Primary Open-angle Glaucoma (POAG)PERISCENCT05539508
Role of Peripheral Vision in Scene Perception (PERISCE)
An observational study of Primary Open-angle Glaucoma (POAG), run by University Hospital, Grenoble.
Trial summary
Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Primary Open-angle Glaucoma (POAG)
- What is being tested?
- Psychophysical evaluation
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 120 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2022to 1 Jul 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: POAG patients and age-matched normally sighted controls
Who may be able to join
- For patients :
- between 18 and 80 years old
- stable bilateral primary open angle glaucoma (POAG)
- visual acuity > 5/10 for distant vision for the eye tested
- peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer
- For healthy volunteers :
Show all 9Show fewer
- between 18 and 80 years old
- visual acuity > 5/10
- absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)
Who cannot join
- ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)
- treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Role of Peripheral Vision in Scene Perception
Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.
- Conditions
- Primary Open-angle Glaucoma (POAG)
- Being tested
- Psychophysical evaluation
- Medical subject headings
- Glaucoma, Open-Angle
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Psychophysical evaluationBehavioural
All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard.
| Study group | Role | What they receive |
|---|---|---|
| Primary open-angle glaucoma (POAG) group | Not described Receives: Behavioral: Psychophysical evaluation | |
| Age-matched normally sighted control group | Not described Receives: Behavioral: Psychophysical evaluation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Psychophysical measure : Percentage of correct response
Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment
Measured: Through study completion of 45 months
Psychophysical measure : Mean reaction time in milliseconds
Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment
Measured: Through study completion of 45 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Sep 2022
- Study start1 Oct 2022 (estimated)
- Primary completion1 Jul 2026 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Primary Open-angle Glaucoma (POAG)Studies of the same condition, open and under way.
- More trials run by University Hospital, GrenobleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05539508
- Sponsor's protocol ID
- 2021-A01986-35
- Acronym
- PERISCE
- Status last verified
- Aug 2022
- First submitted
- 23 Aug 2022
- Last updated
- 14 Sep 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual participant data will be share in the context of publications through the Open Science Framework, a tool that promotes open, centralized workflows.
Publications
Roux-Sibilon A, Rutge F, Aptel F, Attye A, Guyader N, Boucart M, Chiquet C, Peyrin C. Scene and human face recognition in the central vision of patients with glaucoma. PLoS One. 2018 Feb 26;13(2):e0193465. doi: 10.1371/journal.pone.0193465. eCollection 2018.
PubMed 29481572Roux-Sibilon A, Trouilloud A, Kauffmann L, Guyader N, Mermillod M, Peyrin C. Influence of peripheral vision on object categorization in central vision. J Vis. 2019 Dec 2;19(14):7. doi: 10.1167/19.14.7.
PubMed 31826252Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Feb 11:1-15. doi: 10.1162/jocn_a_01689. Online ahead of print.
PubMed 33571079
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of Peripheral Vision in Scene Perception
- ClinicalTrials.gov ID
- NCT05539508
- Acronym / sponsor ID
- PERISCE / 2021-A01986-35
- Conditions
- Primary Open-angle Glaucoma (POAG)
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Study start
- 1 Oct 2022 (estimated)
- Primary completion
- 1 Jul 2026 (estimated)
- Study completion
- 1 Jul 2027 (estimated)
- First posted
- 14 Sep 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Primary open-angle glaucoma (POAG) group | – | Behavioral: Psychophysical evaluation |
| Age-matched normally sighted control group | – | Behavioral: Psychophysical evaluation |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- POAG patients and age-matched normally sighted controls
Key inclusion criteria (9 listed)
- between 18 and 80 years old
- stable bilateral primary open angle glaucoma (POAG)
- visual acuity > 5/10 for distant vision for the eye tested
- peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer
- between 18 and 80 years old
Key exclusion criteria (2 listed)
- ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)
- treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Psychophysical evaluationAll participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard. | Behavioural | Age-matched normally sighted control group, Primary open-angle glaucoma (POAG) group |
Primary outcome
Psychophysical measure : Percentage of correct response
Time frame: Through study completion of 45 months
Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment
Psychophysical measure : Mean reaction time in milliseconds
Time frame: Through study completion of 45 months
Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2022.
- Background: PubMed 29481572Roux-Sibilon A, Rutge F, Aptel F, Attye A, Guyader N, Boucart M, Chiquet C, Peyrin C. Scene and human face recognition in the central vision of patients with glaucoma. PLoS One. 2018 Feb 26;13(2):e0193465. doi: 10.1371/journal.pone.0193465. eCollection 2018.
- Background: PubMed 31826252Roux-Sibilon A, Trouilloud A, Kauffmann L, Guyader N, Mermillod M, Peyrin C. Influence of peripheral vision on object categorization in central vision. J Vis. 2019 Dec 2;19(14):7. doi: 10.1167/19.14.7.
- Background: PubMed 33571079Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Feb 11:1-15. doi: 10.1162/jocn_a_01689. Online ahead of print.
- Individual participant dataSharing planned: Yes. Anonymized individual participant data will be share in the context of publications through the Open Science Framework, a tool that promotes open, centralized workflows.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Primary Open-angle Glaucoma (POAG), run by University Hospital, Grenoble.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Sep 2022. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Carole Peyrin, PhD (04 76 82 58 79, carole.peyrin@univ-grenoble-alpes.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Psychophysical measure : Percentage of correct response (time frame: Through study completion of 45 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05539508, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2022.