DepressionPERMANCT05662254
PERsonalized Mood Augmentation Trial for Depressed Mood
A study testing Personalized Behavioral Intervention in people with Depression, run by University of California, San Diego at 1 site in United States.
Trial summary
The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. Read more about this study
- Who is it for?
- Ages 15 years and olderHealthy volunteers can take part
- Conditions the study is for
- Depression
- What is being tested?
- Personalized Behavioral Intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jun 2022to 11 Oct 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Mild to moderate depression per PHQ9 symptom ratings
Who cannot join
- active substance abuse/dependence
- psychotic disorders
- bipolar disorder
- eating disorder
- displaying acutely suicidal behaviors
Trial locations and contacts
1 site in 1 country.
United States1 site
UC San Diego Health Psychiatry
San Diego, California, 92127
About this study
The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood.
Read the detailed description
The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. After an initial period (2-4 weeks) of mood and lifestyle monitoring using smartphone and smartwatch data, participants will be assigned to an evidenced-based behavioral plan that target their lifestyle for 6 weeks. The trial will evaluate changes in depressed mood, associated health behaviors and cognition.
- Conditions
- Depression
- Being tested
- Personalized Behavioral Intervention
- Medical subject headings
- Depression
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Personalized Behavioral InterventionBehavioural
Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns.
| Study group | Role | What they receive |
|---|---|---|
| Personalized Behavioral Intervention | Experimental | Behavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns. Receives: Behavioral: Personalized Behavioral Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
PHQ9
Depression Symptoms on the Patient Health Questionnaire 9-item (PHQ9) scale, min 0 max 27 with lower scores representing better outcome
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Dec 2022
- Study start1 Jun 2022
- Primary completion15 Jul 2024
- Study completion11 Oct 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for DepressionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of California, San Diego
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jyoti Mishra, University of California, San Diego
- Investigators
- Jyoti Mishra, PhD, Principal investigator, University of California, San Diego
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05662254
- Sponsor's protocol ID
- PERMA
- Acronym
- PERMA
- Status last verified
- Mar 2025
- First submitted
- 10 Dec 2022
- Last updated
- 27 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Nan J, Purpura S, Jaiswal S, Afshar H, Maric V, Manchanda JK, Taylor CT, Ramanathan D, Mishra J. Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study. NPP Digit Psychiatry Neurosci. 2026 May 19;4(1):10. doi: 10.1038/s44277-026-00062-3.
PubMed 42151558
Study at a glance
From the registry record, last updated by the sponsor on 27 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- PERsonalized Mood Augmentation Trial for Depressed Mood
- ClinicalTrials.gov ID
- NCT05662254
- Acronym / sponsor ID
- PERMA / PERMA
- Conditions
- Depression
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- University of California, San DiegoUniversity, hospital or other
- Study start
- 1 Jun 2022 (actual)
- Primary completion
- 15 Jul 2024 (actual)
- Study completion
- 11 Oct 2024 (actual)
- First posted
- 22 Dec 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood.
Detailed description
The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. After an initial period (2-4 weeks) of mood and lifestyle monitoring using smartphone and smartwatch data, participants will be assigned to an evidenced-based behavioral plan that target their lifestyle for 6 weeks. The trial will evaluate changes in depressed mood, associated health behaviors and cognition.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Personalized Behavioral Intervention | Experimental | Behavioral: Personalized Behavioral InterventionBehavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns. |
Who may qualify
- Ages
- 15 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Mild to moderate depression per PHQ9 symptom ratings
Key exclusion criteria (5 listed)
- active substance abuse/dependence
- psychotic disorders
- bipolar disorder
- eating disorder
- displaying acutely suicidal behaviors
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Personalized Behavioral InterventionBehavioral lifestyle intervention assigned according to each participant's mood and lifestyle data patterns. | Behavioural | Personalized Behavioral Intervention |
Primary outcome
PHQ9
Time frame: 12 weeks
Depression Symptoms on the Patient Health Questionnaire 9-item (PHQ9) scale, min 0 max 27 with lower scores representing better outcome
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Mar 2025.
- Derived from this study: PubMed 42151558Nan J, Purpura S, Jaiswal S, Afshar H, Maric V, Manchanda JK, Taylor CT, Ramanathan D, Mishra J. Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study. NPP Digit Psychiatry Neurosci. 2026 May 19;4(1):10. doi: 10.1038/s44277-026-00062-3.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jyoti Mishra, PhD principal investigator
University of California, San Diego
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Personalized Behavioral Intervention in people with Depression, run by University of California, San Diego at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
PHQ9 (time frame: 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05662254, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Mar 2025.