimated)
- Study completion1 Sep 2023 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for AphasiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Cambridge
- Sponsor type
- University, hospital or other
- Collaborators
- Cambridge University Hospitals NHS Foundation Trust
- Responsible party
- Principal investigator, Matthew A. Lambon Ralph, University of Cambridge
- Investigators
- Matthew Lambon Ralph, DPhil, Principal investigator, MRC Cognition and Brain Sciences Unit, University of Cambridge
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05512884
- Sponsor's protocol ID
- 01/8/094
- Status last verified
- Jan 2023
- First submitted
- 17 Aug 2022
- Last updated
- 19 Jan 2023
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Conroy P, Sotiropoulou Drosopoulou C, Humphreys GF, Halai AD, Lambon Ralph MA. Time for a quick word? The striking benefits of training speed and accuracy of word retrieval in post-stroke aphasia. Brain. 2018 Jun 1;141(6):1815-1827. doi: 10.1093/brain/awy087.
PubMed 29672757
Study at a glance
From the registry record, last updated by the sponsor on 19 Jan 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Testing the Effect of Speeded Anomia Therapy in Patients With Chronic Post-stroke Aphasia: a Cross-over Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT05512884
- Acronym / sponsor ID
- 01/8/094
- Conditions
- Aphasia
- Keywords
- Anomia, Speech Disorders, Language Disorders, Communication Disorders
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- University of CambridgeUniversity, hospital or other
- Collaborators
- Cambridge University Hospitals NHS Foundation Trust
- Study start
- 15 Jan 2023 (estimated)
- Primary completion
- 1 Sep 2023 (estimated)
- Study completion
- 1 Sep 2023 (estimated)
- First posted
- 23 Aug 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).
Detailed description
The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production.
This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Speeded anomia therapy | Experimental | Behavioral: Speeded anomia therapy21h of anomia therapy |
| Standard care | No intervention | –Participants' typical daily routine |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- Native English speakers
- Age 18 years or above
- Stroke (any type) greater than 12 months post onset
- No history of neurological disorders / psychiatric disorders
- Normal or corrected-to-normal hearing \& vision
Key exclusion criteria (9 listed)
- Non-native English speakers
- Less than 18 years old
- Stroke less than 12 months post onset
- History of neurological disorders / psychiatric disorders
- Uncorrected hearing \& vision
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Speeded anomia therapyThe speeded anomia therapy was introduced as RISP (Repeated, Increasingly Speeded Production) by Conroy et al. (2018). Participants are asked to name the picture presented to them before an auditory stimulus ('beep' sound) at the end of item presentation. In each session the allotted response time is gradually reduced. After an incorrect response, participants are asked to repeat the word three times. | Behavioural | Speeded anomia therapy |
Primary outcome
Speeded anomia therapy effect in reaction time
Time frame: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Change in reaction time in single-item picture naming
Speeded anomia therapy effect in accuracy
Time frame: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Change in accuracy in single-item picture naming
Generalisation to connected speech
Time frame: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Change in word retrieval in composite picture description. Participants will be asked to describe composite pictures (from the "Where's Waldo/Wally?" publications).
1 secondary outcome
Generalisation to story-telling connected speech
Time frame: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Jan 2023.
- Background: PubMed 29672757Conroy P, Sotiropoulou Drosopoulou C, Humphreys GF, Halai AD, Lambon Ralph MA. Time for a quick word? The striking benefits of training speed and accuracy of word retrieval in post-stroke aphasia. Brain. 2018 Jun 1;141(6):1815-1827. doi: 10.1093/brain/awy087.
Related trials for Aphasia
Not yet recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia (BG-Aphasia-01)
Expressive Aphasia, Aphasia Following Cerebral Infarction
Recruiting
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
Aphasia, Stroke
Not yet recruiting
Restoring Speech With an Intracortical Neuroprosthesis for Post-Stroke Agrammatic Aphasia (BG-Aphasia-02)
Aphasia, ALS
Not yet recruiting
Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
Aphasia, Stroke
Not yet recruitingObservational study
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Stroke, Ischemic Stroke
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Matthew Lambon Ralph, DPhil principal investigator
MRC Cognition and Brain Sciences Unit, University of Cambridge
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Speeded anomia therapy in people with Aphasia, run by University of Cambridge at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 19 Jan 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Eleni Zevgolatakou, MSc (+447724386296, Elena.Zevgolatakou@mrc-cbu.cam.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Speeded anomia therapy effect in reaction time (time frame: Measured over 10 weeks (Week 0, Week 2, Week 4, Week 6, Week 10)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05512884, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Jan 2023.