AzTrials
AzTrials

ObesityPhase 3SURMOUNT-MMONCT05556512

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

A Phase 3 study testing Tirzepatide in people with Obesity and Overweight, run by Eli Lilly and Company at 671 sites in 28 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population. Read more about this study

Who is it for?
Ages 40 years and older
Conditions the study is for
Obesity, Overweight
What is being tested?
Tirzepatide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
15,374 participants
Where
671 sitesin 28 countries
Study dates
11 Oct 2022to Oct 2027
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m ²)
  • Are either
  • individuals ≥40 years of age with established cardiovascular disease (CVD).
  • CVD is defined as meeting at least one of the following:
  • Coronary artery disease
  • Cerebrovascular disease
Show all 10Show fewer
  • Peripheral arterial disease OR
  • individuals without established CVD but have the presence of cardiovascular (CV) risk factors (primary prevention)
  • women 55-69 years of age or men 50-64 years of age with at least 3 risk factors like tobacco use, dyslipidemia, hypertension at screening, or
  • women ≥70 years of age or men, ≥65 years of age with at least 2 risk factors at screening.

Who cannot join

  • Have type 1 diabetes (T1D) or (T2D), history of ketoacidosis, or hyperosmolar state/coma
  • Have laboratory evidence diagnostic of diabetes mellitus at screening of HbA1c ≥6.5% (≥48 millimole/mole (mmol/mol) or fasting glucose (FG) ≥126 milligram/deciliter (≥7.0 millimole/liter (mmol/L).
  • Any one of the following CV conditions within 90 days prior to screening
  • MI
  • acute coronary syndrome
  • stroke
Show all 13Show fewer
  • coronary or peripheral arterial revascularization procedure, which may also include carotid artery revascularization, or
  • acute decompensated heart failure
  • Have a known clinically significant gastric emptying abnormality such as severe gastroparesis or gastric outlet obstruction or have undergone or currently planning any gastric bypass (metabolic) surgery or restrictive bariatric surgery. Note: Liposuction or abdominoplasty are not considered as gastric bypass procedures.
  • Have a history of chronic or acute pancreatitis
  • Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
  • Have acute or chronic hepatitis, or clinical signs or symptoms of any other liver disease, or have elevated liver enzyme measurements, determined by the central laboratory at screening
  • Have a presence or history of malignant neoplasms within the past 5 years prior to screening.

Trial locations and contacts

671 sites in 28 countries.

671 sites in 28 countries

United States165 sites

  • Albany Medical College, Division of Community Endocrinology

    Albany, New York, 12203

  • IMA Clinical Research

    Albuquerque, New Mexico, 87109

  • Smart Cures Clinical Research

    Anaheim, California, 92806

  • Trident Clinical Research Services, Inc.

    Apple Valley, California, 92307

  • Masters of Clinical Research

    Augusta, Georgia, 30909

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045

  • Texas Diabetes & Endocrinology, P.A.

    Austin, Texas, 78749

  • Pinnacle Clinical Research

    Austin, Texas, 78757

  • American Health Network of Indiana, LLC - Avon

    Avon, Indiana, 46123

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229

  • Heritage Valley Medical Group, Inc.

    Beaver, Pennsylvania, 15009

  • Billings Clinic

    Billings, Montana, 59101

  • Meridian Clinical Research, LLC

    Binghamton, New York, 13905

  • Elite Clinical Trials

    Blackfoot, Idaho, 83221

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114

  • Brigham and Women's Hospital Diabetes Program

    Boston, Massachusetts, 02115

  • Qualmedica Research

    Bowling Green, Kentucky, 42101

  • Encore Medical Research of Boynton Beach

    Boynton Beach, Florida, 33436

  • Capital Area Research, LLC

    Camp Hill, Pennsylvania, 17011

  • Hope Clinical Research, Inc.

    Canoga Park, California, 91303

  • WR-Clinsearch, LLC

    Chattanooga, Tennessee, 37421

  • IMA Clinical Research Chicago

    Chicago, Illinois, 60634

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303

  • Clinical Research of West Florida, Inc. (Clearwater)

    Clearwater, Florida, 33765

  • Optum- Southwestern

    Colorado Springs, Colorado, 80906

  • Centennial Medical Group

    Columbia, Maryland, 21045

  • Centricity Research Columbus Ohio Multispecialty

    Columbus, Ohio, 43213

  • John Muir Physician Network Research Center

    Concord, California, 94520

  • HOPE Clinical Research & Wellness

    Conyers, Georgia, 30094

  • The Corvallis Clinic, P.C.

    Corvallis, Oregon, 97330

  • Dallas Diabetes Research Center

    Dallas, Texas, 75230

  • Soma Clinical Trials

    Denison, Texas, 75020

  • Kidney Associates of Colorado

    Denver, Colorado, 80210

  • Memorial Hospital at Gulfport

    Diamondhead, Mississippi, 39525

  • UniMed Center

    East Brunswick, New Jersey, 08816

  • Medresearch Inc

    El Paso, Texas, 79902

  • Neighborhood Healthcare Institute of Health

    Escondido, California, 92025

  • Qualmedica Research, LLC

    Evansville, Indiana, 47715

  • NECCR PrimaCare Research

    Fall River, Massachusetts, 02721

  • Lillestol Research

    Fargo, North Dakota, 58104

  • Prime Health and Wellness/SKYCRNG

    Fayette, Mississippi, 39069

  • Northeast Research Institute (NERI)

    Fleming Island, Florida, 32003

  • Diabetes and Thyroid Center of Ft. Worth

    Fort Worth, Texas, 76132

  • Valley Institute of Research - Fort Worth

    Fort Worth, Texas, 76164

  • HB Clinical Trials - Fountain Valley

    Fountain Valley, California, 92708

  • Center for Advanced Research & Education

    Gainesville, Georgia, 30501

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC

    Gilbert, Arizona, 85296

  • OptumCare Clinical Trials, LLC

    Golden, Colorado, 80401

  • St. Vincent Hospital d/b/a Prevea Health

    Green Bay, Wisconsin, 54303

  • American Health Network of Indiana, LLC - Greenfield

    Greenfield, Indiana, 46140

  • Healthcare Research Network - St. Louis

    Hazelwood, Missouri, 63042

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814

  • AngioCardiac Care of Texas, PA

    Houston, Texas, 77025

  • Houston Methodist Hospital

    Houston, Texas, 77030

  • Biopharma Informatic, LLC

    Houston, Texas, 77043

  • Next Level Urgent Care

    Houston, Texas, 77057

  • Biopharma Informatic, LLC

    Houston, Texas, 77084

  • Research Physicians Network, LLC

    Houston, Texas, 77089

  • Valiance Clinical Research

    Huntington Park, California, 90255

  • Rocky Mountain Clinical Research

    Idaho Falls, Idaho, 83404

  • Northeast Research Institute - Downtown Office

    Jacksonville, Florida, 32204

  • NSC Research

    Johns Creek, Georgia, 30024

  • IHS Health Research

    Kissimmee, Florida, 34741

  • Scripps Whittier Diabetes Institute

    La Jolla, California, 92037

  • Velocity Clinical Research, San Diego

    La Mesa, California, 91942

  • Clinical Research of Central Florida

    Lakeland, Florida, 33805

  • First Valley Medical Group

    Lancaster, California, 93534

  • DaVita Clinical Research - Las Vegas

    Las Vegas, Nevada, 89107

  • Excel Clinical Research, LLC

    Las Vegas, Nevada, 89109

  • Palm Research Center Tenaya

    Las Vegas, Nevada, 89128

  • Palm Research Center Sunset

    Las Vegas, Nevada, 89148

  • Balanced Life Health Care Solutions/SKYCRNG

    Lawrenceville, Georgia, 30046

  • Epic Clinical Research

    Lewisville, Texas, 75057

  • NJ MedCare & NJ Heart

    Linden, New Jersey, 07036

  • KLR Business Group, Inc. dba Arkansas Clinical Research

    Little Rock, Arkansas, 72205

  • Long Beach Clinical Trials

    Long Beach, California, 90806

  • Monroe Biomedical Research - Louisville

    Louisville, Kentucky, 40213

  • Texas Institute for Kidney and Endocrine Disorders

    Lufkin, Texas, 75904

  • M Health Fairview St. John's Hospital

    Maplewood, Minnesota, 55109

  • South Florida Clinical Research Institute

    Margate, Florida, 33063

  • Hassman Research Institute Marlton Site

    Marlton, New Jersey, 08053

  • Biopharma Informatic, LLC

    McAllen, Texas, 78503

  • Texas Institute of Cardiology, PA

    McKinney, Texas, 75071

  • Velocity Clinical Research, Boise

    Meridian, Idaho, 83642

  • Solaris Clinical Research

    Meridian, Idaho, 83646

  • Aventiv Research

    Mesa, Arizona, 85206

  • Southern Endocrinology Associates

    Mesquite, Texas, 75149

  • ActivMed Practices and Research

    Methuen, Massachusetts, 01844

  • Felicidad Medical Research

    Miami, Florida, 33184

  • Floridian Clinical Research, LLC

    Miami Lakes, Florida, 33016-1518

  • Indago Research & Health Center, Inc

    Miami Lakes, Florida, 33016

  • Clinical Research Consulting

    Milford, Connecticut, 06460

  • IMA Clinical Research

    Morgantown, West Virginia, 26505

  • NYU Langone Health

    New York, New York, 10016

  • IMA Clinical Research

    New York, New York, 10036

  • Infinity Clinical Research - Norco

    Norco, California, 92860

  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma, 73069

  • North Hills Family Medicine/North Hills Medical Research

    North Richland Hills, Texas, 76180

  • California Medical Research Associates

    Northridge, California, 91324

  • Advanced Research Institute

    Ogden, Utah, 84405

  • Olive Branch Family Medical Center

    Olive Branch, Mississippi, 38654-3514

  • VA Nebraska-Western Iowa Health Care System

    Omaha, Nebraska, 68105

  • Diabetes Associates Medical Group

    Orange, California, 92868

  • University of California Irvine Medical Center

    Orange, California, 92868

  • Florida Institute For Clinical Research, LLC

    Orlando, Florida, 32825

  • Qualmedica Research, LLC

    Owensboro, Kentucky, 42301

  • FOMAT Medical Research

    Oxnard, California, 93030

  • Desert Oasis Healthcare Medical Group

    Palm Springs, California, 92262

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107

  • Tristar Clinical Investigations

    Philadelphia, Pennsylvania, 19114

  • Elite Clinical Studies

    Phoenix, Arizona, 85018

  • Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair

    Pittsburgh, Pennsylvania, 15243

  • Dream Team Clinical Research

    Pomona, California, 91767

  • Peace River Cardiovascular Center

    Port Charlotte, Florida, 33952

  • Rancho Cucamonga Clinical Research

    Rancho Cucamonga, California, 91730

  • Eastside Research Associates

    Redmond, Washington, 98052

  • Advanced Research Institute - Reno

    Reno, Nevada, 89511

  • Rainier Clinical Research Center

    Renton, Washington, 98057

  • Dominion Medical Associates, Inc.

    Richmond, Virginia, 23219

  • National Clinical Research, Inc

    Richmond, Virginia, 23294

  • SKY Integrative Medical Center/SKYCRNG

    Ridgeland, Mississippi, 39157

  • Artemis Institute for Clinical Research

    Riverside, California, 92503

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609

  • Northeast Research Institute - St. Augustine

    Saint Augustine, Florida, 32080

  • Clinical Trials of Texas, LLC

    San Antonio, Texas, 78229

  • Pinnacle Clinical Research

    San Antonio, Texas, 78229

  • VIP Trials

    San Antonio, Texas, 78230

  • Acclaim Clinical Research

    San Diego, California, 92120

  • Artemis Institute for Clinical Research

    San Diego, California, 92123

  • Advanced Research Institute - Sandy

    Sandy City, Utah, 84070

  • WR-Mount Vernon Clinical Research, LLC

    Sandy Springs, Georgia, 30328

  • Velocity Clinical Research, Santa Ana

    Santa Ana, California, 92704

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231

  • DaVita Clinical Research - North Houston

    Shenandoah, Texas, 77384

  • Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative

    Springfield, Illinois, 62702

  • Clinvest Research LLC

    Springfield, Missouri, 65807

  • IMA Clinical Research - St. Louis

    St Louis, Missouri, 63117

  • IMA Clinical Research St. Petersburg

    St. Petersburg, Florida, 33704

  • Cardiology Associates of Fairfield County, P.C.

    Stamford, Connecticut, 06905

  • Clinical Research of West Florida

    Tampa, Florida, 33606

  • Valiance Clinical Research

    Tarzana, California, 91356

  • Healthcare Research Network - Chicago

    Tinley Park, Illinois, 60477

  • Northwest Houston Heart Center

    Tomball, Texas, 77375

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, Kansas, 66606

  • Cotton O'Neil Mulvane

    Topeka, Kansas, 66606

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Torrance, California, 90502

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098

  • Pima Heart

    Tucson, Arizona, 85741

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia, 30291

  • Meridian Clinical Research, LLC

    Vestal, New York, 13850

  • Velocity Clinical Research, Waco

    Waco, Texas, 76710

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598

  • IMA Clinical Research Warren

    Warren Township, New Jersey, 07059

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708

  • Central Washington Health Services Association d/b/a Confluence Health

    Wenatchee, Washington, 98801

  • Texas Valley Clinical Research

    Weslaco, Texas, 78596

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa, 50266

  • Metabolic Research Institute, Inc.

    West Palm Beach, Florida, 33401

  • Kalo Clinical Research

    West Valley City, Utah, 84120

  • Millennium Clinical Trials

    Westlake Village, California, 91361

  • American Health Network of Indiana, LLC - Whiteland

    Whiteland, Indiana, 46184

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189

  • Soma Clinical Trials

    Wylie, Texas, 75098

  • Cardiology Consultants of Philadelphia Yardley

    Yardley, Pennsylvania, 19067

Other trials in United States

Argentina60 sites

  • CONEXA Investigacion Clinica S.A.

    Buenos Aires, 1012

  • Instituto Médico Especializado (IME)

    Buenos Aires, 1405

  • CEMEDIC

    Buenos Aires, 1407

  • Centro Privado de Medicina Familiar / Mindout Research

    Buenos Aires, 1417

  • Cicemo Srl

    Buenos Aires, 1424

  • Stat Research S.A.

    Buenos Aires, C1023AAB

  • Investigaciones Medicas Imoba Srl

    Buenos Aires, C1056ABH

  • Centro de Investigaciones Metabólicas (CINME)

    Buenos Aires, C1056ABI

  • Centro Médico Viamonte

    Buenos Aires, C1120AAC

  • Mautalen Salud e Investigación

    Buenos Aires, C1128AAF

  • Asociación de Beneficencia Hospital Sirio Libanés

    Buenos Aires, C1419AHN

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, C1425AGC

  • Fundación Respirar

    Buenos Aires, C1426ABP

  • Glenny Corp. S.A.

    Buenos Aires, C1430CKE

  • CENUDIAB

    Buenos Aires, C1440AAD

  • CEMEDIAB

    C.a.b.a., C1205AAO

  • CEDIC

    CABA, C1060ABN

  • CIPREC

    CABA, C1061AAS

  • Centro Medico Privado CEMAIC

    Capital, X5008HHW

  • Hospital San Roque

    Córdoba, 5000

  • Instituto de Investigaciones Clínicas Córdoba

    Córdoba, 5000

  • Sanatorio Privado Duarte Quirós

    Córdoba, 5002

  • Instituto Médico DAMIC

    Córdoba, 5003DCE

  • Centro Medico Privado San Vicente Diabetes

    Córdoba, 5006

  • Clínica Privada Velez Sarsfield

    Córdoba, 5016

  • CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani

    Córdoba, X5000AVE

  • Instituto Medico Strusberg

    Córdoba, X5000EDC

  • Centro de Investigaciones Clinicas Instituto del Corazon (CICIC)

    Córdoba, X5002HWE

  • MICA - Medicina e Investigación Cardiometabólica

    Del Viso, 1669

  • CIPADI - Centro Integral de Prevencion y Atencion en Diabetes

    Godoy Cruz, M5501ARP

  • Centro de Investigaciones Clínicas Baigorria

    Granadero Baigorria, 2152

  • CIMeL Clinical Research

    Lanus, B1824KAJ

  • Centro de Investigaciones Médicas Mar del Plata

    Mar del Plata, 7600

  • Instituto de Investigaciones Clínicas Mar del Plata

    Mar del Plata, 7600

  • Omega Salud

    Mar del Plata, 7602

  • Instituto de Cardiología Wolff

    Mendoza, 5500

  • CIAD Moron

    Morón, B1708EPE

  • DIM Clínica Privada

    Ramos Mejía, 1704

  • Instituto Médico Río Cuarto

    Río Cuarto, 5800

  • INECO Neurociencias Oroño

    Rosario, 2000

  • Instituto de Investigaciones Clinicas Rosario

    Rosario, 2000

  • Instituto Especialidades de la Salud Rosario

    Rosario, 2000

  • Instituto Médico Catamarca IMEC

    Rosario, 2000

  • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

    Rosario, 2000

  • Laboratorio de Hemostasia y Trombosis

    Rosario, 2000

  • Fundacion Estudios Clinicos

    Rosario, S2000DEJ

  • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan

    San Juan, 5400

  • Centro de Investigaciones Médicas Tucuman

    SAN M. de Tucuman, T4000AXL

  • Centro Modelo de Cardiología

    San Miguel de Tucumán, 4000

  • Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L

    San Miguel de Tucumán, 4000

  • Investigaciones Clínicas Tucumán

    San Miguel de Tucumán, 4000

  • Go Centro Medico San Nicolás

    San Nicolás, 2900

  • Centro de Diagnóstico y Rehabilitación (CEDIR)

    Santa Fe, 3000

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, 3000

  • Centro de Salud e Investigaciones Médicas

    Santa Rosa, 6300

  • Sanatorio Norte

    Santiago del Estero, 4200

  • Centro de Investigaciones Medicas Temperley

    Temperley, 1834

  • Sanatorio San Martin

    Venado Tuerto, 2600

  • Clinica Central

    Villa Regina, 8336

  • Instituto de Investigaciones Clinicas Zarate

    Zárate, B2800DGH

Other trials in Argentina

Mexico41 sites

  • Fundación Cardiovascular de Aguascalientes A.C.

    Aguascalientes, 20230

  • Investigacion En Salud Y Metabolismo Sc

    Chihuahua City, 31110

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares

    Ciudad Madero, 89440

  • Centro de Investigación y Gastroenterología

    Cuauhtémoc, 06700

  • Instituto de Diabetes, Obesidad y Nutricion

    Cuernavaca, 62250

  • Medical Group Culiacan

    Culiacán, 80200

  • Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.

    Culiacán, 80230

  • Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia

    Durango, 34000

  • Instituto Jalisciense de Investigacion en Diabetes y Obesidad

    Guadalajara, 04460

  • Diseno y Planeacion en Investigacion Medica

    Guadalajara, 44130

  • Centro de Investigacion Medica Integral

    Guadalajara, 44160

  • Universidad de Guadalajara

    Guadalajara, 44340

  • Clinica de Investigacion en Reumatologia y Obesidad S. C.

    Guadalajara, 44650

  • CICEJ Centro de Investigación Clínica Endocrinológica de Jalisco S.C

    Guadalajara, 44670

  • Private Practice - Dr. Arechavaleta Granell Maria del Rosario

    Guadalajara, 44670

  • Private Practice - Dr. Francisco Gerardo Padilla

    Guadalajara, 44670

  • Unidad de Investigación Clínica y Atención Médica HEPA

    Guadalajara, 44670

  • Virgen Cardiovascular Research SC

    Guadalajara, 44670

  • Investigación Médica Sonora, S.C.

    Hermosillo, 83270

  • EME RED Hospitalaria

    Mérida, 97000

  • Medical Care and Research SA de CV

    Mérida, 97070

  • Centro de Investigacion en Artritis y Osteoporosis SC

    Mexicali, 21200

  • RM Pharma Specialists

    Mexico City, 03100

  • Hospital de Jésus, I.A.P.

    Mexico City, 06090

  • Caimed Investigacion En Salud S.A. de C.V.

    Mexico City, 06760

  • Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares

    Mexico City, 11650

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

    Mexico City, 14080

  • Cardiolink Clin Trials

    Monterrey, 64060

  • IMED Internal Medicine Clin Trials

    Monterrey, 64060

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

    Monterrey, 64460

  • UBAM Unidad Biomedica Avanzada Monterrey

    Monterrey, 64460

  • Eukarya PharmaSite

    Monterrey, 64718

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

    Monterrey, 66460

  • Centro de Estudios Clínicos de Querétaro (CECLIQ)

    Querétaro, 76000

  • PanAmerican Clinical Research - Querétaro - Avenida Antea

    Querétaro, 76100

  • Unidad Médica para la Salud Integral

    San Nicolás de los Garza, 66465

  • Centro de Investigacion Cardiovascular y Metabólica

    Tijuana, 22500

  • Instituto Veracruzano en Investigación Clínica S.C.

    Veracruz, 91851

  • Arké SMO S.A de C.V

    Veracruz, 91910

  • Consultorio de Medicina Especilizada del Sector Privado

    Xalapa, 91193

  • Centro de Investigacion Medica de Occidente, S.C.

    Zapopan, 44260

Other trials in Mexico

China32 sites

  • Peking University People's Hospital

    Beijing, 100034

  • Beijing Friendship Hospital Affiliate of Capital University

    Beijing, 100050

  • Beijing Pinggu District Hospital

    Beijing, 101200

  • China-Japan Union Hospital

    Changchun, 130033

  • Beijing Tsinghua Changgung Hospital

    Changping, 102202

  • Chengdu Fifth People's Hospital

    Chengdu, 611130

  • West China Hospital Sichuan University

    Chengdu, 610041

  • Chongqing General Hospital

    Chongqing, 400014

  • Hainan General Hospital

    Haikou, 570311

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, 150001

  • Hebei Medical University - Harrison International Peace Hospital

    Hengshui Shi, 053000

  • First Huai'an Hospital Affiliated to Nanjing Medical University

    Huai'an, 223300

  • Huzhou Central Hospital

    Huzhou, 313000

  • Jinan Central Hospital

    Jinan, 250013

  • The First People's Hospital of Yunnan Province

    Kunming, 650034

  • Lanzhou university second hospital

    Lanzhou, 730030

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003

  • The Third Hospital of Nanchang

    Nanchang, 330008

  • Nanjing First Hospital

    Nanjing, 210006

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210011

  • Nanjing Medical University - Nanjing Jiangning Hospital

    Nanjing, 211100

  • Third People's Hospital of Hainan Province

    Sanya, 572000

  • Shanghai 9th People hospital

    Shanghai, 200023

  • The People's Hospital of Liaoning Province

    Shenyang, 110000

  • Siping Central People's Hospital

    Siping, 136000

  • Tianjin Medical University General Hospital

    Tianjin, 300052

  • Tianjin People' s Hospital

    Tianjin, 300121

  • Wuhan University Medical College - Hubei Zhongshan Hospital

    Wuhan, 430030

  • Wuxi People's Hospital

    Wuxi, 214023

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, 710061

  • Shaanxi provincial people's hospital

    Xi'an, 710068

  • The Second Affiliated Hospital of Zhengzhou University

    Zhengzhou, 450014

Other trials in China

Spain29 sites

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, 15006

  • Centro Periférico de Especialidades Bola Azul

    Almería, 04009

  • Hospital Universitario de La Ribera

    Alzira, 46600

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035

  • Hospital Clínic de Barcelona

    Barcelona, 08036

  • Osi Bilbao-Basurto

    Bilbao, 48013

  • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval

    Ferrol, 15405

  • Hospital Universitario San Cecilio

    Granada, 18016

  • Complejo Asistencial Universitario de León - Hospital de León

    León, 24008

  • Hospital Universitario Arnau de Vilanova de Lleida

    Lleida, 25198

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28009

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040

  • Hospital Quirón Málaga

    Málaga, 29004

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010

  • Hospital Universitario Central de Asturias

    Oviedo, 33011

  • Clínica Juaneda

    Palma de Mallorca, 07014

  • Clinica Universidad de Navarra

    Pamplona, 31008

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, 28223

  • Hospital Universitario de Canarias

    San Cristóbal de La Laguna, 38320

  • Hospital Virgen del Camino

    Sanlúcar de Barrameda, 11540

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    Seville, 41003

  • Hospital Quiron Infanta Luisa

    Seville, 41010

  • Vithas Hospital Sevilla

    Seville, 41950

  • Hospital Clinico de Valencia

    Valencia, 46010

  • Hospital General Universitario de Valencia

    Valencia, 46014

  • Hospital Universitario Doctor Peset

    Valencia, 46017

  • Hospital Virgen de las Montañas

    Villamartín, 11650

Other trials in Spain

Brazil28 sites

  • Centro de Pesquisa Clinica do Brasil

    Brasília, 71625-175

  • Chronos Pesquisa Clínica

    Brasília, 72145-450

  • Centro de Pesquisa Sao Lucas

    Campinas, 13034-685

  • Instituto de Pesquisa clinica de Campinas

    Campinas, 13060-080

  • Loema Instituto de Pesquisa Clinica

    Campinas, 13092133

  • Cline Research Center

    Curitiba, 80030-480

  • Quanta Diagnóstico e Terapia

    Curitiba, 80045170

  • Centro de Diabetes Curitiba

    Curitiba, 80810-040

  • Centro De Diabetes Metabolismo E Endocrinologia

    Fortaleza, 60175-047

  • Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas

    Fortaleza, 60430-350

  • Instituto Do Coracao De Marilia

    Marília, 17515-000

  • CHN - Complexo Hospitalar de Niterói

    Niterói, 24020-096

  • Núcleo de Pesquisa Clínica do Rio Grande do Sul

    Porto Alegre, 90430-001

  • IBPClin - Instituto Brasil de Pesquisa Clínica

    Rio de Janeiro, 22241-180

  • Pesquisare Saude

    Santo André, 09080-110

  • Praxis Pesquisa Medica

    Santo André, 09790790

  • Centro Multidisciplinar de Estudos Clinicos

    São Bernardo do Campo, 09715-090

  • ISPEM - Instituto São José dos Campos em Pesquisas Médicas

    São José dos Campos, 12243-280

  • Instituto de Pesquisa Clinica

    São Paulo, 01223-001

  • CPQuali Pesquisa Clínica

    São Paulo, 01228-000

  • CPCLIN

    São Paulo, 01228-200

  • NotreDame Intermedica Saude S.A

    São Paulo, 01229-010

  • BR Trials - Ensaios Clinicos e Consultoria

    São Paulo, 01236030

  • Hospital 9 De Julho

    São Paulo, 01409-902

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, 04266-010

  • Hospital das Clinicas FMUSP

    São Paulo, 05403-000

  • CEDOES

    Vitória, 29055450

  • Integral Pesquisa e Ensino

    Votuporanga, 15500-269

Other trials in Brazil

Canada26 sites

  • LMC Clinical Research Inc. (Brampton)

    Brampton, L6S 0C6

  • C-health Research

    Calgary, T2V 4J2

  • Ecogene-21

    Chicoutimi, G7H 7K9

  • Med Trust Research

    Courtice, L1E 2J5

  • Medicor Research

    Greater Sudbury, P3C 1X3

  • Health Sciences North

    Greater Sudbury, P3E 5J1

  • NSHA-QEII Health Sciences Centre-Dickson Bldg

    Halifax, B3H 1V7

  • Premier Clinical Trial Network

    Hamilton, L8L 5G4

  • The Wharton Medical Clinic Clinical Trials Inc

    Hamilton, L8L 5G8

  • Manna Research

    Lévis, G6W 0M5

  • Viacar Recherche Clinique

    Longueuil, J4H 4B9

  • G A Research Associates

    Moncton, E1G 1A7

  • Power Clinical Research

    Montreal, H3M 1L3

  • Fraser Clinical Trials Inc

    New Westminster, V3L 3W4

  • North York Diagnostic and Cardiac Centre

    North York, M6B 3H7

  • Centricity Research Oshawa

    Oshawa, L1J 2K9

  • Manna Research Montreal

    Pointe-Claire, H9R 4S3

  • Alpha Recherche Clinique

    Québec, G2J 0C4

  • ALPHA Recherche Clinique

    Québec, G3K 2P8

  • Bluewater Clinical Research Group Inc.

    Sarnia, N7T 4X3

  • Synergy Medical Clinic

    Sherwood Park, T8H 0N2

  • Centre de Medecine Metabolique de Lanaudiere (CMML)

    Terrebonne, J6X 4P7

  • LMC Clinical Research Inc. (Bayview)

    Toronto, M4G 3E8

  • Diabetes Heart Research Centre

    Toronto, M6G 1M2

  • Dr. Anil K. Gupta Medicine Professional Corporation

    Toronto, M9V 4B4

  • Dr. M.B. Jones Inc.

    Victoria, V8V 4A1

Other trials in Canada

Romania25 sites

  • SC Minimed SRL

    Bacau, 600274

  • CMI Cardiologie - Dr. Mercea Corina Delia

    Baia Mare, 430124

  • CMI DNBM Dr. Pop Lavinia

    Baia Mare, 430222

  • C.M.D.T.A. Neomed

    Brasov, 500283

  • Nicodiab

    Bucharest, 010507

  • Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului

    Bucharest, 011053

  • Centrul Medical NutriLife

    Bucharest, 013764

  • Centrul Medical Endocrinologie si Diabet Dr. Paveliu

    Bucharest, 50538

  • S.C. Cardiomed S.R.L.

    Craiova, 200513

  • Spitalul Clinic Județean de Urgență

    Craiova, 200642

  • Milena Sante

    Galați, 800001

  • Diamed Obesity

    Galați, 800291

  • Centrul Medical Consultmed

    Iași, 700547

  • Gama Diamed

    Mangalia, 905500

  • Diabdana

    Oradea, 410147

  • Centrul Medical Grandmed

    Oradea, 410159

  • Sal Med Srl

    Piteşti, 110424

  • Dianutrilife Medica

    Ploieşti, 100561

  • Clinica Korall

    Satu Mare, 440055

  • Gensan S.R.L. - Policlinica Astra Sibiu

    Sibiu, 550371

  • Centrul Medical Mediab

    Târgu Mureş, 540142

  • Private Practice - Dr. Cristian Podoleanu

    Târgu Mureş, 540143

  • Cabinet Medical Dr.Geru

    Timișoara, 300288

  • Institutul de Boli Cardiovasculare Timișoara

    Timișoara, 300310

  • Centrul Medical Medicalis

    Timișoara, 300362

Other trials in Romania

Poland23 sites

  • Osteo Medic sc A. Racewicz, J. Supronik

    Bialystok, 15-351

  • Legeartis - Poradnie Specjalistyczne

    Bialystok, 15-404

  • Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna

    Bialystok, 15445

  • Centrum Medyczne NEUROMED

    Bydgoszcz, 85-163

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85-231

  • INTERCOR

    Bydgoszcz, 85-605

  • Diab Serwis Popenda Spółka Jawna

    Chorzów, 41-500

  • Ambulatorium Sp. z o.o.

    Elblag, 82-300

  • Centrum Kliniczno-Badawcze

    Elblag, 82-300

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    Gdansk, 80-546

  • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

    Krakow, 31-261

  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, 90338

  • Gabinety TERPA

    Lublin, 20-333

  • Drelich Grzegorz Centrum Kardiologiczne Kardio-Med

    Lublin, 20-518

  • Ekamed

    Lublin, 20-718

  • Gaja Poradnie Lekarskie Maciej Wiza

    Poznan, 61-251

  • Nzoz Neuro-Kard Ilkowski i Partnerzy SPL

    Poznan, 61-853

  • Centrum Medyczne "Diabetika"

    Radom, 26-600

  • NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

    Ruda Śląska, 41-709

  • NBR Polska

    Warsaw, 00-710

  • Centralny Szpital Kliniczny MSW w Warszawie

    Warsaw, 02-507

  • Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej

    Wroclaw, 50-403

  • 4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ

    Wroclaw, 50-981

Other trials in Poland

Australia21 sites

  • Nightingale Research

    Adelaide, 5000

  • Royal Adelaide Hospital

    Adelaide, 5000

  • Paratus Clinical Research Western Sydney

    Blacktown, 2148

  • Box Hill Hospital

    Box Hill, 3128

  • Royal Brisbane and Women's Hospital

    Brisbane, 4029

  • Core Research Group

    Brisbane, 4064

  • Emeritus Research

    Camberwell, 3124

  • Victorian Heart Hospital

    Clayton, 3168

  • Paratus Clinical Research Canberra

    Deakin, 2600

  • Barwon Health

    Geelong, 3220

  • Austin Health - Repatriation Hospital

    Heidelberg West, 3081

  • Royal Hobart Hospital

    Hobart, 7000

  • Advara HeartCare Joondalup

    Joondalup, 6027

  • Paratus Clinical Research Central Coast

    Kanwal, 2259

  • Logan Hospital

    Meadowbrook, 4131

  • Baker IDI Heart and Diabetes Institute - Melbourne

    Melbourne, 3004

  • The AIM Centre / Hunter Diabetes Centre

    Merewether, 2291

  • GenesisCare - Murdoch - Murdoch Drive

    Murdoch, 6150

  • Southern Adelaide Diabetes & Endocrine Services

    Oaklands Park, 5046

  • University of Sydney - Charles Perkins Centre

    Sydney, 2006

  • The Queen Elizabeth Hospital

    Woodville, 5011

Other trials in Australia

Germany21 sites

  • Zentrum für klinische Studien Bad Homburg

    Bad Homburg, 61348

  • Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen

    Bad Oeynhausen, 32545

  • Klinische Forschung Berlin

    Berlin, 10787

  • Universitaetsklinikum Carl Gustav Carus Dresden

    Dresden, 01307

  • InnoDiab Forschung Gmbh

    Essen, 45136

  • Medizentrum Essen Borbeck

    Essen, 45355

  • Praxis am Markt - Dr. Bernd Becker

    Essen, 45355

  • Universitätsklinikum Frankfurt Goethe-Universität

    Frankfurt, 60590

  • ClinPhenomics CVC GmbH

    Frankfurt, 60596

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, 79106

  • Velocity Clinical Research Hamburg GmbH

    Hamburg, 20095

  • Diabeteszentrum Hamburg West

    Hamburg, 22607

  • AmBeNet GmbH

    Leipzig, 04107

  • UKSH Campus Lübeck, Med. 1 - AG Meyhöfer

    Lübeck, 23562

  • Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz

    Ludwigshafen am Rhein, 67059

  • Institut für Diabetesforschung GmbH Münster

    Münster, 48145

  • Arztpraxis Christine Kosch Pirna

    Pirna, 01796

  • Zentrum für klinische Studien

    Saint Ingbert, 66386

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076

  • Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob

    Villingen-Schwenningen, 78048

  • Praxis Sauter & Sauter & Vorbach

    Wangen, 88239

Other trials in Germany

Hungary18 sites

  • DRC Gyógyszervizsgáló Központ

    Balatonfüred, 8230

  • Szent Margit Rendelintézet

    Budapest, 1032

  • Clinexpert Kft.

    Budapest, 1033

  • Óbudai Egészségügyi Centrum

    Budapest, 1036

  • Semmelweis University

    Budapest, 1083

  • Dél-Pesti Centrumkórház

    Budapest, 1097

  • Magyar Honvedseg Egeszsegugyi Kozpont

    Budapest, 1134

  • Szatmari-Med Egeszsegugyi Szolgaltato

    Budapest, 1213

  • Újpesti Egészségügyi Nonprofit Kft

    Budapest, H-1046

  • Strazsahegy Medicina Bt.

    Budapest, H1171

  • Bajcsy-Zsilinszky Kórház

    Budapest

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • Kistarcsai Flor Ferenc Korhaz

    Kistarcsa, 2143

  • Selye János Kórház

    Komárom, 2900

  • Nagykanizsai Kanizsai Dorottya Korhaz

    Nagykanizsa, 8800

  • Allergo-Derm Bakos Kft

    Szolnok, 5000

  • Markusovszky Egyetemi Oktatokorhaz

    Szombathely, 9700

  • Minoseg Orvoscsoport Kft

    Veszprém, 8200

Other trials in Hungary

Turkey (Türkiye)17 sites

  • Çukurova Üniversitesi Tıp Fakültesi Adana Hastanesi

    Adana, 01790

  • Ankara Universitesi Tip Fakultesi Hastanesi

    Ankara, 06230

  • Akdeniz Universitesi Hastanesi

    Antalya, 07070

  • Adnan Menderes University Medical Faculty

    Aydin, 09100

  • Dokuz Eylül Üniversitesi

    Balçova, 35340

  • Ege Universitesi Hastanesi

    Bornova, 35100

  • Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre

    Denizli, 20070

  • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

    Gaziantep, 27310

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Kadıköy, 34722

  • Erciyes University Medical Faculty

    Kayseri, 38030

  • Necmettin Erbakan Meram Medical Fac.

    Konya, 42080

  • Inonu Universitesi Turgut Ozal Tıp Merkezi

    Malatya, 44000

  • Mersin University

    Mersin, 33343

  • Sisli Etfal Training and Research Hospital

    Sariyer, 34396

  • Cumhuriyet Universitesi

    Sivas, 58140

  • Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi

    Yıldırım, 16310

  • Baskent University Dr. Turgut Noyan Research and Training Center

    Yüreğir, 01250

Other trials in Turkey (Türkiye)

Israel15 sites

  • Barzilai Medical Center

    Ashkelon, 7830604

  • Rambam Health Care Campus

    Haifa, 3109601

  • Linn Medical Center

    Haifa, 3515209

  • Edith Wolfson Medical Center

    Holon, 5810001

  • Hadassah Medical Center

    Jerusalem, 9112001

  • Meir Medical Center

    Kfar Saba, 4428164

  • Galilee Medical Center

    Nahariya, 2210001

  • Rabin Medical Center

    Petah Tikva, 49100

  • Rabin Medical Center - Hasharon Campus

    Petah Tikva, 4937211

  • Rabin Medical Center

    Petah Tikva, 4941492

  • Sheba Medical Center

    Ramat Gan, 5262100

  • Kaplan Medical Center

    Rehovot, 7610001

  • Clalit Health Services - Sakhnin Community Clinic

    Sakhnin, 3081000

  • Sourasky Medical Center

    Tel Aviv, 6423906

  • Yitzhak Shamir Medical Center

    Tsrifin, 70300

Other trials in Israel

Italy15 sites

  • A.O.U.C. Policlinico di Bari

    Bari, 70124

  • IRCCS - AOU di Bologna

    Bologna, 40138

  • Presidio Ospedaliero Ospedale Sant'Anna

    Como, 22042

  • Azienda Ospedaliero Universitaria S.Anna

    Ferrara, 44124

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134

  • Ospedale Santa Maria Goretti

    Latina, 04100

  • Azienda Ospedale - Università Padova

    Padova, 35128

  • A.O.U. Policlinico Paolo Giaccone

    Palermo, 90127

  • Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli

    Palermo, 90127

  • Azienda Ospedaliera Universitaria Pisana

    Pisa, 56124

  • Azienda Ospedaliera Universitaria Pisana

    Pisa, 56126

  • Fondazione Policlinico Universitario Campus Bio-Medico

    Rome, 00128

  • Fondazione Policlinico Tor Vergata

    Rome, 00133

  • IRCCS Policlinico San Donato

    San Donato Milanese, 20097

  • Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino

    Torino, 10126

Other trials in Italy

United Kingdom15 sites

  • Oakenhurst Medical Practice

    Blackburn, BB2 1AX

  • Southmead Hospital

    Bristol, BS10 5NB

  • University Hospital Coventry & Warwickshire

    Coventry, CV2 2DX

  • Ninewells Hospital and Medical School

    Dundee, DD1 9SY

  • Staploe Medical Centre

    Ely, CB7 5JD

  • Fowey River Practice

    Fowey, PL23 1DT

  • Hull Royal Infirmary

    Hull, HU3 2JZ

  • Ipswich Hospital

    Ipswich, IP4 5PD

  • Leicester General Hospital

    Leicester, LE5 4PW

  • Royal Victoria Infirmary

    Newcastle upon Tyne, NE1 4LP

  • Knowle House Surgery

    Plymouth, PL5 3JB

  • Wickersley Health Centre - Clifton Medical Centre

    Rotherham, S65 1DA

  • Lister Hospital

    Stevenage, SG1 4AB

  • Rame Group Practice

    Torpoint, PL11 2TB

  • The Royal Cornwall Hospital

    Truro, TR1 3LJ

Other trials in United Kingdom

Czechia14 sites

  • MEDICUS SERVICES s.r.o., kardiologicka ambulance

    Brandýs nad Labem, 250 01

  • Nemocnice Cesky Krumlov

    Český Krumlov, 381 01

  • Asclepiades - interna a gastroenterologie s.r.o.

    Havířov, 736 01

  • CTC Hodonin s.r.o.

    Hodonín, 695 01

  • GAE s.r.o.

    Jindřichův Hradec, 377 38

  • PreventaMed

    Olomouc, 779 00

  • Kardiologicka a Angiologicka Ambulance

    Ostrava, 700 30

  • Nefrologie

    Prague, 149 00

  • FaraCol s.r.o.

    Prague, 150 00

  • Poliklinika Lípa Centrum

    Prague, 158 00

  • Kardiologicka ambulance s.r.o.

    Příbram, 261 01

  • Angionika

    Slaný, 274 01

  • Kardiologicka ambulance MUDr. Ferkl s.r.o.

    Trutnov, 541 01

  • Cardio Research, s.r.o

    Zlín, 760 01

Other trials in Czechia

Greece14 sites

  • General Hospital of Athens "G. Gennimatas"

    Athens, 11527

  • General Hospital of Athens Laiko

    Athens, 11527

  • Athens Medical Center

    Athens, 151 25

  • Attikon General University Hospital

    Chaïdári, 12462

  • University General Hospital of Heraklion

    Heraklion, 71110

  • University Hospital of Ioannina

    Ioannina, 45500

  • General Hospital of Lamia

    Lamia, 351 00

  • University General Hospital of Larissa

    Larissa, 41110

  • Iatriko Paleou Falirou Medical Center

    Palaió Fáliro, 17562

  • Thermi Clinic

    Thermi,Thessaloniki, 570 01

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 546 36

  • Euromedica General Clinic of Thessaloniki

    Thessaloniki, 546 45

  • Ippokrateio General Hospital of Thessaloniki

    Thessaloniki, 54642

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 564 03

Other trials in Greece

France13 sites

  • Centre Hospitalier Sud Francilien

    Corbeil-Essonnes, 91106

  • Chu Grenoble Alpes

    La Tronche, 38700

  • Centre Hospitalier Louis Pasteur

    Le Coudray, 28630

  • Hôtel-Dieu du Creusot - site Harfleur

    Le Creusot, 71200

  • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren

    Limoges, 87042

  • Centre Hospitalier Universitaire de Nice - Hôpital l'Archet

    Nice, 06202

  • Assistance Publique Hôpitaux de Paris - Groupe Hospitalier 10e - Hôpital Lariboisière

    Paris, 75010

  • Hôpital Européen Georges Pompidou

    Paris, 75015

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69494 Cédex

  • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

    Saint-Herblain, 44800

  • CHU Strasbourg-Hautepierre

    Strasbourg, 67098

  • CHU Rangueil

    Toulouse, 31059

  • Groupe Hospitalier Mutualiste Les Portes du Sud

    Vénissieux, 69200

Other trials in France

Netherlands11 sites

  • Ziekenhuisgroep Twente, locatie Almelo

    Almelo, 7609 PP

  • Meander Medisch Centrum

    Amersfoort, 3813 TZ

  • Reinier de Graaf Ziekenhuis, locatie Delft

    Delft, 2625 AD

  • Albert Schweitzer Ziekenhuis, locatie Dordwijk

    Dordrecht, 3318 AT

  • Treant, locatie Scheper Ziekenhuis

    Emmen, 7824 AA

  • General Practitioners Research Institute (GPRI)

    Groningen, 9713 GH

  • Martini Ziekenhuis

    Groningen, 9728 NT

  • Spaarne Gasthuis, Haarlem Zuid

    Haarlem, 2035 RC

  • Elkerliek Ziekenhuis

    Helmond, 5707 HA

  • Franciscus Gasthuis & Vlietland, Locatie Gasthuis

    Rotterdam, 3045 PM

  • Ziekenhuis Rivierenland

    Tiel, 4002 WP

Other trials in Netherlands

Taiwan11 sites

  • Hsinchu Mackay Memorial Hospital

    Hsinchu, 300

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

  • Chang Gung Memorial Hospital at Kaohsiung

    Kaohsiung Niao Sung Dist, 83301

  • Far Eastern Memorial Hospital

    New Taipei City, 220

  • Taipei Medical University Shuang Ho Hospital

    New Taipei City, 235

  • Mackay Memorial Hospital -Tamshui Branch

    New Taipei City, 251

  • National Cheng Kung University Hospital

    Tainan, 704

  • Chi Mei Medical Center

    Tainan, 71004

  • Taipei Medical University Hospital

    Taipei, 110

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Tri-Service General Hospital

    Taipei, 114

Other trials in Taiwan

India10 sites

  • Gujarat Endocrin Pvt Ltd

    Ahmedabad, 380052

  • Sardar Patel Medical College

    Bikaner, 334001

  • Osmania General Hospital

    Hyderabad, 500012

  • King George's Medical University

    Lucknow, 226003

  • Dayanand Medical College and Hospital

    Ludhiana, 141001

  • Sir JJ Group of Hospitals

    Mumbai, 400008

  • Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)

    Nagpur, 440001

  • G.B. Pant Institute of Postgraduate Medical Education & Research

    New Delhi, 110002

  • Nirmal Hospital Pvt Ltd.

    Surat, 395002

  • Shri Bachubhai Dahyabhai Mehta Mahavir Heart Institute

    Surat, 395002

Other trials in India

Belgium9 sites

  • AZORG Campus Aalst-Moorselbaan

    Aalst, 9300

  • Imelda General Hospital

    Bonheiden, 2820

  • Université Libre de Bruxelles - Hôpital Erasme

    Brussels, 1070

  • Antwerp University Hospital

    Edegem, 2650

  • UZ Gent

    Ghent, 9000

  • Jessa Ziekenhuis

    Hasselt, 3500

  • UZ Leuven

    Leuven, 3000

  • Az Damiaan vzw

    Ostend, 8400

  • AZ Nikolaas

    Sint-Niklaas, B-9100

Other trials in Belgium

Japan9 sites

  • Tokyo-Eki Center-building Clinic

    Chūōku, 103-0027

  • Fukuoka Wajiro Hospital

    Fukuoka, 811-0213

  • Rinku General Medical Center

    Izumisano, 598-8577

  • Rakuwakai Otowa Hospital

    Kyoto, 607-8062

  • Tokyo Saiseikai Central Hospital

    Minatoku, 108-0073

  • Fukuoka Shinmizumaki Hospital

    Onga-gun, 807-0051

  • AMC Nishiumeda Clinic

    Osaka, 530-0001

  • Shimada Clinic - Osaka

    Osaka, 535-0002

  • Uji-Tokushukai Medical Center

    Uji, 611-0041

Other trials in Japan

South Korea8 sites

  • Korea University Ansan Hospital

    Ansan-si, 15355

  • Pusan National University Hospital

    Busan, 49241

  • Seoul National University Bundang Hospital

    Seongnam, 13620

  • Kyung Hee University Hospital

    Seoul, 02447

  • Korea University Anam Hospital

    Seoul, 02841

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722

  • Samsung Medical Center

    Seoul, 06351

  • Wonju Severance Christian Hospital

    Wŏnju, 26426

Other trials in South Korea

Austria7 sites

  • VIVIT

    Feldkirch, 6800

  • Medizinische Universität Graz

    Graz, 8036

  • Medizinische Universitaet Innsbruck

    Innsbruck, 6020

  • Klinik Landstraße

    Vienna, 1030

  • Zentrum für klinische Studien Dr Hanusch Gmbh

    Vienna, 1060

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090

  • Klinik Hietzing

    Vienna, 1130

Other trials in Austria

Puerto Rico7 sites

  • Advanced Clinical Research, LLC

    Bayamón, 00959

  • Dorado Medical Complex

    Dorado, 00646

  • Puerto Rico Health Institute

    Dorado, 00646

  • Manati Center for Clinical Research

    Manati, 00674

  • Puerto Rico Medical Research

    Ponce, 00717

  • Research and Cardiovascular Corp.

    Ponce, 00717

  • GCM Medical Group, PSC - Hato Rey Site

    San Juan, 00917

Other trials in Puerto Rico

Slovakia7 sites

  • MediTask

    Bratislava, 831 03

  • JM-Interna s.r.o

    Dolný Kubín, 02601

  • AMBORA s.r.o. Interna ambulancia

    Martin, 036 01

  • FUNKYSTUFF s.r.o.

    Nové Zámky, 940 01

  • BENIMED s.r.o. Kardiologicka ambulancia

    Piešťany, 921 01

  • DIA-MED CENTRUM s.r.o.

    Púchov, 020 01

  • PENTES s.r.o. Kardiologicka ambulancia

    Žilina, 010 01

Other trials in Slovakia

About this study

Official title: A Phase 3, Randomized, Double-blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults With Obesity

This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

Conditions
Obesity, Overweight
Being tested
Tirzepatide, Placebo
Medical subject headings
Obesity, Overweight

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • TirzepatideDrug

    Also called LY3298176

    Administered SC

  • PlaceboDrug

    Administered SC

Study groups in NCT05556512
Study groupRoleWhat they receive
TirzepatideExperimentalParticipants will receive escalated doses of tirzepatide subcutaneously (SC) up to a maximum tolerated dose.
Receives: Drug: Tirzepatide
PlaceboPlacebo comparatorParticipants will receive tirzepatide matched placebo.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of Any Component Event of Composite (All-Cause Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Coronary Revascularization, or Heart Failure Events)

    Time to first occurrence of any component event of composite, all-cause death, nonfatal MI, nonfatal stroke, coronary revascularization, or heart failure events that results in hospitalization or urgent visits.

    Measured: Up to 5 Years

Secondary outcomes (18)

  1. Time to Onset of Type 2 Diabetes (T2D)

    Measured: Up to 5 Years

  2. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)

    In participants with high or very high risk chronic kidney disease

    Measured: Up to 5 Years

  3. Time to First Occurrence of Any Component Event of Major Adverse Cardiovascular Events-3 (MACE-3) (CV Death, Nonfatal MI or Nonfatal Stroke)

    Time to first occurrence of any component event of MACE-3 (CV death, nonfatal MI or nonfatal stroke)

    Measured: Up to 5 Years

  4. Mean Change from Baseline Short Form-36 Version 2 (SF-36 v2) Acute Form Physical Functioning Domain Score

    The SF-36 v2 acute, 1-week recall version is a 36-item generic, participant-administered measure designed to assess the following 8 domains (Physical Functioning, Role-Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role - Emotional, and Mental Health. Each domain is scored individually and further aggregated into 2 health component summary scores, physical component and mental component summary. Scoring of each domain and both summary scores are norm-based and presented in the form of T-scores, with a mean of 50 and standard deviation of 10; higher scores indicate better levels of function and/or better health.

    Measured: Baseline, 2 Years

  5. Time to the Occurrence of All-cause Death

    Measured: Up to 5 Years

  6. Time to First Occurrence of CV Death

    Measured: Up to 5 Years

  7. Time to First Occurrence of MI

    Measured: Up to 5 Years

  8. Time to First Occurrence of Stroke

    Measured: Up to 5 Years

  9. Time to First Occurrence of Coronary Revascularization

    Measured: Up to 5 Years

  10. Time to First Occurrence Heart Failure (HF) Events

    Time to first occurrence heart failure (HF) events that result in hospitalization or urgent visits

    Measured: Up to 5 Years

  11. Time to First Occurrence of Hospitalization for Unstable Angina

    Measured: Up to 5 Years

  12. Time to first occurrence of Hospitalization or Urgent Visit

    Time to first occurrence of hospitalization or urgent visit due to atrial fibrillation, or cardioversion or ablation for atrial fibrillation

    Measured: Up to 5 Years

  13. Time to First Occurrence of Any Component Event of the Composite Endpoint (eGFR, ESRD, or Renal Death)

    Time to first occurrence of any component event of the composite endpoint ≥40% sustained decline in eGFR, ESRD, or renal death.

    Measured: Up to 5 Years

  14. Percent Change from Baseline in Body Weight

    Measured: Baseline, 156 Weeks

  15. Change from Baseline in Systolic Blood Pressure (SBP) in Millimeter Mercury (mmHg)

    Measured: Baseline, 156 Weeks

  16. Change from Baseline Diastolic Blood Pressure (DBP) (mmHg)

    Measured: Baseline, 156 Weeks

  17. Percentage of Participants with Hemoglobin A1c (HbA1c) <39 Millimole/Mole (mmol/mol) (5.7%)

    Percentage of participants with HbA1c <39 mmol/mol (5.7%) at each time where HbA1c is assessed for participants with a screening HbA1c ≥39 mmol/mol.

    Measured: Up to 5 Years

  18. Time to First Occurrence of Any Component Event of Composite Endpoint (All-Cause Death, Nonfatal MI, Nonfatal Stroke, Coronary Revascularization, Heart Failure Events, > 40% Sustained Decline in eGFR, or End Stage Renal Disease)

    In participants with prediabetes

    Measured: Up to 5 Years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Sep 2022
  2. Study start11 Oct 2022
  3. Primary completionOct 2027 (estimated)
  4. Study completionOct 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
15,374 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05556512
Sponsor's protocol ID
17253
Other IDs
I8F-MC-GPIJ, 2022-501744-15-00
Acronym
SURMOUNT-MMO
Status last verified
Oct 2026
First submitted
22 Sep 2022
Last updated
7 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Publications

  • Antza C, Anyfanti P, Poutachidis A, Poulis D, Belancic A, Kotsis V. Hypertension in young adults with obesity: new mechanisms and therapeutic options. Pol Arch Intern Med. 2026 Feb 26;136(2):17203. doi: 10.20452/pamw.17203. Epub 2026 Jan 23.

    PubMed 41589430

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Tirzepatide in people with Obesity and Overweight, run by Eli Lilly and Company at 671 sites in 28 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 10 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 671 sites in United States, Argentina, Mexico, China, Spain and 23 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of Any Component Event of Composite (All-Cause Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Coronary Revascularization, or Heart Failure Events) (time frame: Up to 5 Years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05556512, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.

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