Ejaculatory DysfunctionNCT05650853
Exploration of eJaculatory Anatomy Concept Study (EJAC Study)
A study testing Transrectal ultrasound and Urethroscopy in people with Ejaculatory Dysfunction, run by Clinique Pasteur at 1 site in France.
Trial summary
Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ED is a cause for concern for almost a third of patients who need surgery. Read more about this study
- Who is it for?
- Ages 18 years and older, men onlyHealthy volunteers can take part
- Conditions the study is for
- Ejaculatory Dysfunction
- What is being tested?
- Transrectal ultrasound and Urethroscopy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 3 participants
- Where
- 1 siteFrance
- Study dates
- 12 Dec 2022to 9 Jan 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Men only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Affiliated subject or beneficiary of a social security scheme
- Subject agreeing to participate and having signed the free, informed consent.
Who cannot join
- Subject with ejaculatory dysfunction
- Subject with urinary dysfunction
- History of urinary or penile surgery
- Subject with untreated urinary tract infection
- History of chronic prostatitis
- Pathology making it impossible to introduce the endorectal probe or the ureteroscope
Show all 11Show fewer
- History of colorectal inflammatory disease
- Recent intake (within 30 days) of drugs known to interfere with ejaculation
- History of intolerance or allergy to any of the drugs used in the study
- Subject participating in another clinical study
- Adults under guardianship, curatorship or other legal protection; deprived of liberty by judicial or administrative decision; Hospitalized without consent.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Study of the Biomechanical Anatomy of Ejaculation
Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ED is a cause for concern for almost a third of patients who need surgery. Surgical techniques have been developed to limit the occurrence of postoperative ED, but their results remain heterogeneous.
There are very few studies on the biomechanical anatomy of ejaculation. Ejaculation is a complex phenomenon involving different structures and in particular the Veru Montanum. This is the key element in the emission of ejaculate within the prostatic urethra. In addition, there is a structure located in the resection zone of the prostate adenoma. It has therefore been suggested that its resection was a primary source of ED.
Read more
A single observational study carried out in by Gil Vernet et al in 1994 evaluated on a single healthy 18-year-old volunteer the ejaculatory mechanism of expulsion using an endorectal probe recording the movements of the prostate, the bladder neck and of the proximal urethra during ejaculation.
A contemporary study of the biomechanics of the ejaculatory expulsion phase could confirm and improve understanding of the involvement of anatomical structures. The results of our study aim to adapt surgical techniques aimed at limiting the risk of postoperative ED.
- Conditions
- Ejaculatory Dysfunction
- Being tested
- Transrectal ultrasound, Urethroscopy
- Medical subject headings
- Ejaculatory Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transrectal ultrasoundOther
Examinations for observation of the pre, per and post-ejaculatory phases
UrethroscopyOther
Examinations for observation of the pre, per and post-ejaculatory phases
| Study group | Role | What they receive |
|---|---|---|
| Study intervention | Experimental | Transrectal ultrasound and Urethroscopy Receives: Other: Transrectal ultrasound; Other: Urethroscopy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Peri-urethral muscle contraction
Qualitative description of peri-urethral muscle contraction according to ultrasound videos analysis
Measured: At Day 0
Urethra, bladder neck and prostate movements
Qualitative description of movements of the urethra, bladder neck and prostate according to ultrasound videos analysis
Measured: At Day 0
Sperm flow within the prostatic urethra
Qualitative description of sperm flow within the prostatic urethra according to ultrasound videos analysis
Measured: At Day 0
Spermatic fluid via the ejaculatory ducts
Qualitative description of the expulsion and flow of spermatic fluid via the ejaculatory ducts according to urethroscopy videos analysis
Measured: At Day 6
Veru montanum mobility and urethral contraction.
Qualitative description of veru montanum mobility and urethral contraction according to urethroscopy videos analysis
Measured: At Day 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Dec 2022
- Study start12 Dec 2022
- Primary completion9 Jan 2023
- Study completion9 Jan 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ejaculatory DysfunctionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 3 participants (actual)
Sponsor and investigators
- Lead sponsor
- Clinique Pasteur
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Benjamin Pradère, MD, Study director, Clinique La Croix du SudEric Bruguière, MD, Study director, Clinique PasteurVincent Misraï, MD, Study director, Clinique Pasteur
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05650853
- Sponsor's protocol ID
- 2022-A01594-39
- Status last verified
- Jan 2023
- First submitted
- 10 Nov 2022
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Pradere B, Uleri A, Bruguiere E, Misrai V. Exploration of the Ejaculatory Anatomy Concept: The EJAC Study. Eur Urol. 2025 Aug 25:S0302-2838(25)00451-8. doi: 10.1016/j.eururo.2025.08.001. Online ahead of print.
PubMed 40858456
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of the Biomechanical Anatomy of Ejaculation
- ClinicalTrials.gov ID
- NCT05650853
- Acronym / sponsor ID
- 2022-A01594-39
- Conditions
- Ejaculatory Dysfunction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 3 participants (actual)
- Lead sponsor
- Clinique PasteurUniversity, hospital or other
- Study start
- 12 Dec 2022 (actual)
- Primary completion
- 9 Jan 2023 (actual)
- Study completion
- 9 Jan 2023 (actual)
- First posted
- 14 Dec 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ED is a cause for concern for almost a third of patients who need surgery. Surgical techniques have been developed to limit the occurrence of postoperative ED, but their results remain heterogeneous.
There are very few studies on the biomechanical anatomy of ejaculation. Ejaculation is a complex phenomenon involving different structures and in particular the Veru Montanum. This is the key element in the emission of ejaculate within the prostatic urethra. In addition, there is a structure located in the resection zone of the prostate adenoma. It has therefore been suggested that its resection was a primary source of ED.
A single observational study carried out in by Gil Vernet et al in 1994 evaluated on a single healthy 18-year-old volunteer the ejaculatory mechanism of expulsion using an endorectal probe recording the movements of the prostate, the bladder neck and of the proximal urethra during ejaculation.
A contemporary study of the biomechanics of the ejaculatory expulsion phase could confirm and improve understanding of the involvement of anatomical structures. The results of our study aim to adapt surgical techniques aimed at limiting the risk of postoperative ED.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study intervention | Experimental | Other: Transrectal ultrasound, Other: UrethroscopyTransrectal ultrasound and Urethroscopy |
Who may qualify
- Ages
- 18 years and older
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Affiliated subject or beneficiary of a social security scheme
- Subject agreeing to participate and having signed the free, informed consent.
Key exclusion criteria (11 listed)
- Subject with ejaculatory dysfunction
- Subject with urinary dysfunction
- History of urinary or penile surgery
- Subject with untreated urinary tract infection
- History of chronic prostatitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transrectal ultrasoundExaminations for observation of the pre, per and post-ejaculatory phases | Other | Study intervention |
| UrethroscopyExaminations for observation of the pre, per and post-ejaculatory phases | Other | Study intervention |
Primary outcome
Peri-urethral muscle contraction
Time frame: At Day 0
Qualitative description of peri-urethral muscle contraction according to ultrasound videos analysis
Urethra, bladder neck and prostate movements
Time frame: At Day 0
Qualitative description of movements of the urethra, bladder neck and prostate according to ultrasound videos analysis
Sperm flow within the prostatic urethra
Time frame: At Day 0
Qualitative description of sperm flow within the prostatic urethra according to ultrasound videos analysis
Spermatic fluid via the ejaculatory ducts
Time frame: At Day 6
Qualitative description of the expulsion and flow of spermatic fluid via the ejaculatory ducts according to urethroscopy videos analysis
Veru montanum mobility and urethral contraction.
Time frame: At Day 6
Qualitative description of veru montanum mobility and urethral contraction according to urethroscopy videos analysis
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Results publication: PubMed 40858456Pradere B, Uleri A, Bruguiere E, Misrai V. Exploration of the Ejaculatory Anatomy Concept: The EJAC Study. Eur Urol. 2025 Aug 25:S0302-2838(25)00451-8. doi: 10.1016/j.eururo.2025.08.001. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Benjamin Pradère, MD study director
Clinique La Croix du Sud
Eric Bruguière, MD study director
Clinique Pasteur
Vincent Misraï, MD study director
Clinique Pasteur
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transrectal ultrasound and Urethroscopy in people with Ejaculatory Dysfunction, run by Clinique Pasteur at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Peri-urethral muscle contraction (time frame: At Day 0). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05650853, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.