Non-small Cell Lung CancerPhase 2NCT05534113

Envafolimab Immunotherapy After ctDNA EGFR Clearance by Treatment With Almonertinib in EGFR-Mutant, PD-LI Positive NSCLC

A Phase 2 study testing Almonertinib Envafolimab in people with Non-small Cell Lung Cancer, run by The First Affiliated Hospital with Nanjing Medical University.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Official record

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Trial summary

This is a prospective, single-arm, open-label, interventional clinical study, aimed at exploring the efficacy and safety of sequential Envafolimab immunotherapy after patients with ctDNA EGFR mutation clearance and achieved stable radiographically deep esponse after first line treatment with Almonertinib in… Read more about this study

Who is it for?: Ages 18 years and older
Conditions the study is for: Non-small Cell Lung Cancer
What is being tested?: Almonertinib Envafolimab
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 38 participants
Where: No sites listed yet
Study dates: 1 Dec 2022to 1 Jun 2025
Phase: Phase 2
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Over 18 years old (including 18 years old) .
The Eastern Cooperative Oncology Group (ECOG) physical status score is 0 to 1, and it has not deteriorated in the previous 2 weeks, and the minimum expected survival is 12 weeks.
Unresectable advanced or metastatic non-squamous cell non-small cell lung cancer.
Blood samples were confirmed to contain EGFR-sensitive mutations by ctDNA testing(including exon 19 deletion or L858R, both alone or coexist with other EGFR mutations.Patients with EGFR20 exon insertion mutations could not be enrolled).
No systematic antitumor treatment before enrollment.
PD-L1 expression is positive, defined as TPS (tumor proportion score) ≥10%.

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The patient has at least one tumor lesion that can be accurately measured at baseline, and the longest diameter at baseline is ≥10 mm (if it is a lymph node, the short diameter is required to be ≥15 mm). The selected measurement method is suitable for accurate repeat measurement, which can be computed tomography (CT) or magnetic resonance scan (MRI). If there is only one measurable lesion, it can be accepted as the target lesion, and a baseline assessment of the tumor lesion should be performed at least 14 days after the diagnostic biopsy.
Women of childbearing age should take appropriate contraceptive measures from screening to 3 months after stopping the study treatment and should not breastfeed. Before starting the administration, the pregnancy test is negative, or meeting one of the following criteria proves that there is no risk of pregnancy:
Postmenopausal is defined as age greater than 50 years，and amenorrhea for at least 12 months after stopping all exogenous hormone replacement therapy.
For women younger than 50 years old, if the amenorrhea is 12 months or more after stopping all exogenous hormone treatments, and the luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels are within the laboratory postmenopausal reference value range, also It can be considered postmenopausal.
Have received irreversible sterilization, including hysterectomy, bilateral ovariectomy or bilateral fallopian tube resection, except for bilateral fallopian tube ligation.
Male subjects should use barrier contraception (ie, condoms) from screening to 3 months after the study treatment is stopped.
The subjects themselves participated voluntarily and signed a written informed consent form.

Who cannot join

Subjects who meet any of the following criteria cannot be included in this study:
Have received any of the following treatments:
Previously received antitumor treatment for lung cancer in the past;
Previously received Chinese patent medicine with anti-tumor effect. If Chinese patent medicine with anti-tumor effect has been received for no more than 7 days, and the medicine has been stopped for 2 weeks or more before the drug treatment of this study, it can be included in the group.
Patients who had received open surgery on other parts except lungs within 14 days before using the study drug ≤ 14 days.
Refractory nausea, vomiting or chronic gastrointestinal diseases, inability to swallow the study drug or having undergone extensive intestinal resection may affect the full absorption of Almonertinib.

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Patients with other malignant tumors in recent 5 years (excluding completely resected basal cell carcinoma, bladder cancer in situ and cervical carcinoma in situ).
Have a history of interstitial lung disease, a history of drug-induced interstitial lung disease, a history of interstitial pneumonia requiring steroid treatment, or any evidence of clinically active interstitial lung disease.
As judged by the investigator, there are any serious or poorly controlled systemic disease, such as poorly controlled hypertension, active bleeding or active infection (including active fungal, bacterial and / or viral infections requiring systemic treatment or full-body anti infective drugs used within one week before the first administration).
At the beginning of the study treatment, there were unresponsive residual toxicity from previous treatment that was greater than CTCAE grade 3, except for hair loss.
Meet any of the following cardiac examination results:
The average value of QT interval (QTcF) corrected by Fridericia's formula obtained from 3 ECG examinations at rest> 470 msec;
Resting ECG suggests that there are various clinically significant rhythms, conduction or ECG morphological abnormalities that are judged by the investigator (such as complete left bundle branch block, 3 degree atrioventricular block, 2 degree atrium Ventricular block and PR interval> 250 msec, etc.);
There are any factors that increase the risk of QTc prolongation or arrhythmia events, such as heart failure, hypokalemia, congenital long QT syndrome, family history of long QT syndrome, or unexplained sudden death or prolonged QT of immediate family members under 40 Any concomitant drugs in the interval;
Left ventricular ejection fraction (LVEF) <50%.
Insufficient bone marrow reserve or organ function, reaching any one of the following laboratory limits (no corrective treatment within 1 week before laboratory examination of blood draw):
Absolute neutrophil count <1.5×109 / L; Platelet count <100×109 / L; Hemoglobin <90 g/L (<9 g/dL);
Liver function: alanine aminotransferase > 3 times the upper limit of normal (ULN); Aspartate aminotransferase > 3uln; Total bilirubin > 1.5uln; Serum albumin (ALB) < 28 g / L.
Renal function: creatinine > 1.5 ULN or creatinine clearance < 50ml / min (calculated by Cockcroft Gault formula). Only when creatinine ≥ 1.5 ULN, it is necessary to confirm creatinine clearance.
Female subjects who are pregnant, lactating, or planning to become pregnant during the study period.
Have a history of hypersensitivity to any active or inactive ingredients of almonertinib or to drugs with similar chemical structure to almonertinib or the same class of almonertinib.
Any serious or uncontrolled eye disease (especially severe dry eye syndrome, dry keratoconjunctivitis, severe exposure keratitis or other diseases that may increase epithelial damage) may increase the safety of the patient by the doctor's judgment Sexual risk; or those with eye abnormalities that require surgery or are expected to require surgical treatment during the study period.
Use / eat drugs or foods that are known to have strong CYP3A4 inhibition effect within 2 weeks (including but not limited to azanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nefenavir, ritonavir, saquinavir, telithromycin, acephaeomycin, voriconazole and grapefruit or grapefruit juice).
Use drugs known to have strong CYP3A4 inducing effect (including but not limited to carbamazepine, phenobarbital, phenytoin, rifampin, rifampicin and Hypericum perforatum) within 2 weeks.
Use drugs (including but not limited to dihydroergotamine, ergotamine, pimozide, astemizole, cisapride and terfenadine) as CYP3A4 substrates (with narrow therapeutic index) within 2 weeks.
Have used strong P-gp inhibitors within 2 weeks (including but not limited to verapamil, cyclosporine A and dexverapamil)
Patients with previous autoimmune diseases or undergoing immunomodulatory treatment.
Subjects who may have poor compliance with the study procedures and requirements at the judgment of the investigator, such as those who have a clear history of neurological or mental disorders (including epilepsy or dementia) in the past, and those who currently suffer from mental disorders.
Patients who need long-term systemic corticosteroids. Patients with COPD and asthma requiring intermittent use of bronchodilators, inhaled corticosteroids, or local injection of corticosteroids can be enrolled.
Symptomatic central nervous system metastasis. Patients with asymptomatic brain metastases or brain metastases whose symptoms are stable after treatment can participate in this study as long as they meet all the following criteria: there are measurable lesions outside the central nervous system; No midbrain, pons, cerebellum, meninges, medulla oblongata or spinal cord metastasis; Maintain clinical stability for at least 2 weeks; Hormone therapy was stopped 3 days before the first dose of study drug.
Known history of human immunodeficiency virus (HIV) infection (i.e., HIV 1 / 2 antibody positive).
Untreated active hepatitis B (defined as HBsAg positive and HBV-DNA copy number detected is greater than the upper limit of the normal value of the laboratory of the research center); Note: hepatitis B subjects meeting the following criteria can also be included in the group:
HBV viral load before the first administration was < 1000 copies / ml (200 IU / ml), and the subject should receive anti HBV treatment during the whole study chemotherapy drug treatment period to avoid virus reactivation;
For subjects with anti HBC (+), HBsAg (-), anti HBS (-) and HBV viral load (-), preventive anti HBV treatment is not required, but viral reactivation needs to be closely monitored..
Active HCV infected subjects (HCV antibody is positive and HCV-RNA level is higher than the lower limit of detection).
Have received live vaccine within 30 days before the first administration (cycle 1, day 1); Note: it is allowed to receive inactivated virus vaccine for injection against seasonal influenza within 30 days before the first administration; subjects have received live attenuated influenza vaccine for intranasal administration is not allowed.
Investigator judges that there are any patients with conditions that endanger the safety of the patient or interfere with the evaluation of the study.

Trial locations and contacts

No sites are listed yet.

Yongqian Shu, PhD contact

0086-025-68306428

shuyongqian@csco.org.cn

About this study

Official title: Sequential Envafolimab Immunotherapy After Patients With ctDNA EGFR Mutation Clearance by Treatment With Almonertinib in EGFR-Mutant, PD-LI Positive Non-small-cell Lung Cancer：Efficacy and Safety Clinical Trial

Read the detailed description

The study includes a screening period (not more than 28 days after the subject signs informed consent to before the first medication), treatment period (including Almonertinib treatment in 6-8 weeks after enrollment\ctDNA testing and radiographically imaging assessment\ctDNA guiding sequential Envafolimab immunotherapy) and follow-up period (including survival and safety) .

Eligible subjects receive 110 mg of Almonertinib once a day for 6-8 consecutive weeks of treatment，and receive ctDNA testing and radiographically imaging assessment again. According to test results, there are two types:

EGFR mutation is positive, subjects subsequent treament is up to the investigator (continue to receive 110 mg of Almonertinib once a day or combination therapy regimen), follow up every 6 weeks.
EGFR mutation is negative and achieve stable radiographically deep response after 6-8 weeks treatment with Almonertinib, subjects will stop Almonertinib treatment，and receive sequential Envafolimab immunotherapy (ctDNA dynamic monitoring guided treatment，every 6 weeks test ctDNA once, if it is negative, subjects continue to receive Envafolimab immunotherapy until ctDNA EGFR turns positive; if ctDNA EGFR is positive, subjects stop Envafolimab immunotherapy and receive Almonertinib 110 mg once a day again until ctDNA EGFR turns negative).

The treatment will continue until disease progression assessed by the investigator according to RECIST 1.1 criteria, or withdrawal or termination criteria are reached.

Conditions: Non-small Cell Lung Cancer
Being tested: Almonertinib Envafolimab
Keywords: EGFR, ctDNA, PD-L1, NSCLC
Medical subject headings: Carcinoma, Non-Small-Cell Lung

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Almonertinib EnvafolimabDrug
Subjects will receive Almonertinib treatment for 6-8 weeks after enrollment, and receive ctDNA detection and radiography assessment again.
If the EGFR mutation is positive, according to the patient's condition and clinical actual situation, subjects will receive combination therapy scheme, follow-up once every 6 weeks. The treatment will continue until the disease progress assessed by radiography.
If the EGFR mutation turns negative and stable radiographically deep response, stop Almonertinib treatment and receive the relevant assessment before immunotherapy and receive Envafolimab treatment，and follow-up once every 6 weeks. The treatment of Envafolimab will continue until the EGFR mutation is positive again or disease progress assessed by radiography.

Study groups in NCT05534113
Study group	Role	What they receive
sequential Envafolimab therapy after Almonertinib treatment	Experimental	Sequential Envafolimab therapy after patients with ctDNA EGFR mutation clearance and achieve stable radiographically deep response after treatment with Almonertinib Receives: Drug: Almonertinib Envafolimab

What is being measured

The primary outcome is the main question the study is designed to answer.

PFS
The progression-free survival is defined as the time from date of baseline until the the date of first documented progression or date of death from any cause, whichever came first.
Measured: 24 months.
TRP
Time to retest positive is defined as the time from date of sequential Envafolimab treatment until blood sample ctDNA detected for EGFR mutation recurrence or disease progression assessed by radiological imaging，assessed up to 24 months.
Measured: 24 months.

Secondary outcomes (3)

ORR
ORR is defined as the percentage of patients who have at least 1 response of CR or PR prior to any evidence of progression, assessed up to 24 months.
Measured: From baseline, then every 6 weeks, until disease progression or discontinuation from study. ORR is defined as the percentage of patients who have at least 1 response of CR or PR prior to any evidence of progression assessed up to 24 months.
DCR
The disease control rate is defined as the proportion of patients with a best overall response of CR, PR, or SD.
Measured: 24 months.
OS
OS is defined as the time from the starting date of study drug to the date of death，due to any cause.
Measured: 24 months after the last subject participating in.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Dec 20221 Jun 2025

First posted9 Sep 2022
Study start1 Dec 2022 (estimated)
Primary completion1 Jun 2025 (estimated)
Study completion1 Jun 2025 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Non-small Cell Lung CancerStudies of the same condition, open and under way.
More trials run by The First Affiliated Hospital with Nanjing Medical UniversityThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase 2
Primary purpose: Treatment
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Enrolment: 38 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT05534113
Sponsor's protocol ID: 2022-SR-439
Status last verified: Sep 2022
First submitted: 2 Sep 2022
Last updated: 14 Sep 2022
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Study at a glance

From the registry record, last updated by the sponsor on 14 Sep 2022. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Sequential Envafolimab Immunotherapy After Patients With ctDNA EGFR Mutation Clearance by Treatment With Almonertinib in EGFR-Mutant, PD-LI Positive Non-small-cell Lung Cancer：Efficacy and Safety Clinical Trial
ClinicalTrials.gov ID: NCT05534113
Acronym / sponsor ID: 2022-SR-439
Conditions: Non-small Cell Lung Cancer
Keywords: EGFR, ctDNA, PD-L1, NSCLC
Phase: Phase 2
Study type: Interventional
Recruitment status: Unknown status
Enrolment: 38 participants (estimated)
Lead sponsor: The First Affiliated Hospital with Nanjing Medical UniversityUniversity, hospital or other
Study start: 1 Dec 2022 (estimated)
Primary completion: 1 Jun 2025 (estimated)
Study completion: 1 Jun 2025 (estimated)
First posted: 9 Sep 2022 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

EGFR mutation is positive, subjects subsequent treament is up to the investigator (continue to receive 110 mg of Almonertinib once a day or combination therapy regimen), follow up every 6 weeks.
EGFR mutation is negative and achieve stable radiographically deep response after 6-8 weeks treatment with Almonertinib, subjects will stop Almonertinib treatment，and receive sequential Envafolimab immunotherapy (ctDNA dynamic monitoring guided treatment，every 6 weeks test ctDNA once, if it is negative, subjects continue to receive Envafolimab immunotherapy until ctDNA EGFR turns positive; if ctDNA EGFR is positive, subjects stop Envafolimab immunotherapy and receive Almonertinib 110 mg once a day again until ctDNA EGFR turns negative).

The treatment will continue until disease progression assessed by the investigator according to RECIST 1.1 criteria, or withdrawal or termination criteria are reached.

Study design

Primary purpose: Treatment
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Number of arms: 1

Arm	Type	Receives
sequential Envafolimab therapy after Almonertinib treatment	Experimental	Drug: Almonertinib EnvafolimabSequential Envafolimab therapy after patients with ctDNA EGFR mutation clearance and achieve stable radiographically deep response after treatment with Almonertinib

Who may qualify

Ages: 18 years and older
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (13 listed)

Over 18 years old (including 18 years old) .
The Eastern Cooperative Oncology Group (ECOG) physical status score is 0 to 1, and it has not deteriorated in the previous 2 weeks, and the minimum expected survival is 12 weeks.
Unresectable advanced or metastatic non-squamous cell non-small cell lung cancer.
Blood samples were confirmed to contain EGFR-sensitive mutations by ctDNA testing(including exon 19 deletion or L858R, both alone or coexist with other EGFR mutations.Patients with EGFR20 exon insertion mutations could not be enrolled).
No systematic antitumor treatment before enrollment.

Key exclusion criteria (37 listed)

Have received any of the following treatments:
Patients who had received open surgery on other parts except lungs within 14 days before using the study drug ≤ 14 days.
Refractory nausea, vomiting or chronic gastrointestinal diseases, inability to swallow the study drug or having undergone extensive intestinal resection may affect the full absorption of Almonertinib.
Patients with other malignant tumors in recent 5 years (excluding completely resected basal cell carcinoma, bladder cancer in situ and cervical carcinoma in situ).
Have a history of interstitial lung disease, a history of drug-induced interstitial lung disease, a history of interstitial pneumonia requiring steroid treatment, or any evidence of clinically active interstitial lung disease.

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Almonertinib EnvafolimabSubjects will receive Almonertinib treatment for 6-8 weeks after enrollment, and receive ctDNA detection and radiography assessment again. If the EGFR mutation is positive, according to the patient's condition and clinical actual situation, subjects will receive combination therapy scheme, follow-up once every 6 weeks. The treatment will continue until the disease progress assessed by radiography. If the EGFR mutation turns negative and stable radiographically deep response, stop Almonertinib treatment and receive the relevant assessment before immunotherapy and receive Envafolimab treatment，and follow-up once every 6 weeks. The treatment of Envafolimab will continue until the EGFR mutation is positive again or disease progress assessed by radiography.	Drug	sequential Envafolimab therapy after Almonertinib treatment

Primary outcome

PFS
Time frame: 24 months.
The progression-free survival is defined as the time from date of baseline until the the date of first documented progression or date of death from any cause, whichever came first.
TRP
Time frame: 24 months.
Time to retest positive is defined as the time from date of sequential Envafolimab treatment until blood sample ctDNA detected for EGFR mutation recurrence or disease progression assessed by radiological imaging，assessed up to 24 months.

3 secondary outcomes

ORR
Time frame: From baseline, then every 6 weeks, until disease progression or discontinuation from study. ORR is defined as the percentage of patients who have at least 1 response of CR or PR prior to any evidence of progression assessed up to 24 months.
DCR
Time frame: 24 months.
OS
Time frame: 24 months after the last subject participating in.

Results and safety

Results are not available in the source record.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2022.
Individual participant dataSharing planned: No

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Yongqian Shu, PhD contact

0086-025-68306428

shuyongqian@csco.org.cn

Yong Qian Shu principal investigator

Jiangsu Provincial People's Hospital

Wen Gao principal investigator

Jiangsu Provincial People's Hospital

Pei Ma principal investigator

Jiangsu Provincial People's Hospital

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing Almonertinib Envafolimab in people with Non-small Cell Lung Cancer, run by The First Affiliated Hospital with Nanjing Medical University.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 13 inclusion and 37 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: status not confirmed, as of the sponsor's last update on 14 Sep 2022. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

Contact Yongqian Shu, PhD (0086-025-68306428, shuyongqian@csco.org.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

PFS (time frame: 24 months.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05534113.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2022.