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Drug UseGAME-OvBLOCNCT05609864

Drug Wastage : Observational Study in the Operating Rooms of France

An observational study of Drug Use, run by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer at 83 sites in 4 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

Environmental awareness is leading medical field to question its responsibility and possibilities for action. Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. Read more about this study

Who is it for?
Any age
Conditions the study is for
Drug Use
What is being tested?
Quantification of injectable drugs wastage
Type of treatment
Injection or infusion
How many people
3,763 participants
Where
83 sitesin 4 countries
Study dates
6 Apr 2023to 20 Jul 2023
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: All patients who will need an anesthesia act in operating room during a 24 hours period

Who may be able to join

  • All patients who will need an anesthesia act in operating room during a 24 hours period

Who cannot join

  • Patient opposition to participate in the study or parents opposition if the patient is a child or patient family opposition if the patient is not capable of being informed

Trial locations and contacts

83 sites in 4 countries.

83 sites in 4 countries

France80 sites

  • CHU d'Amiens

    Amiens, Somme, 80054

  • Clinique Victor Pauchet

    Amiens, Somme, 80090

  • Centre Hospitalier de l'Agglomération Montargoise

    Amilly, Loiret, 45200

  • CHU d'Angers

    Angers, Maine-et-Loire, 49100

  • Hôpital privé Arras les Bonnettes

    Arras, Pas-de-Calais, 62000

  • Centre Hospitalier Henri Mondor

    Aurillac, Cantal, 15000

  • Hôpital Privé de la Chataigneraie

    Beaumont, Val d'Oise, 63110

  • Hôpital NOVO - Site de Beaumont-sur-Oise

    Beaumont-sur-Oise, Val d'Oise, 95260

  • CHU Jean Minjoz

    Besançon, Doubs, 25000

  • Clinique Aguilera

    Biarritz, Pyrénées-Atlantiques, 64200

  • CHU de Bordeaux - Groupe hospitalier Pellegrin

    Bordeaux, Gironde, 33000

  • HIA Clermont Tonnerre

    Brest, Finistère, 29240

  • CHRU de Brest

    Brest, Finistère, 29609

  • Centre Hospitalier de Brive-la-Gaillarde

    Brive-la-Gaillarde, Corrèze, 19100

  • Hôpital mère-enfant (HCL)

    Bron, Rhône, 69500

  • CHU de Caen

    Caen, Calvados, 14000

  • Centre Hospitalier de Cannes

    Cannes, Alpes-Maritimes, 06400

  • Centre Hospitalier Intercommunal Castres-Mazamet

    Castres, Tarn

  • Hôpital NOVO - Site de Pontoise

    Cergy-Pontoise, Val d'Oise, 90079

  • Centre Hospitalier de Charleville-Mézières

    Charleville-Mézières, Ardennes, 08000

  • HIA Percy Clamart

    Clamart, Hauts-de-Seine, 92141

  • CHU de Clermont-Ferrand

    Clermont-Ferrand, Puy-de-Dôme, 63000

  • Clinique de la Plaine Santé

    Clermont-Ferrand, Puy-de-Dôme, 63000

  • Centre hospitalier Sud Francilien

    Corbeil-Essonnes, Essonne, 91106

  • Clinique des Cèdres

    Cornebarrieu, Haute-Garonne, 31700

  • Centre Hospitalier de Dax

    Dax, Landes, 40100

  • CHU de Dijon

    Dijon, Côte d'Or, 21000

  • CHU de Grenoble

    Grenoble, Isère, 38100

  • Centre Hospitalier Départemental de Vendée

    La Roche-sur-Yon, Vendée, 85000

  • Groupe Hospitalier Littoral Atlantique

    La Rochelle, Charente-Maritime, 17019

  • Centre Hospitalier d'Arcachon

    La Teste-de-Buch, Gironde, 33260

  • Hôpital Marie Lannelongue

    Le Plessis-Robinson, Hauts-de-Seine, 92350

  • Centre Hospitalier Emile Roux

    Le Puy-en-Velay, Haute-Loire, 43012

  • Centre Hospitalier de Lens

    Lens, Pas-de-Calais, 62300

  • Centre Oscar Lambret

    Lille, Nord, 59000

  • CHU de Lille - Institut coeur poumon

    Lille, Nord, 59000

  • CHU de Lille - Hôpital Huriez

    Lille, Nord, 59037

  • CHU de Lille - Hôpital Jeanne de Flandre

    Lille, Nord, 59037

  • CHU de Lille - Hôpital Roger Salengro

    Lille, Nord, 59037

  • CHU de Limoges

    Limoges, Haute Vienne, 87042

  • Groupe Hospitalier Bretagne Sud

    Lorient, Morbihan, 56322

  • Hôpital Edouard Herriot

    Lyon, Rhône, 69003

  • Centre Léon Bérard

    Lyon, Rhône, 69008

  • Clinique de la Sauvegarde

    Lyon, Rhône, 69009

  • Hôpital La Timone (AP-HM)

    Marseille, Bouches-du-Rhône, 13005

  • Hôpital Nord (AP-HM)

    Marseille, Bouches-du-Rhône, 13015

  • CHU de Nîmes

    Nîmes, Gard, 30900

  • Clinique de l'Archette

    Olivet, Loiret, 45160

  • Hôpital Lariboisière (AP-HP)

    Paris, 75010

  • Hôpital Saint Louis (AP-HP)

    Paris, 75010

  • Hôpital Trousseau (AP-HP)

    Paris, 75012

  • Hôpital La Pitié-Salpêtrière

    Paris, 75013

  • Hôpital Européen Georges Pompidou

    Paris, 75015

  • Groupe Hospitalier Diaconesses Croix Saint Simon

    Paris, 75020

  • Hôpital Tenon (AP-HP)

    Paris, 75020

  • Institut mutualiste Montsouris

    Paris, 75674

  • Centre Hospitalier de Pau

    Pau, Pyrénées-Atlantiques, 64046

  • CHU de Bordeaux, Groupe Sud

    Pessac, Gironde, 33600

  • Clinique mutualiste de Pessac

    Pessac, Gironde, 33600

  • Centre Hospitalier de Cornouailles

    Quimper, Finistère, 29000

  • Clinique la Croix du Sud

    Quint-Fonsegrives, Haute-Garonne, 31130

  • Institut Godinot

    Reims, Marne, 51100

  • CHU de Rennes - Pontchaillou

    Rennes, Ille-et-Vilaine, 35033

  • CHU de Rennes - Hôpital Sud

    Rennes, Ille-et-Vilaine, 35200

  • Clinique mutualiste La Sagesse

    Rennes, Ille-et-Vilaine, 44345

  • Centre Hospitalier Jacques Puel

    Rodez, Aveyron, 12000

  • CHU de Rouen

    Rouen, Seine-Maritime, 76000

  • CHU de la Réunion

    Saint-Denis, La Réunion, 97400

  • Clinique de l'Union

    Saint-Jean, Haute-Garonne, 31240

  • CHU de Strasbourg - IHU

    Strasbourg, Bas-Rhin, 67000

  • Sainte-Anne Military Teaching Hospital

    Toulon, Var, 83000

  • Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer

    Toulon, Var, 83100

  • CHU de Toulouse - Hôpital Rangueil

    Toulouse, Haute-Garonne, 31400

  • Hôpital Nord Franche-Comté

    Trévenans, Territoire De Belfort, 90400

  • Centre Hospitalier de Valence

    Valence, Drôme, 26000

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54519

  • Hôpital Robert Schuman-Groupe UNEOS

    Vantoux, Vaucluse, 57070

  • Institut Gustave Roussy

    Villejuif, Val-de-Marne, 94805

  • Hôpital Paul Brousse (AP-HP)

    Villejuif, 94800

  • Centre Hospitalier Intercommunal de Villeneuve Saint Georges

    Villeneuve-Saint-Georges, Val-de-Marne, 94190

Other trials in France

Guadeloupe1 site

  • CHU de Guadeloupe

    Pointe-à-Pitre, 97159

Other trials in Guadeloupe

Mayotte1 site

  • Centre Hospitalier de Mayotte

    Mamoudzou, 97600

Monaco1 site

  • Centre Hospitalier Princesse Grace

    Monaco, 98000

Other trials in Monaco

About this study

Environmental awareness is leading medical field to question its responsibility and possibilities for action.

Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice this is not systematic. Moreover, data on drug wastage in the operating rooms by anesthesia department are rare.

The GAME-OvBLOC observational study aim to evaluate drug wastage in the operating rooms by anesthesia department in France and to propose ways of improving health care practices.

Read the detailed description

Observational study with data collection over a 24-hour business day. Data collected refer to healthcare team's practices and patients.

Conditions
Drug Use
Being tested
Quantification of injectable drugs wastage
Keywords
Drug wastage, Green Anesthesia, Environmental sustainability, Injectable drugs, Eco-design of care, Operating Room

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Quantification of injectable drugs wastageOther

    Drugs are prescribed at discretion of physicians. For each patient who have anesthesia in the operating room, all labelled syringes having contained drugs (name + dilution) are collected and analyzed.

Study groups in NCT05609864
Study groupRoleWhat they receive
Injectable drugsPatient's data and data relating to prepared/administrated/discarded injectable drugs will be collected during 24 hours in the operating rooms by anesthesia department
Receives: Other: Quantification of injectable drugs wastage

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Ratio of overall wastage in milliliter (mL) of prepared and discarded injectable drugs, to overall volume in milliliter (mL) of prepared injectable drugs

    Wastage is defined as : any prepared and unused drug that remains in syringe

    Measured: 24 hours

Secondary outcomes (7)

  1. Reason for discarding drug residues

    The reason of waste full syringe will be noticed : 1/ prepared in advance and not used ; 2/ prescription change ; 3/ preparation error ; 4/ other reason

    Measured: 24 hours

  2. Describe drug wastage for each kind of surgery/anesthesia

    Drug wastage according to type of surgery and anaesthesia

    Measured: 24 hours

  3. Drug residues discarding process

    Questionnaire on nursing practices on the choice of waste disposal circuits according to drugs

    Measured: 24 hours

  4. Cost of overall injectable drugs wastage

    Estimated cost of drug residues will be evaluated for each drug by the following formula :

    volume of discarded injectable drugs x theoretical price

    Measured: 24 hours

  5. Describe drug wastage for each age group

    Drug wastage according to the following age groups : adult (≥18 years old) and pediatrics (< 1 year old, 1-5 years old, ≥ 6 years old)

    Measured: 24 hours

  6. Describe waste and environmental impact of used plastic syringes

    Number and volume of used syringes, use of pre-filled syringes, refilling of syringes and multi-patient use.

    Environmental impact is indirectly assessed by type of plastic used and the transport distance from the production site to France.

    Measured: 24 hours

  7. Use of alternative to injectable drugs

    Alternatives : local anaesthesia and anaesthetic gases

    Measured: 24 hours

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Nov 2022
  2. Study start6 Apr 2023
  3. Primary completion20 Jul 2023
  4. Study completion20 Jul 2023

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
3,763 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05609864
Sponsor's protocol ID
2023-CHITS-001
Acronym
GAME-OvBLOC
Status last verified
Jul 2026
First submitted
2 Nov 2022
Last updated
7 Jul 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • McGain F, Muret J, Lawson C, Sherman JD. Environmental sustainability in anaesthesia and critical care. Br J Anaesth. 2020 Nov;125(5):680-692. doi: 10.1016/j.bja.2020.06.055. Epub 2020 Aug 12.

    PubMed 32798068

  • Barbariol F, Deana C, Lucchese F, Cataldi G, Bassi F, Bove T, Vetrugno L, De Monte A. Evaluation of Drug Wastage in the Operating Rooms and Intensive Care Units of a Regional Health Service. Anesth Analg. 2021 May 1;132(5):1450-1456. doi: 10.1213/ANE.0000000000005457.

    PubMed 33667211

  • Mankes RF. Propofol wastage in anesthesia. Anesth Analg. 2012 May;114(5):1091-2. doi: 10.1213/ANE.0b013e31824ea491. Epub 2012 Mar 13.

    PubMed 22415537

  • Ramstrom H, Martini S, Borgendahl J, Agerstrand M, Larfars G, Ovesjo ML. Pharmaceuticals and Environment: a web-based decision support for considering environmental aspects of medicines in use. Eur J Clin Pharmacol. 2020 Aug;76(8):1151-1160. doi: 10.1007/s00228-020-02885-1. Epub 2020 May 9.

    PubMed 32388641

Questions about this trial

What is this clinical trial studying?

An observational study of Drug Use, run by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer at 83 sites in 4 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 83 sites in France, Guadeloupe, Mayotte, Monaco. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Ratio of overall wastage in milliliter (mL) of prepared and discarded injectable drugs, to overall volume in milliliter (mL) of prepared injectable drugs (time frame: 24 hours). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05609864, which also lists 4 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.

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