Osteo Arthritis KneeNCT05577403
Effect of Mulligans Mobilization With Movement in Osteoarthritis Knee.
A study testing Mulligan's mobilization with movement MWM added isometric strength training in people with Osteo Arthritis Knee, run by Majmaah University at 1 site in Saudi Arabia.
Trial summary
To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee. Read more about this study
- Who is it for?
- Ages 40 to 65 years
- Conditions the study is for
- Osteo Arthritis Knee
- What is being tested?
- Mulligan's mobilization with movement MWM added isometric strength training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 5 Nov 2022to 14 Nov 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale.
- Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee.
Who cannot join
- Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement.
- They had received steroids or intra-articular injection within the previous three months, uncooperative patients.
Trial locations and contacts
1 site in 1 country.
Saudi Arabia1 site
Rehabilitation center, Majmaah University
Al Majma'ah, Riyadh Region, 15341
About this study
Official title: Effect of Mulligan's Mobilization With Movement Added With Isometric Exercises on Muscle Strength Pain and Disability Associated With Knee Osteoarthritis: A Randomized Controlled Study
To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee.
Read the detailed description
Patients with knee OA diagnosed at the orthopaedic clinic of Tumair general hospital and referred to the physiotherapy department who attended the rehabilitation centre of Majmaah university will be recruited.
Patients will be excluded if they have had a knee or hip injury, sensory deficits in the lower extremity, a history of lower-extremity surgery, a history of a quadriceps or hamstring muscle injury, low back-related leg pain, or any contraindication to manual therapy.
The protocol was submitted to and approved by the Rehabilitation Research Chair, King Saud University Research Ethics Committee (RRC-2021-17)
Participants will be requested to sign a written informed consent form approved by the institutional ethics committee. A total of 60 participants were randomly assigned to group A (experimental group): Mulligan's mobilization with movement MWM added isometric strength training, and group B (control group): Sham MWM added isometric strength training. Pre and post-test readings were taken at baseline, week 2, and week 4, respectively. The outcome measures for this study will be maximal voluntary isometric contraction of quadriceps strength (measured by ISOMOVE dynamometer), ROM, and Western Ontario and McMaster universities osteoarthritis (WOMAC) index.
- Conditions
- Osteo Arthritis Knee
- Being tested
- Mulligan's mobilization with movement MWM added isometric strength training
- Keywords
- Isometric exercise, Osteoarthritis, Rehabilitation
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mulligan's mobilization with movement MWM added isometric strength trainingBehavioural
Also called Sham MWM added isometric strength training
Mulligan's mobilization with movement added isometric exercise:
the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise.
Treatment will be given for the period of three weeks, for five days a week in both groups.
Data will be collected before intervention and after 2nd \& 4th week of intervention.
| Study group | Role | What they receive |
|---|---|---|
| Experimental Group | Experimental | Mulligan's mobilization with movement added isometric strength training will be given 3 days a week for six weeks. Receives: Behavioral: Mulligan's mobilization with movement MWM added isometric strength training |
| Control Group | Active comparator | Mobilization-added isometric strength training will be given 3 days a week for six weeks. Receives: Behavioral: Mulligan's mobilization with movement MWM added isometric strength training |
What is being measured
The primary outcome is the main question the study is designed to answer.
pain intensity
Visual Analogue scale on 0 to10 cm
Measured: 6 weeks
Range of Motion
Standard goniometer.
Measured: 6 weeks
Western Ontario and McMaster universities osteoarthritis (WOMAC) index
Western Ontario and McMaster universities osteoarthritis scale
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Oct 2022
- Study start5 Nov 2022
- Primary completion10 Nov 2023
- Study completion14 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Osteo Arthritis KneeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Allocation: Randomized
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Majmaah University
- Sponsor type
- University, hospital or other
- Collaborators
- King Saud University
- Responsible party
- Principal investigator, Shahnaz Hasan, PhD, Majmaah University
- Investigators
- Shahnaz Hasan, PhD, Principal investigator, Majmah University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05577403
- Sponsor's protocol ID
- RRC-2021-17
- Status last verified
- Nov 2023
- First submitted
- 7 Dec 2021
- Last updated
- 18 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data will be kept secure with the principal investigator (Dr. Shahnaz Hasan) and sub-investigator (Dr. Naiyer Shahzad) due to confidentiality issues.
Publications
Hasan S, Iqbal A, Ibrahim AR, Diab RH, Iqbal ZA, Hasan T, Anwer S, Alghadir AH. Mobilization with movement enhances early rehabilitation outcomes in knee osteoarthritis: a six-week randomized controlled trial. Chiropr Man Therap. 2026 Mar 22;34(1):11. doi: 10.1186/s12998-026-00636-0.
PubMed 41866518
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Mulligan's Mobilization With Movement Added With Isometric Exercises on Muscle Strength Pain and Disability Associated With Knee Osteoarthritis: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT05577403
- Acronym / sponsor ID
- RRC-2021-17
- Conditions
- Osteo Arthritis Knee
- Keywords
- Isometric exercise, Osteoarthritis, Rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Majmaah UniversityUniversity, hospital or other
- Collaborators
- King Saud University
- Study start
- 5 Nov 2022 (actual)
- Primary completion
- 10 Nov 2023 (actual)
- Study completion
- 14 Nov 2023 (actual)
- First posted
- 13 Oct 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee.
Detailed description
Patients with knee OA diagnosed at the orthopaedic clinic of Tumair general hospital and referred to the physiotherapy department who attended the rehabilitation centre of Majmaah university will be recruited.
Patients will be excluded if they have had a knee or hip injury, sensory deficits in the lower extremity, a history of lower-extremity surgery, a history of a quadriceps or hamstring muscle injury, low back-related leg pain, or any contraindication to manual therapy.
The protocol was submitted to and approved by the Rehabilitation Research Chair, King Saud University Research Ethics Committee (RRC-2021-17)
Participants will be requested to sign a written informed consent form approved by the institutional ethics committee. A total of 60 participants were randomly assigned to group A (experimental group): Mulligan's mobilization with movement MWM added isometric strength training, and group B (control group): Sham MWM added isometric strength training. Pre and post-test readings were taken at baseline, week 2, and week 4, respectively. The outcome measures for this study will be maximal voluntary isometric contraction of quadriceps strength (measured by ISOMOVE dynamometer), ROM, and Western Ontario and McMaster universities osteoarthritis (WOMAC) index.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Allocation: Randomized
| Arm | Type | Receives |
|---|---|---|
| Experimental Group | Experimental | Behavioral: Mulligan's mobilization with movement MWM added isometric strength trainingMulligan's mobilization with movement added isometric strength training will be given 3 days a week for six weeks. |
| Control Group | Active comparator | Behavioral: Mulligan's mobilization with movement MWM added isometric strength trainingMobilization-added isometric strength training will be given 3 days a week for six weeks. |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale.
- Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee.
Key exclusion criteria (2 listed)
- Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement.
- They had received steroids or intra-articular injection within the previous three months, uncooperative patients.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mulligan's mobilization with movement MWM added isometric strength trainingAlso: Sham MWM added isometric strength trainingMulligan's mobilization with movement added isometric exercise: the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise. Treatment will be given for the period of three weeks, for five days a week in both groups. Data will be collected before intervention and after 2nd \& 4th week of intervention. | Behavioural | Control Group, Experimental Group |
Primary outcome
pain intensity
Time frame: 6 weeks
Visual Analogue scale on 0 to10 cm
Range of Motion
Time frame: 6 weeks
Standard goniometer.
Western Ontario and McMaster universities osteoarthritis (WOMAC) index
Time frame: 6 weeks
Western Ontario and McMaster universities osteoarthritis scale
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2025.
- Derived from this study: PubMed 41866518Hasan S, Iqbal A, Ibrahim AR, Diab RH, Iqbal ZA, Hasan T, Anwer S, Alghadir AH. Mobilization with movement enhances early rehabilitation outcomes in knee osteoarthritis: a six-week randomized controlled trial. Chiropr Man Therap. 2026 Mar 22;34(1):11. doi: 10.1186/s12998-026-00636-0.
- Individual participant dataSharing planned: No. Data will be kept secure with the principal investigator (Dr. Shahnaz Hasan) and sub-investigator (Dr. Naiyer Shahzad) due to confidentiality issues.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shahnaz Hasan, PhD principal investigator
Majmah University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mulligan's mobilization with movement MWM added isometric strength training in people with Osteo Arthritis Knee, run by Majmaah University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pain intensity (time frame: 6 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05577403, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2025.