Obsessive-Compulsive DisorderNCT05552014
Study on the Efficacy Mechanism of Natural Psychotherapy for Neurosis
A study testing Natural Psychotherapy in people with Obsessive-Compulsive Disorder, run by Beijing HuiLongGuan Hospital at 2 sites in China.
Trial summary
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder Read more about this study
- Who is it for?
- Ages 16 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Obsessive-Compulsive Disorder
- What is being tested?
- Natural Psychotherapy
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 2 sitesChina
- Study dates
- 1 May 2022to 1 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 55 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- were between 16 and 55 years old;
- were diagnosed with OCD by an experienced psychiatrist utilizing the Structured Clinical Interview for DSM-5 (SCID);
- had an illness duration of at least 12 months;
- were able to participate in the entire trial and face-to-face on-site assessment
Who cannot join
- pregnant or breastfeeding;
- suffered from organic brain diseases or severe physical illness;
- had a history of substance or alcohol abuse
- were at high risk of suicide
Trial locations and contacts
2 sites in 1 country.
China2 sites
Institute of Psychology, Chinese Academy of Sciences
Beijing, China, 100096
Anhui Mental Health Center
Hefei, Anhui, 230022
About this study
Official title: Research on the Efficacy Mechanism of Natural Psychotherapy for Neurosis
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
Read the detailed description
- To evaluate the cognitive function, Cognitive control, emotion and other aspects of neurosis patients, and to understand and master the cognitive behavior indicators of this population.
- Investigate the pathological mechanism of neurotic patients from the aspects of EEG/fMRI and biology.
- To investigate the therapeutic effect of natural psychotherapy on cognitive impairment and related mood, sleep and symptom intervention in neurotic patients. In order to achieve the symptoms of neurosis patients, cognitive impairment and related mood and sleep intervention and promotion, while providing a scientific basis for neurosis rehabilitation.
- Conditions
- Obsessive-Compulsive Disorder
- Being tested
- Natural Psychotherapy, waitlist control group
- Keywords
- obsessive-compulsive disorder, natural psychotherapy
- Medical subject headings
- Obsessive-Compulsive Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Natural PsychotherapyBehavioural
Natural psychotherapy is based on "Morita therapy" and is a psychotherapy that fully reflects the characteristics of Chinese culture, taking into account the Chinese cultural background and actual clinical characteristics.
waitlist control groupBehavioural
waitlist control group
| Study group | Role | What they receive |
|---|---|---|
| Natural Psychotherapy | Active comparator | Intervention using natural psychotherapy for OCD patients for two to three hours once a week for eight weeks Receives: Behavioral: Natural Psychotherapy |
| waitlist control group | Other | The waiting group will not undergo any intervention adjustments within the next two months and will not receive any other psychological interventions. Receives: Behavioral: waitlist control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Obsessive-compulsive symptoms
Using the score of Yale-Brown Obsessive-Compulsive Scale as the primary outcome, a decrease in score of ≥35% was considered a 'response to treatment', also referred to as a 'full response', and a decrease in score of ≥25% was considered a 'partial response'
Measured: Baseline, week 4, week 8
Secondary outcomes (5)
Self-reported obsessive-compulsive symptoms
The reduction rate of the score of Obsessive-Compulsive Inventory-Revised (OCI-R), a self-rating scale of OCD symptoms severity, was employed as a secondary outcome
Measured: Baseline, week 4, week 8
Cognitive inhibition
Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability.
Measured: Baseline, week 8
Behavioral inhibition
Behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability.
Measured: Baseline, week 8
ERP components associated with cognitive function
To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis
Measured: Baseline, week 8
rest fMRI in Obsessive-compulsive patients
The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences.
Measured: Baseline, week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Sep 2022
- Study start1 May 2022
- Primary completion1 Dec 2025
- Study completion1 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obsessive-Compulsive DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Beijing HuiLongGuan Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Xiang Yang Zhang, Beijing HuiLongGuan Hospital
- Investigators
- Xiang Y Zhang, M.D, Ph.D, Principal investigator, Institute of Psychology, Chinese Academy of Science
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05552014
- Sponsor's protocol ID
- CASPsy5
- Status last verified
- Jul 2026
- First submitted
- 21 Sep 2022
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data with be available on request
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Research on the Efficacy Mechanism of Natural Psychotherapy for Neurosis
- ClinicalTrials.gov ID
- NCT05552014
- Acronym / sponsor ID
- CASPsy5
- Conditions
- Obsessive-Compulsive Disorder
- Keywords
- obsessive-compulsive disorder, natural psychotherapy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Beijing HuiLongGuan HospitalUniversity, hospital or other
- Study start
- 1 May 2022 (actual)
- Primary completion
- 1 Dec 2025 (actual)
- Study completion
- 1 Dec 2025 (actual)
- First posted
- 23 Sep 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
Detailed description
- To evaluate the cognitive function, Cognitive control, emotion and other aspects of neurosis patients, and to understand and master the cognitive behavior indicators of this population.
- Investigate the pathological mechanism of neurotic patients from the aspects of EEG/fMRI and biology.
- To investigate the therapeutic effect of natural psychotherapy on cognitive impairment and related mood, sleep and symptom intervention in neurotic patients. In order to achieve the symptoms of neurosis patients, cognitive impairment and related mood and sleep intervention and promotion, while providing a scientific basis for neurosis rehabilitation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Natural Psychotherapy | Active comparator | Behavioral: Natural PsychotherapyIntervention using natural psychotherapy for OCD patients for two to three hours once a week for eight weeks |
| waitlist control group | Other | Behavioral: waitlist control groupThe waiting group will not undergo any intervention adjustments within the next two months and will not receive any other psychological interventions. |
Who may qualify
- Ages
- 16 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- were between 16 and 55 years old;
- were diagnosed with OCD by an experienced psychiatrist utilizing the Structured Clinical Interview for DSM-5 (SCID);
- had an illness duration of at least 12 months;
- were able to participate in the entire trial and face-to-face on-site assessment
Key exclusion criteria (4 listed)
- pregnant or breastfeeding;
- suffered from organic brain diseases or severe physical illness;
- had a history of substance or alcohol abuse
- were at high risk of suicide
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Natural PsychotherapyNatural psychotherapy is based on "Morita therapy" and is a psychotherapy that fully reflects the characteristics of Chinese culture, taking into account the Chinese cultural background and actual clinical characteristics. | Behavioural | Natural Psychotherapy |
| waitlist control groupwaitlist control group | Behavioural | waitlist control group |
Primary outcome
Obsessive-compulsive symptoms
Time frame: Baseline, week 4, week 8
Using the score of Yale-Brown Obsessive-Compulsive Scale as the primary outcome, a decrease in score of ≥35% was considered a 'response to treatment', also referred to as a 'full response', and a decrease in score of ≥25% was considered a 'partial response'
5 secondary outcomes
Self-reported obsessive-compulsive symptoms
Time frame: Baseline, week 4, week 8
Cognitive inhibition
Time frame: Baseline, week 8
Behavioral inhibition
Time frame: Baseline, week 8
ERP components associated with cognitive function
Time frame: Baseline, week 8
rest fMRI in Obsessive-compulsive patients
Time frame: Baseline, week 8
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
- Individual participant dataSharing planned: No. Data with be available on request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Xiang Y Zhang, M.D, Ph.D principal investigator
Institute of Psychology, Chinese Academy of Science
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Natural Psychotherapy in people with Obsessive-Compulsive Disorder, run by Beijing HuiLongGuan Hospital at 2 sites in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Obsessive-compulsive symptoms (time frame: Baseline, week 4, week 8). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026.