Prevention of Stroke or Systemic EmbolismPhase 3OCEANIC-AFNCT05643573
A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke
A Phase 3 study testing Asundexian (BAY2433334) and Apixaban in people with Prevention of Stroke or Systemic Embolism and Atrial Fibrillation, run by Bayer at 1,069 sites in 38 countries.
Trial summary
Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel). Atrial fibrillation is a condition of having irregular and often rapid heartbeat. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Prevention of Stroke or Systemic Embolism, Atrial Fibrillation
- What is being tested?
- Asundexian (BAY2433334) and Apixaban
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 14,830 participants
- Where
- 1,069 sitesin 38 countries
- Study dates
- 5 Dec 2022to 31 Jan 2024
- Phase
- Phase 3
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18 years of age or older
- The patient willing and able to understand the Patient information Sheet and provide written informed consent
- Atrial fibrillation with an indication for indefinite treatment with an oral anticoagulant
- CHA2DS2-VASc score ≥ 3 if male or ≥ 4 if female, OR CHA2DS2-VASc score of 2 if male or 3 if female and at least one of the following enrichment criteria:
- age ≥ 70
- previous stroke, transient ischemic attack, or systemic embolism
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- renal dysfunction with eGFR < 50 ml/min within 14 days prior to randomization
- prior episode of non-traumatic major bleeding
- current single agent antiplatelet therapy planned to continue for at least 6 months after randomization
- ≤ 6 consecutive weeks of treatment with oral anticoagulant prior to randomization.
Who cannot join
- Mechanical heart valve prosthesis
- Moderate-to-severe mitral stenosis at the time of study inclusion.
- Atrial fibrillation only due to reversible cause.
- Participants after successful ablation therapy without documented recurrent AF or participants after left atrial appendage occlusion / exclusion or plan for ablation or Left atrial appendage (LAA) occlusion / exclusion within the next 6 months.
- Recent ischemic stroke (within 7 days prior to randomization).
- Active non-trivial bleeding; known chronic bleeding disorder ; history of non-traumatic intracranial hemorrhage.
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- Known significant liver disease or known hepatic insufficiency classified as Child-Pugh B or C at randomization.
- Estimated glomerular filtration rate (eGFR) < 25 mL/min/1.73 m2 within 14 days prior to randomization or on dialysis or expected to be started on dialysis within the next 12 months starting from randomization.
- Major surgery during the last 30 days prior to randomization.
- Known allergy, intolerance or hypersensitivity to either of the study interventions.
- Any contraindication for the use of an anticoagulant or listed in the local labelling for apixaban.
- Requirement for chronic anticoagulation for a different indication than AF, e.g. mechanical heart valve or left ventricular cardiac thrombus (atrial thrombus is allowed), or dual antiplatelet therapy (single agent therapy is allowed).
- Treatment with Vitamin K antagonist (VKA) in the 10 days prior to randomization.
- Concomitant use of or anticipated need for:
- daily or near daily (> 5 days per week) therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) for more than 4 weeks during the study
- herbal or traditional medicine, and / or supplements with known anticoagulant and / or antiplatelet effect
- combined P-glycoprotein (P-gp) and strong cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors
- combined P-gp and strong / moderate CYP3A4 inducers Respective substances (apart from NSAIDs) must be stopped - in case of combined inhibitors / inducers of CYP3A4 and P-gp for at least 14 days before randomization.
- Previous (within 30 days or 5 half-lives of the investigational drug, whichever is longer) or concomitant participation in another clinical study with investigational medicinal product(s) or device(s). Registries and observational studies are allowed.
- Known current alcohol and / or illicit drug abuse.
- Close affiliation with the investigational site.
- Any other history, condition or therapy, or uncontrolled intercurrent illness which would make the participant unsuitable for the study vulnerable or life expectancy < 12 months.
Trial locations and contacts
1,069 sites in 38 countries.
1069 sites in 38 countries
United States163 sites
Cambridge Medical Trials
Alexandria, Louisiana, 71301
PharmaTex Research, LLC
Amarillo, Texas, 79109
Accellacare | Ames, IA
Ames, Iowa, 50010
AnMed Clinical Research
Anderson, South Carolina, 29621
Morehouse School of Medicine | Clinical Research Centre
Atlanta, Georgia, 30303-3031
University of Colorado Hospital - Cardiology
Aurora, Colorado, 80045
LifeBridge Health | Sinai Hospital - Platelet and Thrombosis Research Department
Baltimore, Maryland, 21215
Spectrum Clinical Research | Maryland Cardiovascular Specialists
Baltimore, Maryland, 21229
Johns Hopkins Hospital/Health System
Baltimore, Maryland, 21287
Northeast Cardiology Associates
Bangor, Maine, 04401
Ochsner Clinic Foundation
Baton Rouge, Louisiana, 70836
McLaren Health Care | McLaren Bay Region - Research Department
Bay City, Michigan, 48708
Integrity Clinical Research | Florida Premier Cardiology
Boynton Beach, Florida, 33437
Integrity Clinical Research | Cardiology Associates of South Florida
Boynton Beach, Florida, 33472
Cardiovascular & Vein Center of Florida | Bradenton, FL
Bradenton, Florida, 34209
Nova Clinical Research | Brandenton, FL
Bradenton, Florida, 34209
Advanced Heart Care, LLC | Bridgewater, NJ
Bridgewater, New Jersey, 08807
Holston Medical Group - Bristol
Bristol, Tennessee, 37620
Capital Area Research | Camp Hill, PA
Camp Hill, Pennsylvania, 17011
Aultman | Aultman Hospital Main Campus - Clinical Trials
Canton, Ohio, 44710
University of North Carolina at Chapel Hill | Cardiology Department
Chapel Hill, North Carolina, 27514
Medical University of South Carolina - Cardiology
Charleston, South Carolina, 29425
Erlanger Health, Inc.
Chattanooga, Tennessee, 37403
Northwestern University
Chicago, Illinois, 60611
Clearwater Cardiovascular Associates | Clearwater, FL
Clearwater, Florida, 33756
Johns Hopkins University School of Medicine | CAPRES
Columbia, Maryland, 21044
Valley Clinical Trials, Inc. | Covina, CA
Covina, California, 91723
Cardiovascular Associates Research, LLC
Covington, Louisiana, 70433
Science 37
Culver City, California, 90230
NSC Cardiology | Johns Creek, GA
Cumming, Georgia, 30041
Southwest Family Medicine Associates | Dallas, TX
Dallas, Texas, 75235
Cardiology Consultants, PA
Daytona Beach, Florida, 32114
Cardiology Associates Research Company
Daytona Beach, Florida, 32117
Integrity Clinical Research | Heller Heart Health
Delray Beach, Florida, 33446
Prime Revival Reserach Institute, LLC | Denton, TX
Denton, Texas, 76201
Henry Ford Health System
Detroit, Michigan, 48202
SEC Clinical Research
Dothan, Alabama, 36305
Doylestown Hospital
Doylestown, Pennsylvania, 18901
Duke University | Duke Clinical Research Institute - Participant Research Operations
Durham, North Carolina, 27710-4000
Duke Univ. Medical Center
Durham, North Carolina, 27710
David Turbay MD PLLC
El Paso, Texas, 79905
Midwest Cardiovascular Research and Education Foundation | Elkhart, IN
Elkhart, Indiana, 46514
University of Pittsburgh Medical Center, Hamot | Clinical Trials and Research
Erie, Pennsylvania, 16507
Inova Fairfax Hospital - Fairfax
Fairfax, Virginia, 22031
Eastern Shore Research Institute, LLC | Fairhope, AL
Fairhope, Alabama, 36532
Virginia Heart
Falls Church, Virginia, 22042
Lillestol Research LLC | Fargo, ND
Fargo, North Dakota, 58104
AA Medical Research Center | Flint, MI
Flint, Michigan, 48504
Piedmont Research Partners LLC
Fort Mill, South Carolina, 29707
Texas Health Research & Education Institute
Fort Worth, Texas, 76104
Texas Health Physicians Group - Fort Worth
Fort Worth, Texas, 76107
Anderson Medical Group and Cardiology | Anderson Medical Research, LLC
Ft. Washington, Maryland, 20744
North Florida Foundation For Research And Education | Veterans Benefits Administration
Gainesville, Florida, 32608
University of Texas Medical Branch at Galveston
Galveston, Texas, 77555-0587
Stern Cardiovascular Center
Germantown, Tennessee, 38138
Northshore Medical Center
Glenview, Illinois, 60026
CHI Health Clinic Heart Institute - Grand Island
Grand Island, Nebraska, 68803
Medication Management | Greensboro - Cardiology
Greensboro, North Carolina, 27408
Cardiovascular Research of Northwest Indiana, LLC. | Munster, IN
Hammond, Indiana, 46320
Pennsylvania State University College of Medicine
Hershey, Pennsylvania, 17033
Indago Research and Health Center | Hialeah, FL
Hialeah, Florida, 33012
Houston Methodist Hospital
Houston, Texas, 77030
IU Health Physicians Cardiology
Indianapolis, Indiana, 46202
Encore Research Group | Nature Coast Clinical Research - Inverness
Inverness, Florida, 34452
University of Iowa
Iowa City, Iowa, 52242
University of California, Irvine
Irvine, California, 92697
Jackson Heart Clinic | Jackson, MS
Jackson, Mississippi, 39216
Apex Research Foundation, LLC. | Jackson, TN
Jackson, Tennessee, 38301
University of Florida - Jacksonville
Jacksonville, Florida, 32209
Kettering Health Network | Research Institute
Kettering, Ohio, 45429
TCR Institute
Kingwood, Texas, 77339
Accellacare | Mt. Pleasant, SC
Ladson, South Carolina, 29456
Carolina Heart Specialists | Lancaster, SC
Lancaster, South Carolina, 29720
Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research Department
Lansing, Michigan, 48912
Baptist Health Lexington
Lexington, Kentucky, 40503
NJ Heart | Linden, NJ
Linden, New Jersey, 07036
Arkansas Cardiology | Little Rock
Little Rock, Arkansas, 72205
South Denver Cardiology Associates, PC
Littleton, Colorado, 80120
VA Long Beach Healthcare System
Long Beach, California, 90822
Heart Vein & Vascular | Longwood, FL
Longwood, Florida, 32779
VA Greater Los Angeles Healthcare System | West Los Angeles VA Medical Center - Cardiology Department
Los Angeles, California, 90073-1003
Baptist Health Medical Group - Louisville Cardiology
Louisville, Kentucky, 40207
Garden State Heart Care
Manalapan, New Jersey, 07726
Carient Heart and Vascular
Manassas, Virginia, 20109
M Health Fairview
Maplewood, Minnesota, 55109
Rama Research LLC | Marion, OH
Marion, Ohio, 43302-6774
North Dallas Research Associate | McKinney, TX
McKinney, Texas, 75069-1780
North Texas Research Associates
McKinney, Texas, 75071
St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology Associates
Meridian, Idaho, 83642
Life Spring Research | Miami, FL
Miami, Florida, 33130
Circuit Clinical/Crystal Run
Middletown, New York, 10941
Veterans Benefits Administration | Minneapolis VA Medical Center - Cardiology Department
Minneapolis, Minnesota, 55417
Mobile Heart Specialists, PC
Mobile, Alabama, 36608
University of South Alabama Medical Center
Mobile, Alabama, 36617
Clinical Trials of America, Inc.
Mount Airy, North Carolina, 27030
Inspira Medical Centers | Clinical Research Office
Mullica Hill, New Jersey, 08062
Intermountain Healthcare | Cardiovascular Research Department
Murray, Utah, 84107
Southwest Florida Research | Naples, FL
Naples, Florida, 34102-8143
Advanced Research for Health Improvement, LLC | Naples, FL
Naples, Florida, 34102
Vanderbilt University Medical Center
Nashville, Tennessee, 37232
Ochsner Medical Center - New Orleans
New Orleans, Louisiana, 70121
NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular Research
New York, New York, 10001
Radin Cardiovascular Medical Group
Newport Beach, California, 92663
York Clinical Research, LLC | Norfolk, VA
Norfolk, Virginia, 23504
Amicis Research Center | Northridge, CA
Northridge, California, 91324
Cardiology Associates of Fairfield County, P.C. | Stamford, CT
Norwalk, Connecticut, 06851
Affinity Health Research Institute | Oak Brook, IL
Oak Brook, Illinois, 60523
South Oklahoma Heart Research, LLC
Oklahoma City, Oklahoma, 73135
Research Integrity, LLC
Owensboro, Kentucky, 42303
Cardiology Partners Clinical Research Institute | Palm Beach Gardens Office
Palm Beach Gardens, Florida, 33410
Alta Pharmaceutical Research Center, LLC
Peachtree Corners, Georgia, 30092
Baptist Heart and Vascular/Cardiology Consultants
Pensacola, Florida, 32503
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Einstein Healthcare Network
Philadelphia, Pennsylvania, 19141
University of Pittsburgh Medical Center Health System
Pittsburgh, Pennsylvania, 15219
Styde Research LLC | Plano, TX
Plano, Texas, 75093
Peace River Cardiovascular Center | Port Charlotte, FL
Port Charlotte, Florida, 33592
Sound Medical Research | Sound Medical Research of Port Orchard
Port Orchard, Washington, 98366
Oregon Health and Science University
Portland, Oregon, 97239
Cardiovascular Research of Knoxville
Powell, Tennessee, 37849
Lifespan | The Miriam Hospital - Cardiovascular Research
Providence, Rhode Island, 02906
Rapid City Regional Hospital
Rapid City, South Dakota, 57701
Reid Physician Associates | Cardiology Department
Richmond, Indiana, 47374
Hunter Holmes McGuire Veterans Affairs Medical Center
Richmond, Virginia, 23249-0001
Virginia Commonwealth University
Richmond, Virginia, 23284
The Valley Hospital, Inc.
Ridgewood, New Jersey, 07450
Division of Cardiovascular Research at Peconic Bay Med Ctr
Riverhead, New York, 11901
Mayo Clinic - Rochester
Rochester, Minnesota, 55905
Encore Research Group | St. Johns Center for Clinical Research
Saint Augustine, Florida, 32081
East Coast Institute for Research | St. Augustine, FL
Saint Augustine, Florida, 32086
Minneapolis Heart Institute
Saint Paul, Minnesota, 55102
South Texas Cardiovascular Consultants, PLLC
San Antonio, Texas, 78201
Clinical Advancement Center, PLLC
San Antonio, Texas, 78212-4740
Cottage Health | Santa Barbara Cottage Hospital - Cardiology Department
Santa Barbara, California, 93102
NorthBay Clinical Research, LLC | Santa Rosa, CA
Santa Rosa, California, 95405
Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota, FL
Sarasota, Florida, 34239
MaineHealth Maine Medical Center | Maine Medical Partners Cardiology
Scarborough, Maine, 04039
Geisinger Community Medical Center
Scranton, Pennsylvania, 18510
Adventist HealthCare | White Oak Medical Center
Silver Spring, Maryland, 20904
Sanford USD Medical Center
Sioux Falls, South Dakota, 57117
Louisiana Heart Center Research - Slidell
Slidell, Louisiana, 70458
St. Louis Heart & Vascular, PC
St Louis, Missouri, 63136
Mt. Olympus Medical Research
Sugar Land, Texas, 77479
ProMedica Toledo Hospital
Toledo, Ohio, 43615
Northwest Houston Clinical Research, PLLC - Houston Heart Center | Tomball, TX
Tomball, Texas, 77375
The Lundquist Institute | Cardiology Department
Torrance, California, 90502-2004
Harbor - UCLA Medical Center
Torrance, California, 90502
Atlanta Heart Specialists, LLC
Tucker, Georgia, 30084
Cardiology Associates Research, LLC
Tupelo, Mississippi, 38801
Tyler Cardiovascular Consultants | Tyler, TX
Tyler, Texas, 75701
CHRISTUS Trinity | Mother Frances Louis and Peaches Owen Heart Hospital - Electrophysiology Clinic
Tyler, Texas, 75702
Blue Coast Research Center, LLC
Vista, California, 92081
Cooper Specialty Care at Voorhees
Voorhees Township, New Jersey, 08043
IMA Clinical Research | Warren, NJ
Warren Township, New Jersey, 07059
Cardiology Partners Clinical Research Institute | Wellington Office
Wellington, Florida, 33449
Confluence Health
Wenatchee, Washington, 98801
Interventional Cardiology Medical Group | West Hills, CA
West Hills, California, 91307
St. Mary's Medical Center | West Palm Beach - Neurology Department
West Palm Beach, Florida, 33407-2495
Great Lakes Medical Research | Westfield, NY
Westfield, New York, 14787
Kansas Nephrology Physicians, PA
Wichita, Kansas, 67226
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711
Main Line Health
Wynnewood, Pennsylvania, 19096
Cardiology Consultants of Philadelphia | Yardley
Yardley, Pennsylvania, 19067
Japan119 sites
Ageo Central General Hospital
Ageo, Saitama, 362-8588
Akashi Medical Center | Hyogo, Japan
Akashi, Hyōgo, 674-0063
Mazda Motor Corporation Mazda Hospital
Aki-gun, Hiroshima, 735-8585
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki, Hyōgo, 660-8550
Asahikawa City Hospital
Asahikawa, Hokkaido, 070-8610
Japan Red Cross Society Azumino Hospital
Azumino, Nagano, 399-8292
Tokyo Medical and Dental University Hospital
Bunkyo-ku, Tokyo, 113-8519
CliniPro Co.,Ltd. | Tokyo-Eki Center-building Clinic - Tokyo, Japan
Chuo-ku, Tokyo, 103-0027
Fujisawa City Hospital
Fujisawa, Kanagawa, 251-8550
Fukui General Clinic
Fukui, 910-0067
Fukui Prefectural Hospital
Fukui, 910-8526
Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital
Fukuoka, 811-0213
Fukuoka University Hospital
Fukuoka, 814-0180
Fukuoka University Nishijin Hospital
Fukuoka, 814-8522
Kyushu Central Hospital
Fukuoka, 815-8588
Munakata Suikokai General Hospital | Cardiology Department
Fukutsu, Fukuoka, 811-3298
Chiba Tokushukai Hospital | Clinical Trial Center
Funabashi, Chiba, 274-8503
Gifu Heart Center
Gifu, 500-8384
Minamino Cardiovascular Hospital
Hachiōji, Tokyo, 192-0918
Tokyo Angel Hospital | Clinical Trial Department
Hachiōji, Tokyo, 193-0811
Hakodate National Hospital
Hakodate, Hokkaido, 041-8512
Hakodate Municipal Hospital
Hakodate, Hokkaido, 041-8680
Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office
Hakusan, Ishikawa-ken, 924-8588
National Hospital Organization Hamada Medical Center
Hamada, Shimane, 697-8511
National hospital Organization Mito Medical Center
Higashiibaraki, Ibaraki, 311-3193
Hyogo Prefectural HarimaHimeji General Medical Center
Himeji, Hyōgo, 670-8560
Hiroshima City Hiroshima Citizens Hospital
Hiroshima, 730-8518
Iida Hospital
Iida, Nagano, 395-8505
Nippon Medical School Chiba Hokusoh Hospital | Clinical Trial Office
Inzai, Chiba, 270-1694
Nihon University Itabashi Hospital
Itabashi-ku, Tokyo, 173-8610
Nakamura Cardiovascular Clinic
Itoshima, Fukuoka, 819-1104
Tenyoukai Central Clinic
Kagoshima, 892-0822
Kagoshima Medical Center
Kagoshima, 892-0853
Kanazawa Medical University Hospital
Kahoku-gun, Ishikawa-ken, 920-0293
Ishikawa Prefectural Central Hospital
Kanazawa, Ishikawa-ken, 920-8530
National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office
Kanazawa, Ishikawa-ken, 920-8650
Oosumikanoya Hospital
Kanoya, Kagoshima-ken, 893-0015
Ibaraki Prefectural Central Hospital
Kasama, Ibaraki, 309-1793
Kasugai Municipal Hospital
Kasugai, Aichi-ken, 486-8510
Kawaguchi Cardiovascular and Respiratory Hospital
Kawaguchi, Saitama, 333-0842
The Veritas Hospital
Kawanishi, Hyōgo, 666-0125
Kimitsu Chuo Hospital
Kisarazu, Chiba, 292-8535
Kishiwada Tokushukai Hospital
Kishiwada, Osaka, 596-0042
North Alps Medical Center Azumi Hospital
Kitaazumi-gun, Nagano, 399-8695
Kokura Memorial Hospital
Kitakyushu, Fukuoka, 802-8555
Steel Memorial Yawata Hospital
Kitakyushu, Fukuoka, 805-8508
Kobe City Medical Center General Hospital
Kobe, Hyōgo, 650-0047
Chikamori Hospital
Kochi, 780-8522
Yamanashi Prefectural Central Hospital
Kofu, Yamanashi, 400-8506
Komatsu Municipal Hospital
Komatsu, Ishikawa-ken, 923-8560
Asama Nanroku Komoro Medical Center | Komoro, Japan
Komoro, Nagano, 384-8588
Kumamoto Kinoh Hospital
Kumamoto, 860-8518
Rakuwakai Otowa Hospital
Kyoto, 607-8062
National Hospital Organization Kyoto Medical Center
Kyoto, 612-8555
Machida Municipal Hospital
Machida, Tokyo, 194-0023
Matsuyama Shimin Hospital
Matsuyama, Ehime, 790-0067
National Hospital Organization Tokyo Medical Center
Meguro-ku, Tokyo, 152-8902
Tokyo Saiseikai Central Hospital | Clinical Research Center
Minato-ku, Tokyo, 108-0073
Mito Saiseikai General Hospital
Mito, Ibaraki, 311-4198
Hayama Heart Center | Clinical Trial Center
Miura-gun, Kanagawa, 240-0116
Miyazaki Medical Association Hospital
Miyazaki, 880-2102
Iwate Prefectural Central Hospital
Morioka, Iwate, 020-0066
Japan Community Healthcare. Organization Chukyo Hospital
Nagoya, Aichi-ken, 457-8510
Japanese RedCross Aichi Medical Center Nagoya Daini Hospital
Nagoya, Aichi-ken, 466-8650
R.I.A.C Naha City Hospital
Naha, Okinawa, 902-8511
Go Neurosurgical Clinic
Nakagawa, Fukuoka, 811-1244
Japan Culture and Welfare Federation of Agricultural Cooperatives | Hokushin General Hospital
Nakano, Nagano, 383-8505
Oita Prefectural Hospital
Ōita, 870-8511
The Sakakibara Heart Institute of Okayama
Okayama, 700-0804
CMIC HealthCare Institute Co. Ltd. | Local IAA OCGMC - Okayama City Civic Hospital - Clinical Trial Centre
Okayama, 7008557
CMIC HealthCare Institute Co. Ltd. | Okayama Rosai Hospital - Clinical Trial Centre
Okayama, 7028055
Omihachiman Community Medical Center
Ōmihachiman, Shiga, 523-0082
Onga Nakama Medical Association Onga Hospital
Onga-gun, Fukuoka, 811-4342
Osaka Saiseikai Nakatsu Hospital
Osaka, 530-0012
Kitada Clinic
Osaka, 538-0044
Osaka Police Hospital | Clinical Research and Trial Center
Osaka, 543-0035
Nippon Life Hospital
Osaka, 550-0006
Japan Community Health Care Organization Osaka Hospital
Osaka, 553-0003
Saga Memorial Hospital
Saga, 849-0917
Sainokuni Higashiomiya Medical Center
Saitama, 331-8577
Sanai hospital
Saitama, 338-0837
Iwatsuki-minami Hospital
Saitama, 339-0033
Toho University Sakura Medical Center
Sakura, Chiba, 285-8741
Matsuda Cardiovascular clinic
Sapporo, Hokkaido, 003-0026
Mita Internist and Cardiology Clinic | Hokkaido, Japan
Sapporo, Hokkaido, 006-0852
Teine Keijinkai Hospital
Sapporo, Hokkaido, 006-8555
Hanaoka Seishu Memorial Hospital
Sapporo, Hokkaido, 062-0003
Miyanosawa Clinic of Internal Medicine and Cardiology
Sapporo, Hokkaido, 063-0826
Miyanomori Memorial Hospital
Sapporo, Hokkaido, 064-8570
Sapporo Higashi Tokushukai Hospital
Sapporo, Hokkaido, 065-0033
Sendai Cardiovascular Center
Sendai, Miyagi, 981-3133
Tohoku Medical and Pharmaceutical University Hospital | Center for Clinical Research Promotion and Development
Sendai, Miyagi, 983-8512
Dokkyo Medical University Hospital
Shimotsuga-gun, Tochigi, 321-0293
Tokyo Yamate Medical Center
Shinjuku-ku, Tokyo, 169-0073
Japan Culture and Welfare Federation of Agricultural Cooperatives | ShirakawaKosei General Hospital
Shirakawa, Fukushima, 105-0021
Shizuoka City Shizuoka Hospital
Shizuoka, 420-8630
JCHO Tokuyama Central Hospital
Shūnan, Yamaguchi, 745-8522
NewHeart Watanabe Institute
Suginami-ku, Tokyo, 168-0065
Osaka Saiseikai Senri Hospital
Suita, Osaka, 565-0862
Japanese Red Cross Society Suwa Hospital
Suwa, Nagano, 392-8510
Japan Culture and Welfare Federation of Agricultural Cooperatives | Suzuka Chuo General Hospital
Suzuka-shi, Mie-ken, 513-8630
National Hospital Organization Disaster Medical Center
Tachikawa, Tokyo, 190-0014
Kagawa Prefectural Central Hospital
Takamatsu, Kagawa-ken, 760-8557
Higashi Takarazuka Satoh Hospital
Takarazuka, Hyōgo, 665-0873
National Hospital Organization Takasaki General Medical Center
Takasaki, Gunma, 370-0829
Fukuoka Shinmizumaki Hospital | Clinical Trial Management Office
Tateyashiki, Mizumakimachi, on, Fukuoka, 807-0051
Oji General Hospital
Tomakomai, Hokkaido, 053-8506
Tomakomai City Hospital
Tomakomai, Hokkaido, 053-8567
JA Toride Medical Center
Toride, Ibaraki, 302-0022
Mitoyo General Hospital | Kagawa, Japan
Toyohama-Cho,Kanonji-City, Kagawa-ken, 769-1695
Japan Culture and Welfare Federation of Agricultural Cooperatives | Toyota Kosei Hospital
Toyota, Aichi-ken, 470-0396
Tsuchiura Kyodo General Hospital
Tsuchiura, Ibaraki, 300-0028
Sakurabashi Watanabe Future Medical Hospital | Department of Cardiology
Umeda Kita-Ku, Osaka-shi, Osaka, 5320001
Urasoe General Hospital | Clinical Research Support Center
Urasoe, Okinawa, 901-2102
Saiseikai Wakayama Hospital | Pharmaceutical department
Wakayama, 640-8158
Yanagawa Hospital
Yanagawa, Fukuoka, 832-0077
Yao Tokushukai General Hospital | Clinical Research Center
Yao, Osaka, 581-0011
Yokohama City University Medical Center
Yokohama, Kanagawa, 232-0024
Yokohama Sakae Kyosai Hospital
Yokohama, Kanagawa, 247-8581
China88 sites
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, 14010
Baotou Central Hospital
Baotou, Inner Mongolia, 14040
Beijing Chaoyang Hospital, Capital Medical University
Beijing, 100020
Beijing Anzhen Hospital, Capital Medical University
Beijing, 100029
China-Japan Friendship Hospital
Beijing, 100029
Peking University First Hospital
Beijing, 100034
Xuanwu Hospital Capital Medical University
Beijing, 100053
Beijing Tongren Hospital, Capital Medical University (West)
Beijing, 100730
Peking Union Medical College Hospital CAMS
Beijing, 100730
Beijing Tsinghua Changgung Hospital
Beijing, MISSING
Cangzhou Central Hospital
Cangzhou, Hebei, 61000
China-Japan Union Hospital of Jilin University
Changchun, Jilin, 130031
The Third Xiangya Hospital of Central South University
Changsha, Hunan, 410000
The Third Hospital of Changsha
Changsha, Hunan, 410011
Chengdu Second People's Hospital
Chengdu, Sichuan, 610021
West China Hospital,Sichuan University
Chengdu, Sichuan, 610041
SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
Chengdu, Sichuan, 610072
Daqing Oilfield General Hospital
Daqing, Heilongjiang, 163311
People's Hospital of Deyang City
Deyang, Sichuan, 618000
The 1st Affiliated Hospital Fujian Medical University
Fuzhou, Fujian, TBC
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510000
Guangzhou First People Hospital
Guangzhou, Guangdong, 510180
The First Affiliated Hospital of Guangzhou University of TCM
Guangzhou, Guangdong, 510405
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510630
Guangzhou Panyu Central Hospital
Guangzhou, Guangdong, 511400
The 2nd Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, TBC
Hainan Provincial People's Hospital
Haikou, Hainan, 570311
The 1st Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, 310000
Affiliated Hangzhou First People's Hospital, Zhejiang Univ
Hangzhou, Zhejiang, 310006
The 4th Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001
Inner Mongolia People's Hospital
Hohhot, Inner Mongolia, 010017
Huai'an First People's Hospital, Nanjing Medical University
Huai'an, Jiangsu, 223300
Huizhou Central People's Hospital
Huizhou, Guangdong, 516001
Affiliated Hospital of Jiangsu University
JiangSu, Jiangsu, 212001
Jinan Central Hospital
Jinan, Shandong, 250013
The 2nd Affiliated Hospital of Shandong University
Jinan, Shandong, 250033
Qilu Hosp., Shandong Univ.
Jinan, Shandong, TBC
Affiliated Hospital of Jining Medical University
Jining, Shandong, 272007
Jining No.1 People's Hospital
Jining, Shandong, 272011
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, Liaoning, 121001
Lanzhou University Second Hospital
Lanzhou, Gansu, 730030
Liuzhou Worker's Hospital
Liuzhou, Guangxi, 545005
1st Affiliated Hospital of Henan Science and Technology Univ
Luoyang, Henan, 471000
Luoyang Third People's Hospital
Luoyang, Henan, 471002
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, 330006
The First Affiliated Hospital of NanChang University
Nanchang, Jiangxi, 330006
The Third Hospital of Nanchang
Nanchang, Jiangxi, 330009
The Second Affiliated Hospital of Nanjing Medical university
Nanjing, Jiangsu, 210000
Nanjing First Hospital
Nanjing, Jiangsu, 210006
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009
Nanjing Jiangning Hospital
Nanjing, Jiangsu, 211103
Ningbo First Hospital
Ningbo, Zhejiang, 315010
Hwa Mei Hospital, University of Chinese Academy Sciences
Ningbo, Zhejiang, 31510
Panjin Liaohe Oilfield Gem Flower Hospital
Panjin, Liaoning, 124010
Jiangxi PingXiang people's Hospital
Pingxiang, Jiangxi, 337055
Hainan Third People's Hospital (Province Nongken Sanya Hopt)
Sanya, Hainan, 572000
Zhongshan Hospital, Fudan University
Shanghai, 200032
Huashan Hospital, Fudan University
Shanghai, 200040
Shanghai General Hospital
Shanghai, 200080
Shanghai Putuo District Central Hospital
Shanghai, 200333
The First Hospital of Hebei Medical Univesity
Shijiazhuang, Hebei, 50000
Taian City Central Hospital
Taian, Shandong, 271099
Shanxi Candiovascular Hospital
Taiyuan, Shanxi, 30024
Shanxi Bethune Hospital
Taiyuan, Shanxi, 30032
Taizhou People's Hospital
Taizhou, Jiangsu, MISSING
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, 317099
Tianjin People's Hospital
Tianjin, 300000
Teda International Cardiovascular Hospital
Tianjin, 300457
Tonghua Central Hospital
Tonghua, Jilin, 134001
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, MISSING
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, 325000
The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...
Wuhan, Hubei, 430014
Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech
Wuhan, Hubei, 430030
Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech
Wuhan, Hubei, 430034
Renmin Hosp., Wuhan Univ.
Wuhan, Hubei, 430040
Shaanxi Provincial People's Hospital
Xi’an, Shanxi, 710068
Xiamen Cardiovascular Hospital Xiamen University
Xiamen, Fujian, 361006
Yan'an University Xianyang Hospital
Xianyang, Shaanxi, 716000
Qinghai University Affiliated Hospital
Xining, Qinghai, 810001
Xinxiang Central Hospital
Xinxiang, Henan, 453000
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, 225001
Affiliated Hospital of Yangzhou University (Yangzhou First People's Hospital)
Yangzhou, Jiangsu, 225012
Yinchuan No.1 People's Hospital
Yinchuan, Ningxia, 750001
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750004
Yuncheng Central Hospital
Yuncheng, Shanxi, 44099
The First affiliated Hospital of Hebei North University
Zhangjiakou, Hebei, 075000
Zibo Central Hospital
Zibo, Shandong, 250036
Canada40 sites
Viacar Recherches Cliniques Inc.
Brossard, Quebec, J4Z 2K9
Cambridge Cardiac Care Center
Cambridge, Ontario, N1R 6V6
CIUSSS Saguenay Lac-St-Jean
Chicoutimi, Quebec, G7H 5H6
Edmonton Cardiology Consultants
Edmonton, Alberta, T5H 4B9
University of Alberta Hospital
Edmonton, Alberta, T6G 2B7
QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 3A7
Hamilton Health Sciences
Hamilton, Ontario, L8L 2X2
McMaster University Medical Centre
Hamilton, Ontario, L8L 2X2
Hamilton Med.Research Group - DCT
Hamilton, Ontario, L8M 1K7
Hamilton Medical Research Group
Hamilton, Ontario, L8M 1K7
St. Joseph's Healthcare - Hamilton
Hamilton, Ontario, L8N 4A6
Interior Health - Royal Inland Hospital
Kamloops, British Columbia, V2C 2T1
Centre intégré de santé et de services sociaux de Laval, Hôp
Laval, Quebec, H7M 3L9
Milestone Research
London, Ontario, N5W 6A2
London Health Sciences Centre | University Hospital - London Heart Rhythm Program - Cardiology
London, Ontario, N6A5A5
Centricity Research Mirabel Multispecialty
Mirabel, Quebec, J7J 2K8
G.A. Research Associates, Ltd.
Moncton, New Brunswick, E1G 1A7
Montreal Heart Institute
Montreal, Quebec, H1T 1C8
CHUM - Centre hospitalier de l'Université de Montréal
Montreal, Quebec, H2X 0C1
McGill University Health Centre - Glen Site
Montreal, Quebec, H3G1A4
CIUSSS NÎM Hôpital Sacré-Coeur
Montreal, Quebec, H4J 1C5
Fraser Clinical Trials, Inc.
New Westminster, British Columbia, V3L 3W4
Oakville Cardiovascular Research
Oakville, Ontario, L6K 3W7
Dr. James Cha
Oshawa, Ontario, L1J2K1
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
CHU de Québec-Université Laval
Québec, Quebec, G1R 2J6
Institut universitaire de cardiologie et de pneumologie de Q
Québec, G1V 4G5
Heart Health Institute
Scarborough Village, Ontario, M1B 4Z8
CIUSSS de l'Estrie-CHUS, Hopital Fleurimont
Sherbrooke, Quebec, J1H 5N4
Niagara Health - St. Catharines Site
St. Catharines, Ontario, L2S 0A9
Memorial University of Newfoundland
St. John's, Newfoundland and Labrador, A1B3V6
CISSSL - Hopital Pierre-Le Gardeur
Terrebonne, Quebec, J6V 2H2
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5
St. Michael's Hospital
Toronto, Ontario, M5B 1W8
Toronto General Hospital UHN
Toronto, Ontario, M5G 2C4
Women's College Hospital | WCH Main Site - Women's College Research Institute - Cardiology Department
Toronto, Ontario, M5S 1B2
Diex Research Trois-Rivières Inc.
Trois-Rivières, Quebec, G9A 4P3
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R 1B2
Dr. Louis Yao
York, Ontario, M9N 1W4
France33 sites
Centre Hospitalier Universitaire - Angers
Angers, 49933
Centre Hospitalier Intercommunal de la Côte Basque-Bayonne
Bayonne, 64100
Hopital Charles Nicolle Chu Rouen
Bois-Guillaume, 76320
Hôpital La Cavale Blanche - CHU de Brest
Brest, 29200
Hôpital Louis Pradel - Bron
Bron, 69677
CHU de Caen - Hôpital Côte de Nacre
Caen, 14033
Hôpital Trousseau - Tours
Chambray-lès-Tours, 37170
Centre Hospitalier - Cholet
Cholet, 49325
Hôpital Henri Mondor
Créteil, 94010
CHU GRENOBLE - Hopital Michallon
Grenoble, 38043
Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, 85925
Centre Hospitalier Louis Pasteur
Le Coudray, 28630
Centre Hospitalier du Docteur Schnaffer - Lens
Lens, 62307
Hôpital Dupuytren
Limoges, 87042
Hôpital Arnaud de Villeneuve - Montpellier
Montpellier, 34059
Hôpital Guillaume et René Laennec - Nantes
Nantes, 44035
Nouvelles Cliniques Nantaises - Nantes
Nantes, 44277
Hôpital Pasteur - Nice
Nice, 6002
Hopital Carémeau - Nîmes
Nîmes, 30029
Institut Mutualiste Montsouris
Paris, 75014
Hôpital de la Pitié-Salpétrière
Paris, 75651
Hopital Européen Georges Pompidou - Paris
Paris, 75908
Hôpital Cardiologique - Pessac
Pessac, 33604
CHU Rennes, H Pontchaillou, Cardiologie
Rennes, 35033
Centre Hospitalier Régional - Saint Brieuc
Saint-Brieuc, 22000
Centre de Cardiologie Nord - Saint Denis
Saint-Denis, 93207
Hôpital Civil - Strasbourg
Strasbourg, 67091
CHI Toulon - H La Seyne - Cardiologie
Toulon, 83000
Hôpital de Rangueil - Toulouse
Toulouse, 31059
Clinique Pasteur - Toulouse
Toulouse, 31076
Centre Hospitalier Gustave Dron - Tourcoing
Tourcoing, 59280
Centre Hospitalier - Valenciennes Cedex
Valenciennes, 59322
Centre Hospitalier Universitaire de Nancy
Vandœuvre-lès-Nancy, 54500
Australia30 sites
Nightingale Research
Adelaide, South Australia, 5000
Royal Adelaide Hospital
Adelaide, South Australia, 5000
Advara HealthCare Wesley
Auchenflower, Queensland, 4066
Grampians Health Ballarat
Ballarat, Victoria, 3350
Flinders Medical Centre
Bedford Park, South Australia, 5042
Sunshine Coast University Hospital
Birtinya, Queensland, 4575
Blacktown Hospital
Blacktownn, New South Wales, 2148
Eastern Health
Box Hill, Victoria, 3128
Royal Brisbane & Women's Hospital
Brisbane, Queensland, 4029
Concord Repatriation General Hospital
Concord, New South Wales, 2139
The Canberra Hospital
Garran, Australian Capital Territory, 2605
Barwon Health
Geelong, Victoria, 3220
The Prince Charles Hospital
Herston, Queensland, 4029
Baker Heart and Diabetes Institute
Hoppers Crossing, Victoria, 3029
Nepean Hospital
Kingswood, 2747
Advara HealthCare Leabrook
Leabrook, South Australia, 5068
South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department
Liverpool, New South Wales, 2170
Cabrini Malvern
Malvern, Victoria, 3144
The Alfred Hospital
Melbourne, Victoria, 3004
Fiona Stanley Hospital
Murdoch, Western Australia, 6961
John Hunter Hospital
New Lambton, New South Wales, 2305
Royal Melbourne Hospital
Parkville, Victoria, 3050
Advara HealthCare Joondalup
Perth, Western Australia, 6150
Redcliffe District Hospital
Redcliffe, Queensland, 4020
Advara HeartCare Melbourne
Ringwood, Victoria, 3135
Gold Coast University Hospital
Southport, Queensland, 4215
The Avenue Cardiovascular Centre
St Kilda East, Victoria, 3183
Core Research Group Pty Ltd. | Brisbane, Australia
Taringa QLD, Queensland, 4068
Illawarra Shoalhaven Local Health District
Wollongong, New South Wales, 2500
Queen Elizabeth Hospital AUS
Woodville South, South Australia, 5011
Germany29 sites
UniKlinikum Aachen|Kardio, Angio, Intensivmedizin
Aachen, North Rhine-Westphalia, 52074
Universitaets Herzzentrum Bad Krozingen
Bad Krozingen, Baden-Wurttemberg, 79189
St. Vinzenz-Hospital|Innere Medizin III, Kardiologie
Cologne, North Rhine-Westphalia, 50733
St.Johannes-Hospital|Klinik fuer Innere Medizin I
Dortmund, North Rhine-Westphalia, 44137
Klinische Forschung Dresden | Dresden, Germany
Dresden, Saxony, 01069
Krankenhaus Dresden-Friedrichstadt
Dresden, Saxony, 1067
Praxisklinik Herz und Gefaesse|Kardiologische Ambulanz
Dresden, Saxony, 1099
Klinikum Fulda gAG|Medizinische Klinik I
Fulda, Hesse, 36043
Ev. Krankenhaus Hagen-Haspe|Kardiologie und Rhythmologie
Hagen, North Rhine-Westphalia, 58135
Uniklinikum Hamburg-Eppendorf|Klinik für Kardiologie
Hamburg, 20246
Klinische Forschung Hamburg GmbH
Hamburg, 20253
Cardiologicum Hamburg
Hamburg, 22041
Medizinische Hochschule Hannover|Kardiologie und Angiologie
Hanover, Lower Saxony, 30625
Uni-Klinikum Heidelberg | Kardiologie Angiologie Pneumologie
Heidelberg, Baden-Wurttemberg, 69120
Uniklinik Jena / Kardiologie
Jena, Thuringia, 7747
MEDICLIN Herzzentrum Lahr|Kardiologie
Lahr, Baden-Wurttemberg, 77933
Uniklinik Leipzig / Kardiologie
Leipzig, Saxony, 4103
Klinikum Lüdenscheid - Märkische Kliniken GmbH
Lüdenscheid, North Rhine-Westphalia, 58515
Cardio Centrum Ludwigsburg
Ludwigsburg, Baden-Wurttemberg, 71634
Universitätsmedizin der Johannes Gutenberg Universität Mainz
Mainz, Rhineland-Palatinate, 55101
Praxis Hr. Dr. med. Jens Taggeselle
Markkleeberg, Saxony, 04416
Kliniken Maria Hilf GmbH
Mönchengladbach, North Rhine-Westphalia, 41063
Sana-Klinikum Remscheid|Kardio, Angio, Pneumo u. Intensivmed
Remscheid, North Rhine-Westphalia, 42859
Hegau-Bodensee-Klinikum Singen|I. Medizinische Klinik
Singen, Baden-Wurttemberg, 78224
Siteworks Pruefzentrum Voelklingen
Völklingen, Saarland, 66333
Josephs-Hospital|Kardiologie, Rhythmologie und Angiologie
Warendorf, North Rhine-Westphalia, 48231
Kardiologische Praxis Hr. Dr. A. Al-Zoebi
Wermsdorf, Saxony, 4779
Forschungszentrum Ruhr KliFoCenter GmbH
Witten, North Rhine-Westphalia, 58455
Klinikum Worms gGmbH|Kardiologie und Angiologie
Worms, Rhineland-Palatinate, 67550
Italy29 sites
A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"
Ancona, The Marches, 60126
AUSL Toscana Sud-Est
Arezzo, Tuscany, 52044
ASUR Marche - Area Vasta 5
Ascoli Piceno, The Marches, 63074
Ente Ecclesiastico Ospedale Generale Regionale Miulli
Bari, Apulia, 70021
ASST Papa Giovanni XXIII
Bergamo, Lombardy, 24127
Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Cardiologia
Bologna, Emilia-Romagna, 40133
ASST del Garda
Brescia, Lombardy, 25085
A.O Sant'Anna-San Sebastiano
Caserta, Campania, 81100
ASL2 Lanciano-Vasto-Chieti
Chieti, Abruzzo, 66013
A.O.U. di Ferrara
Ferrara, Emilia-Romagna, 44124
A.O.U. Careggi
Florence, Tuscany, 50134
A.O.U. Ospedali Riuniti Foggia
Foggia, Apulia, 71122
A.O.U. Policlinico G. Martino
Messina, Sicily, 98124
Ospedale San Raffaele s.r.l. - Cardiologia Clinica
Milan, Lombardy, 20132
IRCCS Centro Cardiologico Monzino
Milan, Lombardy, 20138
A.O.U. di Modena - Policlinico
Modena, Emilia-Romagna, 41100
A.O.R.N. Ospedali dei Colli (Monaldi-Cotugno-CTO)
Naples, Campania, 80131
A.O.U. Policlinico Federico II Napoli
Naples, Campania, 80131
A.O.U. Maggiore della Carità
Novara, Piedmont, 28100
A.O.U. di Padova
Padova, Veneto, 35128
A.O.U. di Parma
Parma, Emilia-Romagna, 43126
A.O. di Perugia
Perugia, Umbria, 6129
A.O.U. Pisana
Pisa, Tuscany, 56126
Asl Roma 2
Rome, Lazio, 157
A.O.U. Policlinico Umberto I
Rome, Lazio, 161
Humanitas Mirasole S.p.A. - Centro Trombosi e Malattie Emorragiche
Rozzano, Lombardy, 20089
ULSS2 Marca Trevigiana
Treviso, Veneto, 31015
ASST Sette Laghi
Varese, Lombardy, 21049
ULSS3 Serenissima
Venezia, Veneto, 30174
Brazil26 sites
Centro de Pesquisa Clinica do Coração | Aracaju, Brasil
Aracaju, Sergipe, 49055-530
Cardresearch Cardiologia Assistencial e de Pesquisa | Belo Horizonte, Brazil
Belo Horizonte, Minas Gerais, 30150-240
CardioBlu | Unidade Sabin
Blumenau, Santa Catarina, 89010-500
UNESP Faculdade de Medicina de Botucatu | UPECLIN
Botucatu, São Paulo, 18618-970
Campinas Clinical Research Institute (IPECC) | Campinas, Brazil
Campinas, São Paulo, 13060-080
Quanta Diagnostico Por Imagem | Research and Innovation Department
Curitiba, Paraná, 80045-170
Nucleo de Pesquisa Clinica | Curitiba, Brazil
Curitiba, Paraná, 80730-150
Centro Medico Sao Francisco | Curitiba, Brazil
Curitiba, Paraná, 80810-050
Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia
Goiânia, Goiás, 74605-020
Instituto do Coração de Marilia | Marilia, Brasil
Marília, São Paulo, 17515-000
Eurolatino Pesquisas Medicas | Uberlandia, MG
Minas Gerais, 38400-368
Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa
Paraná, Paraná, 83430-000
Hospital Maternidade e Pronto Socorro Santa Lucia | Hospital do Coracao - Research Center
Poços de Caldas, Minas Gerais, 37706-106
Irmandade da Santa Casa de Misericordia de Porto Alegre | Hospital Sao Francisco - Centro Medico Pesquisa Clinica Cardiologia
Porto Alegre, Rio Grande do Sul, 90020-090
Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center
Porto Alegre, Rio Grande do Sul, 90035-903
FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil
Porto Alegre, Rio Grande do Sul, 91350-200
Hospital Sao Lucas Copacabana | Clinical Research Department
Rio de Janeiro, 22.0080-040
Hospital Cardio Pulmonar | Salvador, Brazil
Salvador, Estado de Bahia, 40170-130
Hospital e Maternidade Christovao da Gama | Santo Andre Medical Centre - Cardiology Department
Santo André, São Paulo, 09030-010
Hospital de Base | Integrated Research Center
São José do Rio Preto, São Paulo, 15090-000
Irmandade da Santa Casa de Misericordia de Sao Paulo | Hospital Central - Cardiology Department
São Paulo, São Paulo, 01221-020
Hospital Samaritano Paulista | Clinical Research Department
São Paulo, São Paulo, 01317-002
Instituto Dante Pazzanese de Cardiologia | Divisao de Pesquisa
São Paulo, São Paulo, 04012-909
Hospital e Maternidade Sao Luiz
São Paulo, São Paulo, 04321-150
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas
São Paulo, São Paulo, 13034-685
Hospital Alemao Oswaldo Cruz | Centro Internacional de Pesquisa
São Paulo, 01321-001
Poland26 sites
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15-276
KLIMED Marek Klimkiewicz
Bialystok, 15-704
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, 85-065
Centrum Medyczne KerMed
Bydgoszcz, 85-231
Uniwersyteckie Centrum Kliniczne
Gdansk, 80-214
Samodzielny Publiczny Specjalistyczny Szpital Zachodni
Grodzisk Mazowiecki, 05 825
CLINICAL MEDICAL RESEARCH Sp. z o. o.
Katowice, 40-156
Vita Longa Sp. z o.o.
Katowice, 40-748
Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn
Krakow, 31-271
Centrum Terapii Wspolczesnej
Lodz, 90-338
CM MED-GASTR Sp. z o.o.
Lodz, 91-034
Centrum Medyczne Ogrodowa G. i M. Kania Lekarze i Lekarze Dentysci Spólka Partnerska z siedziba w Skierniewicach
Lowicz, 99-400
1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie
Lublin, 20-049
NZOZ "Twoja Przychodnia" Sp. z o.o.
Lublin, 20-857
Futuremeds sp. z o. o.
Olsztyn, 10-010
Etyka Osrodek Badan Klinicznych
Olsztyn, 10-117
NZOZ Heureka
Piaseczno, 05-500
Irmed Klimkiewicz, Rudziewicz-Kowalska Sp.j.
Piotrkow Trybunalski, 97-300
Solumed Centrum Medyczne
Poznan, 60-529
Velocity Pulawy
Puławy, 24-100
EMED Centrum Uslug Medycznych
Rzeszów, 35-205
ClinMedica Research Sp. z o.o.
Skierniewice, 96-100
"Nowe Zdrowie-Ck" Kieltucki I Wspolnicy Spolka Jawna
Staszów, 28-200
NBR Polska Tomasz Klodawski
Warsaw, 00-465
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji
Warsaw, 02-637
KO-MED Centra Kliniczne Zamosc
Zamość, 22-400
Netherlands24 sites
Ziekenhuis Amstelland
Amstelveen, 1186 AM
Amsterdam UMC | Heart Centre - Curius Research Department
Amsterdam, 1105 AZ
Gelre Apeldoorn Ziekenhuizen | Cardiology Department
Apeldoorn, 7334 DZ
Rijnstate | Arnhem - Cardiology Department - Cardio Research
Arnhem, 6815 AD
Rode Kruis Ziekenhuis
Beverwijk, 1942 LE
Tergooiziekenhuizen-Blaricum
Blaricum, 1261 AN
Amphia Breda | Department of Cardiology, BMC Research
Breda, 4818 CK
The Van Weel-Bethesda Hospital | Research Department
Dirksland, 3247 BW
Albert Schweitzer Ziekenhuis | Dordwijk - Cardiology Department
Dordrecht, 3318 AT
Catharina Hospital | Cardiology Department
Eindhoven, 5623 EJ
Treant locatie Scheper
Emmen, 7824 AA
Medisch Spectrum Twente | Thorax Centrum Twente - Foundation Cardiovascular Research and Education Enschede
Enschede, 7611 JH
Admiraal de Ruyterziekenhuis
Goes, Zeeland, 4462RA
Rivas | Beatrix Hospital Gorinchem - Cardiology Department
Gorinchem, 4204 AA
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ
Martini Ziekenhuis, Locatie van Swieten
Groningen, 9728 NT
Spaarne Gasthuis | Haarlem Zuid - Cardiology
Haarlem, 2035 RC
Saxenburgh Medisch Centrum | Cardiology Department
Hardenberg, 7772 SE
Bravis Ziekenhuis | Roosendaal - Cardiology Department
Roosendaal, 4708 AE
Medisch Centrum Haaglanden, Locatie Westeinde
The Hague, 2512 VA
HagaZiekenhuis | Cardiology Department
The Hague, 2545 AA
Ziekenhuis Rivierenland | Cardiology Research Department
Tiel, 4002 WP
VieCuri - Medisch Centrum voor Noord-Limburg locatie Venlo
Venlo, 5912 BL
Zaans Medisch Centrum | Hartvaatcentrum
Zaandam, 1502 DV
United Kingdom24 sites
Wansbeck General Hospital
Ashington, Northumberland, NE63 9JJ
North Hampshire Hospital
Basingstoke, Hampshire, RG24 9NA
Soho Health Centre, Future Meds
Birmingham, West Midlands, B21 9RY
Ely Bridge Medical Centre
Cardiff, CF5 4AD
Countess of Chester Hospital
Chester, Cheshire, CH2 1UL
Chesterfield Royal Hospital
Chesterfield, Derbyshire, S44 5BL
St Richard's Hospital
Chichester, West Sussex, PO19 6SE
Craigavon Area Hospital
Craigavon, North Ireland, BT63 5QQ
Russells Hall Hospital
Dudley, West Midlands, DY1 2HQ
Staploe Medical Centre
Ely, Cambridgeshire, CB7 5SQ
Glasgow Royal Infirmary | Stroke Unit
Glasgow, Glasgow City, G4 0SF
Northwick Park Hospital
Harrow, London, HA1 3UJ
University Hospitals Leicester
Leicester, Leicestershire, LE3 9QP
Heart and Chest Hospital
Liverpool, L14 3PE
Charing Cross Hospital
London, London, W6 8RF
King's College Hospital - NHS Foundation Trust
London, SE5 9RS
Queen Elizabeth the Queen Mother Hospital
Margate, Kent, CT9 4AN
Future Meds - Bromborough
Metropolitan Borough of Wirral, CH62 6EE
James Cook University Hospital South Tees
Middlesbrough, Yorkshire, TS43BW
Freeman Hospital
Newcastle, Tyne and Wear, NE7 7DN
Poole Hospital NHS Trust
Poole, Dorset, BH15 2JB
Lister Hospital
Stevenage, Hertfordshire, SG1 4AB
Torbay Hospital
Torbay, Devon, TQ2 7AA
Worcestershire Acute Hospital Trust
Worcester, Worcestershire, WR5 1DD
Belgium23 sites
Algemeen Stedelijk Ziekenhuis Campus Aalst
Aalst, 9300
OL Vrouwziekenhuis - Campus Aalst
Aalst, 9300
ZNA Middelheim
Antwerp, 2020
Imelda Vzw | Study Cardiology
Bonheiden, Antwerpen, 2820
Algemeen Ziekenhuis Klina | Cardiology Department
Brasschaat, 2930
AZ Sint-Jan Brugge-Oostende | Sint-Jan - Cardiology
Bruges, 8000
CU Saint-Luc/UZ St-Luc
Bruxelles - Brussel, 1200
AZ Sint Blasius, Cardiology, Dendermonde
Dendermonde, 9200
AZ Sint-Maarten
Duffel, 2570
Antwerp University Hospital | Cardiology Department
Edegem, Antwerpen, 2650
Ziekenhuis Oost-Limburg | Genk, Sint-Jan campus - Cardiology Department
Genk, 3600
AZ St-Lucas Campus St-Lucas - Cardiology
Ghent, Oost-Vlaanderen, 9000
Maria Middelares General Hospital | Cardiology Department
Ghent, Oost-Vlaanderen, 9000
Grand Hôpital de Charleroi
Gilly, 6060
Jessa Ziekenhuis
Hasselt, 3500
Groeninge Algemeen Ziekenhuis | Campus Kennedylaan - Cardiology Departement
Kortrijk, West-Vlaanderen, 8500
UZ Leuven Gasthuisberg
Leuven, Vlaams Brabant, 3000
CHC MontLégia Neurology Department
Liège, Liège, 4000
Citadelle Hospital | Cardiology Department
Liège, 4000
AZ Delta | Clinical Trial Center - Cardiology
Roeselare, 8800
Vitaz | Sint-Niklaas Hospital - Cardiology Department
Sint-Niklaas, 9100
GZA Ziekenhuizen | Saint Augustine Campus - Cardiology Department
Wilrijk, Antwerpen, 2610
University Hospital Louvain Namur | Godinne - Cardiology Department
Yvoir, Namur, 5530
Bulgaria23 sites
Multiprofile Hospital for Active Treatment Puls | Clinical Trial Center
Blagoevgrad, 2700
Multidisciplinary Hospital for Active Treatment Heart and Brain Burgas | Cardiology Department
Burgas, 8000
Medical Center Avitsena Kardzhali | Cardiology Clinic
Kardzhali, 6600
SHATC Sveti Georgi - Pernik | Pernik, Bulgaria
Pernik, 2300
Medical centre Hipokrat - N EOOD
Plovdiv, 4000
Multiprofile Hospital for Active Treatment Medline | Cardiology Department
Plovdiv, 4000
Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department
Plovdiv, 4004
Medical Center Rusemed EOOD | Ruse, Bulgaria
Rousse, 7000
Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine
Shumen, 9700
General Hospital Silistra | Department of Cardiology, Structure for Interventional Cardiology
Silistra, 7500
Cardiohelp Medical Centre | Sofia, Bulgaria
Sofia, 1142
Diagnostic Consultative Center Ascendent | Sofia, Bulgaria
Sofia, 1202
Second Medical Center Sofia EOOD
Sofia, 1202
Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department
Sofia, 1233
Multiprofile Hospital for Active Treatment National Cardiology Hospital | Cardiology Department
Sofia, 1309
University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology Clinic
Sofia, 1527
The University General Hospital for Active Care and Emergency Medicine Pirogov | Cardiology Department
Sofia, 1606
Diagnostic-Consultative Center XX | Cardiology Department
Sofia, 1618
Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department
Sofia, 1618
Multiprofile Hospital for Active Treatment Trakiya Park | Cardiology Department
Stara Zagora, 6000
Medical Center Zara-Med EOOD | Cardiology Department
Stara Zagora, 6010
NOVA Clinic Medical Center | Varna, BG
Varna, 9020
Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department
Veliko Tarnovo, 5000
Israel23 sites
HaEmek Medical Center | Internal Medicine C Department - Research Unit
Afula, 1834111
Samson Assuta Ashdod University Hospital | Cardiology Department
Ashdod, 7747629
Barzilai Ashkelon University Medical Center | Cardiology Department
Ashkelon, 7830604
Clalit Health | Soroka Medical Center - Cardiology Department
Beersheba, 8410101
Clalit Health | Soroka Medical Center - Internal Medicine Department
Beersheba, 8410101
Assuta Hospital Be'er Sheva | Heart Institute - Clinics
Beersheba, 8489507
Hillel Yaffe Medical Center | Cardiology Department
Hadera, 3810101
Rambam Health Care Campus | Cardiology Department - Cardiology Research Unit
Haifa, 3109601
Bnai Zion Medical Center | Cardiology Department
Haifa, 3339419
Carmel Medical Center | Cardiology Department - Cardiac Catheterization Unit
Haifa, 3436212
Edith Wolfson Medical Center | Internal Medicine Department
Holon, 5822012
Shaare Zedek Medical Center | The Jesselson Integrated Heart Center - Cardiology Department
Jerusalem, 9103102
Clalit Health | Meir Medical Center - Division of Cardiology - Electrophysiology and Arrhythmias Unit
Jerusalem, 9112001
Hadassah Hebrew University Hospital Ein Kerem
Jerusalem, 9112001
Poria Medical Center | Cardiovascular Department
Lower Galilee, 15208
Galilee Medical Center | Cardiology Department
Nahariya, 2210001
Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department
Petah Tikva, 4941492
Rabin Medical Center | Clinical Trials Unit - Cardiology Department
Petah Tikva, 4941492
Kaplan Medical Center | Cardiology Department - Heart Institute Research
Rehovot, 7610001
Shamir Medical Center | Cardiology Department
Rishon LeZiyyon, 6093000
Ziv Medical Center | Cardiology Department
Safed, 1311001
Tel Aviv Sourasky Medical Center | Ichilov General Hospital - Cardiology Department
Tel Aviv, 6423906
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906
Spain23 sites
University Hospital of A Coruna | Cardiology department
A Coruña, 15006
Hospital General Universitario Doctor Balmis de Alicante | Cardiology Department
Alicante, 03010
Hospital de la Santa Creu i Sant Pau | Cardiology Department
Barcelona, 08025
Vall d'Hebron Barcelona Hospital Campus | Vall d'Hebron Hospital Universitario - Cardiology Department
Barcelona, 08035
Hospital Quironsalud Barcelona | Internal Medicine Department
Barcelona, 8023
Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial
Ferrol, A Coruña, 15405
Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention
L'Hospitalet de Llobregat, Barcelona, 08907
Hospital Alta Resolucion de Lebrija | Cardiology Service Department
Lebrija, Sevilla, 41740
Hospital Universitario de La Princesa | Internal Medicine Department
Madrid, Madrid [es-m], 28006
Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna
Madrid, 28034
Hospital Universitario 12 de Octubre | Cardiology Department
Madrid, 28041
Hospital Universitario La Paz | Cardiology Department - AF, Stroke Prevention
Madrid, 28046
Hospital Universitario La Paz | IdiPAZ - Neurology Department
Madrid, 28046
Hospital Universitario Virgen de la Victoria | Cardiology Department
Málaga, Málaga, 29010
Hospital Clinico Universitario Virgen de la Arrixaca | Cardiology Department
Murcia, 30120
Hospital Universitario Central de Asturias | Servicio de Cardiologia
Oviedo, Principality of Asturias, 33006
Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department
Sanlúcar de Barrameda, Cádiz, 11540
Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department
Santiago de Compostela, A Coruña, 15706
Hospital Universitario Virgen del Rocio | Hospital General - Departamento de Cardiologia y Cirugia Cardiovascular
Seville, 41013
Hospital Alta Resolucion de Utrera | Cardiology Service Department
Utrera, Sevilla, 41710
Hospital General Universitario de Valencia | Cardiology Department
Valencia, 46014
La Fe University and Polytechnic Hospital | Cardiology Department
Valencia, 46026
Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department
Villamartín, Cádiz, 11650
Taiwan23 sites
Changhua Christian Hospital
Changhua, 50006
Mackay Memorial Hospital - Hsinchu Branch
Hsinchu, 300
Buddhist Tzu-Chi General Hospital, Hualien
Hualien City, 970
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Kaohsiung, 807377
Veterans General Hospital
Kaohsiung City, 813414
E-Da Hospital
Kaohsiung City, 82445
Chang Gung Memorial Hospital Kaohsiung
Kaohsiung City, 833
MacKay Memorial Hospital Tamsui Branch
New Taipei City, Taipei, 25160
Chung Shan Medical University Hospital
Taichung, 402306
China Medical University Hospital
Taichung, 404327
Taichung Veterans General Hospital
Taichung, 40705
Chi Mei Medical Center
Taikang, Tainan, 71004
National Cheng Kung University Hospital
Tainan, 704
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taipei, 111
Taipei Municipal Wanfang Hospital
Taipei, Taipei, 116
National Taiwan University Hospital
Taipei, 100
Mackay Memorial Hospital
Taipei, 104
Cathay General Hospital
Taipei, 106
Taipei Medical University | Clinical Research Center
Taipei, 110
Taipei Veterans General Hospital
Taipei, 11217
Tri-Service General Hospital
Taipei, 114
Chang Gung Memorial Hospital at Linkou
Taoyuan, 33305
National Yang Ming Chiao Tung University Hospital
Yilan, Ilan, 260006
Hungary22 sites
Cardiomobile Egeszsegugyi Szolgaltato Kft.
Balatonfüred, 8230
Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
Budapest, 1024
Semmelweis University
Budapest, 1088
Budapesti Uzsoki Utcai Korhaz
Budapest, 1145
Belinus Bt.
Debrecen, 4025
Kardio Egeszseghaz - Dr Amer Sayour Egyeni Vallakozo
Győr, 9024
Trial Pharma Kft. Gyula
Gyula, 5700
Somogy Varmegyei Kaposi Mor Oktato Korhaz
Kaposvár, 7400
Komaromi Selye Janos Korhaz
Komárom, 2900
Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz
Miskolc, 3526
TaNa Med Kft.
Mosonmagyaróvár, 9200
Nagykanizsai Kanizsai Dorottya Korhaz
Nagykanizsa, 8800
Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
Nyíregyháza, 4400
Borbanya Praxis Bt.
Nyíregyháza, 4405
Dr. Laszlo Elek Korhaz es Rendelointezet, Oroshaza
Orosháza, 5900
Dr. Nagy Laszlo Egyeni Egeszsegugyi Vallalkozo
Orosháza, 5900
Coromed Smo Kft
Pécs, 7623
Pecsi Tudomanyegyetem Klinikai Kozpont
Pécs, 7624
Complex Rendelo Med Zrt.
Székesfehérvár, 8000
Tolna Varmegyei Balassa Janos Korhaz
Szekszárd, 7100
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
Szombathely, 9700
Belvarosi Egeszseghaz Kft.
Zalaegerszeg, 8900
Greece21 sites
University General Hospital of Alexandroupolis
Alexandroupoli, 68100
General Hospital of Athens "Evangelismos"
Athens, 10676
HIPPOKRATION General Hospital of Athens
Athens, 115 27
Naval Hospital of Athens
Athens, 11521
G. GENNIMATAS General State Hospital of Athens
Athens, 11527
LAIKO General Hospital of Athens
Athens, 11527
General Hospital of Athens "ALEXANDRA"
Athens, 11528
University General Hospital of Athens "ATTIKON"
Chaïdári, 12462
Thriassio General Hospital of Elefsina
Elefsina, 19018
University General Hospital of Heraklion
Heraklion, 711 10
Univ. General Hospital of Ioannina
Ioannina, 45500
University General Hospital of Ioannina
Ioannina, 45500
KAT General Hospital of Athens
Kifissia, Attica, 14561
Univ. General Hospital of Larissa
Larissa, 41110
University General Hospital of Larissa
Larissa, 41110
MITERA Hospital
Marousi, 15123
Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA
Nea Ionia, 14233
University General Hospital of Patra
Pátrai, 26504
AHEPA University General Hospital of Thessaloniki
Thessaloniki, 54636
Hippokration General Hospital of Thessaloniki
Thessaloniki, 54642
General Hospital ASKLEPIEIO VOULAS
Voula, 16673
Romania21 sites
Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare
Baia Mare, 430031
Emergency County Hospital, Braila
Brăila, 810318
S.C Thera Card S.R.L
Brasov, 500102
S.C. Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL
Brasov, 500283
Spitalul Clinic Colentina
Bucharest, 20125
Emergency Institute for Cardiovascular Diseases
Bucharest, 22322
Spitalul Clinic de Urgenta Sf. Ioan
Bucharest, 42122
Spitatul Universitar de Urgenta Bucaresti
Bucharest, 50098
Cardiomed S.R.L
Cluj-Napoca, Dolj, 400015
Niculae Stancioiu Heart Institute Cluj-Napoca
Cluj-Napoca, 400001
Spitalul Clinic de Recuperare Cluj-Napoca
Cluj-Napoca, 400300
Sfantul Spiridon Emergency Clinical County Hospital
Iași, 700111
S.C. CARDIOMED S.R.L. Iasi
Iași, 700732
S.C. Sal Med SRL
Piteşti, TBC
Spitalul Judetean de Urgenta Satu Mare
Satu Mare, 440192
Spitalul de urgenta Sf. Ioan Cel Nou
Suceava, 720237
CMI. Dr. Podoleanu Cristian
Târgu Mureş, Mureș County, TBC
S.C. Cardio Med S.R.L.
Târgu Mureş, 540124
Emergency Institute of Cardiovascular Diseases & Transplant
Târgu Mureş, 540136
Municipal Clinical Emergency Hospital of Timisoara
Timișoara, Timiș County, 300254
Timisoara Institute of Cardiovascular Diseases
Timișoara, 300310
Slovakia21 sites
ALIAN s.r.o.
Bardejov, 085 01
GALENUM s.r.o.
Bratislava, 821 07
Kardiosanus | Bratislava, Slovakia
Bratislava, 84107
Nemocnica s poliklinikou Brezno, n.o.
Brezno, 977 01
KARDIO R s.r.o.
Košice, 040 11
Medical Group Kosice s.r.o. | Kosice, Slovakia
Košice, 04001
KARDIO-ANGIO s.r.o.
Levice, 93401
KardioLEV s.r.o.
Levoča, 05401
Internal and Diabetes Clinic - IN-DIA s.r.o. | Lucenec, Slovakia
Lučenec, 984 01
KardioMed | Outpatient Cardiology and Internal Medicine II Clinic
Lučenec, 984 01
KARDIO 1 | Lucenec, Slovakia
Lučenec, 98401
ORALEK, s.r.o.
Námestovo, 02901
Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department
Nitra, 949 01
Specializovana nemocnica sv. Svorada Zobor, n.o.
Nitra, 949 88
KaCH, s.r.o.
Nové Zámky, 940 02
BENIMED s.r.o.
Piešťany, 92101
Medikard | Department of Internal Medicine
Prešov, 08001
MEDISPOL s.r.o.
Prešov, 08001
Interna SK s.r.o.
Svidník, 08901
Kardiologicka ambulancia Trnava, MUDr. Vladimir Macek
Trnava, 91701
Medivasa s.r.o.
Žilina, 01001
Czechia20 sites
Kardiologicka ambulance Brno s.r.o.
Brno, 612 00
Fakultni nemocnice Brno
Brno, 625 00
Vojenska nemocnice Brno
Brno, 63600
Amkardia s.r.o.
Brno, 639 00
Kardiologicka ambulance Cormedico
Bruntál, 792 01
Nemocnice Ceske Budejovice, a.s. Department of kardiologie
České Budějovice, 370 01
Mrozek kardiologie
Frýdek-Místek, 73801
MATMED s.r.o.
Hodonín, 69501
Krajska Nemocnice Liberec
Liberec, 460 63
Fakultni Nemocnice Olomouc
Olomouc, 77900
Benedor s.r.o.
Ostrava - Poruba, Moravian-Silesian Region, 708 68
Fakultni nemocnice Plzen
Pilsen, 301 00
Cevni Kulatak
Prague, Prague, 160 00
Fakultni nemocnice Kralovske Vinohrady
Prague, 10034
Institut Klinicke a Experimentalni Mediciny
Prague, 140 21
Fakultni nemocnice v Motole
Prague, 150 06
Medicon Poliklinika Holesovice
Prague, 170 00
Nemocnice Slany
Slaný, 274 01
MUDr. Michalik s.r.o.
Zábřeh nad Odrou, 700 30
Cardio Research s.r.o.
Zlín, Zlín, 760 01
South Korea20 sites
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggido, 14068
Pusan National University Hospital
Busan, Busan Gwang''yeogsi, 49241
Dong-A University Hospital
Busan, 49201
Kyungpook National University Hospital
Daegu, Daegu Gwang''yeogsi, 41944
Keimyung University Dongsan Medical Center
Daegu, 42601
Chonnam National University Hospital
Gwangju, 501-757
Gachon University Gil Medical Center
Incheon, 21565
Bundang Cha Hospital
Seongnam-si, Gyeonggido, 13496
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggido, 13620
The Catholic University of Korea Seoul St. Mary's Hospital
Seoul, Gyeonggido, 137-701
The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital
Seoul, Seoul Teugbyeolsi, 03312
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, 3080
Korea University Anam Hospital
Seoul, 02841
Severance Hospital, Yonsei University Health System
Seoul, 03722
Asan Medical Center
Seoul, 138-736
Chung-Ang University Hospital
Seoul, 156-755
Samsung Medical Center
Seoul, 6351
Ajou University Hospital
Suwon, Gyeonggido, 443-721
Uijeongbu ST. Mary's Hospital
Uijeongbu-si, Gyeonggi-do, Gyeonggido, 11765
Yonsei University Wonju Christian Hospital
Wŏnju, Gang''weondo, 26426
Portugal18 sites
Hospital Garcia de Orta | Research Department
Almada, Setúbal District, 2805-267
Centro Clinico Academico Braga | Braga, Portugal
Braga, 4710-243
Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit
Coimbra, 3004-561
Centro Hospitalar Universitario Cova de Beira | Clinical Research Department
Covilha, Castelo Branco District, 6200-251
Centro Hospitalar de Tamega e Sousa | Hospital Padre Americo - Cardiology Department
Guilhufe, 4564-007
Hospital da Senhora da Oliveira | Clinical Research Department
Guimaraes, Braga, Braga District, 4835-044
Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
Leiria, 2410-197
Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
Lisbon, Lisbon District, 1500-650
Centro Hospitalar Universitario de Lisboa Norte | Heart and Vessels Department
Lisbon, Lisbon District, 1649-035
Centro Hospitalar de Lisboa Ocidental | Clinical Research Department
Lisbon, 1449-005
Lusiadas | Hospital Lusiadas Lisboa - Lusiadas Knowledge Center
Lisbon, 1500-458
Hospital Pedro Hispano | Clinical Research Center
Matosinhos Municipality, Porto District, 4464-513
Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos
Porto, 4200-319
Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center
Porto, 4434-502
Ucardio | Cardiology Department
Riachos, Santarém District, 2350-325
Luz Saude | Hospital da Luz Setubal - Clinical Research Department
Setúbal, 2900-722
Hospital de Vila Franca de Xira | Centro de Desenvolvimento e Investigacao
Vila Franca de Xira, Lisbon District, 2600-009
Centro Hospitalar De Tras os Montes e Alto Douro | Hospital Sao Pedro - Centro de Investigacao Clinica
Vila Real, 5000-508
Sweden18 sites
Södra Älvsborgs Sjukhus
Borås, 501 82
Falu Lasarett
Falun, 791 82
SU/Östra
Gothenburg, 416 85
Helsingborgs Lasarett
Helsingborg, TBC
Universitetssjukhuset i Linköping
Linköping, 581 85
Clemenstorget Hjärtmottagning
Lund, 222 21
Skånes Universitetssjukhus
Lund, 222 42
SU/Mölndal
Mölndal, 431 80
Vrinnevisjukhuset
Norrköping, 601 82
Universitetssjukhuset Örebro
Örebro, 701 85
Skellefteå Lasarett
Skellefteå, 931 86
Södersjukhuset AB
Stockholm, 118 83
Karolinska Universitetssjukhuset Huddinge Stockholm
Stockholm, 141 86
Karolinska Universitetssjukhuset
Stockholm, 171 76
Danderyds sjukhus
Stockholm, 182 88
Norrlands Universitetssjukhus, Umea
Umeå, 901 85
Akademiska Sjukhuset
Uppsala, TBC
Västmanlands Sjukhus Västerås
Västerås, 721 89
Argentina17 sites
Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca, Argentina
Bahía Blanca, Buenos Aires, 8000
Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina
Buenos Aires, Ciudad Auton. de Buenos Aires, C1056ABJ
CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina
CABA, Ciudad Auton. de Buenos Aires, C1018DES
Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina
Corrientes, 3400
Centro de Investigación y Prevención Cardiovascular
General Arenales, Buenos Aires, C1061AAS
Hospital Italiano de La Plata | Clinical Research Department
La Plata, Buenos Aires, B1900
Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina
Lanus, Buenos Aires, B1824
Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, Argentina
Mar del Plata, Buenos Aires, B7600FZ0
Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos
Rosario, Santa Fe Province, S2000DEJ
Laboratorio de Hemostasia y Trombosis | Rosario, AR
Rosario, Santa Fe Province, S2000DTB
CardioAlem Investigaciones | San Isidro, Argentina
San Isidro, Buenos Aires, B1642DCD
Investigaciones Clinicas Tucuman | San Miguel de Tucuman, Argentina
San Miguel de Tucumán, Tucumán Province, T4000ICL
Instituto de Investigaciones Clínicas (IIC) San Nicolas | San Nicolas de los Arroyos, Argentina
San Nicolás de los Arroyos, Buenos Aires, B2900DMH
Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina
Santa Fe, S3000FWO
Centro de Investigaciones Medicas Temperley | Buenos Aires, Argentina
Temperley, Buenos Aires, B1834GUK
Centro de Especialidades Medicas (Cemedic) | Cardiology Department
Villa Luro, Ciudad Auton. de Buenos Aires, C1440CFD
Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina
Zárate, Buenos Aires, B2800DGH
Norway17 sites
Ålesund Sykehus, Kardiologisk Seksjon
Ålesund, 6026
Nordlandssykehuset Bodø Cardio
Bodø, 8092
Vestre Viken HF - Drammen Sykehus Cardiology
Drammen, 3004
Sykehuset Innlandet HF Elverum
Elverum, 2409
Sykehus Østfold Kalnes Cardio
Fredrikstad, NO-1603
Vestre Viken HF - Bærum Sykehus Cardiology
Gjettum, 1346
Sykehuset i Gjøvik Medisinsk
Gjøvik, 2819
UNN Harstad Medisinsk avdeling
Harstad, 9406
Sykehuset Lillehammer Medicine
Lillehammer, 2609
Molde Sjukehus Medisinsk
Molde, 6407
Akershus University Hospital Cardiology Department
Nordbyhagen, 1478
Rikshospitalet Cardiology
Oslo, 27
Diakonhjemmets sykehus
Oslo, 319
OUS Ullevål Cardiology
Oslo, 450
Skedsmo Medisinske Senter
Skedsmokorset, 2020
Stavanger UHospital Cardiology
Stavanger, 4011
UNN Tromsø Cardiology Dep.
Tromsø, 9038
Turkey (Türkiye)17 sites
Afyonkarahisar Saglik Bilimleri Universitesi
Afyonkarahisar, 3218
Baskent Universitesi Tip Fakultesi Hastanesi
Ankara, 6490
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital
Ankara, 6800
Akdeniz Universitesi Tip Fakultesi Hastanesi
Antalya, 7059
Hitit Universitesi Tip Fakultesi
Çorum, 19030
Ataturk Universitesi Tip Fakultesi
Erzurum, 25240
Eskisehir Osmangazi Universitesi Tip Fakultesi
Eskişehir, 26480
Istanbul Universitesi Cerrahpasa - Kardiyoloji Anabilim Dali
Istanbul, 34098
Marmara Uni. Tip Fak. Pendik EAH Kardiyoloji
Istanbul, 34899
Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.
Istanbul, TBC
Dokuz Eylul Universitesi Tip Fakultesi
Izmir, 35100
Izmir Ekonomi Universitesi Medikal Point Hastanesi
Izmir, 35575
Erciyes Universitesi Tip Fakultesi
Kayseri, 38039
Kocaeli Universitesi Tip Fakultesi
Kocaeli, 41380
Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti
Kütahya, 43040
Adana Sehir Egitim ve Arastirma Hastanesi
Medreseboğazı, 1370
Saglik Bilimleri Univ. Samsun EAH Kardiyoloji Departmani
Samsun, 55090
Austria16 sites
Krankenhaus St. Josef Braunau | Innere Medizin I
Braunau am Inn, Upper Austria, 5280
LKH Feldkirch | Innere Medizin I mit Kardiologie
Feldkirch, Vorarlberg, 6800
MedUni Graz | Kardiologie
Graz, Styria, 8036
Landeskrankenhaus Hall | Abteilung fuer Innere Medizin
Hall in Tirol, Tyrol, 6060
MedUni Innsbruck | Kardiologie und Angiologie
Innsbruck, Tyrol, 6020
Klinikum Klagenfurt | Innere Medizin und Kardiologie
Klagenfurt, Carinthia, 9020
Elisabethinen Linz | Kardiologie, Angiologie & Intensiv Med
Linz, Upper Austria, 4020
Kepler UK Linz | Kardiologie & Intensivmedizin Campus III
Linz, Upper Austria, 4021
Landesklinikum Mistelbach|Kardiologie u. Internistische Med
Mistelbach, Lower Austria, 2130
Uniklinikum Salzburg|Innere Medizin II, Kardiologie
Salzburg, 5020
UK St. Poelten | Innere Med III
Sankt Pölten, Lower Austria, 3100
MedUni Wien | Innere Medizin II, Kardiologie
Vienna, State of Vienna, 1090
Klinik Floridsdorf | Herz-, Gefaess- u. Kardio Ambulaz
Vienna, State of Vienna, 1210
Hanusch Krankenhaus | 2. Medizinische Abteilung
Vienna, 1140
Imed19-privat
Vienna, 1190
Klinikum Wels-Grieskirchen | Innere Medizin II
Wels, Upper Austria, 4600
Denmark16 sites
Region Nordjylland | Aalborg University Hospital - Cardiology Department
Aalborg, 9000
Region Midtjylland | Aarhus University Hospital - Heart Diseases - Clinical Research
Århus N, 8200
Capital Region | Amager Hospital - Cardiology Outpatient Clinic
Copenhagen, 2300
Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed
Esbjerg, 6700
Capital Region | Frederiksberg Hospital - Department of Cardiology Research
Frederiksberg, 2000
Capital Region | Gentofte Hospital - Cardiology Research
Hellerup, 2900
Capital Region | Herlev Hospital - Department of Heart Disease
Herlev, 2730
Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research
Herning, 7400
Capital Region | Nordsjaellands Hospital - Hillerod - Cardiology Department
Hilleroed, 3400
Region Nordjylland | Hjoerring - Cardiology Department
Hjørring, DK-9800
Region Sjælland | Holbaek Sygehus - Cardiology department
Holbæk, 4300
Capital Region | Hvidovre Hospital - Department of Cardiology
Hvidovre, 2650
Sygehus Lillebaelt | Kolding Sygehus - Medicinske Sygdomme
Kolding, 6000
Sjællands Universitetshospital Roskilde - Hormon og stofskiftesygdomme
Roskilde, 4000
Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit
Svendborg, 5700
Region Midtjylland | Viborg Regional Hospital - Cardiology - Heart Research
Viborg, 8800
Malaysia15 sites
Hospital Sultanah Bahiyah
Alor Star, 5460
University Hospital Kebangsaan Malaysia
Cheras, 56000
Hospital Sultanah Aminah
Johor Bahru, 80100
Hospital Raja Perempuan Zainab II
Kelantan, 15200
Hospital Universiti Sains Malaysia
Kelantan, TBC
Institute Jantung Negara
Kuala Lumpur, 50400
University Malaya Medical Centre
Kuala Lumpur, 59100
Hospital Tengku Ampuan Afzan
Kuala Pahang, 25100
Hospital Al-Sultan Abdullah (UiTM Hospital)
Kuala Selangor, 42300
Hospital Serdang
Kuala Selangor, 43000
Hospital Sultan Abdul Aziz Shah
Kuala Selangor, 43400
Hospital Seberang Jaya
Pulau Pinang, 13700
Sarawak General Hospital
Sarawak, 93400
Sarawak Heart Centre
Sarawak, 94300
Seremban Hospital Neurology
Seremban, 70300
Latvia14 sites
Doctor's Practice in Cardiology
Daugavpils, LV-5401
SIA ARI Med
Daugavpils, LV-5401
Daugavpils Regional Hospital
Daugavpils, LV-5417
Rutas Eglites GP Practice
Kuldīga, LV-3301
Liepaja Regional Hospital
Liepāja, LV-3414
Lija Mora physician practice
Ogre, LV-5001
1st Riga Clinical Hospital
Riga, LV-1001
P. Stradins Clinical University Hospital
Riga, LV-1002
Health Center Adoria
Riga, LV-1011
Health Center 4
Riga, LV-1012
Riga East Clinical University Hospital "Gailezers"
Riga, LV-1038
APS Clinic
Riga, LV-1050
Vidzemes Hospital
Valmiera, LV-4201
Gita Rancane - cardiology private practice
Ventspils, LV-3601
Lithuania14 sites
Mariu klinika JSC
Kaunas, 45462
LUHS Kauno Hospital (Laisves ave.)
Kaunas, LT-44320
LUHS Kauno Hospital (Josvainiu str.)
Kaunas, LT-47144
Kardiolitos klinikos / BMP
Kaunas, LT-49287
Saules family medicine center
Kaunas, LT-49449
Hospital of LT University of Health Sciences Kaunas Clinics
Kaunas, LT-50161
InMedica clinic Zaliakalnis
Kaunas, LT-50177
Kardiologijos ir reabilitacijos klinika
Klaipėda, LT-91131
Klaipeda Republican Hospital
Klaipėda, LT-92231
Klaipeda Seamen's Hospital Cardiology Department I
Klaipėda, LT-92288
Klaipedos Jurininku Ligonine
Klaipėda, LT-92288
Siauliai Republican hospital
Šiauliai, 76231
InMedica Clinic Santariskes
Vilnius, LT-08431
Vilnius University Hospital Santaros Klinikos
Vilnius, LT-08661
Finland10 sites
HUS Jorvin sairaala
Espoo, 2740
StudyCor Oy
Jyväskylä, 40620
Keski-Pohjanmaan keskussairaala
Kokkola, 67200
Health Step Finland Oy
Kuopio, 70210
Kuopion yliopistollinen sairaala
Kuopio, FIN- 70029
Päijät-Hämeen keskussairaala
Lahti, 15850
Oulun yliopistollinen sairaala
Oulu, 90220
Tays Sydänsairaala
Tampere, 33520
Terveystalo Pulssi
Turku, 20100
Turun yliopistollinen keskussairaala
Turku, 20520
Estonia8 sites
Rapla Family Doctors Centre
Rapla, 79515
Dr Signe Alliksoo Family Doctors Practice
Tallinn, 10138
East Tallinn Central Hospital
Tallinn, 10138
Pirita Family Doctors Centre
Tallinn, 11911
North Estonia Medical Centre Foundation
Tallinn, 13419
Office of Arvo Rosenthal
Tallinn, 13419
West Tallinn Central hospital
Tallinn, EE-10617
Tartu University Hospital
Tartu, 50406
Singapore7 sites
National University Hospital
Singapore, 119074
National Heart Centre Singapore
Singapore, 169609
Tan Tock Seng Hospital
Singapore, 308433
SingHealth Polyclinics - Pasir Ris
Singapore, 519457
Changi General Hospital
Singapore, 529889
Sengkang General Hospital
Singapore, 544886
Ng Teng Fong General Hospital
Singapore, 609606
Switzerland7 sites
Kantonsspital Aarau
Aarau, Canton of Aargau, 5001
Kantonsspital Baden
Baden, Canton of Aargau, 5404
Universitätsspital Basel
Basel, Canton of Basel-City, 4056
Inselspital Universitätsspital Bern
Bern, 3010
Cardiocentro Ticino
Lugano, 6900
Kantonsspital St. Gallen
Sankt Gallen, Canton of St. Gallen, 1009
UniversitätsSpital Zürich
Zurich, 8091
India4 sites
Asian Institute of Gastroenterology (AIG Hospital)
Hyderabad, 500032
Lisie Hospital
Kochi, Kerala, 682017
Vijan Cardiac & Critical Care Centre
Nashik, Maharashtra, 422005
King Edward Memorial (KEM) Hospital - Pune
Pune, 411 011
About this study
Official title: A Multicenter, International, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel-group, 2-arm, Phase 3 Study to Compare the Efficacy and Safety of the Oral FXIa Inhibitor Asundexian (BAY 2433334) With Apixaban for the Prevention of Stroke or Systemic Embolism in Male and Female Participants Aged 18 Years and Older With Atrial Fibrillation at Risk for Stroke
Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).
Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.
Read more
Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.
The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.
To see how well the study treatment asundexian works researchers compare:
- how long asundexian works well and
- how long apixaban works well after the start of the treatment. Working well means that the treatments can prevent the following from happening:
- stroke and/or
- systemic embolism. The study will keep collecting data until a certain number of strokes or embolisms happen in the study.
To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person's health.
The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.
Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.
During the study, the study team will:
- take blood samples
- do physical examinations
- examine heart health using an electrocardiogram (ECG)
- check vital signs such as blood pressure and heart rate
- do pregnancy tests
- ask the participants questions about their quality of life
- ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
- Being tested
- Asundexian (BAY2433334), Apixaban, Asundexian matching placebo, Apixaban matching placebo
- Medical subject headings
- Atrial Fibrillation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Asundexian (BAY2433334)Drug
Once a day
ApixabanDrug
5 mg or 2.5 mg, twice a day, according to product label.
Asundexian matching placeboDrug
Placebo to asundexian, once a day
Apixaban matching placeboDrug
Placebo to apixaban, twice a day
| Study group | Role | What they receive |
|---|---|---|
| Asundexian | Experimental | Participants will receive asundexian and apixaban matching placebo. Receives: Drug: Asundexian (BAY2433334); Drug: Apixaban matching placebo |
| Apixaban | Active comparator | Participants will receive apixaban and asundexian matching placebo. Receives: Drug: Apixaban; Drug: Asundexian matching placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Participants With Composite of Stroke or Systemic Embolism
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Stroke was defined as an acute episode of focal or global neurological dysfunction caused by an injury of the brain, spinal cord, or retina as a result of hemorrhage or infarction.
Systemic embolism is defined as abrupt vascular insufficiency associated with clinical or radiological evidence of arterial occlusion in the absence of other likely mechanisms (this does not include myocardial infarction, thromboembolism of the pulmonary vasculature or venous thrombosis, e.g. pulmonary embolism or deep venous thrombosis).
Measured: Approximately 12 months
Number of Participants With International Society on Thrombosis and Hemostasis (ISTH) Major Bleeding
Assessment based on the (csHR), comparing asundexian with apixaban which is based on time to first event.
ISTH Major Bleeding was defined as an event that meets at least one of the below criteria, based on the definition given by the ISTH (Schulman and Kearon 2005):
- Fatal bleeding, and/or
- Symptomatic bleeding in a critical area or organ (intracranial, intraspinal, intraocular with compromised vision, pericardial, retroperitoneal, intra-articular, or intramuscular with compartment syndrome), and/or
- Clinically overt* bleeding associated with a recent (within 48 hours) decrease in the hemoglobin level of ≥ 2 g/dL (20 g/L; 1.24 mmol/L) compared with the most recent hemoglobin value available before the event, and/or
- Clinically overt* bleeding leading to transfusion of 2 or more units of packed red blood cells or whole blood.
- Overt bleeding required the identification of the bleeding location and the hemoglobin drop and/or transfusion needed to be related to the bleeding.
Measured: Approximately 12 months
Number of Participants With Composite of Stroke, Systemic Embolism, or ISTH Major Bleeding
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Measured: Approximately 12 months
Secondary outcomes (13)
Number of Participants With Composite of Ischemic Stroke or Systemic Embolism
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
An ischemic stroke was defined as the rapid onset (or present on awakening) of a new focal neurological deficit with clinical (> 24 hours symptoms / signs) or imaging evidence of infarction that is not attributable to a non-ischemic cause (i.e. not associated with infection, tumor, seizure, severe metabolic disease).
Measured: Approximately 12 months
Number of Participants With All-cause Mortality
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Measured: Approximately 12 months
Number of Participants With Ischemic Stroke
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
An ischemic stroke was defined as the rapid onset (or present on awakening) of a new focal neurological deficit with clinical (> 24 hours symptoms / signs) or imaging evidence of infarction that is not attributable to a non-ischemic cause (i.e. not associated with infection, tumor, seizure, severe metabolic disease).
Measured: Approximately 12 months
Number of Participants With Cardiovascular (CV) Death
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
CV death included death due to stroke, myocardial infarction, heart failure or cardiogenic shock, sudden death or any other death due to other cardiovascular causes or CV procedures. In addition, death due to non-traumatic cardiovascular hemorrhage will be included, e.g. non-stroke intracranial hemorrhage, non-procedural or non-traumatic vascular rupture (e.g. aortic aneurysm), or hemorrhage causing cardiac tamponade
Measured: Approximately 12 months
Number of Participants With Composite of CV Death, Stroke, or Myocardial Infarction (MI)
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
The diagnosis of MI requires the combination of:
- Presence of acute myocardial injury (changes in cardiac biomarkers) and
- Evidence of acute myocardial ischemia derived from the clinical presentation, electrocardiographic changes, or the results of myocardial or coronary artery imaging, or in case of post mortem pathological findings irrespective of biomarker values.
Measured: Approximately 12 months
Number of Participants With Composite of ISTH Major or Clinically Relevant Non-major Bleeding
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Clinically relevant non-major bleeding was considered any sign or symptom of acute or sub-acute clinically overt bleeding that does not fit the criteria for the ISTH definition of major bleeding, but does meet at least one of the following criteria (based on criteria published by the EMA) (EMA 2014):
- requiring medical or surgical treatment by a healthcare professional for bleeding
- leading to hospitalization or increased level of care for bleeding
- a change in antithrombotic therapy (including study intervention) for bleeding *Overt bleeding required the identification of the bleeding location.
Measured: Approximately 12 months
Number of Participants With Clinically Relevant Non-major Bleeding
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Measured: Approximately 12 months
Number of Participants With Hemorrhagic Stroke
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Hemorrhagic stroke was defined as an acute, atraumatic extravasation of blood into the brain parenchyma, intraventricular or subarachnoid space with associated neurological symptoms. This does not include microbleeds or hemorrhagic transformation of an ischemic stroke.
Measured: Approximately 12 months
Number of Participants With Intracranial Hemorrhage
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Measured: Approximately 12 months
Number of Participants With Fatal Bleeding
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Measured: Approximately 12 months
Number of Participants With Minor Bleeding
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
All other overt bleeding episodes not meeting the criteria for ISTH major or clinically relevant non-major bleeding were classified as minor bleeding (for example, bleeding from a minor wound that does not prompt a treatment for the bleeding, for instance with surgical hemostasis, or epistaxis that does not require a medical treatment for bleeding or a change in antithrombotic therapy).
Measured: Approximately 12 months
Number of Participants With Composite of Stroke, Systemic Embolism, ISTH Major Bleeding, or All-cause Mortality
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Measured: Approximately 12 months
Number of Participants With Composite of Disabling Stroke (mRS ≥ 3), Critical Bleeding, or All-cause Mortality
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Critical bleeding was defined as symptomatic bleeding in either of the following critical locations (intracranial, intraspinal, pericardial, intra-articular, or retroperitoneal) or as intraocular bleeding with compromised vision or intramuscular bleeding with compartment syndrome.
Measured: Approximately 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Dec 2022
- Study start5 Dec 2022
- Primary completion31 Jan 2024
- Study completion31 Jan 2024
Why it stopped: Independent Data Monitoring Committee (IDMC) recommendation to stop the study
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Prevention of Stroke or Systemic EmbolismStudies of the same condition, open and under way.
- More trials run by BayerThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 14,830 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bayer
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05643573
- Sponsor's protocol ID
- 19767
- Other IDs
- 2023-503794-38-00, 2022-000758-28, 2023
- Acronym
- OCEANIC-AF
- Status last verified
- Dec 2024
- First submitted
- 30 Nov 2022
- Last updated
- 9 Dec 2024
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No: Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.
Publications
Alexander JH, Lydon EJ, Piccini JP, Viethen T, Oldgren J, Goodman SG, Steffel J, Russo AM, van Gelder IC, Ferdinand KC, Lopes RD, Mundl H, Benczur B, Gomez-Doblas JJ, Glikson M, Goudev A, Grove EL, Halvorsen S, Kiviniemi T, Martin AC, Sandhu RK, Vinereanu D, Rockhold FW, Caso V, Coppolecchia R, Patel MR. Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use: A Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial. JAMA Cardiol. 2025 Jun 1;10(6):555-563. doi: 10.1001/jamacardio.2025.0277.
PubMed 40136309Piccini JP, Patel MR, Steffel J, Ferdinand K, Van Gelder IC, Russo AM, Ma CS, Goodman SG, Oldgren J, Hammett C, Lopes RD, Akao M, De Caterina R, Kirchhof P, Gorog DA, Hemels M, Rienstra M, Jones WS, Harrington J, Lip GYH, Ellis SJ, Rockhold FW, Neumann C, Alexander JH, Viethen T, Hung J, Coppolecchia R, Mundl H, Caso V; OCEANIC-AF Steering Committee and Investigators. Asundexian versus Apixaban in Patients with Atrial Fibrillation. N Engl J Med. 2025 Jan 2;392(1):23-32. doi: 10.1056/NEJMoa2407105. Epub 2024 Sep 1.
PubMed 39225267
Study at a glance
From the registry record, last updated by the sponsor on 9 Dec 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Multicenter, International, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel-group, 2-arm, Phase 3 Study to Compare the Efficacy and Safety of the Oral FXIa Inhibitor Asundexian (BAY 2433334) With Apixaban for the Prevention of Stroke or Systemic Embolism in Male and Female Participants Aged 18 Years and Older With Atrial Fibrillation at Risk for Stroke
- ClinicalTrials.gov ID
- NCT05643573
- Acronym / sponsor ID
- OCEANIC-AF / 19767
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: Independent Data Monitoring Committee (IDMC) recommendation to stop the study
- Enrolment
- 14,830 participants (actual)
- Lead sponsor
- BayerIndustry (pharma, biotech, devices)
- Study start
- 5 Dec 2022 (actual)
- Primary completion
- 31 Jan 2024 (actual)
- Study completion
- 31 Jan 2024 (actual)
- First posted
- 8 Dec 2022 (actual)
- Results
- Posted 9 Dec 2024
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).
Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.
Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.
The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.
To see how well the study treatment asundexian works researchers compare:
- how long asundexian works well and
- how long apixaban works well after the start of the treatment. Working well means that the treatments can prevent the following from happening:
- stroke and/or
- systemic embolism. The study will keep collecting data until a certain number of strokes or embolisms happen in the study.
To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person's health.
The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.
Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.
During the study, the study team will:
- take blood samples
- do physical examinations
- examine heart health using an electrocardiogram (ECG)
- check vital signs such as blood pressure and heart rate
- do pregnancy tests
- ask the participants questions about their quality of life
- ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Asundexian | Experimental | Drug: Asundexian (BAY2433334), Drug: Apixaban matching placeboParticipants will receive asundexian and apixaban matching placebo. |
| Apixaban | Active comparator | Drug: Apixaban, Drug: Asundexian matching placeboParticipants will receive apixaban and asundexian matching placebo. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- 18 years of age or older
- The patient willing and able to understand the Patient information Sheet and provide written informed consent
- Atrial fibrillation with an indication for indefinite treatment with an oral anticoagulant
- CHA2DS2-VASc score ≥ 3 if male or ≥ 4 if female, OR CHA2DS2-VASc score of 2 if male or 3 if female and at least one of the following enrichment criteria:
Key exclusion criteria (22 listed)
- Mechanical heart valve prosthesis
- Moderate-to-severe mitral stenosis at the time of study inclusion.
- Atrial fibrillation only due to reversible cause.
- Participants after successful ablation therapy without documented recurrent AF or participants after left atrial appendage occlusion / exclusion or plan for ablation or Left atrial appendage (LAA) occlusion / exclusion within the next 6 months.
- Recent ischemic stroke (within 7 days prior to randomization).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Asundexian (BAY2433334)Once a day | Drug | Asundexian |
| Apixaban5 mg or 2.5 mg, twice a day, according to product label. | Drug | Apixaban |
| Asundexian matching placeboPlacebo to asundexian, once a day | Drug | Apixaban |
| Apixaban matching placeboPlacebo to apixaban, twice a day | Drug | Asundexian |
Primary outcome
Number of Participants With Composite of Stroke or Systemic Embolism
Time frame: Approximately 12 months
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event. Stroke was defined as an acute episode of focal or global neurological dysfunction caused by an injury of the brain, spinal cord, or retina as a result of hemorrhage or infarction. Systemic embolism is defined as abrupt vascular insufficiency associated with clinical or radiological evidence of arterial occlusion in the absence of other likely mechanisms (this does not include myocardial infarction, thromboembolism of the pulmonary vasculature or venous thrombosis, e.g. pulmonary embolism or deep venous thrombosis).
Number of Participants With International Society on Thrombosis and Hemostasis (ISTH) Major Bleeding
Time frame: Approximately 12 months
Assessment based on the (csHR), comparing asundexian with apixaban which is based on time to first event. ISTH Major Bleeding was defined as an event that meets at least one of the below criteria, based on the definition given by the ISTH (Schulman and Kearon 2005): * Fatal bleeding, and/or * Symptomatic bleeding in a critical area or organ (intracranial, intraspinal, intraocular with compromised vision, pericardial, retroperitoneal, intra-articular, or intramuscular with compartment syndrome), and/or * Clinically overt* bleeding associated with a recent (within 48 hours) decrease in the hemoglobin level of ≥ 2 g/dL (20 g/L; 1.24 mmol/L) compared with the most recent hemoglobin value available before the event, and/or * Clinically overt* bleeding leading to transfusion of 2 or more units of packed red blood cells or whole blood. * Overt bleeding required the identification of the bleeding location and the hemoglobin drop and/or transfusion needed to be related to the bleeding.
Number of Participants With Composite of Stroke, Systemic Embolism, or ISTH Major Bleeding
Time frame: Approximately 12 months
The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
13 secondary outcomes
Number of Participants With Composite of Ischemic Stroke or Systemic Embolism
Time frame: Approximately 12 months
Number of Participants With All-cause Mortality
Time frame: Approximately 12 months
Number of Participants With Ischemic Stroke
Time frame: Approximately 12 months
Number of Participants With Cardiovascular (CV) Death
Time frame: Approximately 12 months
Number of Participants With Composite of CV Death, Stroke, or Myocardial Infarction (MI)
Time frame: Approximately 12 months
Number of Participants With Composite of ISTH Major or Clinically Relevant Non-major Bleeding
Time frame: Approximately 12 months
Number of Participants With Clinically Relevant Non-major Bleeding
Time frame: Approximately 12 months
Number of Participants With Hemorrhagic Stroke
Time frame: Approximately 12 months
Number of Participants With Intracranial Hemorrhage
Time frame: Approximately 12 months
Number of Participants With Fatal Bleeding
Time frame: Approximately 12 months
Number of Participants With Minor Bleeding
Time frame: Approximately 12 months
Number of Participants With Composite of Stroke, Systemic Embolism, ISTH Major Bleeding, or All-cause Mortality
Time frame: Approximately 12 months
Number of Participants With Composite of Disabling Stroke (mRS ≥ 3), Critical Bleeding, or All-cause Mortality
Time frame: Approximately 12 months
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Dec 2024.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 40136309Alexander JH, Lydon EJ, Piccini JP, Viethen T, Oldgren J, Goodman SG, Steffel J, Russo AM, van Gelder IC, Ferdinand KC, Lopes RD, Mundl H, Benczur B, Gomez-Doblas JJ, Glikson M, Goudev A, Grove EL, Halvorsen S, Kiviniemi T, Martin AC, Sandhu RK, Vinereanu D, Rockhold FW, Caso V, Coppolecchia R, Patel MR. Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use: A Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial. JAMA Cardiol. 2025 Jun 1;10(6):555-563. doi: 10.1001/jamacardio.2025.0277.
- Derived from this study: PubMed 39225267Piccini JP, Patel MR, Steffel J, Ferdinand K, Van Gelder IC, Russo AM, Ma CS, Goodman SG, Oldgren J, Hammett C, Lopes RD, Akao M, De Caterina R, Kirchhof P, Gorog DA, Hemels M, Rienstra M, Jones WS, Harrington J, Lip GYH, Ellis SJ, Rockhold FW, Neumann C, Alexander JH, Viethen T, Hung J, Coppolecchia R, Mundl H, Caso V; OCEANIC-AF Steering Committee and Investigators. Asundexian versus Apixaban in Patients with Atrial Fibrillation. N Engl J Med. 2025 Jan 2;392(1):23-32. doi: 10.1056/NEJMoa2407105. Epub 2024 Sep 1.
- Individual participant dataSharing planned: No. Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1,069 sites in 38 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Asundexian (BAY2433334) and Apixaban in people with Prevention of Stroke or Systemic Embolism and Atrial Fibrillation, run by Bayer at 1,069 sites in 38 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 22 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 9 Dec 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1,069 sites in United States, Japan, China, Canada, France and 33 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 9 Dec 2024). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Participants With Composite of Stroke or Systemic Embolism (time frame: Approximately 12 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05643573, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Dec 2024.