Ischemic Stroke; Ischemic Attack, TransientPhase 3LIBREXIA-STROKNCT05702034
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
A Phase 3 study testing Milvexian in people with Ischemic Stroke; Ischemic Attack, Transient, run by Janssen Research & Development, LLC at 880 sites in 47 countries.
Trial summary
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Ischemic Stroke; Ischemic Attack, Transient
- What is being tested?
- Milvexian
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 12,523 participants
- Where
- 880 sitesin 47 countries
- Study dates
- 15 Feb 2023to 15 Oct 2026
- Phase
- Phase 3
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Ischemic Stroke: a neurological deficit attributable to an acute brain infarction and national institute of health stroke score scale (NIHSS) score less than or equal to (<=) 7 and at least 1 of the following: persistent signs or symptoms of the ischemic event at the time of randomization, or acute, ischemic brain lesion determined by standard-of-care neuroimaging, or participant underwent thrombolysis or thrombectomy, or transient ischemic attack (TIA): acute onset neurological deficit attributable to focal ischemia of the brain by history or examination, with complete symptom resolution of the deficit and no brain infarction on neuroimaging (example, computed tomography (CT) scan or magnetic resonance imaging (MRI), performed as part of standard medical practice), and ABCD2 Score greater than or equal to (>=) 6
- Participants will be randomized as soon as possible after determining eligibility and within 48 hours of onset of event.
- Current or planned antiplatelet treatment per international and/or local guidelines. If acetyl salicylic acid (ASA) is used, it will be limited to low dose (75 to 100 milligrams (mg)/day). Loading dose of antiplatelet agents (including ASA) are allowed per standard-of-care
- A female participant must agree not to be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half lives) after the last dose of study intervention
- Willing and able to adhere to the lifestyle restrictions specified in this protocol
Who cannot join
- Prior history of intracranial hemorrhage except subarachnoid hemorrhage greater than (>) 1 year prior with adequate treatment
- The index stroke or TIA is considered to have a cardio-embolic etiology based on local standard-of-care investigations and for which guidelines recommend anticoagulation
- The index stroke or TIA considered to have another known cause, not related to athero-thrombotic sources (treatment of acute stroke trial [TOAST] Other Determined Etiology), based on local standard-of-care investigations
- Increased risk of bleeding, including clinically significant bleeding within the previous 3 months or known bleeding diathesis or known activated partial thromboplastin time (aPTT) prolongation or spinal cord hemorrhage or retinal hemorrhage
- Current active liver disease, eg, acute hepatitis, known cirrhosis, including participants receiving antiviral treatment for hepatitis
- Known allergies, hypersensitivity, or intolerance to milvexian or its excipients
Trial locations and contacts
880 sites in 47 countries.
880 sites in 47 countries
United States127 sites
Abington Memorial Hospital
Abington, Pennsylvania, 19001
Summa Health System
Akron, Ohio, 44304
Mission Hospital
Asheville, North Carolina, 28801
Augusta University
Augusta, Georgia, 30912
University of Colorado
Aurora, Colorado, 80045
Seton Medical Center
Austin, Texas, 78701
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215
Alta Bates Medical Center Cancer Center
Berkeley, California, 94705
Boca Raton Regional Hospital
Boca Raton, Florida, 33486
Saint Alphonsus Regional Medical Center- Cancer Care Center
Boise, Idaho, 83706
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02216
Nova Clinical Research, LLC 1
Bradenton, Florida, 34209
Nova Clinical Research, LLC
Bradenton, Florida, 34209
SSM Health DePaul Hospital
Bridgeton, Missouri, 63044
Mercy Hospital
Buffalo, New York, 14220
Providence Saint Joseph Medical Center - Cancer Center
Burbank, California, 91505
Mills Peninsula Health Services
Burlingame, California, 94010
M Health Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Sutter Health - Eden Medical Center
Castro Valley, California, 94546
Novant Health
Charlotte, North Carolina, 28204
Rush University Medical Center
Chicago, Illinois, 60612
Insight Hospital and Medical Center Chicago
Chicago, Illinois, 60616
TriHealth Network
Cincinnati, Ohio, 45220
University of Cincinnati
Cincinnati, Ohio, 45267
Morton Plant Hospital
Clearwater, Florida, 33756-3394
The Ohio State University
Columbus, Ohio, 43210
Baylor Research Institute
Dallas, Texas, 75204
Neurology Consultants of Dallas, PA
Dallas, Texas, 75231
Nuvance Health Medical Practices Cardiology Danbury
Danbury, Connecticut, 06810
Detroit Medical Center
Detroit, Michigan, 48201
Henry Ford Hospital
Detroit, Michigan, 48202
St John Hospital and Medical Center
Detroit, Michigan, 48236
Duke University Medical Center
Durham, North Carolina, 27710
Michigan State University
East Lansing, Michigan, 48824
Mayo Clinic Health System
Eau Claire, Wisconsin, 54703
Fairview Southdale Hospital
Edina, Minnesota, 55435
UPMC Hamot
Erie, Pennsylvania, 16550
Northshore University Healthsystem
Evanston, Illinois, 60201
Providence Regional Medical Center Everett
Everett, Washington, 98201
Detroit Clinical Research Center
Farmington Hills, Michigan, 48334
Plaza Neuroscience Clinic
Fayetteville, Arkansas, 72703-3902
Parkview Research Center
Fort Wayne, Indiana, 46845
Neurology Center of North Orange County
Fullerton, California, 92835
Glendale Adventist Medical Center
Glendale, California, 91206
Guilford Neurologic Associates
Greensboro, North Carolina, 27405
Hackensack University Medical Center
Hackensack, New Jersey, 07601-1915
Houston Methodist Hospital
Houston, Texas, 77030
Houston Methodist Neurological Institute
Houston, Texas, 77030
McGovern Medical School UT Physicians Neurosurgery Texas Medical Center
Houston, Texas, 77030
Houston Methodist Willowbrook Hospital
Houston, Texas, 77070
IU Health Methodist Hospital
Indianapolis, Indiana, 46202
UC Irvine Healthcare Center
Irvine, California, 92697
Jamaica Hospital Medical Center
Jamaica, New York, 11418
United Health Services
Johnson City, New York, 13790
St. Joseph's Regional Medical Center
Joliet, Illinois, 60435
University of Kansas Medical Center Research Institute
Kansas City, Kansas, 66160
Multiple Sclerosis Center at Evergreen
Kirkland, Washington, 98034
Mayo Clinic Health System 1
La Crosse, Wisconsin, 54601-4795
Sharp Grossmont Hospital
La Mesa, California, 91942
Lenox Hill Hospital
Lake Success, New York, 11041
University of Kentucky Medical Center
Lexington, Kentucky, 40506
Long Beach Memorial
Long Beach, California, 90806
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
University of Louisville
Louisville, Kentucky, 40202
Emergency Medicine Covenant Medical Center
Lubbock, Texas, 79410
Banner Desert Medical Center
Mesa, Arizona, 85202
Baptist Health 1
Miami, Florida, 33173
Mission Hospital Regional Medical Center
Mission Viejo, California, 92691
Community Hospital Cardiovascular Research
Munster, Indiana, 46321
Centennial Medical Center
Nashville, Tennessee, 37203
TriStar Skyline Medical Center
Nashville, Tennessee, 37207
Saint Thomas Health
Nashville, Tennessee, 37215
Vanderbilt University Medical Center
Nashville, Tennessee, 37232
Jersey Shore University Medical Center
Neptune City, New Jersey, 07753
Long Island Jewish Med Ctr
New Hyde Park, New York, 11040
Weill Cornell Medical College
New York, New York, 10021
Rutgers New Jersey Medical School
Newark, New Jersey, 07103
Hoag Memorial Hospital
Newport Beach, California, 92663
Sentara Medical Group
Norfolk, Virginia, 23502
Hightower Clinical
Oklahoma City, Oklahoma, 73102
University of Nebraska Medical Center
Omaha, Nebraska, 68106
Advent Health Orlando
Orlando, Florida, 32804-5521
Memorial Institute for Neurosciences and Multiple Sclerosis
Owosso, Michigan, 48867
Stanford Stroke Center
Palo Alto, California, 94304-1419
Sacred Heart Hospital
Pensacola, Florida, 32504
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19104
Thomas Jefferson University
Philadelphia, Pennsylvania, 19107
Temple University Hospital Jeanes Campus
Philadelphia, Pennsylvania, 19111
Temple University Hospital
Philadelphia, Pennsylvania, 19140
Einstein Medical Center
Philadelphia, Pennsylvania, 19141
Pikeville Medical Center
Pikeville, Kentucky, 41537
Providence Portland Medical Center
Portland, Oregon, 97213
Providence St Vincent Medical Center
Portland, Oregon, 97225
Oregon Health And Science University
Portland, Oregon, 97239
Rhode Island Hospital Warren Alpert Medical School Brown University
Providence, Rhode Island, 02905
Blessing Hospital
Quincy, Illinois, 62301
Kaiser Permanente 1
Redwood City, California, 94063
Javon Bea Hospital
Rockford, Illinois, 61114
Shady Grove Office
Rockville, Maryland, 20850
William Beaumont Hospital 1
Royal Oak, Michigan, 48073
William Beaumont Hospital
Royal Oak, Michigan, 48073
University of California Davis Health System
Sacramento, California, 95817
Kaiser Permanente
Sacramento, California, 95825-2115
University Of Minnesota Medical Center
Saint Louis Park, Minnesota, 55416
California Pacific Medical Center
San Francisco, California, 94115
Pacific Neuroscience Institute
Santa Monica, California, 90404
Sarasota Memorial Hospital
Sarasota, Florida, 34239
Comprehensive Neurology Services
Silver Spring, Maryland, 20902
Providence & Providence Park Hospital
Southfield, Michigan, 48075
Sacred Heart Medical Center
Spokane, Washington, 99204
Prairie Education And Research Cooperative
Springfield, Illinois, 62769
Cox Health
Springfield, Missouri, 65807
Theia Clincial Research, LLC
Temple Terrace, Florida, 33617
Lincoln Hospital
The Bronx, New York, 10451
Harbor Ucla Medical Center
Torrance, California, 90502
Providence Little Company of Mary
Torrance, California, 90503
Capital Health Regional Medical Center
Trenton, New Jersey, 08638
University of Arizona
Tucson, Arizona, 85721
Ascension Medical Group - St. John Clinic Infectious Disease
Tulsa, Oklahoma, 74104
Cardiology Associates of North Mississippi
Tupelo, Mississippi, 38801
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
MedStar Health Research Institute
Washington D.C., District of Columbia, 20010
Saint Marys Medical Center
West Palm Beach, Florida, 33407
PIH Health Hospital
Whittier, California, 90602
Ascension via Christi Research
Wichita, Kansas, 67214
Winchester Medical Center
Winchester, Virginia, 22601
China78 sites
The People's Hospital of Anyang City
Anyang, 455002
Baoji Central Hospital
Baoji, 721008
Baogang Hospital, Inner Mongolia
Baotou, 014010
Xuanwu Hospital ,Capital Medical University
Beijing, 100053
Beijing Tiantan Hospital, Capital Medical University
Beijing, 100070
Peking University Third Hospital
Beijing, 100191
Jilin Province Peoples Hospital
Changchun, 130021
The First Hospital of Jilin University
Changchun, 130021
Hunan Province People's Hospital The First Affiliated Hospital of Hunan Normal University
Changsha, 410002
The second Xiangya Hospital of Central South University
Changsha, 410011
Changsha Central Hospital
Changsha, 410018
Chengdu Second People's Hospital
Chengdu, 610021
The First Affiliated Hospital of Chengdu Medical College
Chengdu, 610500
Chenzhou No.1 People's Hospital
Chenzhou, 432000
PLA Army Characteristic Medical Center
Chongqing, 400042
Affiliated Zhongshan Hospital of Dalian University
Dalian, 116001
Dalian Municipal Central Hospital
Dalian, 116021
Dazhou Central Hospital
Dazhou, 635000
People's Hospital of Deyang City
Deyang, 618000
Dongguan People s Hospital
Dongguan, 523059
Jiangxi Ganzhou Peoples Hospital
Ganzhou, 341000
Guangdong Provincial People's Hospital
Guangzhou, 510080
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Guangzhou, 510120
Guangzhou First Municipal People's Hospital
Guangzhou, 510180
Guangdong Second Provincial General Hospital
Guangzhou, 510317
The Affiliated Hospital of Hangzhou Normal University
Hangzhou, 310000
Zhejiang Provincial People's Hospital
Hangzhou, 310000
Zhejiang Hospital
Hangzhou, 310007
Inner Mongolia People's Hospital
Hohhot, 010017
Qilu Hospital of Shandong University
Jinan, 250012
Shandong First medical university
Jinan, 250014
Jingdezhen No.1 People's Hospital
Jingdezhen, 333000
Shandong Jining No.1 People's Hospital
Jining, 272011
The No.2 Hospital affiliated to Guizhou Medical college
Kaili, 556000
First Peoples Hospital of Yunnan Province
Kunming, 650032
The First Hospital of Lanzhou University
Lanzhou, 730000
The Second People's Hospital of Lianyungang
Lianyungang, 222006
Liaocheng People s Hospital
Liaocheng, 252000
Linfen Central Hospital
Linfen, 041000
Linyi City People Hospital
Linyi, 276000
Liuzhou people's Hospital
Liuzhou, 545006
No. 2 Hospital Affiliated to Henan Technical University
Luoyang, 471000
The First Affiliated Hospital of NanChang University
Nanchang, 330006
Nanchong Central Hospital
Nanchong, 637000
Zhongda Hospital Southeast University
Nanjing, 210000
Jiangsu Province Hospital
Nanjing, 210029
Nanyang Central Hospital
Nanyang, 473000
Nanshi Hospital of Nanyang
Nanyang, 473065
Pingxiang People's Hospital
Pingxiang, 337055
Qingdao Municipal Hospital
Qingdao, 266011
The First Hospital of Qiqihar
Qiqihar, 161005
Shanghai Seventh People's Hospital
Shanghai, 200137
The First Affiliated Hospital of Shantou University Medical
Shantou, 515041
Shengjing Hospital Of China Medical University
Shenyang, 110004
The first people's hospital of Shenyang
Shenyang, 110041
The Second Hospital of Hebei Medical University
Shijiazhuang, 050000
Second Affiliated Hospital of Soochow University
Suzhou, 215004
Tai An City Center Hospital
Taian, 271000
Shanxi Cardiovascular Hospital
Taiyuan, 030013
Shanxi Provincial People's Hospital
Taiyuan, 30012
Taizhou Peoples Hospital
Taizhou, 225300
Tianjin Medical University General Hospital
Tianjin, 300052
Tonghua Central Hospital
Tonghua
The first affiliated hospital of Xinjiang medical university
Ürümqi, 830054
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
Ruian People's Hospital
Wenzhou, 325200
The Central Hospital of Wuhan
Wuhan, 430014
Wuxi 2nd Peoples Hospital
Wuxi, 214002
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061
Zhongshan Hospital, Xiamen University
Xiamen, 361004
Xiangtan Central Hospital
Xiangtan, 411100
Xuancheng People s Hospital
Xuancheng, 242099
The Affiliated Hospital of Xuzhou Medical College
Xuzhou
Affiliated Hospital of Yangzhou University
Yangzhou, 225012
Yanbian University Hospital
Yanji, 133000
Yantai Yuhuangding Hospital
Yantai, 264000
Yichang Central Pepole's Hospital
Yichang, 443003
Affiliated Hospital Of Guangdong Medical University
Zhanjiang, 524000
Japan71 sites
Funabashi Municipal Medical Center
Chiba, 273 8588
Fukuoka University Chikushi Hospital
Chikushino-shi, 818-8502
Steel Memorial Yawata Hospital
Fukuoka, 805-0050
National Hospital Organization Kyushu Medical Center
Fukuoka, 810 8563
Saiseikai Fukuoka General Hospital
Fukuoka, 810-0001
Fukuoka Neurosurgical Hospital
Fukuoka, 811-1313
Japanese Red Cross Fukuoka Hospital
Fukuoka, 815-8555
Japanese Red Cross Takayama Hospital
Gifu, 506-0025
Tokai University Hachioji Hospital
Hachiōji, 192-0032
Seirei Hamamatsu General Hospital
Hamamatsu, 430-8558
JA Hiroshima General Hospital
Hatsukaichi, 738-8503
Saitama Medical University International Medical Center
Hidaka, 350-1298
Higashihiroshima Medical Center
Higashihiroshima-shi, 739-0041
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-shi, 670-8560
Hiroshima City Hiroshima Citizens Hospital
Hiroshima, 730-8518
Hiroshima City Asa Citizens Hospital
Hiroshima, 731-0293
Hiroshima Prefectural Hospital
Hiroshima, 734-8530
Ja Toride Medical Center
Ibaraki, 302-0022
Ina Central Hospital
Ina-shi, 396-8555
National Hospital Organization Kanazawa Medical Center
Ishikawa, 920 8650
National Hospital Organization Kagoshima Medical Center
Kagoshima, 892-0853
Fukuoka Tokushukai Hospital
Kasuga-shi, 816-0864
Nagoya Tokushukai General Hospital
Kasugai-shi, 487-0016
St Marianna University Hospital
Kawasaki, 216 8511
Kokura Memorial Hospital
Kitakyushu-shi, 802-8555
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, 807-8556
Kobe City Medical Center General Hospital
Kobe, 650-0047
National Hospital Organization Fukuoka Higashi Medical Center
Koga, 811-3195
Asama Nanroku Komoro Medical Center
Komoro-shi, 384-8588
Japanese Red Cross Kumamoto Hospital
Kumamoto, 861 8520
Chugoku Rosai Hospital
Kure, 737-0193
Shinkoga Clinic
Kurume-shi, 830-8577
Koseikai Takeda Hospital
Kyoto, 600-8558
Kyoto University Hospital
Kyoto, 606-8507
Maebashi Red Cross Hospital
Maebashi, 371-0811
Matsubara Tokushukai Hospital
Matsubara-shi, 580-0032
Nagasaki University Hospital
Nagasaki, 852-8501
NHO Nagoya Medical Center
Nagoya, 460-0001
Hyogo Medical University Hospital
Nishinomiya Shi, 663 8501
Okayama City General Medical Center Okayama City Hospital
Okayama, 700-8557
Omuta City Hospital
Omuta-Shi, 836-0861
National Hospital Organization Osaka National Hospital
Osaka, 540-0006
Osaka Metropolitan University Hospital
Osaka, 545 8586
Osaka General Medical Center
Osaka, 558-8558
Osaka University Hospital
Osaka, 565-0871
Rinku General Medical Center
Osaka, 598-8577
Jinikai Makita General Hospital
Ōta-ku, 144-8501
Saga University Hospital
Saga, 849-8501
Kyoyukai Sainokuni Higashi Omiya Medical Center
Saitama-shi, 331-8577
Ijinkai Nakamura Memorial Hospital
Sapporo, 060-8570
Sendai City Hospital
Sendai, 982-8502
Kohnan Hospital
Sendai, 982-8523
Shimonoseki City Hospital
Shimonoseki-shi, 7500061
Kanmon Medical Center
Shimonoseki-shi, 752-8510
Jichi Medical University Hospital
Shimotsuke, 329-0498
Keio University Hospital
Shinjuku-ku, 160-8582
Shizuoka City Shizuoka Hospital
Shizuoka Aoi-ku, 420-8630
National Cerebral and Cardiovascular Center 1
Suita-Shi, 564-8565
National Cerebral and Cardiovascular Center
Suita-Shi, 564-8565
Nippon Medical School Hospital
Tokyo, 113 8603
NTT Medical Center Tokyo
Tokyo, 141-8625
Nihon University Itabashi Hospital
Tokyo, 173 8610
Kyorin University Hospital
Tokyo, 181-8611
Tokyo Medical University Hachioji Medical Center
Tokyo, 193-0998
Fujita Health University Hospital
Toyoake, 470-1192
National Hospital Organization Toyohashi Medical Center
Toyohasi-shi, 440-8510
Toyota Memorial Hospital
Toyota-shi, 471-8513
University of Tsukuba Hospital
Tsukuba, 305 8576
Juntendo University Hospital Urayasu
Urayasu-shi, 279-0021
Uwajima City Hospital
Uwajima-shi, 798-8510
Sanyudo Hospital
Yonezawa-shi, 992-0045
India54 sites
NHL Medical College (SVP Hospital IMSR)
Ahmedabad, 380006
J L N Medical College and Attached Hospitals
Ajmer, 305001
Shree Krishna Hospital and Medical Research Center
Anand, 388325
Bangalore Medical College and Research Institute
Bangalore, 560002
KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC)
Belagavi, 590010
SUM Ultimate Medicare
Bhubaneswar, 751003
Apollo Hospitals
Bhubaneswar, 751005
S.P.Medical College & AG of Hospitals
Bikaner, 334003
Stanley Medical College
Chennai, 600001
Tamil Nadu Government Multi Super Speciality Hospital
Chennai, 600002
SIMS Multispecialty Hospital
Chennai, 600026
K.G. Hospital and PG Medical Institute
Coimbatore, 641018
ESIC Medical College and Hospital
Faridabad, 121001
Guru Gobind Singh Medical College and Hospital
Farīdkot, 151203
Paras Hospital
Gūrgaon, 122002
Institute of Neurological Sciences GNRC
Guwahati, 781006
Gauhati Medical College and Hospital
Guwahati, 781032
Nizams Institute of Medical Sciences
Hyderabad, 500082
Yashoda Super Speciality Hospitals
Hyderabad, 500082
Care Hospitals
Hyderbad, 500034
Shalby Hospital
Jaipur, 302021
Institute of Neurosciences Kolkata
Kolkata, 700017
Bangur Institute of Neurosciences and Psychiatry
Kolkata, 700025
Baby Memorial Hospital
Kozhikode, 673004
King Georges Medical University
Lucknow, 226003
Dayanand Medical College & Hospital, Tagore Nagar, Civil Lines
Ludhiana, 141001
Christian Medical College
Ludhiana, 141008
Mallikatta Neurocentre
Mangalore, 575002
B. Y. L. Nair Charitable Hospital & Topiwala National Medical College
Mumbai, 400008
Seth G S Medical College and KEM Hospital
Mumbai, 400012
JSS Hospital
Mysuru, 570004
Chopda Medicare & Research Centre
Nashik, 422005
Siddhi Hospital
Nashik, 422007
BLK Super Specialty Hospital
New Delhi, 110005
Sir Ganga Ram Hospital
New Delhi, 110060
Ruby Hall Clinic
Pune, 411001
Sahyadri Speciality Hospital 1
Pune, 411004
Sahyadri Speciality Hospital 2
Pune, 411004
Sahyadri Speciality Hospital
Pune, 411014
Synergy Superspeciality Hospital
Rajkot, 360005
All India Institute of Medical Sciences
Sumthāna, 441108
Institute of Neuroscience
Surat, 395001
Kiran Super Multispecialty Hospital
Surat, 395004
Bhaktivedanta Hospital & Research Institute
Thane, 411107
Government Medical College
Thiruvananthapuram, 695011
City Neurology Centre
Varanasi, 221002
Banaras Hindu University
Varanasi, 221005
Galaxy Life Care Services Pvt. Ltd
Varanasi, 221010
Christian Medical College 1
Vellore, 632004
Government Siddhartha Medical College
Vijayawada, 520008
King George Hospital
Visakhapatnam, 530002
Visakha Institute of Medical Sciences
Visakhapatnam, 530040
Government Medical College Vizianagaram
Vizianagaram, 535002
Mahatma Gandhi Memorial Hospital
Warangal, 506002
Germany38 sites
Universitätsklinikum Aachen
Aachen, 52074
Klinikum Altenburger Land GmbH
Altenburg, 04600
Neurologische Klinik Bad Neustadt Saale
Bad Neustadt an der Saale, 97616
Vivantes Auguste Viktoria Klinikum
Berlin, 12157
Charite Campus Benjamin Franklin
Berlin, 12203
Vivantes Klinikum Neukoelln
Berlin, 12351
Vivantes Humboldt Klinikum
Berlin, 13509
Klinikum Dortmund gGmbH
Dortmund, 44137
Staedtisches Klinikum Dresden Standort Dresden Friedrichstadt
Dresden, 01067
Universitaetsklinikum Carl Gustav Carus TU Dresden
Dresden, 01307
Universitatsklinikum Erlangen
Erlangen, 91054
Alfried Krupp Krankenhaus Ruettenscheid
Essen, 45131
Universitaetsklinikum Essen
Essen, 45147
Universitaetsklinikum Frankfurt Goethe Universitaet
Frankfurt, 60528
Klinikum Frankfurt Hoechst GmbH
Frankfurt, 65929
Klinikum Friedrichshafen GmbH
Friedrichshafen, 88048
Philipps Universitaet Marburg Klinikum Fulda GAG
Fulda, 36043
Universitaetsklinikum Giessen und Marburg GmbH
Giessen, 35392
Universitatsmedizin Gottingen
Göttingen, 37075
Universitaetsklinikum Hamburg Eppendorf
Hamburg, 20246
Asklepios Klinik Wandsbeck
Hamburg, 22043
Asklepios Klinik Nord - Heidberg
Hamburg, 22417
Asklepios Klinik Altona
Hamburg, 22763
Universitaetsklinikum Heidelberg
Heidelberg, 69120
Universitaetsklinikum Schleswig Holstein Campus Kiel
Kiel, 24105
Universitaetsklinikum Leipzig
Leipzig, 04103
Klinikum Main Spessart
Lohr a. Main, 97816
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
Lübeck, 23538
Medizinisches Zentrum Klinikum Lueneburg
Lüneburg, 21339
Johannes Wesling Klinikum Minden
Minden, 32429
Institut fuer Schlaganfall- und Demenzforschung
München, 81377
Universitaetsklinikum Muenster
Münster, 48149
Klinikum Ernst von Bergmann gGmbH
Potsdam, 14467
Nordwest Krankenhaus Sanderbusch
Sande, 26452
Helios Klinikum Schleswig
Schleswig, 24837
Universitaetsklinikum Tuebingen
Tübingen, 72074
Universitaetsklinikum Ulm
Ulm, 89081
Universitaetsklinikum Wuerzburg
Würzburg, 97080
South Korea32 sites
Hallym University Sacred Heart Hospital
Anyang-si, 431-796
Pusan National University Hospital
Busan, 49241
Dong-A University Hospital
Busan, 602 812
Kyungpook National University Hospital
Daegu, 41944
Yeungnam University Hospital
Daegu, 42415
Keimyung University Dongsan Hospital
Daegu, 42601
Chungnam National University Hospital 1
Daejeon, 35015
Inje University Ilsan Paik Hospital
Goyang-si, 10380
Chosun university hospital
Gwangju, 61453
Chonnam National University Hospital
Gwangju, 61469
Gachon University Gil Medical Center
Incheon, 21565
Inha University Hospital
Incheon, 22322
Catholic Kwandong University International ST Marys Hospital
Incheon, 22711
Jeju National University Hospital
Jeju Special, 63241
Chungnam National University Hospital
Sejong-si, 30099
Seoul National University Bundang Hospital
Seongnam-si, 13620
Nowon Eulji Medical Center, Eulji University
Seoul, 01830
Korea University Anam Hospital
Seoul, 02841
Severance Hospital Yonsei University Health System
Seoul, 03722
Hanyang University Medical Center
Seoul, 04763
Asan Medical Center
Seoul, 05505
Samsung Medical Center
Seoul, 06351
The Catholic University of Korea Seoul St Marys Hospital
Seoul, 06591
Seoul National University Boramae Hospital
Seoul, 07061
Ewha Woman's University Seoul Hospital
Seoul, 07804
Kyung Hee University Hospital
Seoul, 130-872
Soon Chun Hyang Univ.Hospital
Seoul, 140-743
Seoul National University Hospital
Seoul, 3080
Korea University Guro Hospital
Seoul, 8308
Uijeongbu Eulji Medical Center Eulji University
Uijeongbu-si, 11759
Ulsan University Hospital
Ulsan, 44033
Yongin Severance Hospital
Yongin-si, 16995
Spain32 sites
Hosp Univ A Coruna
A Coruña, 15006
Hosp. Gral. de Albacete
Albacete, 02008
Hosp. Gral. Univ. de Alicante
Alicante, 03010
Hosp. Univ. Germans Trias I Pujol
Badalona, 08916
Hosp. Univ. de Cruces
Barakaldo, 48903
Hosp. Del Mar
Barcelona, 08003
Hosp Univ Vall D Hebron
Barcelona, 08035
Hosp. de La Santa Creu I Sant Pau
Barcelona, 08041
Hosp Reina Sofia
Córdoba, 14004
Hosp. Univ. Dr. Josep Trueta
Girona, 17007
Hosp. Univ. de Bellvitge
L'Hospitalet de Llobregat, 08907
Hosp. Univ. Arnau de Vilanova de Lleida
Lleida, 25198
Complejo Hosp Ruber Juan Bravo
Madrid, 28006
Hosp. Univ. de La Princesa
Madrid, 28006
Hosp. Univ. Ramon Y Cajal
Madrid, 28034
Hosp. Clinico San Carlos
Madrid, 28040
Hosp. Univ. 12 de Octubre
Madrid, 28041
Hosp. Univ. de La Paz
Madrid, 28046
Hosp Regional Univ de Malaga
Málaga, 29010
Hosp. Puerta Del Sur
Móstoles, 28938
Hosp. Univ. Son Espases
Palma de Mallorca, 07120
Hosp Clinico Univ de Salamanca
Salamanca, 37007
Hosp. Clinico Univ. de Santiago
Santiago de Compostela, 15706
Hosp. Virgen Macarena
Seville, 41009
Hosp. Virgen Del Rocio
Seville, 41013
Hosp Univ de Tarragona Joan Xxiii
Tarragona, 43005
Hosp. Mutua Terrassa
Terrassa, 08221
Hosp. Clinico Univ. de Valencia
Valencia, 46010
Hosp. Univ. I Politecni La Fe
Valencia, 46026
Hosp. Clinico Univ. de Valladolid
Valladolid, 470003
Hosp. Alvaro Cunqueiro
Vigo, 36213
Hosp. Univ. Miguel Servet
Zaragoza, 50009
United Kingdom29 sites
Aberdeen Royal Infirmary
Aberdeen, AB25 2ZN
University Hospital Monklands
Airdrie, ML6 0JS
Royal United Hospital
Bath, BA1 3NG
Bury Care Organisation
Bury
Cheltenham General Hospital
Cheltenham, GL53 7AN
Darent Valley Hospital
Dartford, DA2 8DA
Doncaster Royal Infirmary
Doncaster, DN2 5LT
Ninewells Hospital
Dundee, DD1 9SY
Hairmyres Hospital
East Kilbride, G75 8RG
Royal Devon and Exeter Hospital(Wonford)
Exeter, EX2 5DW
Queen Elizabeth University Hospital
Glasgow, G51 4TF
Calderdale Royal Hospital
Halifax, HX3 0PW
Hull Royal Infirmary
Hull, HU3 2JZ
Leicester General Hospital
Leicester, LE5 4PW
Lincoln County Hospital
Lincoln, LN2 5QY
Royal London Hospital
London, E1 1BB
Kings College Hospital
London, SE5 8EF
Luton and Dunstable Hospital
Luton, LU4 0DZ
Arrowe Park Hospital
Metropolitan Borough of Wirral, CH49 5PE
Nottingham University Hospitals
Nottingham, NG5 1PB
Derriford Hospital
Plymouth, PL6 8DH
Royal Preston Hospital
Preston, PR2 9HT
Royal Hallamshire Hospital
Sheffield, S10 2JF
Royal Stoke University Hospital
Stoke-on-Trent, ST4 6QG
Musgrove Park Hospital
Taunton, TA1 5DA
Royal Cornwall Hospital
Truro, TR1 3LQ
Pinderfields General Hospital - Dept. of Neurology
Wakefield, WF1 4DG
Watford General Hospital
Watford, WD18 0HB
York Hospital
York, YO31 8HE
France27 sites
Centre Hospitalier du Pays d'Aix Service de Neurologie
Aix-en-Provence, 13616
CHRU Besancon Hopital Jean Minjoz
Besançon, 25030
Groupe Hospitalier Pellegrin CHU de Bordeaux
Bordeaux, 33076
CHU Bourg en Bresse
Bourg-en-Bresse, 01012
CHU de Brest - Hopital de la Cavale Blanche
Brest, 29609
Hopital Neurologique Pierre Wertheimer
Bron, 69677
Centre Hospitalier de Chartres
Chartres, 28018
CHU Clermont-Ferrand - Hopital Gabriel Montpied
Clermont-Ferrand, 63003
CHU Dijon
Dijon, 21033
Hopital Raymond Poincare
Garches, 92380
Centre Hospitalier
La Roche-sur-Yon, 85925
CHR Metz Thionville Hopital de Mercy
Laquenexy, 57530
Hopital Roger Salengro - CHU Lille
Lille, 59037
CHU de Limoges Hopital Dupuytren
Limoges, 87000
Hopital de la Timone
Marseille, 13385
Centre Hospitalier Annecy Genevois
Metz-Tessy, 74374
Hopital Gui de Chauliac
Montpellier, 34295
Centre Hospitalier Universitaire de Nancy - Hôpital Central
Nancy, 54035
Hopital Lariboisiere
Paris, 75010
Hopital Saint Joseph
Paris, 75014
Hôpital Bichat - Claude Bernard
Paris, 75018
Fondation Adolphe de Rothschild Hospital
Paris, 75019
Centre Hospitalier De Perpignan - Hopital Marechal Joffre
Perpignan, 66046
CHU Poitiers - Hopital la Miletrie
Poitiers, 86000
CHU Rouen Hopital Charles Nicolle
Rouen, 76031
Hopital Pierre Paul Riquet - Purpan
Toulouse, 31059
CHU Tours - Hopital Bretonneau - Maladies Infectieuses
Tours, 37044
Brazil26 sites
Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
Belo Horizonte, 30380-090
Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu)
Botucatu, 18618-686
Hospital Brasilia
Brasília, 71.681-603
Sociedade Hospitalar Angelina Caron
Campina Grande do Sul, 83430-000
Hospital das Clínicas da Faculdade de Medicina da UNICAMP
Campinas, 13083-888
Hospital do Rocio
Campo Largo, 83606-177
Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose
Criciúma, 88811-508
Universidade Federal do Parana - Hospital de Clínicas
Curitiba, 80060-900
Instituto Presbiteriano Mackenzie - Hospital Universitario Evangelico Mackenzie
Curitiba, 80730-150
HGF - Hospital Geral de Fortaleza
Fortaleza, 60155-290
Associacao Hospital de Caridade Ijui
Ijuí, 98700-000
Clinica Neurologica e Neurocirurgica de Joinville
Joinville, 89202-165
Complexo Hospitalar de Niteroi
Niterói, 24030-103
Instituto Mederi de Pesquisa e Saude
Passo Fundo, 99010-120
Associacao Hospitalar Moinhos de Vento
Porto Alegre, 90035-001
Hospital das Clinicas de Porto Alegre
Porto Alegre, 90035-903
IMV Pesquisa Neurológica
Porto Alegre, 90110-000
Associacao Educadora Sao Carlos AESC Hospital Mae De Deus
Porto Alegre, 90470-340
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
Ribeirão Preto, 14098-900
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
São José do Rio Preto, 15090-000
Irmandade Santa Casa de Misericordia de Sao Paulo
São Paulo, 01221-020
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903
Hospital Nove de Julho
São Paulo, 01409902
Casa de Saude Santa Marcelina - Hospital Santa Marcelina
São Paulo, 08270-070
HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro
Uberaba
Hospital Estadual Central
Vitória, 29018-140
Italy25 sites
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Presidio Spedali Civili
Brescia, 25123
Azienda Ospedaliera Istituti Ospitalieri di Cremona
Cremona, 26100
Nuovo Ospedale San Giovanni Battista
Foligno, 06034
Ospedale Policlinico San Martino IRCCS 1
Genova, 16132
Ospedale Policlinico San Martino IRCCS
Genova, 16132
Azienda Sanitaria Locale 1 Umbria - Ospedale di Gubbio e Gualdo Tadino
Gubbio, 06024
Ospedale San Salvatore
L’Aquila, 67100
Ospedale Vito Fazzi
Lecce, 73100
Azienda Ospedaliera della Provincia di Lecco_Presidio Ospedaliero 'A. Manzoni' - S.C.di Cardiologia
Lecco, 23900
Ospedale Apuane
Massa, 54100
Ospedale San Raffaele
Milan, 20132
Nuovo Ospedale Civile S.Agostino - Estense
Modena, 41126
Fondazione Istituto Neurologico Casimiro Mondino
Pavia, 27100
Azienda Unita Sanitaria Locale Umbria 1 Ospedale di Citta di Castello
Perugia, 06012
Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia
Perugia, 06156
Azienda Ospedaliera Ospedale Santa Corona
Pietra Ligure, 17027
Azienda Ospedaliero Universitaria Pisana
Pisa, 56126
Arcispedale S Maria Nuova (Civic Hospital)
Reggio Emilia, 42100
Ospedale S. Eugenio
Roma, 00144
Azienda Ospedaliera San Camillo-Forlanini
Roma, 00152
Policlinico Umberto I
Roma, 00161
Policlinico Universitario Agostino Gemelli
Roma, 00168
Azienda sanitaria universitaria Giuliano Isontina ASU GI
Trieste, 34149
ASUI Santa Maria della Misericordia di Udine
Udine, 33100
Azienda Ospedaliera Universitaria Integrata Verona
Verona, 37126
Argentina22 sites
Fundacion Favaloro
Buenos Aires, 1093
Hospital Aleman
Buenos Aires, C1118AAT
Sanatorio Finochietto
Buenos Aires, C1187AAN
Hospital Britanico de Buenos Aires
Buenos Aires, C1280AEB
Sanatorio Los Arcos
Buenos Aires, C1425FSD
Sanatorio Guemes
CABA, C1180AAX
Sanatorio Mater Dei
Ciudad Autonoma Buenos Aires, C1425DND
Hospital Gral Agudos Ignacio Pirovano
Ciudad Autonoma Buenos Aires, C1430BKC
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, C1430EGF
Clinica Privada Velez Sarsfield
Córdoba, 5000
Clínica Colombo
Córdoba, 5000
Hospital San Roque
Córdoba, 5000
Clínica Chutro
Córdoba, X5000EPU
Sanatorio Allende
Córdoba, X5000JHQ
Sanatorio de la Canada
Córdoba, X5000
Hospital Cordoba
Córdoba, X5004CDT
Hospital Municipal Dr Raul Alfredo Caccavo
Coronel Suárez, B7540GHD
Hospital General de Agudos Dr. J. M. Ramos Mejia
Federal, 1221
Sanatorio Parque
Rosario, S2000SDV
Hospital Interzonal General de Agudos Eva Perón
San Martin, B1650 NBN
Clinica Mayo de UMCB
San Miguel de Tucumán, 4000
Estudios Clinicos de los Arroyos
San Nicolás, 2900
Australia21 sites
Royal Adelaide Hospital
Adelaide, 5000
Flinders Medical Centre
Adelaide, 5042
Box Hill Hospital
Box Hill, 3128
Campbelltown Hospital
Campbelltown, 2560
Royal Prince Alfred Hospital
Camperdown, 2050
Monash Medical Centre
Clayton, 3168
St Vincent's Hospital - Melbourne
Fitzroy, 3065
Austin Health
Heidelberg, 3084
Royal Brisbane and Women's Hospital
Herston, 4029
Launceston General Hospital
Launceston, 7250
Liverpool Hospital
Liverpool, 2170
The Alfred Hospital
Melbourne, 3004
Fiona Stanley Hospital
Murdoch, 6150
John Hunter Hospital
New Lambton Heights, 2305
Royal Melbourne Hospital
Parkville, 3050
Prince Of Wales Hospital
Randwick, 2031
Mater Hospital Brisbane
South Brisbane, 4101
Gold Coast University Hospital
Southport, 4215
Royal Darwin Hospital
Tiwi, 0810
Latrobe Regional Hospital
Traralgon, 3844
Princess Alexandra Hospital
Woolloongabba, 4102
Bulgaria21 sites
Multiprofile Hospital for Active Treatment Puls
Blagoevgrad, 2700
MHAT Botevgrad EOOD
Botevgrad, 2140
MHAT Sveti Ivan Rilski 1
Dupnitsa
MHAT Sveti Ivan Rilski
Gorna Oryahovitsa, 5100
Multiprofile Hospital for Active Treatment - Haskovo
Haskovo, 6300
Mhat Sveti Georgi
Montana, 3400
MHAT - Pazardzhik AD
Pazardzhik, 4400
MHAT Avis - Medica OOD
Pleven, 5800
UMHAT 'Dr. Georgi Stranski', EAD
Pleven, 5800
UMHAT Kaspela
Plovdiv, 4001
UMHAT Sveti Georgi
Plovdiv, 4002
UMHAT 'Kanev' EAD
Rousse, 7002
MHAT Southwest hospital OOD
Sandanski, 2800
MHAT Hadzhi Dimitar
Sliven, 8800
Medical Center St. Naum
Sofia, 1113
University First MHAT-Sofia St Joan Krastitel EAD
Sofia, 1142
Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead
Sofia, 1309
Acibadem City Clinic Tokuda Hospital
Sofia, 1407
University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD
Sofia, 1527
UMHATEM N I Pirogov
Sofia, 1606
University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
Sofia, 1750
Poland21 sites
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15 276
Szpital Sw Lukasza w Boleslawcu Centrum Profilaktyki I leczenia udarow Mozgu
Bolesławiec, 59 700
Szpital Uniwersytecki NR 1 IM Dr Antoniego Jurasza
Bydgoszcz, 85 096
Samodzielny Publiczny Wojewodzki Szpital Specjalistyczny w Chelmie
Chelmie, 22-100
Samodzielny Publiczny ZOZ w Dzialdowie
Działdowo, 13-200
SP Specjalistyczny Szpital Zachodni im. Jana Pawla II
Grodzisk Mazowiecki, 05-825
Samodzielny Publiczny Zespol Zakladow Opieki Zdrowotnej Medicam Gryfice
Gryfice, 72-300
Uniwersyteckie Centrum Kliniczne im prof K Gibinskiego SUM
Katowice, 40 752
SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im Prof Leszka Gieca
Katowice Ochojec, 40635
Oddzial Ortopedii i Traumatologii Narzadu Ruchu Szpital Specjalistyczny im Ludwika Rydygiera
Krakow, 31 637
Wojewodzki Szpital Zespolony w Lesznie Oddzial Neurologiczny z Pododzialem udarowym
Leszno, 64-100
Uniwersytecki Szpital Kliniczny nr 1 im. N. Barlickiego
Lodz, 90-153
III Szpital Miejski im. Dr. K. Jonschera w Lodzi
Lodz, 93-113
1 Wojskowy Szpital Kliniczny Z Poliklinika SPZOZ W Lublinie
Lublin, 20 049
Wojewodzki Szpital Specjalistyczny w Olsztynie
Olsztyn, 10 561
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny nr 3 w Rybniku
Rybnik, 44 200
Zespol Opieki Zdrowotnej w Skarzysku-Kamiennej Szpital Powiatowy im. M.Curie-Sklodowskiej
Skarżysko-Kamienna, 26-110
KO-MED Centra Kliniczne Staszow
Staszów, 28 200
Specjalistyczny Szpital Miejski im. M.Kopernika
Torun, 87-100
Uniwersyteckie Centrum Kliniczne
Warsaw, 02 097
Szpital Specjalistyczny im. F. Ceynowy Szpitale Pomorskie
Wejherowo, 84-200
Canada19 sites
Brandon Regional Health Centre
Brandon, Manitoba, R7A 2B3
University of Calgary
Calgary, Alberta, T2N 4Z6
University of Alberta Hospital
Edmonton, Alberta, T6G 2B7
Health Sciences North
Greater Sudbury, Ontario, P3E 5J1
CISSS de la Monteregie Centre
Greenfield Park, Quebec, J4V 2H1
QEII Health Sciences Centre
Halifax, Nova Scotia, B3H1V7
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
Kingston Health Sciences Centre
Kingston, Ontario, K7L 2V7
Lethbridge Regional Hospital
Lethbridge, Alberta, T1J 1W8
Medicine Hat Regional Hospital - Medical Arts Clinic
Medicine Hat, Alberta, T1A 8M7
Trillium Health Partners
Mississauga, Ontario, L5B 1B8
Royal Columbian Hospital
New Westminster, British Columbia, V3L 3W4
Niagara Health System - Greater Niagara General Site
Niagara Falls, Ontario, L2E 6X2
CHU de Quebec - Hôpital de l' Enfant Jésus
Québec, Quebec, G1J 1Z4
CHUS
Sherbrooke, Quebec, J1H 5N4
Unity Health Toronto
Toronto, Ontario, M5B 1W8
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9
Windsor Regional Hospital
Windsor, Ontario, N8X 5A6
Health Sciences Centre Winnipeg
Winnipeg, Manitoba, R3P 1W7
Turkey (Türkiye)17 sites
Ankara University
Ankara, 06800
Hacettepe Universitesi Hastanesi
Ankara, 6230
Gazi University Medical Faculty
Ankara, 6500
Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, 16330
Dicle University Medical Faculty
Diyarbakır, 21280
Firat University Hospital
Elâzığ, 23119
Erciyes University Medical Faculty
Erciyes, 38039
Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurology Hospital
Istanbul, 34147
Bakirkoy Training and Research Hospital
Istanbul, 34147
Sisli Etfal Research Training Hospital
Istanbul, 34371
Kartal Dr Lutfi Kirdar Egitim ve Arastirma Hastanesi
Istanbul, 34890
Ege University Medical Faculty
Izmir, 35100
Dokuz Eylul University Medical Faculty
Izmir, 35340
Necmettin Erbakan University Meram Medical Faculty
Konya, 42090
Sakarya University Training and Research Hospital
Sakarya, 54100
Ondokuz Mayis University
Samsun, 55139
Izmir Katip Celebi University Ataturk Training and Research Hospital
Turkey, 35360
Hungary16 sites
Péterfy Sándor utcai Kórház
Budapest, 1076
Semmelweis Egyetem
Budapest, 1083
Bajcsy-Zsilinszky Kórház és Rendelőintézet
Budapest, 1106
Esza-Kozep-budai Centrum, Uj Szent Janos Korhaz es Szakrendelo
Budapest, 1125
Magyar Honvedseg Egeszsegugyi Kozpont
Budapest, 1134
Semmelweis Egyetem 1
Budapest, 1145
Debreceni Egyetem Klinikai Központ,Infektológiai Klinika
Debrecen, 4031
Szent Pantaleon Kórház-Rendelointézet Dunaújváros
Dunaújváros, 2600
Markhot Ferenc Oktatokorhaz es Rendelointezet
Eger, 3300
Petz Aladar Megyei Oktato Korhaz
Győr, 9023
Pest Megyei Flor Ferenc Korhaz
Kistarcsa, 2143
Szent Damjan Gorogkatolikus Korhaz
Kisvárda, 4600
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, 3526
Szent Lazar Megyei Korhaz
Salgótarján, 3100
Szent Borbala Hospital Tatabanya
Tatabánya, 2800
Javorszky Odon Korhaz
Vác, 2600
Philippines14 sites
Cebu Doctors University Hospital
Cebu, 6000
Davao Doctors Hospital
Davao City, 8000
St.Paul's Hospital-Iloilo
Iloilo City, 5000
West Visayas State University Medical Center
Iloilo City, 5000
Mary Mediatrix Medical Center
Lipa City, 4217
Manila Doctors Hospital
Manila, 1000
Chinese General Hospital & Medical Center
Manila, 1003
Metropolitan Medical Center
Manila, 1003
Amang Rodriguez Memorial Medical Center
Marikina City, 1800
San Juan de Dios Educational Foundation, Inc (Hospital)
Pasay, 1300
The Medical City
Pasig, 1605
St. Luke's Medical Center
Quezon, 1102
Capitol Medical Center Inc.
Quezon City, 1100
GreenCity Medical Center
San Fernando City, 2000
Taiwan14 sites
Changhua Christian Hospital
Changhua, 50006
Chia-Yi Christian Hospital
Chia-Yi City, 600
Chang Gung Memorial Hospital, Chiayi Branch
Chiayi City, 613
National Taiwan University Hospital 1
Douliu, 640
Hualien Tzu Chi Hospital
Hualien City, 97002
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301
Chang Gung Medical Foundation
Keelung, 20401
Taipei Medical University Shuang Ho Hospital
New Taipei City, 23561
En Chu Kong Hospital
New Taipei City, 237
China Medical University Hospital
Taichung, 404327
National Cheng Kung University Hospital
Tainan, 70403
National Taiwan University Hospital
Taipei, 10002
Taipei Veterans General Hospital
Taipei, 11217
Chang Gung Memorial Hospital- Linkou
Taoyuan County, 33305
Slovakia13 sites
FNsP F. D. Roosevelta Banska Bystrica
Banská Bystrica, 97517
Univerzitna nemocnica Bratislava
Bratislava, 82601
Univerzitna nemocnica L. Pasteura Kosice
Košice, 04011
Nemocnica AGEL Levice, s.r.o.
Levice, 93401
Nemocnica S Poliklinikou SV. Barbory
Lučenec, 98401
Univerzitná nemocnica Martin
Martin, 036 59
Fakultna nemocnica s poliklinikou Nove Zamky
Nové Zámky, 940 34
Centrum Intervencnej Neuroradiologie a Endovaskularnej Liecby CINRE
Petržalka, 85105
Nemocnica s poliklinikou Spisska Nova Ves, a.s.
Spišská Nová Ves, 05201
Nemocnica Trebisov
Trebišov, 07501
FN Trencin
Trenčín, 91101
Fakultna nemocnica Trnava
Trnava, 917 75
Fakultna nemocnica s poliklinikou v Ziline
Žilina, 1207
Belgium12 sites
ZNA Middelheim
Antwerp, 2020
Centre Hospitalier EPICURA Ath-Baudour-Hornu
Ath, 7800
Imeldaziekenhuis
Bonheiden, 2820
C.H.U. Brugmann
Brussels, 1020
Cliniques Universitaires Saint Luc
Brussels, 1200
AZ Sint-Blasius
Dendermonde, 9200
UZA
Edegem, 2650
Az Groeninge
Kortrijk, 8500
Chu Tivoli
La Louvière, 7100
UZ Leuven
Leuven, 3000
CHC MontLegia
Liège, 4000
CHU Ambroise Pare
Mons, 7000
Greece12 sites
Uni General Hospital of Alexandroupolis
Alexandroupoli, 68100
Laiko General Hospital of Athens
Athens, 11527
Alexandra General Hospital of Athens
Athens, 11528
General Hospital of Athens Attikon
Athens, 12462
Tzanio General Hospital of Piraeus
Athens, 18536
University General Hospital of Ioannina
Ioannina, 45500
University Hospital Of Larissa 1
Larissa, 41110
University Hospital Of Larissa
Larissa, 41110
Ahepa University General Hospital of Thessaloniki
Thessaloniki, 54636
Hippokration Hospital
Thessaloniki, 54642
Papageorgiou General Hospital
Thessaloniki, 56429
G Papanikolaou Hospital of Thessaloniki
Thessaloniki, 57010
Portugal12 sites
Hospital de Braga
Braga, 4710-243
Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra
Coimbra, 3040-278
Centro Hospitalar Cova da Beira, E.P.E.
Covilha, 6200-502
Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes
Guimarães, 4835 044
Centro Hospitalar de Lisboa Central
Lisbon, 1150-199
Uls Lisboa Ocidental - Hosp. Egas Moniz
Lisbon, 1349-019
Centro Hospitalar de Lisboa Norte Hospital Santa Maria
Lisbon, 1649-035
H. Santo António - Centro Hospitalar do Porto
Porto, 4099-001
Hospital Garcia de Orta, EPE
Pragal, 2808-267
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
Santa Maria da Feira, 4520-211
Centro Hospitalar de Vila Nova de Gaia Espinho E P E
Vila Nova de Gaia, 4434-502
Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE - Unidade de Vila Real
Vila Real, 5000-508
Czechia11 sites
Fakultni nemocnice Brno
Brno, 636 00
Fakultni nemocnice u sv. Anny v Brne
Brno, 656 91
Nemocnice Jihlava
Jihlava, 586 33
Fakultni nemocnice Olomouc
Olomouc, 775 20
Nemocnice AGEL Ostrava Vitkovice a s
Ostrava - Vitkovice, 703 84
Nemocnice Pisek, a.s.
Písek, 397 23
Fakultni Nemocnice Ostrava
Poruba, 708 52
Fakultni nemocnice Kralovske Vinohrady
Prague, 100 34
Vseobecna fakultni nemocnice v Praze
Prague, 128 21
Fakultni nemocnice v Motole
Prague, 150 06
Ustredni vojenske nemocnice Praha
Prague, 169 02
South Africa10 sites
Iatros International
Bloemfontein, 9324
Tread Research
Cape Town, 7500
Naidoo A
Durban, 4319
Synergy Biomed Research Institute (SBRI)
East London, 5241
TASK Central
George, 06530
Garda, RA
Johannesburg, 2192
Into Research
Pretoria, 0181
Dr J.M. Engelbrecht Trial Site
Somerset West, 7130
Drs Sarvan and Moodley
Tongaat, 4399
Clinical Projects Research SA (PTY) LTD
Worcester, 6850
Israel9 sites
Soroka University Medical Center
Beersheba, 151
Rambam Health Care Campus
Haifa, 31096
Carmel Medical Center
Haifa, 3436212
Shaare Zedek Medical Center
Jerusalem, 9103102
Health Corporation of Galilee Medical Center
Naharya, 2633737
Rabin Medical Center
Petah Tikva, 49100
Chaim Sheba Medical Center
Ramat Gan, 52621
Ziv Medical Center
Safed, 13100
Tel Aviv Sourasky Medical Center
Tel Aviv, 64239
Vietnam9 sites
Da Nang General Hospital
Da Nang, 00000
Bach Mai Hospital
Hanoi, 100000
103 Military Hospital
Hanoi
Hanoi Medical University Hospital
Hanoi
People's Hospital 115
Ho Chi Minh City, 700000
Thong Nhat HOSPITAL
Ho Chi Minh City, 700000
University Medical Center Ho Chi Minh city
Ho Chi Minh City, 748806
Gia Dinh People Hospital
Ho Chi Minh City
Nguyen Tri Phuong Hospital
Ho Chi Minh City
Croatia8 sites
Opca bolnica Bjelovar
Bjelovar, 43000
Clinic hospital Osijek
Osijek, 31000
Clinical Hospital Centre Rijeka
Rijeka, 51000
Clinical Hospital Center Split
Split, 21000
OB Varazdin
Varaždin, 42000
Clinical Hospital Centre Zagreb
Zagreb, 10000
Clinical Hospital Sestre Milosrdnice
Zagreb, 10000
University Hospital Sveti Duh
Zagreb, 10000
Malaysia8 sites
Hospital Raja Permaisuri Bainun
Ipoh, 30990
Hospital Tengku Ampuan Rahimah
Klang, 41200
Hospital University Sains Malaysia
Kota Bharu, 15200
Hospital Kuala Lumpur
Kuala Lumpur, 50586
University Kebangsaan Malaysia Medical Centre
Kuala Lumpur, 56000
Sarawak General Hospital
Kuching, 93200
Hospital Seberang Jaya
Seberang Jaya, 13700
Hospital Sungai Buloh
Sungai Buloh, 47000
Serbia8 sites
Special Hospital for Cerebrovascular Disease Sveti Sava
Belgrade, 11000
University Clinical Center of Serbia
Belgrade, 11000
University Clinical Center Kragujevac
Kragujevac, 34000
Clinical Center Nis
Niš, 18000
Clinical Center of Vojvodina
Novi Sad, 21000
General Hospital 'Dr Radivoj Simonovic'
Sombor, 25101
Health Center Subotica
Subotica, 24000
General Hospital Uzice
Užice, 31000
Thailand8 sites
Phramongkutklao Hospital and Medical College
Bangkok, 10400
Ramathibodi Hospital
Bangkok, 10400
Siriraj Hospital
Bangkoknoi, 10700
Maharaj Nakorn Chiang Mai hospital Faculty of Medicine
Chiang Mai, 50200
Lampang Hospital
Muang, 52000
Srinagarind Hospital
Nai Mueang Subdistrict Mueang, 40000
King Chulalongkorn Memorial Hospital
Pathum Wan, 10330
Prasat Neurological Institute
Rajathevi, 10400
Denmark6 sites
Aarhus Universitetshospital
Aarhus, 8200
Bispebjerg Og Frederiksberg Hospital
Copenhagen NV, 2400
Aalborg Universitetshospital
Gistrup, 9260
Rigshospitalet
Glostrup Municipality, 2600
Herlev Hospital
Herlev, 2730
Herning Regional Hospital
Herning, 7400
Mexico6 sites
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230
Centenario Hospital Miguel Hidalgo
Aguascalientes, 20259
Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Distrito Federal, 14269
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080
Centro de Investigacion Clinica Chapultepec S.A. de C.V.
Morelia, 58260
PRISMA Neurociencias A.C.
San Luis Potosí City, 78216
New Zealand6 sites
Auckland City Hospital
Auckland, 1023
Hawkes Bay Hospital
Hastings, 4120
Middlemore Hospital
Otahuhu, 2025
Rotorua Hospital
Rotorua, 3010
Tauranga Hospital
Tauranga, 3143
Wellington Hospital
Wellington, 6021
Romania6 sites
Spitalul Clinic Judetean de Urgenta Arad
Arad, 310037
Spitalul de Psihiatrie si Neurologie Brasov
Brasov, 500123
Institutul National de Neurologie si Boli Neurovasculare Bucuresti
Bucharest, 077160
Emergency Clinical County Hospital Constanta
Constanța, 900591
Spitalul Clinic Judetean de Urgenta Targu Mures
Târgu Mureş, RO540136
Spitalul Clinic Judetean de Urgenta Pius Brinzeu
Timișoara, 300723
Switzerland5 sites
Kantonsspital Aarau
Aarau, 5001
Universitatsspital Basel
Basel, 4031
Inselspital Universitatsspital Bern
Bern, 3010
Centre Hospitalier Universitaire Vaudois CHUV
Lausanne, CH-1011
Kantonsspital St Gallen
Sankt Gallen, CH-9007
Chile4 sites
Hospital Base de Osorno
Osorno, 5290000
Clinica Alemana de Santiago S.A.
Santiago
Hospital Dipreca
Santiago
Hospital Clinico Vina del Mar
Viña del Mar, 2520612
Sweden4 sites
Sahlgrenska University Hospital
Gothenburg, 41345
Hässleholms sjukhus
Hässleholm, 28138
Skanes universitetssjukhus
Malmö, 205 02
Skaraborgs sjukhus Skövde
Skövde, 54142
Finland3 sites
Helsinki University Hospital
HUS, 00029
Turun yliopistollinen keskussairaala
Turku, 20520
Vaasa Central Hospital
Vaasa, 65130
Hong Kong3 sites
The University of Hong Kong
Hong Kong
The Chinese University of Hong Kong
N T
North District Hospital
New Territories
Netherlands3 sites
Amphia Ziekenhuis
Breda, 4818 CK
Reinier de Graaf Gasthuis
Delft, 2625 AD
Bernhoven Uden
Uden, 5406 PT
Singapore3 sites
National University Hospital
Singapore, 119074
Singapore General Hospital
Singapore, 169608
National Neuroscience Institute
Singapore, 308433
Austria2 sites
Klinikum Klagenfurt am Worthersee
Klagenfurt, 9020
Klinikum Wels Grieskirchen
Wels, 4600
Latvia2 sites
Riga East Clinical University Hospital
Riga, LV-1038
Pauls Stradins Clinical University Hospital
Riga, LV1002
Lithuania2 sites
Vilnius University Hospital Santariskiu Clinic, Public Institution
Vilnius, LT-08661
Republican Vilnius University Hospital, Public Institution
Vilnius, LT04130
About this study
Official title: A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.
- Being tested
- Milvexian, Placebo
- Medical subject headings
- Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MilvexianDrug
Also called JNJ-70033093, BMS-986177
Milvexian will be administered orally.
PlaceboDrug
Placebo will be administered orally
| Study group | Role | What they receive |
|---|---|---|
| Milvexian | Experimental | Participants after an acute ischemic stroke or high-risk transient ischemic attack (TIA) who are receiving antiplatelet therapy standard-of-care (SAPT [single antiplatelet therapy] or DAPT [dual antiplatelet therapy]) will receive milvexian 25 milligrams (mg), orally, twice daily. Receives: Drug: Milvexian |
| Placebo | Placebo comparator | Participants after an acute ischemic stroke or high-risk TIA who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) will receive placebo orally twice daily. Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to First Occurrence of Ischemic Stroke
Time to first occurrence of ischemic stroke will be reported.
Measured: Up to global targeted endpoint date (approximately 41 months)
Secondary outcomes (3)
Time to First Occurrence of any Component of the Composite of Cardiovascular Death (CVD), Myocardial Infraction (MI), or Ischemic Stroke
Time to first occurrence of any component of the composite of CVD, MI, or ischemic stroke will be reported.
Measured: Up to global targeted endpoint date (approximately 41 months)
Time to First Occurrence of Ischemic Stroke
Time to first occurrence of ischemic stroke in the first 90 days will be reported.
Measured: Up to Day 90
Time to First Occurrence of any Component of Major Adverse Vascular Events (MAVE)
Time to first occurrence of any component of MAVE will be reported. MAVE is a composite of (CVD), myocardial infarction (MI), ischemic stroke, major adverse limb events (MALE), symptomatic pulmonary embolism (PE) or deep vein thrombosis (DVT).
Measured: Up to global targeted endpoint date (approximately 41 months)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jan 2023
- Study start15 Feb 2023
- Primary completion15 Oct 2026 (estimated)
- Study completion15 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ischemic Stroke; Ischemic Attack, TransientStudies of the same condition, open and under way.
- More trials run by Janssen Research & Development, LLCThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 12,523 participants (actual)
Sponsor and investigators
- Lead sponsor
- Janssen Research & Development, LLC
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Bristol Myers Squibb Company (BMS)
- Responsible party
- Sponsor
- Investigators
- Janssen Research & Development, LLC Clinical Trial, Study director, Janssen Research & Development, LLC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05702034
- Sponsor's protocol ID
- CR109231
- Other IDs
- 70033093STR3001, 2022-501176-26-00
- Acronym
- LIBREXIA-STROK
- Status last verified
- Sep 2026
- First submitted
- 19 Jan 2023
- Last updated
- 25 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu
Publications
Weitz JI, Harrington RA; LIBREXIA Program Executive Council. Rationale for the milvexian dosing in the phase 3 LIBREXIA program. J Thromb Haemost. 2026 Jun;24(6):2158-2169. doi: 10.1016/j.jtha.2026.02.020. Epub 2026 Mar 4.
PubMed 41791675
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack
- ClinicalTrials.gov ID
- NCT05702034
- Acronym / sponsor ID
- LIBREXIA-STROK / CR109231
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 12,523 participants (actual)
- Lead sponsor
- Janssen Research & Development, LLCIndustry (pharma, biotech, devices)
- Collaborators
- Bristol Myers Squibb Company (BMS)
- Study start
- 15 Feb 2023 (actual)
- Primary completion
- 15 Oct 2026 (estimated)
- Study completion
- 15 Oct 2026 (estimated)
- First posted
- 27 Jan 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Milvexian | Experimental | Drug: MilvexianParticipants after an acute ischemic stroke or high-risk transient ischemic attack (TIA) who are receiving antiplatelet therapy standard-of-care (SAPT [single antiplatelet therapy] or DAPT [dual antiplatelet therapy]) will receive milvexian 25 milligrams (mg), orally, twice daily. |
| Placebo | Placebo comparator | Drug: PlaceboParticipants after an acute ischemic stroke or high-risk TIA who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) will receive placebo orally twice daily. |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Ischemic Stroke: a neurological deficit attributable to an acute brain infarction and national institute of health stroke score scale (NIHSS) score less than or equal to (<=) 7 and at least 1 of the following: persistent signs or symptoms of the ischemic event at the time of randomization, or acute, ischemic brain lesion determined by standard-of-care neuroimaging, or participant underwent thrombolysis or thrombectomy, or transient ischemic attack (TIA): acute onset neurological deficit attributable to focal ischemia of the brain by history or examination, with complete symptom resolution of the deficit and no brain infarction on neuroimaging (example, computed tomography (CT) scan or magnetic resonance imaging (MRI), performed as part of standard medical practice), and ABCD2 Score greater than or equal to (>=) 6
- Participants will be randomized as soon as possible after determining eligibility and within 48 hours of onset of event.
- Current or planned antiplatelet treatment per international and/or local guidelines. If acetyl salicylic acid (ASA) is used, it will be limited to low dose (75 to 100 milligrams (mg)/day). Loading dose of antiplatelet agents (including ASA) are allowed per standard-of-care
- A female participant must agree not to be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half lives) after the last dose of study intervention
- Willing and able to adhere to the lifestyle restrictions specified in this protocol
Key exclusion criteria (6 listed)
- Prior history of intracranial hemorrhage except subarachnoid hemorrhage greater than (>) 1 year prior with adequate treatment
- The index stroke or TIA is considered to have a cardio-embolic etiology based on local standard-of-care investigations and for which guidelines recommend anticoagulation
- The index stroke or TIA considered to have another known cause, not related to athero-thrombotic sources (treatment of acute stroke trial [TOAST] Other Determined Etiology), based on local standard-of-care investigations
- Increased risk of bleeding, including clinically significant bleeding within the previous 3 months or known bleeding diathesis or known activated partial thromboplastin time (aPTT) prolongation or spinal cord hemorrhage or retinal hemorrhage
- Current active liver disease, eg, acute hepatitis, known cirrhosis, including participants receiving antiviral treatment for hepatitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MilvexianAlso: JNJ-70033093, BMS-986177Milvexian will be administered orally. | Drug | Milvexian |
| PlaceboPlacebo will be administered orally | Drug | Placebo |
Primary outcome
Time to First Occurrence of Ischemic Stroke
Time frame: Up to global targeted endpoint date (approximately 41 months)
Time to first occurrence of ischemic stroke will be reported.
3 secondary outcomes
Time to First Occurrence of any Component of the Composite of Cardiovascular Death (CVD), Myocardial Infraction (MI), or Ischemic Stroke
Time frame: Up to global targeted endpoint date (approximately 41 months)
Time to First Occurrence of Ischemic Stroke
Time frame: Up to Day 90
Time to First Occurrence of any Component of Major Adverse Vascular Events (MAVE)
Time frame: Up to global targeted endpoint date (approximately 41 months)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Derived from this study: PubMed 41791675Weitz JI, Harrington RA; LIBREXIA Program Executive Council. Rationale for the milvexian dosing in the phase 3 LIBREXIA program. J Thromb Haemost. 2026 Jun;24(6):2158-2169. doi: 10.1016/j.jtha.2026.02.020. Epub 2026 Mar 4.
- Individual participant dataSharing planned: Yes. The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Janssen Research & Development, LLC Clinical Trial study director
Janssen Research & Development, LLC
880 sites in 47 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Milvexian in people with Ischemic Stroke; Ischemic Attack, Transient, run by Janssen Research & Development, LLC at 880 sites in 47 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 880 sites in United States, China, Japan, India, Germany and 42 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to First Occurrence of Ischemic Stroke (time frame: Up to global targeted endpoint date (approximately 41 months)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05702034, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.