GlaucomaNCT05690152
Persistence of Glaucoma Patients With Web-Browser-Based Visual Field Test
A study testing EyeSimplify web-browser-based visual field test in people with Glaucoma, run by Andrew Pouw, MD at 1 site in United States.
Trial summary
The goal of this clinical trial is to assess patient persistence and adherence with a 6-month period of at-home visual field testing, using a novel web-based visual field test (EyeSimplify, M\&S Technologies, Niles, IL). The main questions this clinical trials aims to answer are: 1. Read more about this study
- Who is it for?
- Ages 18 to 100 years
- Conditions the study is for
- Glaucoma
- What is being tested?
- EyeSimplify web-browser-based visual field test
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 8 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Feb 2024to 10 Mar 2025
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 100 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients between 18-100 years of age with suspected, mild, moderate, or severe glaucoma
Who cannot join
- Non-English speakers, patients with systemic or ocular disease affecting central vision, best corrected visual acuity less than 20/80, neurocognitive or psychiatric disorders that would confound visual field testing, those with physical inability to perform testing, and astigmatism with absolute values greater than 2.00 diopters
Trial locations and contacts
1 site in 1 country.
About this study
The goal of this clinical trial is to assess patient persistence and adherence with a 6-month period of at-home visual field testing, using a novel web-based visual field test (EyeSimplify, M\&S Technologies, Niles, IL).
The main questions this clinical trials aims to answer are:
Read more
- How adherent patients are to biweekly testing at home for 6 months, and
- How patients feel the ease of user experience of the test was, and
- Whether the EyeSimplify platform is able to detect any worsening of glaucoma-related visual field performance that can be corroborated by standard of care, office-based testing.
Participants will be given iPads with links to the EyeSimplify visual field test, and asked to take the EyeSimplify tests at home biweekly for six months. The test takes between 10 to 15 minutes to do and participants will have no additional responsibilities between tests.
Researchers will send reminders for patients to complete the at-home tests at periodic intervals, and if worsening on the at-home test platform is suggested by test results, researchers will arrange for return visits to the office to compare the EyeSimplify test results to standard-of-care, office-based testing. At the conclusion of the study, participant adherence to the 6-month biweekly testing schedule will be assessed and participants will be surveyed for their perceptions regarding the EyeSimplify platform's ease of usability and user experience.
Read the detailed description
The purpose of this prospective study is to assess patient persistence and adherence with a 6-month period of at-home visual field testing using an iPad with a novel web-browser-based visual field test, the EyeSimplify platform (M\&S Technologies, Niles, IL). Use of this test is intended to supplement, but not replace, regular clinic visits.
The proposed study will be conducted at the University of Iowa Hospitals and Clinics. We estimate 50 subjects will be recruited to participate in the study. Data collected will not include patient identifiers, but will instead be coded.
The research will involve prospective collection of visual field tests. Patients with suspected, mild, moderate, or severe glaucoma will be included. Clinical data including age, gender, ethnicity, visual acuity, intraocular pressure, severity of disease, past and comparative Humphrey HFA-III visual field test performance, EyeSimplify visual field test performance, and EyeSimplify usability survey will be recorded.
Following study recruitment, subjects will be asked to take EyeSimplify visual field tests at home biweekly for six months. They will have no additional responsibilities between tests. Subjects will access the EyeSimplify web browser on an iPad provided by the research team, using a link and login credentials provided to them by a research assistant. Upon logging into the EyeSimplify web browser, subjects will click the "Start Test" button found along the left side of the window and follow the prompts presented on screen to calibrate their screen. Screen calibration involves holding a driver's license/credit card/ID to the screen to ensure the test window is the appropriate dimensions. Following screen calibration, subjects will follow the test prompts presented on screen to complete their visual field test. Test results are automatically sent to the research assistant who issued the exam, so subjects may exit the browser after each test. Upon study completion, subjects will be asked to fill out a brief user experience survey.
M\&S Technologies is the developer of the EyeSimplify visual field test platform. As the developers, M\&S Technologies maintains a secure, encrypted, HIPAA-compliant database of test participants. This database includes patient profiles containing unique subject IDs (de-identified), birth year (but not specific date), and visual field testing results. Outside of this testing information, M\&S Technologies does not have access to any additional patient information.
- Conditions
- Glaucoma
- Being tested
- EyeSimplify web-browser-based visual field test
- Medical subject headings
- Glaucoma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EyeSimplify web-browser-based visual field testDevice
All patients will be in a single arm: patients will have one or both eyes (dependent on inclusion/exclusion criteria) tested with the EyeSimplify visual field test biweekly for 6 months.
| Study group | Role | What they receive |
|---|---|---|
| Single Arm | Experimental | All patients will be in a single arm: patients will have one or both eyes (dependent on inclusion/exclusion criteria) tested with the EyeSimplify visual field test biweekly for 6 months. Receives: Device: EyeSimplify web-browser-based visual field test |
What is being measured
The primary outcome is the main question the study is designed to answer.
EyeSimplify Self-Test Adherence
For the purposes of this study, adherence is defined as number of times a subject self-tests divided by the number of times they are expected to self-test during the six-month study period. There will be a total of 14 expected self tests. Adherence will be evaluated at the conclusion of the six-month study period.
Measured: Subjects will be asked to self-test once every two weeks for six months.
EyeSimplify Self-Test Persistence
For the purposes of this study, persistence is defined as the number of consecutive self-tests a subject completes without a lapse. Persistence will be evaluated at the conclusion of the six-month study period.
Measured: Subjects will be asked to self-test once every two weeks for six months.
Secondary outcomes (21)
Visual Field Reliability Metric #1 - False Positive Rate
In perimetry (visual field testing), a "false positive error" occurs when a subject/patient records a response when no stimulus is presented. This is one metric by which the reliability of a visual field test is measured. The measurement is reported as a percentage.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Reliability Metric #2 - False Negative Rate
In perimetry (visual field testing), a "false negative error" occurs when a subject/patient fails to record a response to a stimulus that is brighter than one they had previously responded to in the same visual location. This is one metric by which the reliability of a visual field test is measured. The measurement is reported as a percentage.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Reliability Metric #3 - Fixation Loss Rate
In perimetry (visual field testing), a "fixation loss" occurs when a subject/patient records a response to a stimulus presented in the physiologic blind spot. If the patient responds, it indicates their gaze is not fixed straight ahead. This is one metric by which the reliability of a visual field test is measured. The measurement is reported as a percentage.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #1 - Mean Deviation
Mean deviation indicates how much, on average, an entire visual field deviates from the age-normal value. It is the center-weighted average of the decibel deviations at each point tested in the visual field test. The measurement is reported in decibels.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #2 - Pattern Standard Deviation
Pattern standard deviation reflects irregularities in a visual field, such as those caused by localized defects. This metric shows sensitivity losses after adjusting for generalized depression or elevation in the overall hill of vision (e.g. cataracts). The measurement is reported in decibels.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #3 - Total Deviation
Total deviation probability plots identify test locations that are outside normal limits. Threshold sensitivity levels are compared to age-corrected normal values at each test location to produce a total deviation map. Each measurement is reported in decibels.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #4 - Foveal Threshold
Foveal threshold is the minimum amount of luminance increment on a uniform background that can be detected by a subject/patient at the center of fixation. The measurement is reported in decibels.
Measured: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Loss Trend Metric #1 - Guided Progression Analysis Trend Analysis
Guided Progression Analysis (GPA) is a visual field analysis aid used to quantify visual field progression. This analysis aid is specific to Humphrey perimeters. The GPA Trend Analysis component quantifies the observed rate of change of the visual field. This metric is reported as percent loss per year (VFI) OR estimated mean deviation decibel loss per year, along with confidence limits for the slope estimate.
Measured: This measurement will automatically be generated after five Humphrey visual field tests and is updated with each subsequent test.
Visual Field Loss Trend Metric #2 - EyeSimplify Mean Deviation Progression Trend
The EyeSimplify Progression Trend is a visual field analysis aid used to quantify visual field progression. This analysis aid is specific to EyeSimplify and quantifies the observed rate of change of subjects' mean deviation. This metric is reported as estimated decibel loss per year.
Measured: This measurement will automatically be generated after five EyeSimplify visual field tests and is updated with each subsequent test. This metric will be recorded upon completion of the six-month study period.
EyeSimplify User Experience Question #1 - "Please Select What Type of Device You Used to Take Your EyeSimplify Visual Field Tests."
Response options will include "Laptop", "Tablet", "Smartphone", and "Other".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #2 - "Please Describe What Accessories, if Any, You Used to Take Your EyeSimplify Visual Field Tests."
Response options will include "Keyboard", "Touchscreen", "Stylus", and "Other".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #3 - "How Hard or Easy Was it for You to Achieve a Comfortable Testing Environment for Yourself While Using the EyeSimplify Online Test?"
This question will be rated using a Likert scale. Response options will include "Very hard", "Hard", "Neutral", "Easy", and "Very easy".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #4 - "How Hard or Easy Was it for You to Achieve a Functional Testing Environment for Yourself While Using the EyeSimplify Online Test?"
This question will be rated using a Likert scale. Response options will include "Very hard", "Hard", "Neutral", "Easy", and "Very easy".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #5 - "What Time of Day Did You Typically Take Your EyeSimplify Visual Field Tests?"
Response options will include "Early morning (5AM-9AM)", "Late morning (9AM-12PM)", "Early afternoon (12PM-3PM)", "Late afternoon (3PM-5PM)", "Evening (5PM-12AM)", and "Overnight (12AM-5AM)".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #6 - "Please Describe the Level of Ambient Light You Typically Took Your EyeSimplify Visual Field Tests in."
This question will be rated using a Likert scale. Response options will include "Much Darker than Average (example: a room without the lights on at night)", "Somewhat Darker than Average", "About Average Light", "Somewhat Brighter than Average", and "Much Brighter than Average (example: outside on a sunny day)".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #7 - "Did You Ever Have to Block Out Ambient Light Using Curtains or Other Methods When Taking Your EyeSimplify Visual Field Tests?"
Response options will include "Yes" and "No".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #8 - "How Hard or Easy Was it for You to Navigate the EyeSimplify Website?"
This question will be rated using a Likert scale. Response options will include "Very hard", "Hard", "Neutral", "Easy", and "Very easy".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #9 - "How Hard or Easy Was it to Understand the Instructions for the Visual Field Test Using EyeSimplify?"
This question will be rated using a Likert scale. Response options will include "Very hard", "Hard", "Neutral", "Easy", and "Very easy".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #10 - "How Much Anxiety or Concern Did You Have About Your Test Performance While Using the EyeSimplify Online Visual Field Test?"
This question will be rated using a Likert scale. Response options will include "very anxious/concerned", "anxious/concerned", "neutral", "relaxed", and "very relaxed".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #11 - "How Confident Were You Taking the EyeSimplify Visual Field Test by Yourself at Home?"
This question will be rated using a Likert scale. Response options will include "Not confident at all", "Not very confident", "Neutral", "Confident", and "Extremely confident".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #12 - "If EyeSimplify Visual Field Testing Were Available for Regular Home Use Outside of This Study, Would You Use it?"
Response options will include "Yes", "No", and "Maybe".
Measured: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Jan 2023
- Study start6 Feb 2024
- Primary completion10 Mar 2025
- Study completion10 Mar 2025
Why it stopped: Study software was discontinued prior to completion of the study. 8 total subjects had been recruited at that time, but none completed the duration of the study period.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for GlaucomaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 8 participants (actual)
Sponsor and investigators
- Lead sponsor
- Andrew Pouw, MD
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Andrew Pouw, MD, University of Iowa
- Investigators
- Andrew Pouw, MD, Principal investigator, University of Iowa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05690152
- Sponsor's protocol ID
- 202207403
- Status last verified
- Apr 2026
- First submitted
- 3 Jan 2023
- Last updated
- 18 May 2026
- Results posted
- Yes, on ClinicalTrials.gov
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Publications
Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996 May;80(5):389-93. doi: 10.1136/bjo.80.5.389.
PubMed 8695555Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006 Mar;90(3):262-7. doi: 10.1136/bjo.2005.081224.
PubMed 16488940Beck RW, Bergstrom TJ, Lichter PR. A clinical comparison of visual field testing with a new automated perimeter, the Humphrey Field Analyzer, and the Goldmann perimeter. Ophthalmology. 1985 Jan;92(1):77-82. doi: 10.1016/s0161-6420(85)34065-4.
PubMed 3974997Prager AJ, Kang JM, Tanna AP. Advances in perimetry for glaucoma. Curr Opin Ophthalmol. 2021 Mar 1;32(2):92-97. doi: 10.1097/ICU.0000000000000735.
PubMed 33443958
Study at a glance
From the registry record, last updated by the sponsor on 18 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Persistence of Glaucoma Patients With Web-Browser-Based Visual Field Test
- ClinicalTrials.gov ID
- NCT05690152
- Acronym / sponsor ID
- 202207403
- Conditions
- Glaucoma
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: Study software was discontinued prior to completion of the study. 8 total subjects had been recruited at that time, but none completed the duration of the study period.
- Enrolment
- 8 participants (actual)
- Lead sponsor
- Andrew Pouw, MDUniversity, hospital or other
- Study start
- 6 Feb 2024 (actual)
- Primary completion
- 10 Mar 2025 (actual)
- Study completion
- 10 Mar 2025 (actual)
- First posted
- 19 Jan 2023 (actual)
- Results
- Posted 18 May 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to assess patient persistence and adherence with a 6-month period of at-home visual field testing, using a novel web-based visual field test (EyeSimplify, M\&S Technologies, Niles, IL).
The main questions this clinical trials aims to answer are:
- How adherent patients are to biweekly testing at home for 6 months, and
- How patients feel the ease of user experience of the test was, and
- Whether the EyeSimplify platform is able to detect any worsening of glaucoma-related visual field performance that can be corroborated by standard of care, office-based testing.
Participants will be given iPads with links to the EyeSimplify visual field test, and asked to take the EyeSimplify tests at home biweekly for six months. The test takes between 10 to 15 minutes to do and participants will have no additional responsibilities between tests.
Researchers will send reminders for patients to complete the at-home tests at periodic intervals, and if worsening on the at-home test platform is suggested by test results, researchers will arrange for return visits to the office to compare the EyeSimplify test results to standard-of-care, office-based testing. At the conclusion of the study, participant adherence to the 6-month biweekly testing schedule will be assessed and participants will be surveyed for their perceptions regarding the EyeSimplify platform's ease of usability and user experience.
Detailed description
The purpose of this prospective study is to assess patient persistence and adherence with a 6-month period of at-home visual field testing using an iPad with a novel web-browser-based visual field test, the EyeSimplify platform (M\&S Technologies, Niles, IL). Use of this test is intended to supplement, but not replace, regular clinic visits.
The proposed study will be conducted at the University of Iowa Hospitals and Clinics. We estimate 50 subjects will be recruited to participate in the study. Data collected will not include patient identifiers, but will instead be coded.
The research will involve prospective collection of visual field tests. Patients with suspected, mild, moderate, or severe glaucoma will be included. Clinical data including age, gender, ethnicity, visual acuity, intraocular pressure, severity of disease, past and comparative Humphrey HFA-III visual field test performance, EyeSimplify visual field test performance, and EyeSimplify usability survey will be recorded.
Following study recruitment, subjects will be asked to take EyeSimplify visual field tests at home biweekly for six months. They will have no additional responsibilities between tests. Subjects will access the EyeSimplify web browser on an iPad provided by the research team, using a link and login credentials provided to them by a research assistant. Upon logging into the EyeSimplify web browser, subjects will click the "Start Test" button found along the left side of the window and follow the prompts presented on screen to calibrate their screen. Screen calibration involves holding a driver's license/credit card/ID to the screen to ensure the test window is the appropriate dimensions. Following screen calibration, subjects will follow the test prompts presented on screen to complete their visual field test. Test results are automatically sent to the research assistant who issued the exam, so subjects may exit the browser after each test. Upon study completion, subjects will be asked to fill out a brief user experience survey.
M\&S Technologies is the developer of the EyeSimplify visual field test platform. As the developers, M\&S Technologies maintains a secure, encrypted, HIPAA-compliant database of test participants. This database includes patient profiles containing unique subject IDs (de-identified), birth year (but not specific date), and visual field testing results. Outside of this testing information, M\&S Technologies does not have access to any additional patient information.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Single Arm | Experimental | Device: EyeSimplify web-browser-based visual field testAll patients will be in a single arm: patients will have one or both eyes (dependent on inclusion/exclusion criteria) tested with the EyeSimplify visual field test biweekly for 6 months. |
Who may qualify
- Ages
- 18 to 100 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Patients between 18-100 years of age with suspected, mild, moderate, or severe glaucoma
Key exclusion criteria (1 listed)
- Non-English speakers, patients with systemic or ocular disease affecting central vision, best corrected visual acuity less than 20/80, neurocognitive or psychiatric disorders that would confound visual field testing, those with physical inability to perform testing, and astigmatism with absolute values greater than 2.00 diopters
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EyeSimplify web-browser-based visual field testAll patients will be in a single arm: patients will have one or both eyes (dependent on inclusion/exclusion criteria) tested with the EyeSimplify visual field test biweekly for 6 months. | Device | Single Arm |
Primary outcome
EyeSimplify Self-Test Adherence
Time frame: Subjects will be asked to self-test once every two weeks for six months.
For the purposes of this study, adherence is defined as number of times a subject self-tests divided by the number of times they are expected to self-test during the six-month study period. There will be a total of 14 expected self tests. Adherence will be evaluated at the conclusion of the six-month study period.
EyeSimplify Self-Test Persistence
Time frame: Subjects will be asked to self-test once every two weeks for six months.
For the purposes of this study, persistence is defined as the number of consecutive self-tests a subject completes without a lapse. Persistence will be evaluated at the conclusion of the six-month study period.
21 secondary outcomes
Visual Field Reliability Metric #1 - False Positive Rate
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Reliability Metric #2 - False Negative Rate
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Reliability Metric #3 - Fixation Loss Rate
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #1 - Mean Deviation
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #2 - Pattern Standard Deviation
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #3 - Total Deviation
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Performance Metric #4 - Foveal Threshold
Time frame: This measurement will automatically be reported upon conclusion of each visual field test. Visual field testing is estimated to take 5-15 minutes for each visual field test. Testing will occur every two weeks for the six-month study period.
Visual Field Loss Trend Metric #1 - Guided Progression Analysis Trend Analysis
Time frame: This measurement will automatically be generated after five Humphrey visual field tests and is updated with each subsequent test.
Visual Field Loss Trend Metric #2 - EyeSimplify Mean Deviation Progression Trend
Time frame: This measurement will automatically be generated after five EyeSimplify visual field tests and is updated with each subsequent test. This metric will be recorded upon completion of the six-month study period.
EyeSimplify User Experience Question #1 - "Please Select What Type of Device You Used to Take Your EyeSimplify Visual Field Tests."
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #2 - "Please Describe What Accessories, if Any, You Used to Take Your EyeSimplify Visual Field Tests."
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #3 - "How Hard or Easy Was it for You to Achieve a Comfortable Testing Environment for Yourself While Using the EyeSimplify Online Test?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #4 - "How Hard or Easy Was it for You to Achieve a Functional Testing Environment for Yourself While Using the EyeSimplify Online Test?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #5 - "What Time of Day Did You Typically Take Your EyeSimplify Visual Field Tests?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #6 - "Please Describe the Level of Ambient Light You Typically Took Your EyeSimplify Visual Field Tests in."
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #7 - "Did You Ever Have to Block Out Ambient Light Using Curtains or Other Methods When Taking Your EyeSimplify Visual Field Tests?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #8 - "How Hard or Easy Was it for You to Navigate the EyeSimplify Website?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #9 - "How Hard or Easy Was it to Understand the Instructions for the Visual Field Test Using EyeSimplify?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #10 - "How Much Anxiety or Concern Did You Have About Your Test Performance While Using the EyeSimplify Online Visual Field Test?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #11 - "How Confident Were You Taking the EyeSimplify Visual Field Test by Yourself at Home?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
EyeSimplify User Experience Question #12 - "If EyeSimplify Visual Field Testing Were Available for Regular Home Use Outside of This Study, Would You Use it?"
Time frame: Subjects will respond to an approximately 5-10 minute survey at the conclusion of the six-month study period.
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 May 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 8695555Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996 May;80(5):389-93. doi: 10.1136/bjo.80.5.389.
- Background: PubMed 16488940Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006 Mar;90(3):262-7. doi: 10.1136/bjo.2005.081224.
- Background: PubMed 3974997Beck RW, Bergstrom TJ, Lichter PR. A clinical comparison of visual field testing with a new automated perimeter, the Humphrey Field Analyzer, and the Goldmann perimeter. Ophthalmology. 1985 Jan;92(1):77-82. doi: 10.1016/s0161-6420(85)34065-4.
- Background: PubMed 33443958Prager AJ, Kang JM, Tanna AP. Advances in perimetry for glaucoma. Curr Opin Ophthalmol. 2021 Mar 1;32(2):92-97. doi: 10.1097/ICU.0000000000000735.
- Individual participant dataSharing planned: No
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Glaucoma, Corneal Transplantation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Andrew Pouw, MD principal investigator
University of Iowa
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing EyeSimplify web-browser-based visual field test in people with Glaucoma, run by Andrew Pouw, MD at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 18 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 18 May 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
EyeSimplify Self-Test Adherence (time frame: Subjects will be asked to self-test once every two weeks for six months.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05690152, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 May 2026.