Prevention of Ischemic StrokePhase 3OCEANIC-STROKENCT05686070
A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
A Phase 3 study testing Asundexian (BAY2433334) in people with Prevention of Ischemic Stroke and Acute Non-cardioembolic Ischemic Stroke, run by Bayer at 741 sites in 37 countries.
Trial summary
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had: an acute stroke due to a blood clot that formed outside the heart (acute non-cardioembolic ischemic stroke), or TIA/mini-stroke with a high risk of… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack
- What is being tested?
- Asundexian (BAY2433334)
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 12,327 participants
- Where
- 741 sitesin 37 countries
- Study dates
- 26 Jan 2023to 23 Oct 2025
- Phase
- Phase 3
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants must be ≥ 18 years of age
- Acute non-cardioembolic stroke or high-risk TIA
- Systemic or cerebrovascular atherosclerosis or acute non-lacunar infarct
Who cannot join
- Ischemic stroke ≤ 7 days before the index event
- Index stroke following procedures or strokes due to other rare causes
- History of atrial fibrillation/flutter, left ventricular thrombus, mechanic valve or other cardioembolic source of stroke requiring anticoagulation
Trial locations and contacts
741 sites in 37 countries.
741 sites in 37 countries
United States108 sites
Albany Medical College | Department of Neurology
Albany, New York, 12208
LVH Neurology - 1250 Cedar Crest
Allentown, Pennsylvania, 18103
Mission Hospital | Neurology
Asheville, North Carolina, 28801
HCA Florida JFK Hospital - Neurology
Atlantis, Florida, 33462
University of Maryland Medical Center - Neurology Care Center
Baltimore, Maryland, 21201
Tufts Medical Center - Neurology
Boston, Massachusetts, 02111
Delray Medical Center - Neurology
Boynton Beach, Florida, 33472
Nova Clinical Research - Blake Medical Center
Bradenton, Florida, 34209
St. Vincent's Medical Center - Neurology Clinic
Bridgeport, Connecticut, 06606
SUNY Downstate Health Sciences University - Neurology
Brooklyn, New York, 11203
NYU Langone Hospital Brooklyn - Neurology
Brooklyn, New York, 11220
Mount Sinai Brooklyn - Neurology
Brooklyn, New York, 11234
Trinity Medical Western New York | Trinity Vascular & Endovascular Center - Research Department
Buffalo, New York, 14220
MUSC Health Neurology at Rutledge Tower
Charleston, South Carolina, 29425
Erlanger Neurology
Chattanooga, Tennessee, 37403
University of Illinois Hospital - Neurology
Chicago, Illinois, 60612
The University of Chicago Medical Center - Neurology
Chicago, Illinois, 60637
BayCare Health System | Morton Plant Hospital - Neuroscience Research department
Clearwater, Florida, 33756
Cleveland Clinic - Neurology
Cleveland, Ohio, 44195
Ohio State University Wexner Medical Center - Neurology
Columbus, Ohio, 43210
OhioHealth Neuroscience Center at Riverside
Columbus, Ohio, 43214
Baylor University Medical Center at Dallas - Neurology
Dallas, Texas, 75204
James W. Aston Ambulatory Care Center - Neurology
Dallas, Texas, 75390
Nuvance Health
Danbury, Connecticut, 06810
Wright State University | Boonshoft School of Medicine - WSU and Premier Health Clinical Trials Research Alliance
Dayton, Ohio, 45409
Henry Ford Hospital - Neurology
Detroit, Michigan, 48202
Duke Neurological Disorders Clinic - Clinic 1L
Durham, North Carolina, 27710
MSU Health Care Neurology & Ophthalmology
East Lansing, Michigan, 48824
Doctors Hospital at Renaissance - Neurology
Edinburg, Texas, 78539
University of Pittsburgh Medical Center, Hamot | Clinical Trials and Research
Erie, Pennsylvania, 16507
Eastern Shore Research Institute, LLC | Fairhope, AL
Fairhope, Alabama, 36532
Kaiser Permanente Fontana Medical Center
Fontana, California, 92335
Texas Health Harris Methodist Hospital - Fort Worth - Neurology
Fort Worth, Texas, 76104
UF Health Neuromedicine Hospital
Gainesville, Florida, 32608
Minneapolis Clinic of Neurology | Golden Valley, MN
Golden Valley, Minnesota, 55422
Neuroscience Institute at Great Neck
Great Neck, New York, 11021
Guilford Neurologic Research Partners, LLC.
Greensboro, North Carolina, 27405
ECU Health Medical Center - Neurology
Greenville, North Carolina, 27834
Prisma Health Greenville Memorial Hospital - Comprehensive Stroke Center
Greenville, South Carolina, 29605
Hackensack University Medical Center
Hackensack, New Jersey, 07601
UPMC Harrisburg - Cardiology
Harrisburg, Pennsylvania, 17101
Westchester Medical Center
Hawthorne, New York, 10532
Neurological Associates - Henrico
Henrico, Virginia, 23229
Penn State Milton S. Hershey Medical Center - Neurology
Hershey, Pennsylvania, 17033
Houston Methodist Neurological Institute
Houston, Texas, 77030
UTHealth Houston Neurosciences Neurology - Texas Medical Center
Houston, Texas, 77030
Marshall University Medical Center - Neurology
Huntington, West Virginia, 25701
University Hospital - UMMC - Neurology
Jackson, Mississippi, 39216
Baptist Health Research Institute
Jacksonville, Florida, 32207
Saint Luke's Hospital of Kansas City - Neurology
Kansas City, Missouri, 64111
Kansas City VA Medical Center - Neurology
Kansas City, Missouri, 64128
Kettering Health Main Campus - Neurology
Kettering, Ohio, 45429
The University of Tennessee Medical Center - Main Campus - Neurology
Knoxville, Tennessee, 37920
Lancaster General Health Neuroscience Institute
Lancaster, Pennsylvania, 17601
Dartmouth-Hitchcock Medical Center - Neurology
Lebanon, New Hampshire, 03756
Baptist Health Lexington
Lexington, Kentucky, 40503
Mercy Health - St. Rita's Medical Center - Neurology
Lima, Ohio, 45801
University of Arkansas for Medical Sciences - Neurology
Little Rock, Arkansas, 72205
Long Beach Medical Center - Neurology
Long Beach, California, 90806
Kaiser Permanente Los Angeles Medical Center - Neurology
Los Angeles, California, 90027
Los Angeles - USC Healthcare Center 2 - Neurology
Los Angeles, California, 90033
UCLA NeuroTranslational Research Center
Los Angeles, California, 90095
Loyola University Medical Center - Neurology
Maywood, Illinois, 60153
Baptist Memorial Hospital East - Cardiology
Memphis, Tennessee, 38120
Froedtert Hospital - Neurology
Milwaukee, Wisconsin, 53226
Intermountain Cardiovascular Research Department
Murray, Utah, 84107
Yale University | School of Medicine - Department of Neurology
New Haven, Connecticut, 06519
Ochsner Medical Center - New Orleans - Neurology
New Orleans, Louisiana, 70121
The Neurological Institute - Columbia University Irving Medical Center
New York, New York, 10032
Mount Sinai Hospital - Stroke Center
New York, New York, 33756
ChristianaCare Health Services | Christiana Hospital - Emergency Medicine Research
Newark, Delaware, 19718
Hoag Memorial Hospital - Center for Research & Education
Newport Beach, California, 92663
OU Health University of Oklahoma Med Center - Neurology
Oklahoma City, Oklahoma, 73104
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
UCI Medical Center - Neurology
Orange, California, 92868
Hospital of the University of Pennsylvania - Neurology
Philadelphia, Pennsylvania, 19104
Jefferson Hospital for Neuroscience
Philadelphia, Pennsylvania, 19107
Lewis Katz School of Medicine at Temple University | Neurology
Philadelphia, Pennsylvania, 19140
Jefferson Einstein Philadelphia Hospital - Neurology
Philadelphia, Pennsylvania, 19141
Barrow Neurologic Institute - Petznick Stroke Center
Phoenix, Arizona, 85013
Neurology Consultants of Dallas - Plano
Plano, Texas, 75093
Trinity Health | Oakland Hospital - Clinical Research Department
Pontiac, Michigan, 48341
OHSU Hospital - Neurology
Portland, Oregon, 97239
Vassar Brothers Medical Center
Poughkeepsie, New York, 12601
Rhode Island Hospital - Neurology
Providence, Rhode Island, 20903
North Carolina Heart & Vascular (Capital Heart)
Raleigh, North Carolina, 27607
Mayo Clinic - Rochester - Neurology
Rochester, Minnesota, 55902
Rochester General Hospital
Rochester, New York, 14621
Mercyhealth Javon Bea Hospital - Riverside | Neurology Research Department
Rockford, Illinois, 61114
University of Utah Clinical Neurosciences Center
Salt Lake City, Utah, 84312
UT Health San Antonio - Medical Arts & Research Center - Neurology
San Antonio, Texas, 78229
San Francisco VA Health Care System
San Francisco, California, 94121
Cottage Health | Santa Barbara Cottage Hospital - Research Department
Santa Barbara, California, 93105
Intercoastal Medical Group | Clinical Research
Sarasota, Florida, 34239
HonorHealth Research Institute
Scottsdale, Arizona, 85258
HSHS St. John's Hospital - Neurology
Springfield, Illinois, 62769
Barnes-Jewish Hospital - Cardiology
St Louis, Missouri, 63100
Mercy Research - St. Louis
St Louis, Missouri, 63141
USF Health South Tampa Center for Advanced Healthcare - Neurology
Tampa, Florida, 33606
BayCare Health System | Saint Joseph's Hospital - Neurology Department
Tampa, Florida, 33607
Baylor Scott & White Medical Center - Temple - Neurology
Temple, Texas, 76508
ProMedica | ProMedica Toledo Hospital - Neuro/Stroke Research Department
Toledo, Ohio, 43606
Mercy Health St. Vincent Medical Center - Neurology
Toledo, Ohio, 43608
The Lundquist Institute - Neurology
Torrance, California, 90502
Banner - University Medical Center Tucson - Neurology
Tucson, Arizona, 85724
Novant Health Forsyth Medical Center - Neurology
Winston-Salem, North Carolina, 27103
Atrium Health Wake Forest Baptist | Medical Center - Neurology Department
Winston-Salem, North Carolina, 27157
Mercy Health St. Elizabeth Youngstown Hospital - Neurology
Youngstown, Ohio, 44504
Japan66 sites
Ohnishi Neurological Center
Akashi, Hyōgo, 674-0064
Mazda Motor Corporation Mazda Hospital
Aki-gun, Hiroshima, 735-8585
Japanese Red Cross Asahikawa Hospital
Asahikawa, Hokkaido, 070-8530
National Hospital Organization Beppu Medical Center
Beppu, Oita Prefecture, 874-0011
Nozaki Tokushukai Hospital
Daitō, Osaka, 574-0074
National Hospital Organization Kyushu Medical Center
Fukuoka, Fukuoka, 810-8563
Saiseikai Fukuoka General Hospital
Fukuoka, 810-0001
Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital
Fukuoka, 811-0213
Fukuoka Neurosurgical Hospital
Fukuoka, 811-1313
Kyushu Central Hospital
Fukuoka, 815-8588
Hakodate Shintoshi Hospital
Hakodate, Hokkaido, 041-0802
Hamamatsu Rosai Hospital
Hamamatsu, Shizuoka, 430-8525
Hiroshima General Hospital
Hatsukaichi, Hiroshima, 738-8503
Higashihiroshima Medical Center
Higashihiroshima, Hiroshima, 739-0041
Hyogo Prefectural HarimaHimeji General Medical Center
Himeji, Hyōgo, 670-8560
Hiroshima City North Medical Center Asa Citizens Hospital
Hiroshima, 731-0293
Nippon Medical School Musashikosugi Hospital
Kawasaki-shi, Kanagawa, 211-8533
Kimitsu Chuo Hospital
Kisarazu, Chiba, 292-8535
Kokura Memorial Hospital
Kitakyushu, Fukuoka, 802-8555
Steel Memorial Yawata Hospital
Kitakyushu, Fukuoka, 805-8508
Eishokai Yoshida Hospital
Kobe, Hyōgo, 652-0803
Japanese Red Cross Kochi Hospital
Kochi, 780-8562
Yamanashi Prefectural Central Hospital
Kofu, Yamanashi, 400-8506
Southern Tohoku Medical Clinic
Kōriyama, Fukushima, 963-8052
Kumamoto City Hospital
Kumamoto, 862-8505
Koseikai Takeda Hospital
Kyoto, 600-8558
Ijinkai Takeda General Hospital
Kyoto, 601-1495
Maebashi Red Cross Hospital
Maebashi, Gunma, 371-0811
Japan Organization of Occupational Health and Safety Kagawa Rosai Hospital
Marugame, Kagawa-ken, 763-8502
National Hospital Organization Tokyo Medical Center
Meguro-ku, Tokyo, 152-8902
Mishuku Hospital
Meguro-ku, Tokyo, 153-0051
Kyorin University Hospital
Mitaka, Tokyo, 181-8611
Nagano Municipal Hospital
Nagano, 381-8551
Nagoya Ekisaikai Hospital
Nagoya, Aichi-ken, 454-8502
Chubu Rosai Hospital
Nagoya, Aichi-ken, 455-8530
Japan Culture and Welfare Federation of Agricultural Cooperatives | Hokushin General Hospital
Nakano, Nagano, 383-8505
Seisho Hospital
Odawara, Kanagawa, 250-0001
Japanese Red Cross Okayama Hospital
Okayama, Okayama-ken, 700-8607
CMIC HealthCare Institute Co. Ltd. | Local IAA OCGMC - Okayama City Civic Hospital - Clinical Trial Centre
Okayama, 7008557
Kotobuki Social Medical Corporation Tominaga Hospital
Osaka, Osaka
National Hospital Organization Osaka National Hospital
Osaka, 540-0006
Osaka General Medical Center
Osaka, 558-8558
Toho University Sakura Medical Center
Sakura, Chiba, 285-8741
Teine Keijinkai Hospital
Sapporo, Hokkaido, 006-8555
Kohnan Hospital
Sendai, Miyagi, 982-8523
Tosei General Hospital
Seto, Aichi-ken, 489-8642
JCHO Shimonoseki Medical Center
Shimonoseki, Yamaguchi, 750-0061
Shizuoka City Shizuoka Hospital
Shizuoka, 420-8630
Shizuoka City Shimizu Hospital
Shizuoka, 424-8636
Osaka Saiseikai Senri Hospital
Suita, Osaka, 565-0862
Tokyo Metropolitan Bokutoh Hospital
Sumida-ku, Tokyo, 130-8575
Japanese Red Cross Society Suwa Hospital
Suwa, Nagano, 392-8510
National Hospital Organization Disaster Medical Center
Tachikawa, Tokyo, 190-0014
Takamatsu Red Cross Hospital
Takamatsu, Kagawa-ken, 760-0017
Kagawa Prefectural Central Hospital
Takamatsu, Kagawa-ken, 760-8557
Japanese Red Cross Takayama Hospital
Takayama, Gifu, 506-8550
Minamiwakayama Medical Center
Tanabe, Wakayama, 646-8558
JA Toride Medical Center
Toride, Ibaraki, 302-0022
Fujita Health University Hospital
Toyoake, Aichi-ken, 470-1192
National Hospital Organization Toyohashi Medical Center
Toyohashi, Aichi-ken, 440-8510
Tsuchiura Kyodo General Hospital
Tsuchiura, Ibaraki, 300-0028
Uji-Tokushukai Medical Center
Uji, Kyoto, 611-0041
National Hospital Organization Ureshino Medical Center
Ureshino, Saga-ken, 843-0393
Wakayama Medical University Hospital
Wakayama, 640-8558
Saiseikai Yokohamashi Nanbu Hospital
Yokohama, Kanagawa, 234-0054
National Hospital Organization Yokohama Medical Center
Yokohama, Kanagawa, 245-8575
China59 sites
Baoji Central Hospital
Baoji, Shaanxi, 721008
Baogang hospital
Baotou, Inner Mongolia, 14010
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, 14010
Xuanwu Hospital Capital Medical University
Beijing, 100053
Beijing Tsinghua Changgung Hospital
Beijing, 102218
Cangzhou Central Hospital
Cangzhou, Hebei, 61000
The First Hospital of Jilin University
Changchun, Jilin, 130061
The Third Xiangya Hospital of Central South University
Changsha, Hunan, 410000
Daqing Oilfield General Hospital
Daqing, Heilongjiang, 163311
Daqing People's Hospital
Daqing, Heilongjiang, 163316
People's Hospital of Deyang City
Deyang, Sichuan, 618000
Foshan First People's Hospital
Foshan, Guangdong, 528000
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510000
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, 510280
Guangzhou Overseas Chinese Hospital
Guangzhou, Guangdong, 510630
Hainan General Hospital
Haikou, Hainan, 570311
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine
Hangzhou, Zhejiang, 310016
Hengshui Harrison International Peace Hospital
Hengshui, Hebei, 53000
1st Affiliated Hospital of Nanhua University
Hengyang, Hunan, 421001
The Affiliated Huaian No.1 People's Hospi of NJ Medical Unv.
Huai'an, Jiangsu, 223001
Affiliated Hospital of Jiangsu University
JiangSu, Jiangsu, 212001
Qilu Hosp., Shandong Univ.
Jinan, Shandong, 250012
Jining No.1 people's Hospital
Jining, Shandong, 272001
Affiliated Hospital of Jining Medical University
Jining, Shandong, 272007
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, Liaoning, 121001
Lanzhou University Second Hospital
Lanzhou, Gansu, 730030
Liaocheng People's Hospital
Liaocheng, Shandong, 252000
Linyi People's Hospital
Linyi, Shandong, 276003
People's Hospital of Liuzhou City
Liuzhou, Guangxi, 545006
1st Affiliated Hospital of Henan Science and Technology Univ
Luoyang, Henan, 471000
Luoyang Third People's Hospital
Luoyang, Henan, 471002
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, 330006
The First Affiliated Hospital of NanChang University
Nanchang, Jiangxi, 330006
The Second Affiliated Hospital of Nanjing Medical university
Nanjing, Jiangsu, 210000
Nanjing First Hospital
Nanjing, Jiangsu, 210006
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009
Hwa Mei Hospital, University of Chinese Academy Sciences
Ningbo, Zhejiang, 31510
Huashan Hospital, Fudan University
Shanghai, 200040
Yangpu Hospital, Tongji University
Shanghai, 200090
General Hospital of Northern Theater Command
Shenyang, Liaoning, 110016
The Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, 50051
Taian City Central Hospital
Taian, Shandong, 271099
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, 317099
Tangshan people's Hospital
Tangshan, Hebei, 63001
Tianjin People's Hospital
Tianjin, 300000
Tianjin Huanhu Hospital
Tianjin, 300350
The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...
Wuhan, Hubei, 430014
Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech
Wuhan, Hubei, 430034
Wuxi No.2 People's Hospital
Wuxi, Jiangsu, 214002
Wuxi People's Hospital
Wuxi, Jiangsu, 214023
Shaanxi Provincial People's Hospital
Xi'an, Shaanxi, 710068
Yan'an University Xianyang Hospital
Xianyang, Shaanxi, 716000
Qinghai University Affiliated Hospital
Xining, Qinghai, 810001
Xinxiang Central Hospital
Xinxiang, Henan, 453000
The Third Affiliated Hospital of Xinxiang Medical university
Xinxiang, Henan, 453003
Xuancheng People's Hospital
Xuancheng, Anhui, 242000
Xuzhou Central Hospital
Xuzhou, Jiangsu, 221009
Affiliated Hospital of Yangzhou University
Yangzhou, Jiangsu, 225007
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750004
France29 sites
CHRU Besancon - Hopital Jean Minjoz - Service neurologie
Besançon, 25000
Hopital Pellegrin _ Soins Intensifs Unite Neurovasculaire
Bordeaux, 33000
Centre Hospitalier Boulogne sur Mer - Neurologie
Boulogne-sur-Mer, 62321
CHU de Brest - Hopital La Cavale Blanche
Brest, 29609
HCL - Hopital Louis Pradel - Service de Neurologie
Bron, Auvergne-Rhône-Alpes, 69477
CH Sud Francilien, Neurologie
Corbeil-Essonnes, 91100
CHU Dijon - Hopital Francois Mitterand - Service neurologie generale vasculaire et degenerative
Dijon, 21079
Hopital Raymond-Poincare _ Service de Neurologie
Garches, 92380
Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Bicetre
Le Kremlin-Bicêtre, 94275
Centre Hospitalier - Le Mans _ Service de Neurologie
Le Mans, 72037 Cedex 09
Hopital Salengro _ Service de Neurologie et Pathologie Neurovasculaire
Lille, 59037
GHICL - Hopital Saint-Philibert
Lomme, 59160
AP-HM - Hopital de la Timone - Service de Neurologie
Marseille, Bouches-du-Rhône, 13005
CHRU Nancy - Hopital central - Service de neurologie
Nancy, 54000
CHU de Nice - Hopital Pasteur - Unite Neuro Vasculaire
Nice, 06000
Hopital Caremeau _ Service de Neurologie
Nîmes, 30900
Hopital de la Pitie-Salpetriere _ Service des Urgences Cerebro-Vasculaires
Paris, 75013
Centre hospitalier Sainte Anne
Paris, 75014
APHP Hopital Bichat Claude Bernard - Service de Neurologie
Paris, 75018
APHP - Hopital Fondation Adolphe De Rothschild - Service de Neurologie
Paris, 75019
AP-HP - Hopital Lariboisiere
Paris, 75475
CHU de Reims - Hopital de la Maison Blanche - Service de Neurologie
Reims, 51092
CHU Rennes - Hopital Pontchaillou - Service de neurologie
Rennes, 35033
CHU de Nantes - Hopital Laennec - Unite neurovasculaire
Saint-Herblain, 44800
CHU Strasbourg - Hopital Hautepierre - Service Neurologie
Strasbourg, Grand Est, 67098
Hopital Foch - Service de Neurologie
Suresnes, 92151
Hopital instruction des Armees Sainte Anne
Toulon, 83800
CHU Toulouse - Hopital Pierre Paul Riquet PURPAN
Toulouse, 31059
CHRU de Tours - Hôpital Bretonneau - Service de neurologie
Tours, 37044
Germany28 sites
UniKlinikum Aachen/Neurologie
Aachen, North Rhine-Westphalia, 52074
Klinikum Altenburger Land / Studienzentrum Neurologie
Altenburg, Thuringia, 4600
SRH Wald-Klinikum Gera gGmbH
Bad Langensalza, Thuringia, 99947
Rhön-Klinikum Campus Bad Neustadt/Neurologie
Bad Neustadt an der Saale, Bavaria, 97616
Vivantes Klinikum Neukölln / Neurologie mit Stroke Unit
Berlin, 12351
Uniklinik Bonn / Neurologie
Bonn, North Rhine-Westphalia, 53127
Städtisches Klinikum Dresden / Neurologie
Dresden, Saxony, 1067
Universitätsklinikum Dresden/Neurologie
Dresden, Saxony, 1307
Universitätsklinikum Düsseldorf / Neurologie
Düsseldorf, North Rhine-Westphalia, 40225
Marien Hospital Düsseldorf / Neurologie
Düsseldorf, North Rhine-Westphalia, 40479
Universitätsklinikum Erlangen/Neurologie
Erlangen, Bavaria, 91054
Alfried Krupp Krankenhaus Rüttenscheid /Neurologie
Essen, North Rhine-Westphalia, 45131
Universitätsklinikum Frankfurt / Neurologie
Frankfurt am Main, Hesse, 60590
Universitätsklinikum Freiburg / Neurologie
Freiburg im Breisgau, Baden-Wurttemberg, 79106
Universität Gießen-Marburg, Standort Gießen/Neurologie
Giessen, Hesse, 35385
Universitätsmedizin Göttingen/ Neurologie
Göttingen, Lower Saxony, 37075
Universitätsmedizin Greifswald/Neurologie
Greifswald, Mecklenburg-Vorpommern, 17475
Universitätsklinikum Halle (Saale)/Neurologie
Halle, Saxony-Anhalt, 6120
Asklepios Klinik Wandsbek/Neurologie
Hamburg, 22043
Asklepios Klinik Barmbek/ Neurologie
Hamburg, 22307
Asklepios Klinik Altona Hamburg / Neurologie
Hamburg, 22763
Medizinische Hochschule Hannover/Neurologie
Hanover, Lower Saxony, 30625
Universitaetsklinikum Heidelberg / Neurologie
Heidelberg, Baden-Wurttemberg, 69120
Uniklinik Jena/ Neurologie
Jena, Thuringia, 7747
Universitätsklinik Leipzig /Neurologie
Leipzig, Saxony, 4103
Johannes Gutenberg-Universität Mainz - Neurologie
Mainz, Rhineland-Palatinate, 55131
GFO KlinikTroisdorf/Neurologie
Troisdorf, North Rhine-Westphalia, 53844
Universitätsklinikum Ulm/Neurologische Klinik
Ulm, Baden-Wurttemberg, 89081
Australia25 sites
Royal Adelaide Hospital
Adelaide, South Australia, 5000
Grampians Health Ballarat
Ballarat, Victoria, 3350
Sunshine Coast University Hospital
Birtinya, Queensland, 4575
Blacktown Hospital
Blacktown, New South Wales, 2148
Eastern Health Box Hill Hospital
Box Hill, Victoria, 3128
Royal Brisbane and Women's Hospital
Brisbane, Queensland, 4029
Princess Alexandra Hospital Australia
Brisbane, Queensland, 4102
Monash Medical Centre
Clayton, Victoria, 3168
Lyell McEwin Hospital
Elizabeth Vale, South Australia, 5112
The Canberra Hospital
Garran, Australian Capital Territory, 2605
Launceston General Hospital
Launceston, Tasmania, 7250
South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department
Liverpool, New South Wales, 2170
The Alfred Hospital
Melbourne, Victoria, 3004
Fiona Stanley Hospital
Murdoch, Western Australia, 6961
Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009
John Hunter Hospital
New Lambton, New South Wales, 2305
Royal Prince Alfred Hospital
Newtown, New South Wales, 2042
Royal Melbourne Hospital
Parkville, Victoria, 3050
Prince of Wales Hospital NSW
Randwick, New South Wales, 2031
Redcliffe District Hospital
Redcliffe, Queensland, 4020
Gold Coast University Hospital
Southport, Queensland, 4215
Western Health Neuroscience Research Unit
St Albans, Victoria, 3021
Royal North Shore Hospital
St Leonards, New South Wales, 2065
Nepean Hospital
Sydney, New South Wales, 2751
Westmead Hospital
Westmead, New South Wales, 2145
Spain25 sites
University Hospital of A Coruna | Neurology Department - Stroke, No-Cardioembolic-Tia
A Coruña, A Coruña, 15006
Hospital General Universitario De Albacete - Neurologia
Albacete, 02006
Hospital Alvaro Cunqueiro | Neurology Department - Stroke, No-Cardioembolic-Tia
Babio - Beade, Pontevedra, 36312
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, 08916
IIS Biobizkaia Health Research Institute | Hospital de Cruces - Neurology Department - Stroke, No-Cardioembolic-Tia
Barakaldo, Vizcaya, 48903
Hospital de la Santa Creu i Sant Pau | Neurology Department - Stroke, No-Cardioembolic-Tia
Barcelona, 08025
Ciutat Sanitaria i Universitaria de la Vall d'Hebron
Barcelona, 08035
Hospital Universitari De Girona Doctor Josep Trueta - Neurologia
Girona, 17007
Hospital Universitario De Leon - Neurologia
León, 24008
Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida - Neurologia
Lleida, 25198
COMPLEJO HOSPITALARIO RUBER JUAN BRAVO - Neurología
Madrid, 28006
Hospital Universitario de La Princesa | Neurology Department
Madrid, 28006
H Gregorio Marañon|Neurology|STROKE|NO-CARDIOEMBOLIC-TIA
Madrid, 28007
Hospital Universitario Ramon Y Cajal - Neurologia
Madrid, 28034
Hospital Universitario 12 de Octubre | Neurology Department - Stroke, No-Cardioembolic-Tia
Madrid, 28041
Hospital Universitario La Paz | Neurology Department - Stroke, No-Cardioembolic-Tia
Madrid, 28046
Hospital Universitario Rey Juan Carlos - Neurologia
Móstoles, Madrid, 28933
Hospital Clinico Universitario Virgen de la Arrixaca | Neurology Department - Stroke
Murcia, 30120
Hospital Clinico Universitario de Santiago de Compostela | Neurology Department - Stroke, No-Cardioembolic-Tia
Santiago de Compostela, A Coruña, 15706
Hospital Universitario Virgen De La Macarena - Neurologia
Seville, 41009
Hospital Universitario Virgen Del Rocio S.L. - Neurologia
Seville, 41013
Hospital Universitari Joan XXIII De Tarragona - Neurologia
Tarragona, 43005
Hospital Clinico Universitario de Valencia | Neurology Department
Valencia, 46010
Hospital Universitario Y Politecnico La Fe - Neurologia
Valencia, 46026
Hospital Clinico Universitario De Valladolid - Neurologia
Valladolid, 47003
Taiwan24 sites
Changhua Christian Hospital
Changhua, 50006
National Taiwan University Hospital, Hsin-Chu Branch
Hsinchu, 302
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Kaohsiung, 807377
Kaohsiung Veterans General Hospital
Kaohsiung City, 813414
Chang Gung Memorial Hospital Kaohsiung
Kaohsiung City, 833
Chang Gung Memorial Hospital Keelung
Keelung, 20401
Far Eastern Memorial Hospital Neurology
New Taipei City, Taipei, 220
En Chu Kong Hospital
New Taipei City, Taipei, 237
Fu Jen Catholic University Hospital
New Taipei City, Taipei, 24352
MacKay Memorial Hospital Tamsui Branch
New Taipei City, Taipei, 25160
Taipei Medical University - Shuang Ho Hospital
New Taipei City, 23561
Chung Shan Medical University Hospital
Taichung, 402306
China Medical University Hospital
Taichung, 404327
Taichung Veterans General Hospital
Taichung, 40705
National Cheng Kung University Hospital
Tainan, 704
Chi-Mei Medical Center, Liouyine
Tainan, 736
National Taiwan University Hospital
Taipei, 100
Mackay Memorial Hospital
Taipei, 104
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, 111
Taipei Veterans General Hospital
Taipei, 11217
Tri-Service General Hospital
Taipei, 114
Taipei Municipal Wanfang Hospital
Taipei, 116
Chang Gung Memorial Hospital at Linkou
Taoyuan, 33305
China Medical University Hospital Hsin-Chu Branch
Zhubei, Hsinchu, 302
Canada22 sites
University of Calgary | Foothills Medical Centre - Department of Clinical Neurosciences - Stroke Clinical Trials Group
Calgary, Alberta, T2N 2T9
CIUSSS Saguenay Lac-St-Jean
Chicoutimi, Quebec, G7H 5H6
University of Alberta Hospital - Canada
Edmonton, Alberta, T6G 2B7
Health Sciences North Research Institute | Sudbury, Canada
Greater Sudbury, Ontario, P3E 5A2
Queen Elizabeth II Complex
Halifax, Nova Scotia, B3H 4K4
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
Kelowna General Hospital
Kelowna, British Columbia, V1Y 1T2
Kingston Health Sciences Centre (KGH Site)
Kingston, Ontario, K7L 2V7
Center For Neurologic Research
Lethbridge, Alberta, T1J 0N9
London Health Sciences Centre
London, Ontario, N5R 6M6
CHUM - Centre hospitalier de l'Université de Montréal
Montreal, Quebec, H2X 0C1
McGill University Health Center - Neurology Department
Montreal, Quebec, H3A 2B4
Jewish General Hospital
Montreal, Quebec, H3T 1E2
Royal Columbian Hospital
New Westminster, British Columbia, V3L 3W7
The Ottawa Hospital | The Ottawa Hospital Research Institute - Neurology - Ottawa Stroke Program
Ottawa, Ontario, K1Y4E9
CHU de Québec-Hôpital de l'Enfant-Jésus
Québec, Quebec, G1J 1Z4
University of Saskatchewan, Royal University Hospital
Saskatoon, Saskatchewan, S7N 0W8
CIUSSS de l'Estrie-CHUS, Hopital Fleurimont
Sherbrooke, Quebec, J1H 5N4
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5
Unity Health Toronto | St. Michael's Hospital - Stroke Research
Toronto, Ontario, M5C1R6
Vancouver General Hospital / Vancouver Stroke Program
Vancouver, British Columbia, V5Z 1M9
Winnepeg Health Sciences Centre
Winnipeg, Manitoba, R3E 1B2
Italy22 sites
Azienda Sanitaria Locale Avezzano Sulmona L'Aquila - Ospedale SS. Filippo e Nicola - Neurologia
Avezzano, Abruzzo, 67051
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Neurologia
Bergamo, Lombardy, 24127
Azienda Unita Sanitaria Locale Di Bologna_ Ospedale Maggiore Pizzardi - Neurologia
Bologna, Emilia-Romagna, 40133
AUSL della Romagna_Ospedale Bufalini - Neurologia
Cesena, Emilia-Romagna, 47521
Careggi University Hospital - Stroke Unit
Florence, Tuscany, 50134
ASL Della Provincia Di Lecce_Ospedale Vito Fazzi - Neurologia
Lecce, Apulia, 73100
Azienda Ospedaliera Universitaria Gaetano Martino Messina - Stroke Unit
Messina, Sicily, 98124
Ospedale San Raffaele s.r.l. - Neurologia
Milan, Lombardy, 20132
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli - Neurologia
Naples, Campania, 80131
IRCCS Ospedale Sacro Cuore Don Calabria - Neurologia
Negrar, Veneto, 37024
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Neurologia e Stroke Unit
Palermo, Sicily, 90146
Azienda Ospedaliero Universitaria Parma - SC Percorso Stroke Care
Parma, Emilia-Romagna, 43126
A.O. di Perugia_Hospital Santa Maria della Misericordia - S.S. Stroke Unit
Perugia, Umbria, 06129
Azienda Sociosanitaria Ligure 2_Ospedale Santa Corona - Neurologia Ponente
Pietra Ligure, Liguria, 17027
Azienda Ospedaliera Policlinico Universitario Tor Vergata - UOSD Stroke Unit
Rome, Lazio, 00133
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Neurologia
Rome, Lazio, 00168
A.O.U San Giovanni Di Dio E Ruggi d'Aragona - Neurologia e Stroke Unit
Salerno, Campania, 84131
Azienda Ospedaliera Universitaria Senese - Stroke unit
Siena, Tuscany, 53100
Azienda Sanitaria Locale Citta Di Torino - Ospedale San Giovanni Bosco - Neurologia 2
Torino, 10154
Azienda Ospedaliero Universitaria Delle Marche - Clinica Neurologica
Torrette, Ancona, 60126
ASU Friuli Centrale_Ospedale "Santa Maria della Misericordia" - Neuroscienze
Udine, Friuli Venezia Giulia, 33100
Azienda Ospedaliera Universitaria Integrata Verona_Borgo Trento - Neurologia A
Verona, Veneto, 37126
South Korea21 sites
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggido, 14068
Inje University Busan Paik Hospital
Busan, 47392
Dong-A University Hospital
Busan, 49201
Chungbuk National University Hospital
Cheongju-si, North Chungcheong, 28644
Kyungpook National University Hospital
Daegu, Daegu Gwang''yeogsi, 41944
Keimyung University Dongsan Medical Center
Daegu, 42601
Eulji University Hospital
Daejeon, 35233
Chonnam National University Hospital
Dong-gu, Gwangju, 61469
Inje University Ilsan Paik Hospital
Goyang-si, Gyeonggido, 411-706
Inha University Hospital
Incheon, TBC
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggido, 13620
Severance Hospital, Yonsei University Health System-Neurology instead of Cardiology
Seoul, Seoul Teugbyeolsi, 03722
University of Ulsan College of Medicine - Asan Medical Center (AMC) - Cardiology Department
Seoul, Seoul Teugbyeolsi, 05505
Kyung Hee University Medical Center
Seoul, Seoul Teugbyeolsi, 130-872
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, 3080
Korea University Anam Hospital
Seoul, 02841
SoonChunHyang University Seoul Hospital
Seoul, 04401
Samsung Medical Center-Neurology instead of Cardiology
Seoul, 06351
The Catholic University of Korea Seoul St. Mary's Hospital
Seoul, 137-701
Korea University Guro Hospital
Seoul, 152-703
Nowon Eulji Medical Center, Eulji University
Seoul, 1830
Turkey (Türkiye)21 sites
Ankara Universitesi Tip Fakultesi Hastanesi
Ankara, 6100
Hacettepe Universitesi Tip Fakultesi
Ankara, 6100
Gazi Universitesi Tip Fakultesi
Ankara, 6560
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital
Ankara, 6800
Akdeniz Universitesi Tip Fakultesi Hastanesi
Antalya, 7059
Firat Universitesi Tip Fakultesi
Elâzığ, 23119
Eskisehir Osmangazi Universitesi Tip Fakultesi
Eskişehir, 26480
Istanbul Universitesi Istanbul Tip Fakultesi
Istanbul, 34093
Bakirkoy Prof Dr Mazhar Osman Ruh Sagligi ve Sinir Hast. EAH
Istanbul, 34147
Istanbul Sultan 2. Abdulhamid Han Egitim ve Arastirma Has.
Istanbul, 34668
Kartal Dr Lutfi Kirdar Sehir Hastanesi
Istanbul, 34865
Marmara Uni. Tip Fak. Pendik EAH Noroloji
Istanbul, 34899
Ege Universitesi Tip Fakultesi
Izmir, 35100
Dokuz Eylul Universitesi Tip Fakultesi
Izmir, 35340
Saglik Bilimleri Universitesi Izmir Tepecik EAH
Izmir, 64300
Erciyes Universitesi Tip Fakultesi
Kayseri, 38039
Selcuk University Faculty of Medicine
Konya, 42075
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi
Konya, 42080
Samsun Egitim Arastirma Hastanesi
Samsun, 55090
Ondokuz Mayis Uni Tip Fakultesi
Samsun, 55139
Cumhuriyet Universitesi Tip Fakultesi
Sivas, 58140
Bulgaria18 sites
Multispecialty Hospital for Active Treatment St. Ivan Rilski - 2003 | Neurological Department
Dupnitsa, 2600
Multiprofile Hospital for Active Treatment Haskovo AD | Department of Nervous Diseases
Haskovo, 6300
Multiprofile Hospital for Active Treatment Pazardzhik
Pazardzhik, 4400
Military Medical Academy | Multiprofile Hospital for Active Treatment Pleven - Neurology Department
Pleven, 5800
University Multiprofile Hospital for Active Treatment Dr Georgi Stranski Pleven | Department of Neurology
Pleven, 5800
Multiprofile Hospital for Active Treatment Saint Panteleimon Hospital | Neurology Department
Plovdiv, 4000
University Multiprofile Hospital for Active Treatment Pulmed | Neurology Department
Plovdiv, 4002
University Multispecialty Hospital for Active Treatment 'Kanev' JSC | Department of General and Vascular Neurology
Rousse, 7002
Military Medical Academy | Multiprofile Hospital for Active Treatment Sofia - Clinic of Neurological Diseases
Sofia, 1000
Second Multi-profile Hospital for Active Treatment - Sofia | Clinic of Neurology
Sofia, 1202
Multiprofile Hospital for Active Treatment National Cardiology Hospital | Clinic for Neurological Diseases
Sofia, 1309
Acibadem City Clinic University Multiprofile Hospital For Active Treatment Tokuda - Department of Neurology and Sleep Medicine
Sofia, 1407
University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Neurology Department
Sofia, 1527
University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD - Department of Nervous Diseases
Sofia, 1606
Multiprofile Hospital for Active Treatment Neurology and Psychiatry St. Naum | Intensive Treatment of Nervous System Disorders
Sofia, 1797
University Multiprofile Hospital for Active Treatment Sofiamed | Neurology Department
Sofia, 1797
University Hospital for Active Treatment St. Anna | Neurology Department
Sofia, 1872
MHAT Sveta Marina EAD
Varna, 9010
Brazil17 sites
Hospital da Universidade Federal de Minas Gerais
Belo Horizonte, Minas Gerais, 30130-100
Hospital Madre Tereza
Belo Horizonte, Minas Gerais, 30441-070
Hospital das Clínicas de Botucatu - UNESP Botucatu
Botucatu, São Paulo, TBC
Hospital Universitário UFMS
Campo Grande, Mato Grosso do Sul, 79080 190
Hospital das Clinicas da Universidade Federal do Paraná
Curitiba, Paraná, TBC
Hospital Estadual Central Vitoria - Fundação INOVA - ES
Espirito Santo, Espírito Santo, 29018-140
Hospital Geral de Fortaleza
Fortaleza, Ceará, 60150-160
Clinica Neurologica e Neurocirurgica de Joinville Ltda
Joinville, Santa Catarina, 89202-165
Sociedade Matonense de Benemerência
Matão, São Paulo, 15990-060
Hospital Moinhos de Vento-Centro Clínico
Porto Alegre, Rio Grande do Sul, 90035-001
Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center
Porto Alegre, Rio Grande do Sul, 90035-903
L'Dor - Instituto de Ensino e Pesquisa
Rio de Janeiro, 22281-100
Centro de Pesquisas do Hospital Bahia
Salvador, Estado de Bahia, 41.810-011
Fundação Facu. Reg de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, 15090
Hospital Nove de Julho
São Paulo, São Paulo, 01409-902
Science Valley Research Institute
São Paulo, 04551-010
Unifesp/Epm
São Paulo, TBC
Greece17 sites
University General Hospital Of Alexandroupoli- Department of Neurology
Alexandroupoli, 68100
General Hospital Of Athens Korgialenio Benakio H.R.C.- Department of Neurology
Ampelokipoi Athens, 11526
Evaggelismos Hospital-Department of Neurology
Athens, 10676
Naval Hospital of Athens-Department of Neurology
Athens, 11521
401 General Military Hospital Of Athens- Department of Neurology
Athens, 11525
General Hospital Of Athens G Gennimatas- Department of Neurology
Athens, 11527
Eginitio Hospital-1st Department of Neurology
Athens, 11528
University General Hospital Attikon-2nd Department of Neurology
Athens, 12462
General Hospital Of Thessaloniki Papageorgiou-3rd Department of Internal Medicine
Efkarpia, 56429
University General Hospital of Heraklion - Department of Neurology
Heraklion, 711 10
University General Hospital Of Ioannina-Department of Neurology
Ioannina, 45500
University General Hospital of Larissa-Department of Neurology
Larissa, 41110
General University Hospital Of Patras-Department of Neurology
Pátrai, 26504
Metropolitan Hospital- Stroke Unit
Piraeus, 18547
University General Hospital Of Thessaloniki Ahepa-2nd Department of Neurology
Thessaloniki, 546 36
University General Hospital Of Thessaloniki Ahepa-1st Department of Neurology
Thessaloniki, 54636
Geniko Nosokomeio Thessalonikis George Papanikolaou-3rd Department of Neurology
Thessaloniki, 57010
Colombia16 sites
Cardiomet Cequin Sas
Armenia, Quindío Department, 630004
Clínica de la Costa SAS
Baranquilla, Atlántico, 080020
Hospital Universitario Mayor-MÉDERI
Bogotá, Bogota D.C., 0
Clínica Imbanaco S.A.S
Cali, Valle del Cauca Department, 760042
Fundación Valle de Lili
Cali, 760032
Clínica Universidad de la sabana
Chía, Cundinamarca, 250001
Fundación Oftalmológica de Santander Carlos Ardila Lule
Florida Blanca, 681004
Fundación Cardiovascular de Colombia
Floridablabca, 681011
Hospital Alma Mater de Antioquia
Medellín, Antioquia, 050010
Hospital General de Medellin
Medellín, Antioquia, 050015
Promotora Médica Las Américas S.A.- Clinica Las Americas
Medellín, Antioquia, 050023
Hospital San Vicente Fundación
Medellín, 050010
Clínica Medellín
Medellín, 050030
Clinica Cardio VID
Medellín, 050034
Sociedad Médica Rionegro SOMER S.A.
Rionegro, Antioquia, 054040
Fundación Hospital Universidad del Norte
Soledad, Atlántico, TBC
Hungary16 sites
Bajai Szent Rokus Korhaz
Baja, 6500
Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Neurologiai Klinika
Budapest, 1083
Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet
Budapest, 1106
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, 1134
Semmelweis Egyetem Idegsebeszeti es Neurointervencios Klinika
Budapest, 1145
Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
Budapest, 1204
Debreceni Egyetem Klinikai Kozpont Neurologiai Klinika
Debrecen, 4032
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
Győr, 9024
Kistarcsai Flor Ferenc Korhaz
Kistarcsa, 2143
Szent Damján Görögkatolikus Kórház - Neurologiai es Stroke Osztaly
Kisvárda, 4600
Nagykanizsai Kanizsai Dorottya Korhaz
Nagykanizsa, 8800
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
Nyíregyháza, 4400
Pecsi Tudomanyegyetem Klinikai Kozpont
Pécs, 7624
Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet
Sopron, 9400
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Orvostudomanyi Kar Szent-Gyorgyi Albert Klinikai Kozpont Neurologiai Klinika
Szeged, 6725
Zala Varmegyei Szent Rafael Korhaz
Zalaegerszeg, 8900
Slovakia16 sites
Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
Bratislava, 813 69
Univerzitna nemocnica Bratislava, Nemocnica Ruzinov
Bratislava, 826 06
Univerzitna nemocnica Bratislava, Nemocnica ak. L.Derera
Bratislava, 83305
Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho
Dolný Kubín, 026 14
Nemocnica AGEL Komarno s.r.o.
Komárno, 945 05
Vseobecna nemocnica s poliklinikou Levoca, a.s.
Levoča, 05401
Liptovska nemocnica s poliklinikou MUDr. Ivana Stodolu
Liptovský Mikuláš, 03123
Univerzitna nemocnica Martin
Martin, 036 59
Fakultna nemocnica Nitra
Nitra, 950 01
Fakultna nemocnica s poliklinikou J.A. Reimana
Prešov, 08181
Penta Hospitals | Rimavska Sobota Hospital - Neurology Department
Rimavská Sobota, 979 12
Fakultna nemocnica AGEL Skalica, a.s.
Skalica, 909 82
Nemocnica s poliklinikou Spisska Nova Ves a.s.
Spišská Nová Ves, 05201
Fakultna nemocnica Trnava
Trnava, 91775
ProCare Svet Zdravia | Vranov nad Toplou Hospital - Neurology Department
Vranou Nad Toplou, 09327
Nemocnica AGEL Ziar nad Hronom a Banska Stiavnica s.r.o.
Žiar nad Hronom, 965 37
United Kingdom16 sites
East Kent Hospitals University NHS Foundation Trust | Kent and Canterbury Hospital - Stroke Unit
Canterbury, Kent, CT1 3NG
University Hospitals of Derby and Burton NHS Foundation Trust | Royal Derby Hospital - Cardiology
Derby, DE22 3NE
Edinburgh Royal Infirmary
Edinburgh, EH3 9YW
Royal Devon University Healthcare NHS Foundation Trust | Royal Devon and Exeter Hospital - Stroke Unit
Exeter, EX2 5DW
NHS Greater Glasgow and Clyde | Glasgow Royal Infirmary |Glasgow Research Facility - Cardiology
Glasgow, G31 2ER
St George's University Hospitals NHS Foundation Trust | St George's Hospital | Neurology Department
Kogarah, London, 2217
Leeds Teaching Hospitals NHS Trust | Leeds General Infirmary - Cardiology
Leeds, West Yorkshire, LS1 3EX
Liverpool University Hospitals NHS Foundation Trust | Aintree University Hospital - Stroke Unit
Liverpool, L9 7AL
King's College Hospital NHS Foundation Trust | King's College Hospital - Academic Neuroscience Centre
London, SE5 8AF
Charing Cross Hospital
London, W6 8RF
The Newcastle upon Tyne Hospitals NHS Foundation Trust | Royal Victoria Infirmary - Acute Stroke Unit
Newcastle upon Tyne, Tyne and Wear, NE1 4LP
John Radcliffe Hospital
Oxford, OX3 9DU
Northern Care Alliance NHS Foundation Trust | Salford Royal Hospital - Clinical Research Facility
Salford, Manchester, M6 8HD
Southampton General Hospital
Southampton, Hampshire, SO16 6YD
Royal Stoke University Hospital
Stoke-on-Trent, Staffordshire, ST4 6QG
South Tyneside and Sunderland NHS Foundation Trust | Sunderland Royal Hospital - Acute Stroke Unit
Sunderland, Tyne and Wear, SR4 7TP
Argentina15 sites
Clinica IMA
Adrogué, Buenos Aires, B1846
Galeno | Sanatorio de la Trinidad Mitre - Neurology Department
Buenos Aires, Ciudad Auton. de Buenos Aires, C1039AAO
Fleni | Sede Belgrano - Neurology Department
Buenos Aires, Ciudad Auton. de Buenos Aires, C1428 AQK
Complejo Medico Policial Churruca Visca | Neurology department
Buenos Aires, Ciudad Auton. de Buenos Aires, C1437JCP
Centro Estudios Médicos e Invest. Clínicas "Dr. N. Quirno"
Buenos Aires, TBC
Hospital General de Agudos JM Ramos Mejia | Neurologia Vascular - Enfermedades Cerebrovasculares
Buenos Aires (Capital Federal), Buenos Aires, C1221 ADC
Instituto Universitario Hospital Italiano de Buenos Aires | Hospital Italiano de Buenos Aires - Neurology Department
Ciudad Autonoma de Buenos Aire, Ciudad Auton. de Buenos Aires, C1199ABB
Hospital General de Agudos Dr. Ignacio Pirovano | Infectology
Ciudad Autónoma de Buenos Aire, Buenos Aires, C1430BKC
Sanatorio Allende | Departamento de Investigación Clínica
Córdoba, X5000JHQ
Hospital Italiano de La Plata | Clinical Research Department
La Plata, Buenos Aires, B1900
Policlinico Lomas | Neurology Department
Lomas de Zamora, Buenos Aires, B1832BQD
Hospital Privado de Comunidad | Clinical Research Department
Mar del Plata, Buenos Aires, B7602CBM
Grupo Gamma | Hospital Privado de Rosario, Neurology Department
Rosario, Santa Fe Province, S2000GAP
Sanatorio Parque | Departamento de Neurologia
Rosario, Santa Fe Province, S2000GAP
San Bernardo Hospital | Neurology Department
Salta, A4406CLA
Czechia15 sites
Fakultni nemocnice u sv. Anny - I.neurologicka klinika
Brno, 602 00
Nemocnice Ceske Budejovice, a.s. - Department of neurology
České Budějovice, 370 01
Nemocnice Chomutov, o.z.
Chomutov, 430 12
Karvinska hornicka nemocnice a.s. - Neurologicke oddeleni
Fryštát, 735 06
Nemocnice Jihlava - Neurologicke oddeleni
Jihlava, 586 33
Krajska nemocnice Liberec - neurologicke oddeleni
Liberec, 460 63
Fakultni nemocnice Ostrava - Neurologicka klinika
Ostrava - Poruba, 708 52
Nemocnice AGEL Ostrava-Vítkovice a. s. - Neurologické oddelení
Ostrava - Vitkovice, 703 00
Nemocnice Pardubickeho Kraje, as - Neurologická klinika
Pardubice, 532 03
Fakultni nemocnice Kralovske Vinohrady - Neurologicka klinika
Prague, 100 34
Fakultni Thomayerova Nemocnice - neurology department
Prague, 14059
Ustredni vojenska nemocnice Praha
Prague, 16900
Nemocnice na Homolce - Neurology Department
Praha 5-Motol, 150 00
Krajská Zdravotní, Masarykova nemocnice Ústí nad Labem - Neurologické oddelení
Ústí nad Labem, 401 13
Krajská nemocnice T. Bati - Neurologické oddelení
Zlín, 762 75
Israel15 sites
Assuta Ashdod Public Hospital (R.A)
Ashdod, 7747629
Barzilai Medical Center | Neurology Department
Ashkelon, 7830604
Clalit Health | Soroka Medical Center - Internal Medicine Department
Beersheba, 8410101
Hillel Yaffe Medical Center
Hadera, 3810101
Rambam Health Corporation
Haifa, 3109601
Lady Davis Carmel Medical Center
Haifa, 3436212
Edith Wolfson Medical Center | Internal Medicine Department
Holon, 5822012
Hadassah Hebrew University Hospital Ein Kerem
Jerusalem, 9112001
Shaare Zedek Medical Center
Jerusalem, 9372212
Meir Medical Center
Kfar Saba, 4428164
Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department
Petah Tikva, 4941492
Chaim Sheba Medical Center
Ramat Gan, 5262000
Health Corporation of the Ziv Medical Center (R.A.)
Safed, 1311001
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906
Shamir Medical Center (Assaf Harofeh)
Ẕerifin, 7030000
Poland13 sites
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15-276
Szpital Uniwersytecki Nr 2 im. J. Bizela
Bydgoszcz, 85-168
Copernicus PL, M.Kopernik Hospital
Gdansk, 80-803
Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. sw. Jana Pawla II
Grodzisk Mazowiecki, 05-825
Górnoslaskie Centrum Medyczne im. prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach
Katowice, 40-635
Szpital Uniwersytecki w Krakowie
Krakow, 30-501
Szpital Specjalistyczny im. Rydygiera
Krakow, 31-826
Samodzielny Publiczny Szpital Kliniczny nr 4
Lublin, 20-090
Wojewodzki Szpital Specjalistyczny im. sw. Jadwigi w Opolu
Opole, 45-221
SP Szpital Kliniczny nr 1 PUM im. Prof. T. Sokolowskiego
Szczecin, 71-252
Szpital Wolski im. dr Anny Gostynskiej SPZOZ
Warsaw, 01-211
Instytut Psychiatrii i Neurologii w Warszawie
Warsaw, 02-957
Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy
Warsaw, 04-141
Austria12 sites
LKH Feldkirch / Neurologie
Feldkirch, Vorarlberg, 6800
Universitaetsklinikum Graz | Abteilung für Neurologie
Graz, Styria, 8036
Medizinische Universität Innsbruck
Innsbruck, Tyrol, 6020
Kepler Universitaetsklinikum GmbH- Med Campus III - Klinik fuer Neurologie 2
Linz, Upper Austria, 4020
Barmherzige Brueder Linz | Neurologie
Linz, Upper Austria, 4021
Landesklinikum Moedling | Abteilung für Neurologie
Mödling, Lower Austria, 2340
Universitätsklinikum St. Pölten
Sankt Pölten, Lower Austria, 3100
Kardinal Schwarzenberg Klinikum
Schwarzach im Pongau, State of Salzburg, 5620
Barmherzige Brueder Wien | Abt. fuer Neurologie
Vienna, 1020
AKH Wien | Univ. Klinik fuer Neurologie
Vienna, 1090
Klinik Ottakring | Neurologische Abteilung
Vienna, 1160
Klinik Floridsdorf | Abt. f. Neurologie
Vienna, 1210
Belgium12 sites
Hôpital Erasme/Erasmus Ziekenhuis - Neurology department
Anderlecht, 1070
AZ Sint-Jan Brugge | Neurology
Bruges, 8000
UZ Brussel
Brussels, 1090
CU Saint-Luc/UZ St-Luc
Bruxelles - Brussel, 1200
UZ Gent
Ghent, 9000
Jessa Hospital | Neurology Department
Hasselt, Limburg, 3500
AZ Groeninge Campus Kennedylaan - Neurology department
Kortrijk, 8500
UZ Leuven - Neurology department
Leuven, 3000
CHC MontLégia Neurology Department
Liège, 4000
Kust, Ommeland en Meetjesland (KOM) Network | AZ Damiaan - Neurology Department
Ostend, 8400
Vitaz | Sint-Niklaas Hospital - Cardiology Department
Sint-Niklaas, 9100
Clinique de l'Europe
Uccle, 1180
India12 sites
Zydus Hospital
Ahmedabad, Gujarat, 380054
K.G. Hospital
Coimbatore, 641018
Lalitha Super Specialities Hospital
Guntur, Andhra Pradesh, 522001
Government General Hospital, Guntur
Guntur, Andhra Pradesh, 522004
Artemis Hospitals
Gūrgaon, 122001
Yashoda Hospital
Hyderabad, Telangana, 500082
Shree Krishna Hospital
Karamsad, 388325
Aster MIMS Hospital, Kozhikode
Kozhikode, Kerala, 673016
All India Institute of Medical Sciences (AIIMS) - New Delhi
New Delhi, 110 029
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Thiruvananthapuram, Kerala, 695011
Government Medical College - Thiruvanathapuram
Thiruvananthapuram, 695011
Christian Medical College & Hospital (CMCH) - Vellore
Vellore, 632004
Portugal12 sites
Unidade Local de Saude Almada-Seixal | Hospital Garcia de Orta - Research Department
Almada, Setúbal District, 2805-267
Hospital Professor Doutor Fernando Fonseca | Neurology Department
Amadora, Lisbon District, 2720-276
Centro Hospitalar e Universitario de Coimbra | Hospitais da Universidade de Coimbra - Neurology Department
Coimbra, 3004-561
Centro Hospitalar Universitario do Algarve | Faro - Ensino, Inovacao e Investigacao - Centro de Investigacao e Documentacao
Faro, 8000-386
Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
Leiria, 2410-197
Unidade Local De Saúde De Lisboa Ocidental E.P.E.
Lisbon, 1449-005
Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
Lisbon, 1500-650
CHULN - Hospital Santa Maria
Lisbon, 1649-035
BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos
Lisbon, 1749-004
Hospital Pedro Hispano | Clinical Research Center
Matosinhos Municipality, Porto District, 4464-513
Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica
Porto, 4050-651
Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos
Porto, 4200-319
Netherlands11 sites
Jeroen Bosch Ziekenhuis | Department of Neurology
's-Hertogenbosch, 5223 GZ
OLVG | Location West - Neurology Department
Amsterdam, 1061 AE
Academisch Medisch Centrum (AMC)
Amsterdam, 1105 AZ
Catharina Hospital | Neurology Outpatient Clinic
Eindhoven, North Brabant, 5623 EJ
Medisch Spectrum Twente
Enschede, 7511 JX
Zuyderland Medical Centre | Sittard-Geleen - Neurology Department
Heerlen, 6419 PC
St. Antonius Hospital | Nieuwegein - Neurology Department - Stroke Unit
Nieuwegein, 3435 CM
Maasstad Ziekenhuis | Neurology Department
Rotterdam, 3079DZ
HagaZiekenhuis | Department of Neurology
The Hague, 2545 AA
University Medical Center (UMC) Utrecht | Neurology and Neurosurgery Department
Utrecht, 3584 CX
Isala Zwolle | Neurology Department
Zwolle, 8025 AB
Malaysia9 sites
Hospital Raja Perempuan Zainab II
Kelantan, 15200
Hospital Universiti Sains Malaysia
Kelantan, 16150
Queen Elizabeth Hospital Malaysia
Kota Kinabalu, 88586
Hospital Kuala Lumpur
Kuala Lumpur, 50586
University Malaya Medical Centre
Kuala Lumpur, 59100
Hospital Sultan Abdul Aziz Shah
Kuala Selangor, 43400
Hospital Seberang Jaya
Pulau Pinang, 13700
Sarawak General Hospital
Sarawak, 93400
Hospital Sultanah Nur Zahirah Medical Department
Terengganu, 20400
Switzerland9 sites
Kantonsspital Baden
Baden, Canton of Aargau, 5404
Universitätsspital Basel
Basel, Canton of Basel-City, 4056
Inselspital Universitätsspital Bern
Bern, 3010
Hôpital Cantonal Universitaire de Genève
Geneva, Canton of Geneva, 1205
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Canton of Vaud, 1011
Ospedale regionale di Lugano
Lugano, Canton Ticino, 6900
Kantonsspital St. Gallen
Sankt Gallen, Canton of St. Gallen, 1009
Hospital Cantonal Fribourg
Villars-sur-Glâne, 1752
NeuroZentrum Hirslanden
Zurich, 8032
Denmark8 sites
Aalborg Universitetshospital - Neurologisk afdeling
Aalborg, 9000
Aarhus Universitetshospital, Neurologisk Afdeling
Aarhus N, 8200
Rigshospitalet Glostrup - Hjerne og Nervesygdomme
Glostrup Municipality, 2600
Herlev Hospital - Hjerne og Nervesygdomme
Herlev, 2730
Regionshospitalet Gødstrup - Neurologi
Herning, 7400
Bispebjerg Hospital - Neurologisk afdeling
København NV, 2400
Lillebælt Sygehus Kolding - Hjerne og Nervesygdomme
Kolding, 6000
Odense Universitetshospital - Neurologisk afdeling
Odense C, 5000
Sweden8 sites
Danderyds sjukhus
Danderyd, 18257
Sahlgrenska Universitetssjukhuset
Gothenburg, 413 45
Skånes Universitetssjukhus
Lund, 221 85
Östersunds Sjukhus
Östersund, 831 83
Södersjukhuset AB
Stockholm, 118 83
Karolinska University Hospital, Huddinge Neuroradiology
Stockholm, 141 86
Karolinska University Hospital
Stockholm, 141 86
Akademiska Sjukhuset
Uppsala, 752 85
Norway6 sites
Ålesund sykehus Nevrologisk poliklinikk
Ålesund, 6017
Haukeland Universitetssykehus Nevrologisk Avdeling
Bergen, 5021
Östfold Hospital Trust Fredrikstad
Grålum, 1714
Akershus Universitetssykehus - Nevrologisk Avdeling
Lørenskog, 1478
Molde sykehus Nevrologisk avdeling
Molde, 6412
OUS Ullevål Neurology Department
Oslo, 450
Finland5 sites
HUS, Meilahden sairaala
Helsinki, 29
Pohjois-Karjalan sairaanhoitopiiri
Joensuu, 80210
Kuopion yliopistollinen sairaala
Kuopio, 70210
Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS)
Tampere, 33520
Turun yliopistollinen keskussairaala
Turku, 20520
Latvia5 sites
Daugavpils Regional Hospital
Daugavpils, LV-5417
Jekabpils Regional Hospital
Jēkabpils, LV-5201
Rezekne Hospital
Rēzekne, LV-4601
P. Stradins Clinical University Hospital
Riga, LV-1002
Riga East Clinical University Hospital "Gailezers"
Riga, LV-1038
Lithuania5 sites
Alytus County S. Kudirka Hospital
Alytus, LT-62114
Hospital of LT University of Health Sciences Kaunas Clinics
Kaunas, LT-50161
Siauliai Republican hospital
Šiauliai, 76231
Republican Vilnius University Hospital
Vilnius, LT-04130
Vilnius University Hospital Santaros Klinikos
Vilnius, LT-08661
Kazakhstan3 sites
Multiprofile regional hospital
Aktobe, 030020
City Clinical Hospital No7 - Stroke Unit
Almaty, 50006
Multidisciplinary City Hospital No1 - Stroke Unit
Astana, 160100
About this study
Official title: A Multicenter, International, Randomized, Placebo Controlled, Double-blind, Parallel Group and Event Driven Phase 3 Study of the Oral FXIa Inhibitor Asundexian (BAY 2433334) for the Prevention of Ischemic Stroke in Male and Female Participants Aged 18 Years and Older After an Acute Non-cardioembolic Ischemic Stroke or High-risk TIA
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had:
- an acute stroke due to a blood clot that formed outside the heart (acute non-cardioembolic ischemic stroke), or
- TIA/mini-stroke with a high risk of turning into a stroke (high-risk transient ischemic attack), and who are planned to receive standard of care therapy. Acute ischemic strokes or TIA/mini-stroke result from a blocked or reduced blood flow to a part of the brain. They are caused by blood clots that travel to the brain and block the vessels that supply it. If these blood clots form elsewhere than in the heart, the stroke is called non-cardioembolic. People who already had a non-cardioembolic stroke are more likely to have another stroke. This is why they are treated preventively with an antiplatelet therapy, the current standard of care. Antiplatelet medicines prevent platelets, components of blood clotting, from clumping together.
Read more
Anticoagulants are another type of medicine that prevents blood clots from forming by interfering with a process known as coagulation (or blood clotting).
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care without increasing the risk of bleeding.
The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who recently had a non-cardioembolic ischemic stroke or TIA/mini-stroke when given in addition to standard antiplatelet therapy. A placebo is a treatment that looks like a medicine but does not have any medicine in it.
Another aim is to compare the occurrence of major bleeding events during the study between the asundexian and the placebo group. Major bleedings have a serious or even life-threatening impact on a person's health.
Dependent on the treatment group, the participants will either take asundexian or placebo once a day for at least 3 months up to 31 months.
Approximately every 3 months during the treatment period, either a phone call or a visit to the study site is scheduled on an alternating basis. In addition, one visit before and up to two visits after the treatment period are planned.
During the study, the study team will:
- Check vital signs such as blood pressure and heart rate
- Examine the participants' heart health using an electrocardiogram (ECG)
- Take blood samples
- Ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. In addition, the participants will be asked to complete a questionnaire on quality of life at certain time points during the study.
- Conditions
- Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack
- Being tested
- Asundexian (BAY2433334), Placebo
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Asundexian (BAY2433334)Drug
Once daily, oral
PlaceboDrug
Placebo to asundexian, once daily, oral
| Study group | Role | What they receive |
|---|---|---|
| Asundexian | Experimental | Participants will receive asundexian. Receives: Drug: Asundexian (BAY2433334) |
| Placebo | Placebo comparator | Participants will receive placebo. Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to first occurrence of ischemic stroke
Measured: Up to 31 months
Time to first occurrence of ISTH major bleeding
ISTH=International Society on Thrombosis and Hemostasis
Measured: Up to 31 months
Secondary outcomes (16)
Time to first occurrence of all strokes (ischemic and hemorrhagic)
Measured: Up to 31 months
Time to first occurrence of composite of CV death, MI or stroke
CV=Cardiovascular, MI=Myocardial infarction
Measured: Up to 31 months
Time to first occurrence of composite of all-cause mortality, MI or stroke
Measured: Up to 31 months
Time to first occurrence of disabling stroke (mRS ≥3 at 90 days)
mRS=Modified Rankin Scale
Measured: Up to 31 months
Time to first occurrence of all-cause mortality
Measured: Up to 31 months
Time to first occurrence of transient ischemic attack (TIA)
Measured: Up to 31 months
Time to first occurrence of composite of ISTH major or clinically relevant non-major bleeding
Measured: Up to 31 months
Time to first occurrence of ISTH clinically relevant non-major bleeding
Measured: Up to 31 months
Time to first occurrence of symptomatic intracranial hemorrhage
Measured: Up to 31 months
Time to first occurrence of hemorrhagic stroke
Measured: Up to 31 months
Time to first occurrence of fatal bleeding
Measured: Up to 31 months
Time to first occurrence of minor bleeding
Measured: Up to 31 months
Time to first occurrence of composite of ischemic stroke or ISTH major bleeding
Measured: Up to 31 months
Time to first occurrence of composite of CV death, all stroke, MI or ISTH major bleeding
Measured: Up to 31 months
Time to first occurrence of composite of all-cause mortality, disabling stroke, fatal bleeding, symptomatic intracranial hemorrhage
Measured: Up to 31 months
Time to first occurrence of ischemic stroke in the first 90 days
Measured: Up to 31 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jan 2023
- Study start26 Jan 2023
- Primary completion23 Oct 2025
- Study completion23 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Prevention of Ischemic StrokeStudies of the same condition, open and under way.
- More trials run by BayerThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 12,327 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bayer
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05686070
- Sponsor's protocol ID
- 20604
- Other IDs
- 2023-503793-20-00, 2022-001067-27, 2023
- Acronym
- OCEANIC-STROKE
- Status last verified
- Nov 2025
- First submitted
- 6 Jan 2023
- Last updated
- 12 Nov 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No: Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.
Publications
Eikelboom JW, Xu L, Shoamanesh A, Dong Q, Hirano T, Saver JL, Masjuan J, Demchuk AM, Cordonnier C, Bereczki D, Tsivgoulis G, Veltkamp R, Staikov I, Bae HJ, Campbell BCV, Zini A, Lee IH, Kovar M, Mikulik R, Lemmens R, Ferro JM, Robinson T, Christensen H, Ozturk S, Leker RR, Turcani P, Slowik A, Amaya P, Hoo FK, De Marchis GM, Knoflach M, Sylaja PN, Putaala J, Coutinho JM, van der Worp HB, Miglane E, Matijosaitis V, Lindgren AG, Silva GS, Sandset EC, Turuspekova ST, Colorado P, Kasner SE, Keller L, Neumann C, Muehlhofer E, Iversen HK, Silva Y, Ayo-Martin O, Shuaib A, Wang Z, Schulze K, Joundi RA, Sharma M. Bleeding With Asundexian Versus Placebo in Patients With Noncardioembolic Ischemic Stroke or High-Risk TIA: OCEANIC-STROKE Randomized Trial. Circulation. 2026 Oct 13. doi: 10.1161/CIRCULATIONAHA.126.081836. Online ahead of print.
PubMed 42866879Sharma M, Dong Q, Hirano T, Kasner SE, Saver JL, Masjuan J, Demchuk AM, Cordonnier C, Bereczki D, Tsivgoulis G, Veltkamp R, Staikov I, Bae HJ, Campbell BCV, Zini A, Lee IH, Kovar M, Mikulik R, Lemmens R, Ferro JM, Robinson T, Christensen H, Ozturk S, Leker RR, Turcani P, Slowik A, Amaya P, Hoo FK, De Marchis GM, Knoflach M, Sylaja PN, Putaala J, Coutinho JM, van der Worp HB, Miglane E, Matijosaitis V, Lindgren AG, Sampaio Silva G, Sandset EC, Turuspekova ST, Amarenco P, Sheth KN, Smith EE, Eikelboom JW, Joundi RA, Schulze K, Xu L, Heenan L, Colorado P, Keller L, Muehlhofer E, Neumann C, Mundl H, Shoamanesh A; OCEANIC-STROKE Investigators. Asundexian for Secondary Stroke Prevention. N Engl J Med. 2026 Apr 16;394(15):1467-1479. doi: 10.1056/NEJMoa2513880.
PubMed 41985132Sharma M, Dong Q, Hirano T, Kasner SE, Saver J, Masjuan J, Demchuk AM, Cordonnier C, Bereczki D, Tsivgoulis G, Veltkamp R, Staikov I, Bae HJ, Campbell BCV, Zini A, Lee IH, Ameriso S, Kovar M, Mikulik R, Lemmens R, Ferro JM, Robinson T, Christensen H, Ozturk S, Leker RR, Turcani P, Slowik A, Amaya P, Hoo FK, De Marchis GM, Knoflach M, Sylaja PN, Putaala J, Coutinho JM, Worp HBV, Miglane E, Matijosaitis V, Lindgren AG, Silva GS, Sandset EC, Turuspekova ST, Joundi RA, Schulze K, Shestakovska O, Gilbride J, Bangdiwala SI, Xu L, Muehlhofer E, Colorado P, Mundl H, Keller L, Shoamanesh A. Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention. Eur Stroke J. 2026 Jan 1;11(1):aakaf017. doi: 10.1093/esj/aakaf017.
PubMed 41614533
Study at a glance
From the registry record, last updated by the sponsor on 12 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Multicenter, International, Randomized, Placebo Controlled, Double-blind, Parallel Group and Event Driven Phase 3 Study of the Oral FXIa Inhibitor Asundexian (BAY 2433334) for the Prevention of Ischemic Stroke in Male and Female Participants Aged 18 Years and Older After an Acute Non-cardioembolic Ischemic Stroke or High-risk TIA
- ClinicalTrials.gov ID
- NCT05686070
- Acronym / sponsor ID
- OCEANIC-STROKE / 20604
- Conditions
- Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12,327 participants (actual)
- Lead sponsor
- BayerIndustry (pharma, biotech, devices)
- Study start
- 26 Jan 2023 (actual)
- Primary completion
- 23 Oct 2025 (actual)
- Study completion
- 23 Oct 2025 (actual)
- First posted
- 17 Jan 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had:
- an acute stroke due to a blood clot that formed outside the heart (acute non-cardioembolic ischemic stroke), or
- TIA/mini-stroke with a high risk of turning into a stroke (high-risk transient ischemic attack), and who are planned to receive standard of care therapy. Acute ischemic strokes or TIA/mini-stroke result from a blocked or reduced blood flow to a part of the brain. They are caused by blood clots that travel to the brain and block the vessels that supply it. If these blood clots form elsewhere than in the heart, the stroke is called non-cardioembolic. People who already had a non-cardioembolic stroke are more likely to have another stroke. This is why they are treated preventively with an antiplatelet therapy, the current standard of care. Antiplatelet medicines prevent platelets, components of blood clotting, from clumping together.
Anticoagulants are another type of medicine that prevents blood clots from forming by interfering with a process known as coagulation (or blood clotting).
The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care without increasing the risk of bleeding.
The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who recently had a non-cardioembolic ischemic stroke or TIA/mini-stroke when given in addition to standard antiplatelet therapy. A placebo is a treatment that looks like a medicine but does not have any medicine in it.
Another aim is to compare the occurrence of major bleeding events during the study between the asundexian and the placebo group. Major bleedings have a serious or even life-threatening impact on a person's health.
Dependent on the treatment group, the participants will either take asundexian or placebo once a day for at least 3 months up to 31 months.
Approximately every 3 months during the treatment period, either a phone call or a visit to the study site is scheduled on an alternating basis. In addition, one visit before and up to two visits after the treatment period are planned.
During the study, the study team will:
- Check vital signs such as blood pressure and heart rate
- Examine the participants' heart health using an electrocardiogram (ECG)
- Take blood samples
- Ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. In addition, the participants will be asked to complete a questionnaire on quality of life at certain time points during the study.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Asundexian | Experimental | Drug: Asundexian (BAY2433334)Participants will receive asundexian. |
| Placebo | Placebo comparator | Drug: PlaceboParticipants will receive placebo. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Participants must be ≥ 18 years of age
- Acute non-cardioembolic stroke or high-risk TIA
- Systemic or cerebrovascular atherosclerosis or acute non-lacunar infarct
Key exclusion criteria (3 listed)
- Ischemic stroke ≤ 7 days before the index event
- Index stroke following procedures or strokes due to other rare causes
- History of atrial fibrillation/flutter, left ventricular thrombus, mechanic valve or other cardioembolic source of stroke requiring anticoagulation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Asundexian (BAY2433334)Once daily, oral | Drug | Asundexian |
| PlaceboPlacebo to asundexian, once daily, oral | Drug | Placebo |
Primary outcome
Time to first occurrence of ischemic stroke
Time frame: Up to 31 months
Time to first occurrence of ISTH major bleeding
Time frame: Up to 31 months
ISTH=International Society on Thrombosis and Hemostasis
16 secondary outcomes
Time to first occurrence of all strokes (ischemic and hemorrhagic)
Time frame: Up to 31 months
Time to first occurrence of composite of CV death, MI or stroke
Time frame: Up to 31 months
Time to first occurrence of composite of all-cause mortality, MI or stroke
Time frame: Up to 31 months
Time to first occurrence of disabling stroke (mRS ≥3 at 90 days)
Time frame: Up to 31 months
Time to first occurrence of all-cause mortality
Time frame: Up to 31 months
Time to first occurrence of transient ischemic attack (TIA)
Time frame: Up to 31 months
Time to first occurrence of composite of ISTH major or clinically relevant non-major bleeding
Time frame: Up to 31 months
Time to first occurrence of ISTH clinically relevant non-major bleeding
Time frame: Up to 31 months
Time to first occurrence of symptomatic intracranial hemorrhage
Time frame: Up to 31 months
Time to first occurrence of hemorrhagic stroke
Time frame: Up to 31 months
Time to first occurrence of fatal bleeding
Time frame: Up to 31 months
Time to first occurrence of minor bleeding
Time frame: Up to 31 months
Time to first occurrence of composite of ischemic stroke or ISTH major bleeding
Time frame: Up to 31 months
Time to first occurrence of composite of CV death, all stroke, MI or ISTH major bleeding
Time frame: Up to 31 months
Time to first occurrence of composite of all-cause mortality, disabling stroke, fatal bleeding, symptomatic intracranial hemorrhage
Time frame: Up to 31 months
Time to first occurrence of ischemic stroke in the first 90 days
Time frame: Up to 31 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Nov 2025.
- Derived from this study: PubMed 42866879Eikelboom JW, Xu L, Shoamanesh A, Dong Q, Hirano T, Saver JL, Masjuan J, Demchuk AM, Cordonnier C, Bereczki D, Tsivgoulis G, Veltkamp R, Staikov I, Bae HJ, Campbell BCV, Zini A, Lee IH, Kovar M, Mikulik R, Lemmens R, Ferro JM, Robinson T, Christensen H, Ozturk S, Leker RR, Turcani P, Slowik A, Amaya P, Hoo FK, De Marchis GM, Knoflach M, Sylaja PN, Putaala J, Coutinho JM, van der Worp HB, Miglane E, Matijosaitis V, Lindgren AG, Silva GS, Sandset EC, Turuspekova ST, Colorado P, Kasner SE, Keller L, Neumann C, Muehlhofer E, Iversen HK, Silva Y, Ayo-Martin O, Shuaib A, Wang Z, Schulze K, Joundi RA, Sharma M. Bleeding With Asundexian Versus Placebo in Patients With Noncardioembolic Ischemic Stroke or High-Risk TIA: OCEANIC-STROKE Randomized Trial. Circulation. 2026 Oct 13. doi: 10.1161/CIRCULATIONAHA.126.081836. Online ahead of print.
- Derived from this study: PubMed 41985132Sharma M, Dong Q, Hirano T, Kasner SE, Saver JL, Masjuan J, Demchuk AM, Cordonnier C, Bereczki D, Tsivgoulis G, Veltkamp R, Staikov I, Bae HJ, Campbell BCV, Zini A, Lee IH, Kovar M, Mikulik R, Lemmens R, Ferro JM, Robinson T, Christensen H, Ozturk S, Leker RR, Turcani P, Slowik A, Amaya P, Hoo FK, De Marchis GM, Knoflach M, Sylaja PN, Putaala J, Coutinho JM, van der Worp HB, Miglane E, Matijosaitis V, Lindgren AG, Sampaio Silva G, Sandset EC, Turuspekova ST, Amarenco P, Sheth KN, Smith EE, Eikelboom JW, Joundi RA, Schulze K, Xu L, Heenan L, Colorado P, Keller L, Muehlhofer E, Neumann C, Mundl H, Shoamanesh A; OCEANIC-STROKE Investigators. Asundexian for Secondary Stroke Prevention. N Engl J Med. 2026 Apr 16;394(15):1467-1479. doi: 10.1056/NEJMoa2513880.
- Derived from this study: PubMed 41614533Sharma M, Dong Q, Hirano T, Kasner SE, Saver J, Masjuan J, Demchuk AM, Cordonnier C, Bereczki D, Tsivgoulis G, Veltkamp R, Staikov I, Bae HJ, Campbell BCV, Zini A, Lee IH, Ameriso S, Kovar M, Mikulik R, Lemmens R, Ferro JM, Robinson T, Christensen H, Ozturk S, Leker RR, Turcani P, Slowik A, Amaya P, Hoo FK, De Marchis GM, Knoflach M, Sylaja PN, Putaala J, Coutinho JM, Worp HBV, Miglane E, Matijosaitis V, Lindgren AG, Silva GS, Sandset EC, Turuspekova ST, Joundi RA, Schulze K, Shestakovska O, Gilbride J, Bangdiwala SI, Xu L, Muehlhofer E, Colorado P, Mundl H, Keller L, Shoamanesh A. Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention. Eur Stroke J. 2026 Jan 1;11(1):aakaf017. doi: 10.1093/esj/aakaf017.
- Individual participant dataSharing planned: No. Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
741 sites in 37 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Asundexian (BAY2433334) in people with Prevention of Ischemic Stroke and Acute Non-cardioembolic Ischemic Stroke, run by Bayer at 741 sites in 37 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 741 sites in United States, Japan, China, France, Germany and 32 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to first occurrence of ischemic stroke (time frame: Up to 31 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05686070, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Nov 2025.