Physiological Reactivity to CuesPREPERNCT05610618
Study of Brain Activity Underlying Predictive Mechanisms During the Perception of Visual Scenes
A study testing Visual stimulation in people with Physiological Reactivity to Cues, run by University Hospital, Grenoble at 1 site in France.
Trial summary
This study aims to clarify the mechanisms by which the predictions we have about our visual environment influence the processing of expected or unexpected visual stimuli at the cerebral level. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Physiological Reactivity to Cues
- What is being tested?
- Visual stimulation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteFrance
- Study dates
- 20 Mar 2023to Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Participants between 18 and 35 years old
- Normal or corrected-to-normal visual acuity
- Ability to consent or oppose to the research
- No opposition to the research
Who cannot join
- Important visual impairments
- Neuropsychiatric pathology
- Use of drug or medication with neurocognitive effects
- Minors, or persons under psychiatric care, or protected persons
Trial locations and contacts
1 site in 1 country.
France1 site, 1 recruiting
- Recruiting
Louise KAUFFMANN
Grenoble, Grenoble Cedex 9, 38043
Louise KAUFFMANN, +33476748135, louise.kauffmann@univ-grenoble-alpes.fr
Laurent VERCUEIL
About this study
Official title: Etude de l'activité cérébrale Sous-jacente Aux mécanismes prédictifs Lors de la Perception de scènes Visuelles
This study aims to clarify the mechanisms by which the predictions we have about our visual environment influence the processing of expected or unexpected visual stimuli at the cerebral level.
Read the detailed description
Current models of visual perception agree that perception is a proactive process. According to these models, perception of the visual environment would allow to continuously generate expectations or "predictions" about the likely characteristics of a visual scene, which would facilitate their processing and visual recognition. At the neurobiological level, these models postulate that visual perception is the result of a permanent exchange between prediction signals (i.e., predicted characteristics of the visual stimulus) and prediction error signals (i.e., unprovevised characteristics of the stimulus to update predictions) between consecutive levels of the hierarchy of cortical visual areas. However, the neurophysiological correlates of these mechanisms remain debated. The results of some work suggest that the prediction signals generated by high-level cortical areas would make it possible to pre-process the predicted characteristics of a stimulus within lower-level areas, by inhibiting the activity of neurons dedicated to their processing. Conversely, other work postulates that the prediction signals generated by high-level areas would increase the sensitivity of neurons encoding expected characteristics while inhibiting the response of neurons encoding unexpected features in lower-level areas. Accordingly, brain activity in these regions would rather reflect the processing of expected features of visual stimuli. It has also been proposed that these two mechanisms coexist but that they intervene alternately during the temporal course of brain processing and depending on the quality of the visual signal. However, this hypothesis has never been systematically tested. The objective of the project is to improve fundamental knowledge about the mechanisms of visual perception by studying at the cerebral level how predictions about the visual environment influence its visual perception. Specifically, investigators will use electroencephalography (EEG) recordings from healthy volunteer participants to measure how brain activity related to visual processing of images of objects and scenes is modulated by their expected or unexpected character, taking into account the temporal course of brain processing and considering the quality of visual signals.
- Conditions
- Physiological Reactivity to Cues
- Being tested
- Visual stimulation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Visual stimulationOther
Participants will be displayed with photographs of scenes and objects which predictability and sharpness will be manipulated
| Study group | Role | What they receive |
|---|---|---|
| Healthy adults | Experimental | A single group of healthy adults will undergo all experimental conditions (within subject design) Receives: Other: Visual stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Performance (% of correct classification) of a support vector machine algorithm in classifying the category of objects and scenes based on electroencephalography signals evoked by the visual perception of expected and unexpected objects and scenes
We will use EEG data acquired while participants look at neutral objects and scenes of different categories to train a classifier in decoding the category of these objects and scenes. This classifier will then be tested using EEG data acquired while participants look at novel expected and unexpected objects and scenes. We will record the % accuracy of the classifier in this test phase.
Measured: Through study completion, an average of 1.5 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Nov 2022
- Study start20 Mar 2023
- Primary completionMar 2025 (estimated)
- Study completionMar 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Physiological Reactivity to CuesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Laurent VERCUEIL, Principal investigator, Grenoble Alpes University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05610618
- Sponsor's protocol ID
- 38RC22.0207
- Other IDs
- 2022-A01418-35
- Acronym
- PREPER
- Status last verified
- Mar 2024
- First submitted
- 12 Sep 2022
- Last updated
- 26 Mar 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Mar 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Etude de l'activité cérébrale Sous-jacente Aux mécanismes prédictifs Lors de la Perception de scènes Visuelles
- ClinicalTrials.gov ID
- NCT05610618
- Acronym / sponsor ID
- PREPER / 38RC22.0207
- Conditions
- Physiological Reactivity to Cues
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Study start
- 20 Mar 2023 (actual)
- Primary completion
- Mar 2025 (estimated)
- Study completion
- Mar 2025 (estimated)
- First posted
- 9 Nov 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to clarify the mechanisms by which the predictions we have about our visual environment influence the processing of expected or unexpected visual stimuli at the cerebral level.
Detailed description
Current models of visual perception agree that perception is a proactive process. According to these models, perception of the visual environment would allow to continuously generate expectations or "predictions" about the likely characteristics of a visual scene, which would facilitate their processing and visual recognition. At the neurobiological level, these models postulate that visual perception is the result of a permanent exchange between prediction signals (i.e., predicted characteristics of the visual stimulus) and prediction error signals (i.e., unprovevised characteristics of the stimulus to update predictions) between consecutive levels of the hierarchy of cortical visual areas. However, the neurophysiological correlates of these mechanisms remain debated. The results of some work suggest that the prediction signals generated by high-level cortical areas would make it possible to pre-process the predicted characteristics of a stimulus within lower-level areas, by inhibiting the activity of neurons dedicated to their processing. Conversely, other work postulates that the prediction signals generated by high-level areas would increase the sensitivity of neurons encoding expected characteristics while inhibiting the response of neurons encoding unexpected features in lower-level areas. Accordingly, brain activity in these regions would rather reflect the processing of expected features of visual stimuli. It has also been proposed that these two mechanisms coexist but that they intervene alternately during the temporal course of brain processing and depending on the quality of the visual signal. However, this hypothesis has never been systematically tested. The objective of the project is to improve fundamental knowledge about the mechanisms of visual perception by studying at the cerebral level how predictions about the visual environment influence its visual perception. Specifically, investigators will use electroencephalography (EEG) recordings from healthy volunteer participants to measure how brain activity related to visual processing of images of objects and scenes is modulated by their expected or unexpected character, taking into account the temporal course of brain processing and considering the quality of visual signals.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy adults | Experimental | Other: Visual stimulationA single group of healthy adults will undergo all experimental conditions (within subject design) |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Participants between 18 and 35 years old
- Normal or corrected-to-normal visual acuity
- Ability to consent or oppose to the research
- No opposition to the research
Key exclusion criteria (4 listed)
- Important visual impairments
- Neuropsychiatric pathology
- Use of drug or medication with neurocognitive effects
- Minors, or persons under psychiatric care, or protected persons
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Visual stimulationParticipants will be displayed with photographs of scenes and objects which predictability and sharpness will be manipulated | Other | Healthy adults |
Primary outcome
Performance (% of correct classification) of a support vector machine algorithm in classifying the category of objects and scenes based on electroencephalography signals evoked by the visual perception of expected and unexpected objects and scenes
Time frame: Through study completion, an average of 1.5 year
We will use EEG data acquired while participants look at neutral objects and scenes of different categories to train a classifier in decoding the category of these objects and scenes. This classifier will then be tested using EEG data acquired while participants look at novel expected and unexpected objects and scenes. We will record the % accuracy of the classifier in this test phase.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Mar 2024.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Laurent VERCUEIL principal investigator
Grenoble Alpes University Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Visual stimulation in people with Physiological Reactivity to Cues, run by University Hospital, Grenoble at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 26 Mar 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Louise KAUFFMANN (+33 (0)4 76 74 81 35, louise.kauffmann@univ-grenoble-alpes.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Performance (% of correct classification) of a support vector machine algorithm in classifying the category of objects and scenes based on electroencephalography signals evoked by the visual perception of expected and unexpected objects and scenes (time frame: Through study completion, an average of 1.5 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Mar 2024; AzTrials last refreshed its copy on 31 Oct 2026.