BlockNCT05643040
Comparison of Perioperative Analgesic Efficacy of Femoral Nerve Block, Adductor Canal Block and 4in1 Block
A study testing femoral nerve block, adductor canal block and 4in1 block in people with Block and Analgesia, run by Diskapi Yildirim Beyazit Education and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). Read more about this study
- Who is it for?
- Ages 18 to 99 years
- What is being tested?
- femoral nerve block, adductor canal block and 4in1 block
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Sep 2022to 30 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients between the ages of >18
- undergone knee surgery
- American Society of Anesthesiologists (ASA) classification I-III group.
Who cannot join
- Patients who do not want to participate in the study coagulopathy peripheral neuropathy local anesthetic drug allergy chronic opioid users anticoagulant users pregnant patients
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
University of Medical Science, Yıldırım Beyazıt Training and Research Hospital
Ankara, 06000
About this study
Official title: Comparison of Perioperative Analgesic Efficacy in Patients Who Had Femoral Nerve Block, Adductor Canal Block and 4in1 Block Applied in Knee Surgery
Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). In addition, opioid-related side effects such as postoperative nausea, vomiting, pruritus, sedation, and respiratory depression are less. Therefore, interest in regional blocks such as femoral, sciatic, adductor, combined femoral, and sciatic is increasing. The knee joint is innervated by various nerves (genicular nerves) from the femoral, obturator, and sciatic nerves, and a comprehensive but simple technique is needed for postoperative analgesia. Complete and comprehensive postoperative analgesia was possible with this block, a simple single injection technique. The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block, and 4in1 block in patients who will undergo knee surgery.
- Being tested
- femoral nerve block, adductor canal block, 4in1 block
- Keywords
- 4 in 1 block, femoral block, adductor canal block
- Medical subject headings
- Bites and Stings, Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
femoral nerve blockOther
To evaluate the intraoperative analgesia effectiveness of femoral block in patients who will have knee surgery.
adductor canal blockOther
To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.
4in1 blockOther
To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.
| Study group | Role | What they receive |
|---|---|---|
| femoral nerve block | Experimental | To evaluate the intraoperative analgesia effectiveness of femoral nerve block in patients who will have knee surgery. Receives: Other: femoral nerve block |
| adductor canal block | Experimental | To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery. Receives: Other: adductor canal block |
| 4in1 block | Experimental | To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery. Receives: Other: 4in1 block |
What is being measured
The primary outcome is the main question the study is designed to answer.
intraoperative analgesia efficacy
The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.
Measured: perioperative period
Secondary outcomes (1)
postoperative analgesia efficacy
The aim of our study is to evaluate the postoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.
Measured: perioperative period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Dec 2022
- Study start1 Sep 2022
- Primary completion20 Jun 2025
- Study completion30 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for BlockStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Group I: Femoral nerve block Group II: Adductor canal block Group III: 4in1 block
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Funda Atar, Diskapi Yildirim Beyazit Education and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05643040
- Sponsor's protocol ID
- 06/06/2022 139/13
- Status last verified
- Jun 2025
- First submitted
- 23 Nov 2022
- Last updated
- 3 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundert A, Sage D, Futter M, Saville G, Clark T, MacMahon S. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000 Dec 16;321(7275):1493. doi: 10.1136/bmj.321.7275.1493.
PubMed 11118174Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for total knee arthroplasty: Ultrasound guided single injection modified 4 in 1 block. J Anaesthesiol Clin Pharmacol. 2020 Apr-Jun;36(2):261-264. doi: 10.4103/joacp.JOACP_260_19. Epub 2020 Jun 15.
PubMed 33013045Atar F, Ozkan Sipahioglu F, Altinsoy S, Sezgi A, Ozguner Y, Yamankilic Mumcu O, Ozkan D, Ergil J. Comparison of the 4-in-1 block technique with femoral and adductor canal blocks in arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial. BMC Anesthesiol. 2026 Jul 22;26(1):603. doi: 10.1186/s12871-026-04109-y.
PubMed 42850592
Study at a glance
From the registry record, last updated by the sponsor on 3 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Perioperative Analgesic Efficacy in Patients Who Had Femoral Nerve Block, Adductor Canal Block and 4in1 Block Applied in Knee Surgery
- ClinicalTrials.gov ID
- NCT05643040
- Acronym / sponsor ID
- 06/06/2022 139/13
- Keywords
- 4 in 1 block, femoral block, adductor canal block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Diskapi Yildirim Beyazit Education and Research HospitalOther government
- Study start
- 1 Sep 2022 (actual)
- Primary completion
- 20 Jun 2025 (actual)
- Study completion
- 30 Jun 2025 (actual)
- First posted
- 8 Dec 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). In addition, opioid-related side effects such as postoperative nausea, vomiting, pruritus, sedation, and respiratory depression are less. Therefore, interest in regional blocks such as femoral, sciatic, adductor, combined femoral, and sciatic is increasing. The knee joint is innervated by various nerves (genicular nerves) from the femoral, obturator, and sciatic nerves, and a comprehensive but simple technique is needed for postoperative analgesia. Complete and comprehensive postoperative analgesia was possible with this block, a simple single injection technique. The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block, and 4in1 block in patients who will undergo knee surgery.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
- Model description
- Group I: Femoral nerve block Group II: Adductor canal block Group III: 4in1 block
| Arm | Type | Receives |
|---|---|---|
| femoral nerve block | Experimental | Other: femoral nerve blockTo evaluate the intraoperative analgesia effectiveness of femoral nerve block in patients who will have knee surgery. |
| adductor canal block | Experimental | Other: adductor canal blockTo evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery. |
| 4in1 block | Experimental | Other: 4in1 blockTo evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery. |
Who may qualify
- Ages
- 18 to 99 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients between the ages of >18
- undergone knee surgery
- American Society of Anesthesiologists (ASA) classification I-III group.
Key exclusion criteria (1 listed)
- Patients who do not want to participate in the study coagulopathy peripheral neuropathy local anesthetic drug allergy chronic opioid users anticoagulant users pregnant patients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| femoral nerve blockTo evaluate the intraoperative analgesia effectiveness of femoral block in patients who will have knee surgery. | Other | femoral nerve block |
| adductor canal blockTo evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery. | Other | adductor canal block |
| 4in1 blockTo evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery. | Other | 4in1 block |
Primary outcome
intraoperative analgesia efficacy
Time frame: perioperative period
The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.
1 secondary outcome
postoperative analgesia efficacy
Time frame: perioperative period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jul 2025.
- Background: PubMed 11118174Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundert A, Sage D, Futter M, Saville G, Clark T, MacMahon S. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000 Dec 16;321(7275):1493. doi: 10.1136/bmj.321.7275.1493.
- Background: PubMed 33013045Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for total knee arthroplasty: Ultrasound guided single injection modified 4 in 1 block. J Anaesthesiol Clin Pharmacol. 2020 Apr-Jun;36(2):261-264. doi: 10.4103/joacp.JOACP_260_19. Epub 2020 Jun 15.
- Derived from this study: PubMed 42850592Atar F, Ozkan Sipahioglu F, Altinsoy S, Sezgi A, Ozguner Y, Yamankilic Mumcu O, Ozkan D, Ergil J. Comparison of the 4-in-1 block technique with femoral and adductor canal blocks in arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial. BMC Anesthesiol. 2026 Jul 22;26(1):603. doi: 10.1186/s12871-026-04109-y.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing femoral nerve block, adductor canal block and 4in1 block in people with Block and Analgesia, run by Diskapi Yildirim Beyazit Education and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
intraoperative analgesia efficacy (time frame: perioperative period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05643040, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jul 2025.