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Gastroesophageal RefluxPhase 2NCT05556824

Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD

A Phase 2 study testing MHS-1031 in people with Gastroesophageal Reflux, run by Microbiome Health Sciences at 18 sites in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms. Read more about this study

Who is it for?
Ages 18 to 75 years
Conditions the study is for
Gastroesophageal Reflux
What is being tested?
MHS-1031
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
255 participants
Where
18 sitesUnited States
Study dates
3 Mar 2023to 27 May 2026
Phase
Phase 2
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 75 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • In the opinion of the investigator or sub-investigators, the subject is capable of understanding and complying with protocol requirements, including compliance with completing nightly online questionnaires in one of the IRB-approved languages.
  • Subject signs and dates an electronic (Screening Phase Part 1) and site-specific written informed consent form (ICF) and any required privacy authorization prior to the initiation of any study procedures.
  • Ability, during Remote Screening Phase 2-Week Assessment, to complete all required online nightly RESQ-eD questionnaires, medication questionnaires, 4-item Patient Health Questionnaire for Depression and Anxiety (PHQ-4) questionnaire and Participant Global Assessment questionnaire.
  • Access to a computer/tablet/phone with internet access and active email account in order to complete online questionnaires daily throughout study participation.
  • Males or females ≥18 and ≤75 years of age, with a BMI ≥ 18 and < 35 kg/m2.
  • Female subjects must be postmenopausal or surgically sterile or, if of childbearing potential, must agree to use a medically acceptable form of contraception from the time of signing the informed consent form through completion of study. If only the barrier method is used, a single barrier or better is adequate. Postmenopausal women must have had ≥ 12 months of spontaneous amenorrhea. Surgically sterile women are defined as those who have had a hysterectomy, bilateral ovariectomy, or bilateral tubal ligation. All women of childbearing potential must have a negative pregnancy test result before administration of study drug.
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  • Must be on stable doses of medications, if any, prescribed for chronic conditions other than GERD.
  • Subject must be taking daily PPI (defined as 5-7 days/week on average) for at least four (4) consecutive weeks with self-reported symptom improvement (frequency and/or severity) prior to the Screening Call selected from the following list of medications:
  • omeprazole
  • esomeprazole
  • lansoprazole
  • dexlansoprazole
  • pantoprazole
  • rabeprazole
  • Onset of GERD-related heartburn symptoms for a minimum of 3 months prior to Screening Call (i.e., "burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn" per questions 1, 2 or 3 of RESQ-eD).
  • Subject has maintained a stable diet and exercise regimen for ≥ 30 days prior to the Screening Call and is willing to maintain that diet and exercise regimen for the duration of the study (i.e., if subject is currently following diets including, but not limited to, Keto, FODMAP, Vegan, Vegetarian, s/he must be willing to continue this dietary lifestyle through end-of-study visit).

Who cannot join

  • Current use of any mouthwash (e.g., Listerine, Scope, others) or unwilling to discontinue use for the duration of the study (requires 3-day washout prior to starting the Remote Screening Phase 2-Week Assessment)
  • Teeth whitening within 7 days of Screening Call or current use of teeth whitening substances (not including teeth whitening toothpaste) or unwilling to discontinue use for the duration of the study (requires 7-day washout prior to starting the Remote Screening Phase 2-Week Assessment).
  • Current use of histamine 2 receptor antagonists (H2RAs) (requires 7-day washout prior to starting the Remote Screening Phase 2-Week Assessment).
  • Surgical procedure requiring general anesthesia within 60 days of the Screening Call
  • Colonoscopy, high colonic, colonic cleanse or barium enema in the past 30 days, or scheduled for colonoscopy or barium enema at any time for the duration of the study, and unwilling to postpone until after study completion.
  • History of cancer diagnosis and/or treatment (other than basal cell carcinoma of the skin) within the preceding five (5) years.
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  • Concomitant illness with potential to confound outcome assessments for this study, including, but not limited to:
  • History of untreated peptic or gastric ulcer, Zollinger-Ellison syndrome, or Helicobacter pylori (H. pylori) positivity without a history of successful treatment
  • History of ulcerative colitis or Crohn's disease.
  • Stomach ulcers, pancreaticobiliary disorder (e.g., gallstones bile duct stones, pancreatic stones, pancreatitis), diverticulitis symptomatic within the past 6 months.
  • Acute or chronic hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection.
  • Significant current morbidity of the heart, kidney, liver or lung.
  • History of Long QT Syndrome
  • History of Torsades de pointes (TdP)
  • Current neurological or psychiatric disorder (e.g., Parkinson's, Huntington's chorea, schizophrenia, seizure, bi-polar disorder, major depressive disorder).
  • Known or suspected alcoholism, drug addiction, or significant drug abuse within 1 year of the Screening Call based on subject reporting and PI assessment.
  • Active history of tobacco or nicotine use (of any type) in the last 6 months averaging more than 1 cigar/cigarette per week. Vaping products and e-cigarettes that contain nicotine and/or tobacco are not allowed. Chewing tobacco and nicotine gum are prohibited at any level. Nicotine patches are NOT exclusionary.
  • Alcohol abuse (for alcohol defined as: > 14 drinks/week or 4 drinks/day for men, 7 drinks/week or 3 drinks/day for women).
  • Intake of acetylsalicylic acid (i.e., aspirin) at doses > 162 mg/day.
  • Non-steroidal anti-inflammatory pain relievers (NSAIDs) such as ibuprofen (Advil®, Motrin® IB, others) >/= 4 days/week on average not to exceed half the recommended maximum prescription daily dosing as listed in the Physician's Desk Reference.
  • Acetaminophen > 2,000 mg/day
  • Inhalation or ingestion of products containing delta-9-tetrahydrocannabinol (THC) > 2 days/week on average.
  • Any known medical condition, clinical signs and symptoms, vital signs, abnormal laboratory, or other testing that are not well controlled on stable dosing of medication for at least 90 days prior to the Screening Call or are considered clinically significant by the Principal Investigator (PI), that could interfere with the subject's participation in and completion of the study. Examples of medical conditions including, but not limited to:
  • Uncontrolled hypertension
  • Uncontrolled diabetes
  • History of adrenal disease, diabetic nephropathy, or gastroparesis
  • Uncontrolled hypothyroidism
  • Untreated mental disorder
  • Paraplegia or Quadriplegia
  • Cerebrovascular event (stroke) or myocardial infarction (MI) within the last 6 months.
  • Structural abnormality of the GI tract, or disease or condition that can affect GI motility (e.g., achalasia, esophageal atresia), or defecation.
  • Planned travel outside the US during the study period or routine travel within the US during the study period that results in >2-hour time zone difference.
  • Cyclical work shift (e.g., routinely switching between day shifts and night shifts)
  • Any of the following current (within the past 6 months) symptomatic conditions:
  • pseudo-obstruction,
  • malignant polyps (requiring surgery),
  • abdominal adhesions confirmed via laparoscopy,
  • intestinal ischemia without colitis,
  • laxative or enema abuse.
  • History of ischemic colitis in the past 5 years.
  • Current COVID19 infection, or a history of a prior COVID19 infection with ongoing symptoms suggestive of "Long COVID".
  • Endoscopic evidence of any of the following:
  • Eosinophilic esophagitis, scleroderma, Barrett's esophagus, esophageal cancer, Candida esophagitis confirmed by histopathology.
  • LA grade B, C, or D erosive esophagitis, esophageal stricture or scarring.
  • History of surgery or endoscopic treatment including fundoplication and/or dilation for esophageal stricture.
  • History of fecal impaction that required hospitalization or emergency room treatment within 3 months of the Screening Call.
  • History of eating disorder within the last 2 years.
  • Symptomatic condition (e.g., polycystic kidney disease, endometriosis, ovarian cysts, etc.) during the 12 months prior to the Screening Call that required intervention (i.e., clinic or emergency room visit or hospitalization) that may be associated with chronic abdominal pain or discomfort and might confound the assessments in this study.
  • Surgical history that meets any of the following criteria:
  • Gastric bypass surgery or invasive procedure for the treatment of obesity or surgery to remove a segment of the GI tract at any time prior to the Screening Call
  • Gastric band present within the past 60 days
  • Open surgery of the abdomen, pelvis, or retroperitoneal structures within 6 months prior to the Screening Call
  • Laparoscopic appendectomy or cholecystectomy or other instrumentation of the bowel < 60 days prior to the Screening Call. NOTE: Endoscopic removal of benign polyps is not exclusionary.
  • Prior use of the study medication MHS-1031 or ISOThrive Prebiotic Nectar.
  • Use of fructo-oligosaccharides (FOS) or inulin.
  • Symptomatic condition (e.g., angina, rumination, or other conditions involving the mouth and/or throat) during the 12 months prior to the Screening Call.
  • Use of any of the following medications that have not been stable dosing for at least 90 days at time of Screening Call:
  • Anticholinergics, such as oxybutynin (e.g., Ditropan XL®)
  • Theophylline (e.g., Elixophyllin®, Theochron)
  • Bisphosphonates taken orally, such as alendronate (Fosamax), ibandronate (Boniva) and risedronate (Actonel®, Atelvia®)
  • Quinidine
  • Anticoagulants (e.g., Coumadin, Heparin)
  • Iron supplement (other than contained in multi-vitamin)
  • Potassium supplements in pill form (Elixirs are NOT exclusionary)
  • Asthma medications
  • Prescription medication to control Irritable Bowel Syndrome or Chronic Idiopathic Constipation
  • Use of Nitrates within the last 12 months.
  • Medication for depression, anxiety, or sleep (e.g., benzodiazepines such as diazepam (Valium®) and temazepam (Restoril) with uncontrolled symptoms or medication dosing that has not been stable for at least 90 days at time of Screening Call.
  • Antibiotic use within 60 days of the Screening Call.
  • Narcotic (e.g., opiate) or illicit drug (i.e., illegal at both the Federal and State levels; e.g. Cocaine, Heroin, Methamphetamine) use within 60 days of the Screening Call.
  • Use of any investigational product within 90 days prior to the Screening Call.
  • Use of GLP-1 agonists (e.g., Dulaglutide (Trulicity), Exenatide, Semaglutide (Ozempic/Wegovy), Liraglutide) or prescription medications used for weight loss within 6 months of Screening Call.
  • Current use of potassium-competitive acid blocker (PCAB). PCAB may not be used within one week of screening call.
  • Pregnancy, lactation, planned pregnancy or planned ova donation during the study period.
  • Participation in another investigation (clinical trial) during the course of this study.
  • Any major lifestyle change, such as getting married, change in residence, change in job, or other highly stressful event planned during the study periods.
  • Sustained daily use of PPIs without self-report of improvement of heartburn symptoms.
  • Self or relative employed directly or indirectly by the Sponsor or relative or employee of investigator or investigator's staff.
  • Other conditions or situations that, in the Investigator's opinion, may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study.

Trial locations and contacts

18 sites in 1 country.

18 sites in 1 country

United States18 sites

  • EmVenio-Georgia (EMGA)

    Atlanta, Georgia, 30345

  • University of Virginia Health System

    Charlottesville, Virginia, 22908

  • Charlottesville Medical Research Center

    Charlottesville, Virginia, 22911

  • Wr-Msra, Llc

    Lake City, Florida, 32055

  • Angel City Research

    Los Angeles, California, 90010

  • SMS Clinical Research (SMSR)

    Mesquite, Texas, 75149

  • A Positive Clinical Research

    Miami, Florida, 33186

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232

  • Digestive Disease and Liver Specialists

    Norfolk, Virginia, 23502

  • Advanced Gastroenterology Associates LLC

    Palm Harbor, Florida, 34684

  • Elite Clinical Studies LLC

    Phoenix, Arizona, 85018

  • M3 Wake Research (CPOR)

    Raleigh, North Carolina, 27612

  • GI Research Partners, LLC

    Richmond, Virginia, 23236

  • WR-Mount Vernon Clinical Research (MVCR)

    Sandy Springs, Georgia, 30328

  • A and U Family Medicine (NCR)

    Sugar Land, Texas, 77479

  • Health Synergy Clinical Research

    West Palm Beach, Florida, 33407

  • West Palm Quality Research (WPQR)

    West Palm Beach, Florida, 33407

  • Gastroenterology Associates of Western Michigan PLC (WMCR)

    Wyoming, Michigan, 49519

Other trials in United States

About this study

Official title: A Multi-Center Study of Panosyl-Isomaltooligosaccharides (PIMO) Adjunctive to Proton Pump Inhibitor (PPI) Therapy to Treat Gastroesophageal Reflux Disease (GERD) in Subjects Who Are PPI-Responders or PPI-Partial Responders

This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms.

Read the detailed description

MHS-1031 is a specific proprietary digestion-resistant oligosaccharide carbohydrate that serves as a prebiotic.

This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 adjunctive to PPI therapy on heartburn-free days in subjects with GERD-related heartburn symptoms who self-report improvement while on sustained daily PPI therapy. Heartburn-free days will be determined by subject report specific to any of the three questions ("burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn"; Questions 1, 2 \& 3 of the RESQ-eD). For purposes of this trial, heartburn-free days are defined as subject report of 'Did Not Have', or 'Very Mild' on each of the three RESQ-eD questions listed above.

All candidate subjects must self-report at least partial response to sustained daily PPI acid suppressive therapy (i.e. 'daily' defined as taking PPIs 5-7 days/week on average). Candidate subjects will be screened for medical history of chronic heartburn that may be associated with other medical conditions, and these subjects will be excluded. The entire study consists of three phases: Remote Screening Phase 2-Week Assessment (SP1), on-site Screening Phase Part 2 (SP2) and Treatment Phase (TP).

Efficacy will be assessed using patient reported outcome (PRO) questionnaires, concomitant medication assessments, and assessment of adverse events, from baseline (determined during Remote Screening Phase 2-Week Assessment) to Treatment Phase Weeks 1-4 and Weeks 5-8. The primary analyses will be conducted to assess the efficacy of MHS-1031 adjunctive to PPI therapy, and separately as monotherapy subsequent to combined PPI and MHS-1031 therapy, in randomized subjects with GERD-related heartburn as determined by the RESQ-eD validated questionnaire, validated for use online.

Being tested
MHS-1031, Placebo
Keywords
GERD, microbiome, PIMO, PPI, Heartburn, Gastroesophageal Reflux, Prebiotic
Medical subject headings
Gastroesophageal Reflux, Heartburn

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • MHS-1031Drug

    Also called Panosyl-isomaltooligosaccharide

    Study medication will be supplied as a syrup in individual sachets containing 1g (1.5 mL) of MHS-1031. Subjects will be randomized in 2:1 fashion to either study drug (2) or placebo (1)

  • PlaceboOther

    Matching placebo is an oral solution formulated to have a degree of sweetness and acidity similar to the study medication and will be provided in equivalent sachets containing 1.5g (1.5 mL) of the oral placebo solution.

Study groups in NCT05556824
Study groupRoleWhat they receive
Drug ProductActive comparatorPanosyl-isomaltooligosaccharide (PIMO) liquid 1 g (1.5 ml) per day for 8 weeks
Receives: Drug: MHS-1031
PlaceboPlacebo comparatorPlacebo liquid (1.5 ml) per day for 8 weeks
Receives: Other: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Heartburn-free days/week

    The difference between baseline weekly average heartburn-free days and weekly average heartburn-free days during Treatment Phase Weeks 1-4 and Weeks 5-8 (as measured using questions 1, 2 and 3 of the Reflux Symptom Questionnaire Electronic Diary) (RESQ-eD).

    Measured: 4 and 8 weeks

Secondary outcomes (3)

  1. Heartburn symptom severity

    The difference between baseline daily average heartburn symptom severity score and daily average heartburn symptom severity score during Treatment Phase Weeks 1-4 and Treatment Phase Weeks 5-8 (as measured using questions 1, 2 and 3 of the Reflux Symptom Questionnaire Electronic Diary) (RESQ-eD).

    Measured: 4 and 8 weeks

  2. Heartburn-free day satisfaction

    Any increase between baseline weekly average heartburn-free days and heartburn-free days during Treatment Phase Weeks 1-4 and Weeks 5-8 where Patient Global Assessment Question 1 is ≥ baseline.

    Measured: 4 and 8 weeks

  3. GERD-related severity satisfaction

    Any increase between baseline daily average heartburn severity and heartburn severity during Treatment Phase Weeks 1-4 and Weeks 5-8 where Patient Global Assessment Question 1 is ≥ baseline.

    Measured: 4 and 8 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Sep 2022
  2. Study start3 Mar 2023
  3. Primary completion27 May 2026
  4. Study completion27 May 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
255 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05556824
Sponsor's protocol ID
MHS-1031-04
Status last verified
Jul 2026
First submitted
21 Sep 2022
Last updated
27 Jul 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing MHS-1031 in people with Gastroesophageal Reflux, run by Microbiome Health Sciences at 18 sites in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 16 inclusion and 79 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 27 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 18 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Heartburn-free days/week (time frame: 4 and 8 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05556824.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2026.

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