AphasiaPhase 2NCT05653466
Adaptive Trial Scheduling in Naming Treatment for Aphasia
A Phase 2 study testing Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition and Low-Item Non-Adaptive Spacing Condition in people with Aphasia and Stroke, run by University of Pittsburgh at 1 site in United States.
Trial summary
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Read more about this study
- Who is it for?
- Ages 18 years and older
- What is being tested?
- Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition and Low-Item Non-Adaptive Spacing Condition
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Dec 2023to 31 Jan 2028
- Phase
- Phase 2
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Existing diagnosis of chronic (>6 months) aphasia subsequent to left hemisphere stroke.
- Impaired performance on 2/8 sections of the Comprehensive Aphasia Test.
- Must have access to a high-speed internet connection and be able to participate in telehealth.
Who cannot join
- History of other acquired or progressive neurological disease.
- Significant language comprehension impairments
- Unmanaged drug / alcohol dependence.
- Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh
Pittsburgh, Pennsylvania, 15260
William Evans, PhD, 412-383-6943, will.evans@pitt.edu
William Evans, PhD
About this study
Official title: Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 2: Adaptive Trial Scheduling)
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life.
This study is one of two that are part of a larger grant. This record is for sub-study 2, which will evaluate the benefits of adaptive trial spacing.
Read the detailed description
Study 2: Evaluate the benefits of adaptive trial scheduling.
Study design: Investigators will enroll 32 people with aphasia in a randomized within-subjects crossover design comparing an adaptive scheduling condition to two non-adaptive conditions. For each condition, all treatment procedures will be matched except for the number of treated words and the trial spacing manipulation. Participants will receive 10 weeks of computer-based training per condition, with probes administered at baseline and at 1 week, 3 months, and 6 months post-treatment. Condition order will be randomly assigned and counter-balanced across participants. In total, Study 2 will include typically 3-4 (but up to 6) assessment sessions, 120 one-on-one treatment sessions, and 24 baseline and follow-up probe sessions per participant over an ~1-year period, or up to 18 months. All assessment, treatment, and probe sessions will take place via telehealth.
Treatment description: For each condition, all treatment procedures will be matched except for the number of treated words and the trial spacing manipulation. The treatment phase for each of the three conditions will consist of ten weeks of one-on-one treatment four times per week in which the treating clinician will work alongside participants to complete flashcard practice four days a week. The treatment sessions will each last 30 minutes to approximate realistic treatment dosage in outpatient or home health practice settings. Treatment will consist of effortful retrieval practice: on each trial, participants will see a picture of the target and attempt to name it, then rate their naming accuracy by button press. The experimenter will code their response time and perceived accuracy. Finally, the experimenter will code their accuracy which will reveal the target in verbal and written form. If they are unable to name the word correctly, they will be able to replay the answer and repeat it three times prior to moving on to the next trial, per Conroy et al.
- Being tested
- Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition, Low-Item Non-Adaptive Spacing Condition
- Medical subject headings
- Aphasia, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adaptive Spacing ConditionBehavioural
Each of the 200 target words for practice are presented on a schedule determined by an algorithm that relies on the pattern of correct vs. incorrect responses for each item. Items in the "active learning" state need to be answered correctly a certain number of times before being categorized as "learned." Each item must be answered correctly 3 times in a row (immediately, then at one-minute and five-minute intervals) before it is categorized as "learned." Then, it will be scheduled at ever-increasing intervals, until answered incorrectly, at which point the item would be returned to the "active learning" state, requiring three correct responses in a row to return again to the "learned" expanding interval state.
High-Item Non-Adaptive Spacing ConditionBehavioural
Each of the 200 target words for practice are presented in sequential order randomized within blocks, with each word presented once before the list repeats.
Low-Item Non-Adaptive Spacing ConditionBehavioural
Each of the 40 target words for practice are presented in sequential order randomized within blocks, with each word presented once before the list repeats.
| Study group | Role | What they receive |
|---|---|---|
| Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing | Experimental | All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. Receives: Behavioral: Adaptive Spacing Condition; Behavioral: High-Item Non-Adaptive Spacing Condition; Behavioral: Low-Item Non-Adaptive Spacing Condition |
| Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing | Experimental | All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. Receives: Behavioral: Adaptive Spacing Condition; Behavioral: High-Item Non-Adaptive Spacing Condition; Behavioral: Low-Item Non-Adaptive Spacing Condition |
| High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing | Experimental | All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. Receives: Behavioral: Adaptive Spacing Condition; Behavioral: High-Item Non-Adaptive Spacing Condition; Behavioral: Low-Item Non-Adaptive Spacing Condition |
| High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing | Experimental | All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. Receives: Behavioral: Adaptive Spacing Condition; Behavioral: High-Item Non-Adaptive Spacing Condition; Behavioral: Low-Item Non-Adaptive Spacing Condition |
| Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing | Experimental | All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. Receives: Behavioral: Adaptive Spacing Condition; Behavioral: High-Item Non-Adaptive Spacing Condition; Behavioral: Low-Item Non-Adaptive Spacing Condition |
| Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing | Experimental | All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. Receives: Behavioral: Adaptive Spacing Condition; Behavioral: High-Item Non-Adaptive Spacing Condition; Behavioral: Low-Item Non-Adaptive Spacing Condition |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects
Confrontation naming accuracy pictures targeted for each training condition and corresponding untreated items will serve as a primary outcome. Individualized lists for each participant will be selected from a corpus of pictured objects. Performance will be evaluated twice at each timepoint. Change in performance from initial assessment to the 3-month follow-up timepoint on the treated and untreated items will serve as the primary outcome measure.
Measured: Initial assessment (pre-treatment), 3 months post-treatment
Change in correct responses in Context Generalization of Treated and Untreated Pictured Objects
Production of trained words on the context generalization complex scene description task for each training condition and corresponding untreated items will serve as a primary outcome. Words from complex scenes and wordless picture books will be chosen for each participant. These words will consist of a subset of those selected for confrontation naming. Performance will be evaluated twice at each timepoint. Change in performance from initial assessment to the 3-month follow-up timepoint on the treated and untreated items will serve as the primary outcome measure.
Measured: Initial assessment (pre-treatment), 3 months post-treatment
Secondary outcomes (3)
Change in core lexicon analysis on the Aphasia Bank Discourse Protocol
The Aphasia Bank Discourse Protocol is a brief, but thorough set of language tasks which will characterize participants' language at the discourse level. The protocol requires participants to generate discourse samples within the contexts of free speech, a picture description, a story narrative, and procedural discourse. Change in performance in core lexicon analysis on discourse samples from initial assessment to each post-treatment follow up timepoint will serve as a secondary outcome measure.
Measured: Initial assessment (pre-treatment), 3 months post-treatment
Change in mean scores on the Aphasia Communication Outcome Measure Short-Form
The Aphasia Communication Outcome Measure (ACOM) is a measure of patient-reported "communication functioning," defined as the ability to effectively convey and receive personally relevant messages in natural environments. Results are provided in T scores (sample mean of 50 with a standard deviations of 10), with higher scores indicating better communication functioning.
Measured: Initial assessment (pre-treatment), 1 week post-treatment.
Score on the Adapted Intrinsic Motivation Inventory for Aphasia
The adapted intrinsic motivation Inventory for aphasia is a brief instrument comprised of 7 subscales with a total of 45 items intended to characterize intrinsic motivation in people with aphasia. Each item is scored on a scale of 1-7. Higher total score is associated with higher intrinsic motivation.
Measured: 1 week post-treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Dec 2022
- Study start6 Dec 2023
- Primary completion31 Jan 2027 (estimated)
- Study completion31 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AphasiaStudies of the same condition, open and under way.
- More trials run by University of PittsburghThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 32 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Pittsburgh
- Sponsor type
- University, hospital or other
- Collaborators
- University of Massachusetts, Amherst, National Institute on Deafness and Other Communication Disorders (NIDCD)
- Responsible party
- Principal investigator, William Evans, University of Pittsburgh
- Investigators
- William Evans, PhD, Principal investigator, University of Pittsburgh
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05653466
- Sponsor's protocol ID
- STUDY21120130 (Study 2)
- Other IDs
- 1R01DC019325-01A1
- Status last verified
- Dec 2025
- First submitted
- 7 Dec 2022
- Last updated
- 11 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data sharing plan for this study includes the publication of discourse measures and other study data on Aphasia Bank (R01-DC008524), a large online repository of aphasia behavioral data that supports a great deal of productive aphasia corpora research. De-identified test scores, treatment, and probe data, and audio and/or video recordings of norming, probe, assessment, and treatment data will be shared to this repository for all study participants. Investigators will also make our experimental task files, protocols, and de-identified study data available through Open Science Framework (https://osf.io/) to encourage the replication, collaboration, and expansion of our work by other research groups. Last, investigators plan to publish a modeling and statistical package in open-access software, R, which will include functionality for calculating speed-accuracy tradeoff optimality using our multinomial ex-Gaussian response time model approach.
Study at a glance
From the registry record, last updated by the sponsor on 11 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 2: Adaptive Trial Scheduling)
- ClinicalTrials.gov ID
- NCT05653466
- Acronym / sponsor ID
- STUDY21120130 (Study 2)
- Phase
- Phase 2
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 32 participants (estimated)
- Lead sponsor
- University of PittsburghUniversity, hospital or other
- Collaborators
- University of Massachusetts, Amherst, National Institute on Deafness and Other Communication Disorders (NIDCD)
- Study start
- 6 Dec 2023 (actual)
- Primary completion
- 31 Jan 2027 (estimated)
- Study completion
- 31 Jan 2028 (estimated)
- First posted
- 16 Dec 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life.
This study is one of two that are part of a larger grant. This record is for sub-study 2, which will evaluate the benefits of adaptive trial spacing.
Detailed description
Study 2: Evaluate the benefits of adaptive trial scheduling.
Study design: Investigators will enroll 32 people with aphasia in a randomized within-subjects crossover design comparing an adaptive scheduling condition to two non-adaptive conditions. For each condition, all treatment procedures will be matched except for the number of treated words and the trial spacing manipulation. Participants will receive 10 weeks of computer-based training per condition, with probes administered at baseline and at 1 week, 3 months, and 6 months post-treatment. Condition order will be randomly assigned and counter-balanced across participants. In total, Study 2 will include typically 3-4 (but up to 6) assessment sessions, 120 one-on-one treatment sessions, and 24 baseline and follow-up probe sessions per participant over an ~1-year period, or up to 18 months. All assessment, treatment, and probe sessions will take place via telehealth.
Treatment description: For each condition, all treatment procedures will be matched except for the number of treated words and the trial spacing manipulation. The treatment phase for each of the three conditions will consist of ten weeks of one-on-one treatment four times per week in which the treating clinician will work alongside participants to complete flashcard practice four days a week. The treatment sessions will each last 30 minutes to approximate realistic treatment dosage in outpatient or home health practice settings. Treatment will consist of effortful retrieval practice: on each trial, participants will see a picture of the target and attempt to name it, then rate their naming accuracy by button press. The experimenter will code their response time and perceived accuracy. Finally, the experimenter will code their accuracy which will reveal the target in verbal and written form. If they are unable to name the word correctly, they will be able to replay the answer and repeat it three times prior to moving on to the next trial, per Conroy et al.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 6
| Arm | Type | Receives |
|---|---|---|
| Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing | Experimental | Behavioral: Adaptive Spacing Condition, Behavioral: High-Item Non-Adaptive Spacing Condition, Behavioral: Low-Item Non-Adaptive Spacing ConditionAll participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. |
| Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing | Experimental | Behavioral: Adaptive Spacing Condition, Behavioral: High-Item Non-Adaptive Spacing Condition, Behavioral: Low-Item Non-Adaptive Spacing ConditionAll participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. |
| High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing | Experimental | Behavioral: Adaptive Spacing Condition, Behavioral: High-Item Non-Adaptive Spacing Condition, Behavioral: Low-Item Non-Adaptive Spacing ConditionAll participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. |
| High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing | Experimental | Behavioral: Adaptive Spacing Condition, Behavioral: High-Item Non-Adaptive Spacing Condition, Behavioral: Low-Item Non-Adaptive Spacing ConditionAll participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. |
| Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing | Experimental | Behavioral: Adaptive Spacing Condition, Behavioral: High-Item Non-Adaptive Spacing Condition, Behavioral: Low-Item Non-Adaptive Spacing ConditionAll participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. |
| Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing | Experimental | Behavioral: Adaptive Spacing Condition, Behavioral: High-Item Non-Adaptive Spacing Condition, Behavioral: Low-Item Non-Adaptive Spacing ConditionAll participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Existing diagnosis of chronic (>6 months) aphasia subsequent to left hemisphere stroke.
- Impaired performance on 2/8 sections of the Comprehensive Aphasia Test.
- Must have access to a high-speed internet connection and be able to participate in telehealth.
Key exclusion criteria (4 listed)
- History of other acquired or progressive neurological disease.
- Significant language comprehension impairments
- Unmanaged drug / alcohol dependence.
- Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adaptive Spacing ConditionEach of the 200 target words for practice are presented on a schedule determined by an algorithm that relies on the pattern of correct vs. incorrect responses for each item. Items in the "active learning" state need to be answered correctly a certain number of times before being categorized as "learned." Each item must be answered correctly 3 times in a row (immediately, then at one-minute and five-minute intervals) before it is categorized as "learned." Then, it will be scheduled at ever-increasing intervals, until answered incorrectly, at which point the item would be returned to the "active learning" state, requiring three correct responses in a row to return again to the "learned" expanding interval state. | Behavioural | Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing, Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing, High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing, High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing, Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing, Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing |
| High-Item Non-Adaptive Spacing ConditionEach of the 200 target words for practice are presented in sequential order randomized within blocks, with each word presented once before the list repeats. | Behavioural | Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing, Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing, High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing, High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing, Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing, Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing |
| Low-Item Non-Adaptive Spacing ConditionEach of the 40 target words for practice are presented in sequential order randomized within blocks, with each word presented once before the list repeats. | Behavioural | Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing, Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing, High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing, High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing, Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing, Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing |
Primary outcome
Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects
Time frame: Initial assessment (pre-treatment), 3 months post-treatment
Confrontation naming accuracy pictures targeted for each training condition and corresponding untreated items will serve as a primary outcome. Individualized lists for each participant will be selected from a corpus of pictured objects. Performance will be evaluated twice at each timepoint. Change in performance from initial assessment to the 3-month follow-up timepoint on the treated and untreated items will serve as the primary outcome measure.
Change in correct responses in Context Generalization of Treated and Untreated Pictured Objects
Time frame: Initial assessment (pre-treatment), 3 months post-treatment
Production of trained words on the context generalization complex scene description task for each training condition and corresponding untreated items will serve as a primary outcome. Words from complex scenes and wordless picture books will be chosen for each participant. These words will consist of a subset of those selected for confrontation naming. Performance will be evaluated twice at each timepoint. Change in performance from initial assessment to the 3-month follow-up timepoint on the treated and untreated items will serve as the primary outcome measure.
3 secondary outcomes
Change in core lexicon analysis on the Aphasia Bank Discourse Protocol
Time frame: Initial assessment (pre-treatment), 3 months post-treatment
Change in mean scores on the Aphasia Communication Outcome Measure Short-Form
Time frame: Initial assessment (pre-treatment), 1 week post-treatment.
Score on the Adapted Intrinsic Motivation Inventory for Aphasia
Time frame: 1 week post-treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Dec 2025.
- Individual participant dataSharing planned: Yes. The data sharing plan for this study includes the publication of discourse measures and other study data on Aphasia Bank (R01-DC008524), a large online repository of aphasia behavioral data that supports a great deal of productive aphasia corpora research. De-identified test scores, treatment, and probe data, and audio and/or video recordings of norming, probe, assessment, and treatment data will be shared to this repository for all study participants. Investigators will also make our experimental task files, protocols, and de-identified study data available through Open Science Framework (https://osf.io/) to encourage the replication, collaboration, and expansion of our work by other research groups. Last, investigators plan to publish a modeling and statistical package in open-access software, R, which will include functionality for calculating speed-accuracy tradeoff optimality using our multinomial ex-Gaussian response time model approach.
Related trials for Aphasia
Not yet recruiting
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia (BG-Aphasia-01)
Expressive Aphasia, Aphasia Following Cerebral Infarction
Recruiting
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
Aphasia, Stroke
Not yet recruiting
Restoring Speech With an Intracortical Neuroprosthesis for Post-Stroke Agrammatic Aphasia (BG-Aphasia-02)
Aphasia, ALS
Not yet recruiting
Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
Aphasia, Stroke
Not yet recruitingObservational study
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Stroke, Ischemic Stroke
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
William Evans, PhD principal investigator
University of Pittsburgh
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 2 study testing Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition and Low-Item Non-Adaptive Spacing Condition in people with Aphasia and Stroke, run by University of Pittsburgh at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alyssa Kelly, M.A., CCC-SLP (412-648-3274, ank155@pitt.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects (time frame: Initial assessment (pre-treatment), 3 months post-treatment). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Dec 2025.