Acute Kidney InjuryNCT05672238
Evaluation of Postoperative Acute Kidney Injury (AKI) Incidence and Risk Factors in Patients Underwent Pneumonectomy
An observational study of Acute Kidney Injury and Pneumonectomy; Status, run by Ankara University at 1 site in Turkey (Türkiye).
Trial summary
Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Acute Kidney Injury, Pneumonectomy; Status, Complication,Postoperative
- How many people
- 166 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 16 Oct 2021to 18 Nov 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Adult, Older adult
Study population: Patients underwent pneumonectomy
Who may be able to join
- Patients underwent pneumonectomy, from January 2008 to December 2018
Who cannot join
- Chronic Kidney Disease
Trial locations and contacts
1 site in 1 country.
About this study
Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. The aim of this study is to identify the incidance and outcomes of patients underwent pneumonectomy, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria.
Read the detailed description
Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. Although there is a decrease in pulmonary damage with restrictive fluid management and protective ventilatory strategies in patients who underwent wide lung resection to prevent pulmonary edema development after resection, the relative hypovolemia and hypoperfusion developed in patients may lead to renal dysfunction. The incidence of AKI after thoracic surgery can be up to 15% and is associated with prolonged length of stay (LOS) in hospital. The incidence of AKI is higher in patients with extensive resection such as pneumonectomy compared with lobectomy and wedge resection. Since AKI is not only a rare complication but also a risk factor for mortality, it is important to identify the incidence and risk factors of AKI, to prevent AKI and related complications and to improve patients outcomes. In this study incidence of AKI was defined using the KDIGO criteria according to the change of serum creatine levels.
166 patients who underwent pneumonectomy from January 2008 to December 2018 included the retrospective observational study. Demographic data, intraoperative data, rates of complications, risk factors for AKI, mortality, lenght of stay in intensive care unit (İCU) and hospital were evaluated. AKI was defined using the KDIGO criteria according to the serum creatinine levels. The SPSS 11.5 program was used for statistical analysis.
- Keywords
- Acute Kidney Injury, Pneumonectomy
- Medical subject headings
- Acute Kidney Injury, Postoperative Complications
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative acute kidney injury in patients underwent pneumonectomy
Kidney Disease Improving Global Outcomes (KDIGO) criteria
Measured: One week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jan 2023
- Study start16 Oct 2021
- Primary completion28 Oct 2022
- Study completion18 Nov 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Kidney InjuryStudies of the same condition, open and under way.
- More trials run by Ankara UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 166 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara University
- Sponsor type
- University, hospital or other
- Collaborators
- Bengi Safak, Çiğdem Yıldırım Güçlü, Basak Ceyda MECO, Yusuf KAHYA, Süleyman Gökalp Güneş, İslam Aktürk
- Responsible party
- Principal investigator, Süheyla Karadağ Erkoç, Ankara University
- Investigators
- Süheyla Karadağ Erkoç, Principal investigator, Ankara University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05672238
- Sponsor's protocol ID
- AnkaraUPneumonectomyAKI
- Status last verified
- Jan 2023
- First submitted
- 3 Jan 2023
- Last updated
- 5 Jan 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Jan 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Postoperative Acute Kidney Injury (AKI) Incidence and Risk Factors in Patients Underwent Pneumonectomy
- ClinicalTrials.gov ID
- NCT05672238
- Acronym / sponsor ID
- AnkaraUPneumonectomyAKI
- Keywords
- Acute Kidney Injury, Pneumonectomy
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 166 participants (actual)
- Lead sponsor
- Ankara UniversityUniversity, hospital or other
- Collaborators
- Bengi Safak, Çiğdem Yıldırım Güçlü, Basak Ceyda MECO, Yusuf KAHYA, Süleyman Gökalp Güneş, İslam Aktürk
- Study start
- 16 Oct 2021 (actual)
- Primary completion
- 28 Oct 2022 (actual)
- Study completion
- 18 Nov 2022 (actual)
- First posted
- 5 Jan 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. The aim of this study is to identify the incidance and outcomes of patients underwent pneumonectomy, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria.
Detailed description
Acute kidney injury (AKI) is a critical complication associated with a high incidence of morbidity and mortality that can occur in critically ill patients and after major surgical procedures. Although there is a decrease in pulmonary damage with restrictive fluid management and protective ventilatory strategies in patients who underwent wide lung resection to prevent pulmonary edema development after resection, the relative hypovolemia and hypoperfusion developed in patients may lead to renal dysfunction. The incidence of AKI after thoracic surgery can be up to 15% and is associated with prolonged length of stay (LOS) in hospital. The incidence of AKI is higher in patients with extensive resection such as pneumonectomy compared with lobectomy and wedge resection. Since AKI is not only a rare complication but also a risk factor for mortality, it is important to identify the incidence and risk factors of AKI, to prevent AKI and related complications and to improve patients outcomes. In this study incidence of AKI was defined using the KDIGO criteria according to the change of serum creatine levels.
166 patients who underwent pneumonectomy from January 2008 to December 2018 included the retrospective observational study. Demographic data, intraoperative data, rates of complications, risk factors for AKI, mortality, lenght of stay in intensive care unit (İCU) and hospital were evaluated. AKI was defined using the KDIGO criteria according to the serum creatinine levels. The SPSS 11.5 program was used for statistical analysis.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Patients underwent pneumonectomy
Key inclusion criteria (1 listed)
- Patients underwent pneumonectomy, from January 2008 to December 2018
Key exclusion criteria (1 listed)
- Chronic Kidney Disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Postoperative acute kidney injury in patients underwent pneumonectomy
Time frame: One week
Kidney Disease Improving Global Outcomes (KDIGO) criteria
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jan 2023.
Related trials for Acute Kidney Injury
Not yet recruiting
Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial
Acute-on-Chronic Liver Failure (ACLF)
Not yet recruiting
Early Biomarker Kidney Injury Assessment After Acumen Directed Fluid Management in Cardiac Surgery
Renal Injury, Acute Kidney Injury
Recruiting
Acute Kidney Injury and Ultra-endurance Running
AKI (Acute Kidney Injury) Due to Trauma
Recruiting
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Not yet recruitingObservational study
Diastolic Shock Index for Predicting Hemodynamic Instability During Continuous Renal Replacement Therapy
Acute Kidney Injury, Hypotension (MeSH: D007022)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Süheyla Karadağ Erkoç principal investigator
Ankara University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Kidney Injury and Pneumonectomy; Status, run by Ankara University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Jan 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative acute kidney injury in patients underwent pneumonectomy (time frame: One week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jan 2023.