MemoryESADNCT05642351
Autobiographical Specificity
An observational study of Memory and Alzheimer Disease, run by Nantes University Hospital at 1 site in France.
Trial summary
Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Memory, Alzheimer Disease, Frontotemporal Dementia
- What is being tested?
- Autobiographical reminder
- How many people
- 39 participants
- Where
- 1 siteFrance
- Study dates
- 3 Feb 2023to 6 Mar 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: All participants will be recruited through the active file of memory consultations of the "memory resource and research center" (CMRR) of the Nantes University Hospital.
Who may be able to join
- Alzheimer' disease or avioral variant of frontotemporal dementia
- No opposition from the patient to be included in the study
- For Alzheimer's patients: a score of more than 24 out of 30 on the Mini Mental State Examination (McKhann et al., 1984)
Who cannot join
- Other psychiatric/neurological disorders
- Minor patients
- Adults under guardianship or protection.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Autobiographical Specificity in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia
Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.
Read the detailed description
Patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia will be invited to retrieve autobiographical memories. Memories will be analyzed and categorized into specific, categoric, extended, or semantic autobiographical retrieval.
- Conditions
- Memory, Alzheimer Disease, Frontotemporal Dementia
- Being tested
- Autobiographical reminder
- Keywords
- Autobiographical memory, Alzheimer's disease, with behavioral variant of frontotemporal dementia
- Medical subject headings
- Alzheimer Disease, Frontotemporal Dementia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Autobiographical reminderOther
The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study:
- 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque")
- 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962")
- 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time")
- 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer")
- 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque")
- 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")
| Study group | Role | What they receive |
|---|---|---|
| Alzheimer's Disease | recruited according to criteria by National Institute on Aging (McKhann et al., 2011). Receives: Other: Autobiographical reminder | |
| Behavioral variant of frontotemporal dementia | recruited following criteria by Rascovsky et al. (2011) Receives: Other: Autobiographical reminder |
What is being measured
The primary outcome is the main question the study is designed to answer.
Autobiographical specificity
We will apply the method by Raes et al. (2007) to assess whether each retrieved event refers to a: specific event, categorical event, extended event, or semantic event
Measured: 40 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Dec 2022
- Study start3 Feb 2023
- Primary completion6 Mar 2026
- Study completion6 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MemoryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 39 participants (actual)
Sponsor and investigators
- Lead sponsor
- Nantes University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05642351
- Sponsor's protocol ID
- RC22_0626
- Acronym
- ESAD
- Status last verified
- Apr 2026
- First submitted
- 22 Nov 2022
- Last updated
- 3 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Autobiographical Specificity in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia
- ClinicalTrials.gov ID
- NCT05642351
- Acronym / sponsor ID
- ESAD / RC22_0626
- Conditions
- Memory, Alzheimer Disease, Frontotemporal Dementia
- Keywords
- Autobiographical memory, Alzheimer's disease, with behavioral variant of frontotemporal dementia
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 39 participants (actual)
- Lead sponsor
- Nantes University HospitalUniversity, hospital or other
- Study start
- 3 Feb 2023 (actual)
- Primary completion
- 6 Mar 2026 (actual)
- Study completion
- 6 Mar 2026 (actual)
- First posted
- 8 Dec 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.
Detailed description
Patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia will be invited to retrieve autobiographical memories. Memories will be analyzed and categorized into specific, categoric, extended, or semantic autobiographical retrieval.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Alzheimer's Disease | – | Other: Autobiographical reminderrecruited according to criteria by National Institute on Aging (McKhann et al., 2011). |
| Behavioral variant of frontotemporal dementia | – | Other: Autobiographical reminderrecruited following criteria by Rascovsky et al. (2011) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- All participants will be recruited through the active file of memory consultations of the "memory resource and research center" (CMRR) of the Nantes University Hospital.
Key inclusion criteria (3 listed)
- Alzheimer' disease or avioral variant of frontotemporal dementia
- No opposition from the patient to be included in the study
- For Alzheimer's patients: a score of more than 24 out of 30 on the Mini Mental State Examination (McKhann et al., 1984)
Key exclusion criteria (3 listed)
- Other psychiatric/neurological disorders
- Minor patients
- Adults under guardianship or protection.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Autobiographical reminderThe analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study: * 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque") * 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962") * 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time") * 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer") * 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque") * 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation") | Other | Alzheimer's Disease, Behavioral variant of frontotemporal dementia |
Primary outcome
Autobiographical specificity
Time frame: 40 minutes
We will apply the method by Raes et al. (2007) to assess whether each retrieved event refers to a: specific event, categorical event, extended event, or semantic event
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2026.
- Individual participant dataSharing planned: No
Related trials for Memory
Active, not recruitingObservational study
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy
Breast Cancer, Lymphoma
Enrolling by invitationObservational study
Study of Direct Brain Recording and Stimulation for Memory Enhancement
Epilepsy
Active, not recruitingPhase 1
Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia
B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma, B-Cell Prolymphocytic Leukemia
RecruitingObservational study
Cognitive Aftereffects of Neurotoxicity in Children and Young Adults With Relapsed/Refractory Hematologic Malignancies Who Receive CAR T-cell Therapy
Lymphoma, Leukemia
Recruiting
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
Obstructive Sleep Apnea, Cognitive Decline
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Memory and Alzheimer Disease, run by Nantes University Hospital at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Autobiographical specificity (time frame: 40 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2026.