InflammationNCT05628935
Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio
An observational study of Inflammation and Anesthesia, run by Zonguldak Bulent Ecevit University at 1 site in Turkey (Türkiye).
Trial summary
The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Inflammation, Anesthesia
- What is being tested?
- peripheral nerve block
- Type of treatment
- Surgery or procedure
- How many people
- 1 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2018to 1 Nov 2021
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients aged 18-65 years who have underwent forearm surgery
Who may be able to join
- Underwent forearm surgery
- Between aged 18-70
- Under general anesthesia or peripheral nerve block
Who cannot join
- acute infection
- morbid obesity
- chronic treatment with steroids or immunosuppressants
- recently received chemotherapy
- hepatic and renal dysfunction;
- chronic alcohol abusers
- Multiple trauma
- Patients with missing data in their files
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Zonguldak Bülent Ecevit University Medicine Faculty
Zonguldak, Kozlu, 67600
About this study
Official title: The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery
The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.
- Conditions
- Inflammation, Anesthesia
- Being tested
- peripheral nerve block
- Keywords
- General Anesthesia, Neutrophil Lymphocyte Ratio, Peripheral Nerve Block
- Medical subject headings
- Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
peripheral nerve blockProcedure or surgery
local anesthetic application to the brachial plexus
| Study group | Role | What they receive |
|---|---|---|
| Group G | Patients Undergoing Forearm Surgery under general anesthesia | |
| Group P | Patients Undergoing Forearm Surgery under peripheral nerve block Receives: Procedure: peripheral nerve block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Neutrophil/lymphocyte ratio
Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
Measured: up to 24 hours after surgery
Secondary outcomes (2)
Platelet/lymphocyte ratio
Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
Measured: up to 24 hours after surgery
Mean Platelet Volume
Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block
Measured: up to 24 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Nov 2022
- Study start1 Jan 2018
- Primary completion1 Nov 2020
- Study completion1 Nov 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for InflammationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 1 participants (actual)
Sponsor and investigators
- Lead sponsor
- Zonguldak Bulent Ecevit University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Bengü Gülhan Köksal, Zonguldak Bulent Ecevit University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05628935
- Sponsor's protocol ID
- 2020-22/17
- Status last verified
- Nov 2022
- First submitted
- 17 Nov 2022
- Last updated
- 29 Nov 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Nov 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery
- ClinicalTrials.gov ID
- NCT05628935
- Acronym / sponsor ID
- 2020-22/17
- Conditions
- Inflammation, Anesthesia
- Keywords
- General Anesthesia, Neutrophil Lymphocyte Ratio, Peripheral Nerve Block
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 1 participants (actual)
- Lead sponsor
- Zonguldak Bulent Ecevit UniversityUniversity, hospital or other
- Study start
- 1 Jan 2018 (actual)
- Primary completion
- 1 Nov 2020 (actual)
- Study completion
- 1 Nov 2021 (actual)
- First posted
- 29 Nov 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group G | – | –Patients Undergoing Forearm Surgery under general anesthesia |
| Group P | – | Procedure: peripheral nerve blockPatients Undergoing Forearm Surgery under peripheral nerve block |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients aged 18-65 years who have underwent forearm surgery
Key inclusion criteria (3 listed)
- Underwent forearm surgery
- Between aged 18-70
- Under general anesthesia or peripheral nerve block
Key exclusion criteria (8 listed)
- acute infection
- morbid obesity
- chronic treatment with steroids or immunosuppressants
- recently received chemotherapy
- hepatic and renal dysfunction;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| peripheral nerve blocklocal anesthetic application to the brachial plexus | Procedure or surgery | Group P |
Primary outcome
Neutrophil/lymphocyte ratio
Time frame: up to 24 hours after surgery
Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
2 secondary outcomes
Platelet/lymphocyte ratio
Time frame: up to 24 hours after surgery
Mean Platelet Volume
Time frame: up to 24 hours after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Nov 2022.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Inflammation and Anesthesia, run by Zonguldak Bulent Ecevit University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Nov 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neutrophil/lymphocyte ratio (time frame: up to 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Nov 2022.