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Depressive SymptomsSAAFDNCT05631184

Self-administered Acupressure for Depression

A study testing Self-administered acupressure group and Mental health education group in people with Depressive Symptoms and Depressive Disorder, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The goal of this clinical trial is to examine the effects of self-administered acupressure intervention for alleviating depressive symptoms among people with depression. It is hypothesized that the self-administered acupressure group would have a great improvement in depressive symptoms as measured by the Patient… Read more about this study

Who is it for?
Ages 18 to 65 years
What is being tested?
Self-administered acupressure group and Mental health education group
Could I receive a placebo?
No, everyone receives an active treatment
How many people
250 participants
Where
1 siteHong Kong
Study dates
20 Nov 2022to 1 Sep 2024
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 65 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Hong Kong residents aged 18 to 65
  • Can communicate in Cantonese and comprehend written Chinese
  • Have moderate or above-level depression as measured by the PHQ-9 with a score of 10 or above
  • Willing to give informed consent and comply with the trial protocol.

Who cannot join

  • Have the PHQ score of 20 or above (referral information to community psychological services will be provided)
  • New onset or change of antidepressant medication or dosage in the last 3 months
  • Previous or current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder as screened using the Chinese version of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders.
  • Have cognitive impairment diagnosed by the Hong Kong Montreal Cognitive Assessment with a score < 22
  • Skin lesions or infections at the treatment sites
  • Significant suicidal risk as rated by the Hamilton Depression Rating Scale item on suicide (score ≥3)
  • Pregnant or childbearing potential but not using adequate contraception
  • With any major medical condition that causes depression based on the judgement of a psychiatrist.

Trial locations and contacts

1 site in 1 country.

Hong Kong1 site
  • School of Nursing, the Hong Kong Polytechnic University

    Hong Kong

Other trials in Hong Kong

About this study

Official title: Self-administered Acupressure for Depression: A Randomized Controlled Trial

The goal of this clinical trial is to examine the effects of self-administered acupressure intervention for alleviating depressive symptoms among people with depression. It is hypothesized that the self-administered acupressure group would have a great improvement in depressive symptoms as measured by the Patient Health Questionnaire compared with the mental health education group across the 12-week intervention period.

The main questions it aims to answer are:

  • Is the self-administered acupressure intervention more effective for alleviating depression and other related outcomes compared to the mental health education group among depressed individuals?
  • Is the self-administered acupressure intervention acceptable and feasible for depressed individuals to alleviate depression? Participants will be randomized into self-administered acupressure group or mental health education group based on the group allocation with a 1:1 ratio. Participants will attend two weekly 120-min self-administered acupressure training or mental health education, respectively.
Being tested
Self-administered acupressure group, Mental health education group
Keywords
Depression, Acupressure, Randomized Controlled Trial
Medical subject headings
Depression, Depressive Disorder

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Self-administered acupressure groupBehavioural

    Self-administered acupressure treatment group was developed on the basis of previous systematic reviews and clinical studies of acupuncture and acupressure for depression. It has robust theoretical basis of TCM. The acupoints selected are commonly used for depression according to a recent systematic review and recommended by other clinical practice guidelines.

  • Mental health education groupBehavioural

    Mental health education training group was developed based on the materials regarding depression and mental health from the Centre of Health Protection, Department of Health, the Government of Hong Kong SAR and reviewed by a clinical psychologist.

Study groups in NCT05631184
Study groupRoleWhat they receive
Self-administered acupressure groupExperimentalThe participants in the self-administered acupressure group will attend an acupressure training course (2 sessions, 2 h each) to learn self-administered acupressure from an acupuncturist in a classroom at the School Nursing, the Hong Kong Polytechnic University. Each class will be conducted in a small group of 4 to 7 participants to enhance interaction and ensure the quality of teaching. Participants will then practice two times a day for 8 weeks.
Receives: Behavioral: Self-administered acupressure group
Mental health education groupActive comparatorThe participants in the comparison group will receive mental health education group from a registered nurse with the same frequency as those in the treatment group (2 sessions, 2 h each) in a classroom at the School Nursing, the Hong Kong Polytechnic University, and will be reminded to follow the mental health practice daily for 8 weeks.
Receives: Behavioral: Mental health education group

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Patient Health Questionnaire (PHQ)

    The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27.

    Measured: It will be measured at baseline

  2. Patient Health Questionnaire (PHQ)

    The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27.

    Measured: It will be measured at week 4 from baseline

  3. Patient Health Questionnaire (PHQ)

    The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27.

    Measured: It will be measured at week 8 from baseline

  4. Patient Health Questionnaire (PHQ)

    The PHQ-9, a self-rated questionnaire to assess depressive symptoms over the last 2 weeks on a scale of 0 (not at all) to 3 (nearly every day), with a total score ranging from 0 to 27.

    Measured: It will be measured at week 12 from baseline

Secondary outcomes (20)
  1. Hamilton Depression Rating Scale (HDRS)

    The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression.

    Measured: It will be measured at baseline

  2. Hamilton Depression Rating Scale (HDRS)

    The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression.

    Measured: It will be measured at week 4 from baseline

  3. Hamilton Depression Rating Scale (HDRS)

    The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression.

    Measured: It will be measured at week 8 from baseline

  4. Hamilton Depression Rating Scale (HDRS)

    The HDRS is used to assess the severity of depressive symptoms based on the 17-item scale. Eight items are scored on a 5-point scale, ranging from 0 to 4 and nine items are scored from 0 to 2. The total score varies from 0 (the minimum value) to 52 (the maximum value), with a higher total score indicating more severe depression.

    Measured: It will be measured at week 12 from baseline

  5. The Depression Anxiety Stress Scales (DASS-21) - Stress

    The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at baseline

  6. The Depression Anxiety Stress Scales (DASS-21) - Stress

    The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at week 4 from baseline

  7. The Depression Anxiety Stress Scales (DASS-21) - Stress

    The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at week 8 from baseline

  8. The Depression Anxiety Stress Scales (DASS-21) - Stress

    The DASS-21 Stress subscale will be used to measure the emotional states of stress using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at week 12 from baseline

  9. The Depression Anxiety Stress Scales (DASS-21) - Anxiety

    The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at baseline

  10. The Depression Anxiety Stress Scales (DASS-21) - Anxiety

    The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at week 4 from baseline

  11. The Depression Anxiety Stress Scales (DASS-21) - Anxiety

    The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at week 8 from baseline

  12. The Depression Anxiety Stress Scales (DASS-21) - Anxiety

    The DASS-21 Anxiety subscale will be used to measure the emotional states of anxiety using a 4-point scale ranging from 0 (never) to 3 (almost always).

    Measured: It will be measured at week 12 from baseline

  13. The Insomnia Severity Index (ISI)

    The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale.

    Measured: It will be measured at baseline

  14. The Insomnia Severity Index (ISI)

    The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale.

    Measured: It will be measured at week 4 from baseline

  15. The Insomnia Severity Index (ISI)

    The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale.

    Measured: It will be measured at week 8 from baseline

  16. The Insomnia Severity Index (ISI)

    The ISI is a seven-item self-rating scale to assess the severity of insomnia, distress, and functional impairment associated with insomnia on a 5-point Likert scale.

    Measured: It will be measured at week 12 from baseline

  17. The Short-Form (six-dimension) Health Survey (SF-6D)

    The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life.

    Measured: It will be measured at baseline

  18. The Short-Form (six-dimension) Health Survey (SF-6D)

    The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life.

    Measured: It will be measured at week 4 from baseline

  19. The Short-Form (six-dimension) Health Survey (SF-6D)

    The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life.

    Measured: It will be measured at week 8 from baseline

  20. The Short-Form (six-dimension) Health Survey (SF-6D)

    The SF-6D covers six domains using a scale of 1 to 6 to evaluate participants' general health and quality of life.

    Measured: It will be measured at week 12 from baseline

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Nov 2022
  2. Study start20 Nov 2022
  3. Primary completion19 Aug 2024
  4. Study completion1 Sep 2024

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Two-arm parallel assignment involves two groups of participants. In this study, one group will receive self-administered acupressure, and the other group will receive the mental health education. So during the trial, participants in one group receive self-administered acupressure "in parallel" to participants in the other group, who receive the mental health education.
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
250 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05631184
Sponsor's protocol ID
SelfAcupDep
Other IDs
19200171
Acronym
SAAFD
Status last verified
Feb 2024
First submitted
14 Nov 2022
Last updated
22 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: The individual participant data will be available when the study has been published. The individual participant data will be available upon request.

Publications

  • Zhang Z, Li S, Meng H, Wang Y, Zhang Y, Wu M, Chen Y, Rong P, Wang Y. Efficacy and safety of acupuncture in the treatment of depression: A systematic review of clinical research. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8.

    PubMed 34623754
  • Fernandez-Chinguel JE, Goicochea-Lugo S, Villarreal-Zegarra D, Taype-Rondan A, Zafra-Tanaka JH. Acupuncture for major depressive disorder: A review of the recommendations stated at clinical practice guidelines. Complement Ther Med. 2020 Mar;49:102321. doi: 10.1016/j.ctim.2020.102321. Epub 2020 Jan 24.

    PubMed 32147048
  • Cheung DST, Tiwari A, Yeung WF, Yu DSF, So MKP, Chau PH, Wang XM, Lum TYS, Yuk Fung HYK, Ng BYM, Zhang ZJ, Lao L. Self-Administered Acupressure for Caregivers of Older Family Members: A Randomized Controlled Trial. J Am Geriatr Soc. 2020 Jun;68(6):1193-1201. doi: 10.1111/jgs.16357. Epub 2020 Feb 25.

    PubMed 32096884
  • Kroenke K. Enhancing the clinical utility of depression screening. CMAJ. 2012 Feb 21;184(3):281-2. doi: 10.1503/cmaj.112004. Epub 2012 Jan 9. No abstract available.

    PubMed 22231681
  • Yeung WF, Yu BYM, Ho FY, Wong CKH, Chung KF, Ruan JY, Chen S, Cheung DST, Zhang ZJ, Zick S, Cheng H, Ho YS, Ho LM, Lao L. Self-administered acupressure training for depression in community-dwelling individuals: a randomized controlled trial and cost-effectiveness analysis. EClinicalMedicine. 2026 Jun 16;96:104023. doi: 10.1016/j.eclinm.2026.104023. eCollection 2026 Jun.

    PubMed 42339308

Questions about this trial

What is this clinical trial studying?

A study testing Self-administered acupressure group and Mental health education group in people with Depressive Symptoms and Depressive Disorder, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Patient Health Questionnaire (PHQ) (time frame: It will be measured at baseline). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05631184, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.

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