Alcohol AbuseNCT05619185
A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
A study testing CRAFT Web-Based Intervention, Phone-Based CRAFT and CRAFT Workbook in people with Alcohol Abuse and Alcohol Use Disorder, run by Stanford University at 1 site in United States.
Trial summary
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs). The investigators want to identify for whom this intervention is most efficacious and on what drinking behaviors and mechanisms. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking
- What is being tested?
- CRAFT Web-Based Intervention, Phone-Based CRAFT and CRAFT Workbook
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 744 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Jun 2024to 31 Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- at least 18 years of age;
- be living together with their partner, with no plans to change that status in the next 2 months;
- not be in the military themselves (to reduce concerns about mandated reporting of alcohol use);
- score ≥4 on the AUDIT-C for females or ≥5 for males/other;
- respond yes to "Do you feel safe in your current relationship?" from the Partner Violence Screen;
- report not currently being in mental health or alcohol treatment (CP and SM)
Show all 9Show fewer
- understand English fluently,
- be willing to try an online program to address risky drinking.
- We require cohabitating CPs and SMs with no anticipated changes in the next two months to ensure close contact and opportunity to practice new skills, and those who would feel safe participating.
Who cannot join
- CPs in substance use treatment or their SM was in treatment in the last three months;
- does not feel safe in the current relationship;
- does not understand English fluently;
- has an impaired capacity (cognitive, visual, or hearing);
- is not cohabitating with their SM
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Stanford University
Palo Alto, California, 94305
Kat Nameth, BS, 6505429699, knameth@stanford.edu
Karen Osilla, PhD
About this study
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs). The investigators want to identify for whom this intervention is most efficacious and on what drinking behaviors and mechanisms. The investigators hypothesize that the intervention will reduce concerned partner drinking and increase service member help-seeking, compared to website resources, and that phone-based CRAFT will increase help-seeking behaviors, compared to those who are guided via a CRAFT workbook.
Our outcome is to evaluate the efficacy of an adaptive CP intervention on CP well-being and service member help-seeking.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal, Military Family
- Being tested
- CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook, Gottman Self-Guided Resources
- Keywords
- military, alcohol, drinking, substance use
- Medical subject headings
- Alcoholism, Alcohol Drinking, Substance-Related Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CRAFT Web-Based InterventionBehavioural
Also called WBI, Partners Connect, Web-based intervention (WBI)
Session 1 addresses CPs' mental health issues and drinking. CPs select reasons why they are seeking help and steps they will take towards those goals. Session 2 is focused on improving their relationship through communication exercises. Session 3 is focused on functional analysis of their partner's drinking, and how to positively reinforce their partner's sobriety and negatively reinforce their drinking. Finally, Session 4 focuses on continuing self-care and talking with their partner about their concerns while interacting with them in healthy ways. The WBI contains audio, video, text, and exercises that utilize digital storytelling and vignettes to convey teaching points - a method utilized by the military to address stigma and increase treatment utilization. Actresses portrayed different experiences that the CP may be going through and modeled skills. CPs clicked on the vignette that they most connected with and followed that character across all the sessions.
Phone-Based CRAFTBehavioural
Also called Community Reinforcement and Family Training (CRAFT) phone sessions
The phone-based CRAFT intervention consists of six individual sessions with a CRAFT clinician that will explore what they learned from the WBI and additional skills they need. Session content includes positive reinforcement of non-drinking SM behaviors, refraining from interfering in SM's consequences of alcohol use, communication skills, and self-care.
CRAFT WorkbookBehavioural
Also called Community Reinforcement and Family Training (CRAFT) workbook
The self-directed CRAFT workbook Table 1.Partners Connect WBI has a parent and partner version that uses CRAFT to help the CP help with understanding, self-care, communication, and actions (e.g., how to react when a partner has been using substances and when they have not been using substances, how to talk to partner so that they are more likely to be heard) and includes more information about communicating than the WBI and several interactive worksheets.
Gottman Self-Guided ResourcesBehavioural
To match time spent reviewing the website, CPs will receive an orientation guide that includes the website URL and a 4-week guide for how they can navigate this website for 20-30 minutes per week (e.g., read article "'It's Not My Fault!': Why Defensiveness is Damaging" and write down one tool to dissolve defensiveness you're willing to try). We will send reminder emails each week to visit the website and include questions in the emails and our first online follow-up survey asking CPs approximately how many times they visited the website and how long they spent viewing content on the website. Reminder emails will be programmed such that CPs get directed automatically to the website if the CP notes no time spent on it.
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Experimental | Those randomized to the CRAFT intervention will receive a web-based intervention Receives: Behavioral: CRAFT Web-Based Intervention; Behavioral: Phone-Based CRAFT; Behavioral: CRAFT Workbook |
| Control | Active comparator | Those randomized to CONTROL will complete a self-guided intervention Receives: Behavioral: Gottman Self-Guided Resources |
| Phone Based CRAFT | Experimental | If a member of the recruited dyad does not respond, then participants will be randomized to receive phone-based CRAFT Receives: Behavioral: CRAFT Web-Based Intervention; Behavioral: Phone-Based CRAFT |
| CRAFT Workbook | Active comparator | If a member of the recruited dyad does not respond, then participants will be randomized to receive a CRAFT workbook Receives: Behavioral: CRAFT Web-Based Intervention; Behavioral: CRAFT Workbook |
What is being measured
The primary outcome is the main question the study is designed to answer.
CP Depression
Depression as measured by the global score on the Patient Health Questionnaire 9-item (PHQ-9). Scores range from 0 - 27. Higher scores indicate more severe depression.
Measured: Baseline to 6 month follow-up
CP Anxiety
Anxiety as measured by the global score on the Generalized Anxiety Disorder 7-item scale (GAD-7). Scores range from 0 - 21. Higher scores indicate more severe anxiety.
Measured: Baseline to 6 month follow-up
Service Member help-seeking
Completion of the personalized normalized feedback (PNF) component of the intervention as a signal of increase help-seeking behavior
Measured: Baseline to 6 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Nov 2022
- Study start14 Jun 2024
- Primary completion31 Aug 2027 (estimated)
- Study completion31 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Alcohol AbuseStudies of the same condition, open and under way.
- More trials run by Stanford UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 744 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Stanford University
- Sponsor type
- University, hospital or other
- Collaborators
- University of Southern California, RAND, Northern California Institute of Research and Education, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Responsible party
- Principal investigator, Karen Osilla, Stanford University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05619185
- Sponsor's protocol ID
- 67087
- Other IDs
- 1R01AA030258
- Status last verified
- Oct 2026
- First submitted
- 2 Nov 2022
- Last updated
- 19 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There will be no IPD shared
Publications
Osilla KC, Gore KL, Pedersen ER, Hummer JF, DeYoreo M, Manuel JK, McKay JR, Kim JP, Nameth K. Study protocol for a sequential multiple assignment randomized trial to reduce risky drinking among service members and their partners. Contemp Clin Trials. 2023 Oct;133:107324. doi: 10.1016/j.cct.2023.107324. Epub 2023 Aug 29.
PubMed 37652360
Study at a glance
From the registry record, last updated by the sponsor on 19 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
- ClinicalTrials.gov ID
- NCT05619185
- Acronym / sponsor ID
- 67087
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal, Military Family
- Keywords
- military, alcohol, drinking, substance use
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 744 participants (estimated)
- Lead sponsor
- Stanford UniversityUniversity, hospital or other
- Collaborators
- University of Southern California, RAND, Northern California Institute of Research and Education, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Study start
- 14 Jun 2024 (actual)
- Primary completion
- 31 Aug 2027 (estimated)
- Study completion
- 31 Aug 2027 (estimated)
- First posted
- 16 Nov 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs). The investigators want to identify for whom this intervention is most efficacious and on what drinking behaviors and mechanisms. The investigators hypothesize that the intervention will reduce concerned partner drinking and increase service member help-seeking, compared to website resources, and that phone-based CRAFT will increase help-seeking behaviors, compared to those who are guided via a CRAFT workbook.
Our outcome is to evaluate the efficacy of an adaptive CP intervention on CP well-being and service member help-seeking.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Intervention | Experimental | Behavioral: CRAFT Web-Based Intervention, Behavioral: Phone-Based CRAFT, Behavioral: CRAFT WorkbookThose randomized to the CRAFT intervention will receive a web-based intervention |
| Control | Active comparator | Behavioral: Gottman Self-Guided ResourcesThose randomized to CONTROL will complete a self-guided intervention |
| Phone Based CRAFT | Experimental | Behavioral: CRAFT Web-Based Intervention, Behavioral: Phone-Based CRAFTIf a member of the recruited dyad does not respond, then participants will be randomized to receive phone-based CRAFT |
| CRAFT Workbook | Active comparator | Behavioral: CRAFT Web-Based Intervention, Behavioral: CRAFT WorkbookIf a member of the recruited dyad does not respond, then participants will be randomized to receive a CRAFT workbook |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- at least 18 years of age;
- be living together with their partner, with no plans to change that status in the next 2 months;
- not be in the military themselves (to reduce concerns about mandated reporting of alcohol use);
- score ≥4 on the AUDIT-C for females or ≥5 for males/other;
- respond yes to "Do you feel safe in your current relationship?" from the Partner Violence Screen;
Key exclusion criteria (5 listed)
- CPs in substance use treatment or their SM was in treatment in the last three months;
- does not feel safe in the current relationship;
- does not understand English fluently;
- has an impaired capacity (cognitive, visual, or hearing);
- is not cohabitating with their SM
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CRAFT Web-Based InterventionAlso: WBI, Partners Connect, Web-based intervention (WBI)Session 1 addresses CPs' mental health issues and drinking. CPs select reasons why they are seeking help and steps they will take towards those goals. Session 2 is focused on improving their relationship through communication exercises. Session 3 is focused on functional analysis of their partner's drinking, and how to positively reinforce their partner's sobriety and negatively reinforce their drinking. Finally, Session 4 focuses on continuing self-care and talking with their partner about their concerns while interacting with them in healthy ways. The WBI contains audio, video, text, and exercises that utilize digital storytelling and vignettes to convey teaching points - a method utilized by the military to address stigma and increase treatment utilization. Actresses portrayed different experiences that the CP may be going through and modeled skills. CPs clicked on the vignette that they most connected with and followed that character across all the sessions. | Behavioural | CRAFT Workbook, Intervention, Phone Based CRAFT |
| Phone-Based CRAFTAlso: Community Reinforcement and Family Training (CRAFT) phone sessionsThe phone-based CRAFT intervention consists of six individual sessions with a CRAFT clinician that will explore what they learned from the WBI and additional skills they need. Session content includes positive reinforcement of non-drinking SM behaviors, refraining from interfering in SM's consequences of alcohol use, communication skills, and self-care. | Behavioural | Intervention, Phone Based CRAFT |
| CRAFT WorkbookAlso: Community Reinforcement and Family Training (CRAFT) workbookThe self-directed CRAFT workbook Table 1.Partners Connect WBI has a parent and partner version that uses CRAFT to help the CP help with understanding, self-care, communication, and actions (e.g., how to react when a partner has been using substances and when they have not been using substances, how to talk to partner so that they are more likely to be heard) and includes more information about communicating than the WBI and several interactive worksheets. | Behavioural | CRAFT Workbook, Intervention |
| Gottman Self-Guided ResourcesTo match time spent reviewing the website, CPs will receive an orientation guide that includes the website URL and a 4-week guide for how they can navigate this website for 20-30 minutes per week (e.g., read article "'It's Not My Fault!': Why Defensiveness is Damaging" and write down one tool to dissolve defensiveness you're willing to try). We will send reminder emails each week to visit the website and include questions in the emails and our first online follow-up survey asking CPs approximately how many times they visited the website and how long they spent viewing content on the website. Reminder emails will be programmed such that CPs get directed automatically to the website if the CP notes no time spent on it. | Behavioural | Control |
Primary outcome
CP Depression
Time frame: Baseline to 6 month follow-up
Depression as measured by the global score on the Patient Health Questionnaire 9-item (PHQ-9). Scores range from 0 - 27. Higher scores indicate more severe depression.
CP Anxiety
Time frame: Baseline to 6 month follow-up
Anxiety as measured by the global score on the Generalized Anxiety Disorder 7-item scale (GAD-7). Scores range from 0 - 21. Higher scores indicate more severe anxiety.
Service Member help-seeking
Time frame: Baseline to 6 month
Completion of the personalized normalized feedback (PNF) component of the intervention as a signal of increase help-seeking behavior
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Oct 2026.
- Derived from this study: PubMed 37652360Osilla KC, Gore KL, Pedersen ER, Hummer JF, DeYoreo M, Manuel JK, McKay JR, Kim JP, Nameth K. Study protocol for a sequential multiple assignment randomized trial to reduce risky drinking among service members and their partners. Contemp Clin Trials. 2023 Oct;133:107324. doi: 10.1016/j.cct.2023.107324. Epub 2023 Aug 29.
- Individual participant dataSharing planned: No. There will be no IPD shared
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing CRAFT Web-Based Intervention, Phone-Based CRAFT and CRAFT Workbook in people with Alcohol Abuse and Alcohol Use Disorder, run by Stanford University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Kat Nameth, BS (6505429699, knameth@stanford.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
CP Depression (time frame: Baseline to 6 month follow-up). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05619185, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Oct 2026.