AzTrials
AzTrials

Ischemic Stroke; Ischemic Attack, TransientPhase 3LIBREXIA-STROKNCT05702034

A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

A Phase 3 study testing Milvexian in people with Ischemic Stroke; Ischemic Attack, Transient, run by Janssen Research & Development, LLC at 880 sites in 47 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke. Read more about this study

Who is it for?
Ages 40 years and older
What is being tested?
Milvexian
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
12,523 participants
Where
880 sitesin 47 countries
Study dates
15 Feb 2023to 15 Oct 2026
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Ischemic Stroke: a neurological deficit attributable to an acute brain infarction and national institute of health stroke score scale (NIHSS) score less than or equal to (<=) 7 and at least 1 of the following: persistent signs or symptoms of the ischemic event at the time of randomization, or acute, ischemic brain lesion determined by standard-of-care neuroimaging, or participant underwent thrombolysis or thrombectomy, or transient ischemic attack (TIA): acute onset neurological deficit attributable to focal ischemia of the brain by history or examination, with complete symptom resolution of the deficit and no brain infarction on neuroimaging (example, computed tomography (CT) scan or magnetic resonance imaging (MRI), performed as part of standard medical practice), and ABCD2 Score greater than or equal to (>=) 6
  • Participants will be randomized as soon as possible after determining eligibility and within 48 hours of onset of event.
  • Current or planned antiplatelet treatment per international and/or local guidelines. If acetyl salicylic acid (ASA) is used, it will be limited to low dose (75 to 100 milligrams (mg)/day). Loading dose of antiplatelet agents (including ASA) are allowed per standard-of-care
  • A female participant must agree not to be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half lives) after the last dose of study intervention
  • Willing and able to adhere to the lifestyle restrictions specified in this protocol

Who cannot join

  • Prior history of intracranial hemorrhage except subarachnoid hemorrhage greater than (>) 1 year prior with adequate treatment
  • The index stroke or TIA is considered to have a cardio-embolic etiology based on local standard-of-care investigations and for which guidelines recommend anticoagulation
  • The index stroke or TIA considered to have another known cause, not related to athero-thrombotic sources (treatment of acute stroke trial [TOAST] Other Determined Etiology), based on local standard-of-care investigations
  • Increased risk of bleeding, including clinically significant bleeding within the previous 3 months or known bleeding diathesis or known activated partial thromboplastin time (aPTT) prolongation or spinal cord hemorrhage or retinal hemorrhage
  • Current active liver disease, eg, acute hepatitis, known cirrhosis, including participants receiving antiviral treatment for hepatitis
  • Known allergies, hypersensitivity, or intolerance to milvexian or its excipients

Trial locations and contacts

880 sites in 47 countries.

880 sites in 47 countries

United States127 sites
  • Abington Memorial Hospital

    Abington, Pennsylvania, 19001

  • Summa Health System

    Akron, Ohio, 44304

  • Mission Hospital

    Asheville, North Carolina, 28801

  • Augusta University

    Augusta, Georgia, 30912

  • University of Colorado

    Aurora, Colorado, 80045

  • Seton Medical Center

    Austin, Texas, 78701

  • Sinai Hospital of Baltimore

    Baltimore, Maryland, 21215

  • Alta Bates Medical Center Cancer Center

    Berkeley, California, 94705

  • Boca Raton Regional Hospital

    Boca Raton, Florida, 33486

  • Saint Alphonsus Regional Medical Center- Cancer Care Center

    Boise, Idaho, 83706

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02216

  • Nova Clinical Research, LLC 1

    Bradenton, Florida, 34209

  • Nova Clinical Research, LLC

    Bradenton, Florida, 34209

  • SSM Health DePaul Hospital

    Bridgeton, Missouri, 63044

  • Mercy Hospital

    Buffalo, New York, 14220

  • Providence Saint Joseph Medical Center - Cancer Center

    Burbank, California, 91505

  • Mills Peninsula Health Services

    Burlingame, California, 94010

  • M Health Fairview Ridges Hospital

    Burnsville, Minnesota, 55337

  • Sutter Health - Eden Medical Center

    Castro Valley, California, 94546

  • Novant Health

    Charlotte, North Carolina, 28204

  • Rush University Medical Center

    Chicago, Illinois, 60612

  • Insight Hospital and Medical Center Chicago

    Chicago, Illinois, 60616

  • TriHealth Network

    Cincinnati, Ohio, 45220

  • University of Cincinnati

    Cincinnati, Ohio, 45267

  • Morton Plant Hospital

    Clearwater, Florida, 33756-3394

  • The Ohio State University

    Columbus, Ohio, 43210

  • Baylor Research Institute

    Dallas, Texas, 75204

  • Neurology Consultants of Dallas, PA

    Dallas, Texas, 75231

  • Nuvance Health Medical Practices Cardiology Danbury

    Danbury, Connecticut, 06810

  • Detroit Medical Center

    Detroit, Michigan, 48201

  • Henry Ford Hospital

    Detroit, Michigan, 48202

  • St John Hospital and Medical Center

    Detroit, Michigan, 48236

  • Duke University Medical Center

    Durham, North Carolina, 27710

  • Michigan State University

    East Lansing, Michigan, 48824

  • Mayo Clinic Health System

    Eau Claire, Wisconsin, 54703

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435

  • UPMC Hamot

    Erie, Pennsylvania, 16550

  • Northshore University Healthsystem

    Evanston, Illinois, 60201

  • Providence Regional Medical Center Everett

    Everett, Washington, 98201

  • Detroit Clinical Research Center

    Farmington Hills, Michigan, 48334

  • Plaza Neuroscience Clinic

    Fayetteville, Arkansas, 72703-3902

  • Parkview Research Center

    Fort Wayne, Indiana, 46845

  • Neurology Center of North Orange County

    Fullerton, California, 92835

  • Glendale Adventist Medical Center

    Glendale, California, 91206

  • Guilford Neurologic Associates

    Greensboro, North Carolina, 27405

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601-1915

  • Houston Methodist Hospital

    Houston, Texas, 77030

  • Houston Methodist Neurological Institute

    Houston, Texas, 77030

  • McGovern Medical School UT Physicians Neurosurgery Texas Medical Center

    Houston, Texas, 77030

  • Houston Methodist Willowbrook Hospital

    Houston, Texas, 77070

  • IU Health Methodist Hospital

    Indianapolis, Indiana, 46202

  • UC Irvine Healthcare Center

    Irvine, California, 92697

  • Jamaica Hospital Medical Center

    Jamaica, New York, 11418

  • United Health Services

    Johnson City, New York, 13790

  • St. Joseph's Regional Medical Center

    Joliet, Illinois, 60435

  • University of Kansas Medical Center Research Institute

    Kansas City, Kansas, 66160

  • Multiple Sclerosis Center at Evergreen

    Kirkland, Washington, 98034

  • Mayo Clinic Health System 1

    La Crosse, Wisconsin, 54601-4795

  • Sharp Grossmont Hospital

    La Mesa, California, 91942

  • Lenox Hill Hospital

    Lake Success, New York, 11041

  • University of Kentucky Medical Center

    Lexington, Kentucky, 40506

  • Long Beach Memorial

    Long Beach, California, 90806

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027

  • University of Louisville

    Louisville, Kentucky, 40202

  • Emergency Medicine Covenant Medical Center

    Lubbock, Texas, 79410

  • Banner Desert Medical Center

    Mesa, Arizona, 85202

  • Baptist Health 1

    Miami, Florida, 33173

  • Mission Hospital Regional Medical Center

    Mission Viejo, California, 92691

  • Community Hospital Cardiovascular Research

    Munster, Indiana, 46321

  • Centennial Medical Center

    Nashville, Tennessee, 37203

  • TriStar Skyline Medical Center

    Nashville, Tennessee, 37207

  • Saint Thomas Health

    Nashville, Tennessee, 37215

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232

  • Jersey Shore University Medical Center

    Neptune City, New Jersey, 07753

  • Long Island Jewish Med Ctr

    New Hyde Park, New York, 11040

  • Weill Cornell Medical College

    New York, New York, 10021

  • Rutgers New Jersey Medical School

    Newark, New Jersey, 07103

  • Hoag Memorial Hospital

    Newport Beach, California, 92663

  • Sentara Medical Group

    Norfolk, Virginia, 23502

  • Hightower Clinical

    Oklahoma City, Oklahoma, 73102

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68106

  • Advent Health Orlando

    Orlando, Florida, 32804-5521

  • Memorial Institute for Neurosciences and Multiple Sclerosis

    Owosso, Michigan, 48867

  • Stanford Stroke Center

    Palo Alto, California, 94304-1419

  • Sacred Heart Hospital

    Pensacola, Florida, 32504

  • OSF Saint Francis Medical Center

    Peoria, Illinois, 61637

  • University of Pennsylvania Health System

    Philadelphia, Pennsylvania, 19104

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107

  • Temple University Hospital Jeanes Campus

    Philadelphia, Pennsylvania, 19111

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140

  • Einstein Medical Center

    Philadelphia, Pennsylvania, 19141

  • Pikeville Medical Center

    Pikeville, Kentucky, 41537

  • Providence Portland Medical Center

    Portland, Oregon, 97213

  • Providence St Vincent Medical Center

    Portland, Oregon, 97225

  • Oregon Health And Science University

    Portland, Oregon, 97239

  • Rhode Island Hospital Warren Alpert Medical School Brown University

    Providence, Rhode Island, 02905

  • Blessing Hospital

    Quincy, Illinois, 62301

  • Kaiser Permanente 1

    Redwood City, California, 94063

  • Javon Bea Hospital

    Rockford, Illinois, 61114

  • Shady Grove Office

    Rockville, Maryland, 20850

  • William Beaumont Hospital 1

    Royal Oak, Michigan, 48073

  • William Beaumont Hospital

    Royal Oak, Michigan, 48073

  • University of California Davis Health System

    Sacramento, California, 95817

  • Kaiser Permanente

    Sacramento, California, 95825-2115

  • University Of Minnesota Medical Center

    Saint Louis Park, Minnesota, 55416

  • California Pacific Medical Center

    San Francisco, California, 94115

  • Pacific Neuroscience Institute

    Santa Monica, California, 90404

  • Sarasota Memorial Hospital

    Sarasota, Florida, 34239

  • Comprehensive Neurology Services

    Silver Spring, Maryland, 20902

  • Providence & Providence Park Hospital

    Southfield, Michigan, 48075

  • Sacred Heart Medical Center

    Spokane, Washington, 99204

  • Prairie Education And Research Cooperative

    Springfield, Illinois, 62769

  • Cox Health

    Springfield, Missouri, 65807

  • Theia Clincial Research, LLC

    Temple Terrace, Florida, 33617

  • Lincoln Hospital

    The Bronx, New York, 10451

  • Harbor Ucla Medical Center

    Torrance, California, 90502

  • Providence Little Company of Mary

    Torrance, California, 90503

  • Capital Health Regional Medical Center

    Trenton, New Jersey, 08638

  • University of Arizona

    Tucson, Arizona, 85721

  • Ascension Medical Group - St. John Clinic Infectious Disease

    Tulsa, Oklahoma, 74104

  • Cardiology Associates of North Mississippi

    Tupelo, Mississippi, 38801

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007

  • MedStar Health Research Institute

    Washington D.C., District of Columbia, 20010

  • Saint Marys Medical Center

    West Palm Beach, Florida, 33407

  • PIH Health Hospital

    Whittier, California, 90602

  • Ascension via Christi Research

    Wichita, Kansas, 67214

  • Winchester Medical Center

    Winchester, Virginia, 22601

Other trials in United States

China78 sites
  • The People's Hospital of Anyang City

    Anyang, 455002

  • Baoji Central Hospital

    Baoji, 721008

  • Baogang Hospital, Inner Mongolia

    Baotou, 014010

  • Xuanwu Hospital ,Capital Medical University

    Beijing, 100053

  • Beijing Tiantan Hospital, Capital Medical University

    Beijing, 100070

  • Peking University Third Hospital

    Beijing, 100191

  • Jilin Province Peoples Hospital

    Changchun, 130021

  • The First Hospital of Jilin University

    Changchun, 130021

  • Hunan Province People's Hospital The First Affiliated Hospital of Hunan Normal University

    Changsha, 410002

  • The second Xiangya Hospital of Central South University

    Changsha, 410011

  • Changsha Central Hospital

    Changsha, 410018

  • Chengdu Second People's Hospital

    Chengdu, 610021

  • The First Affiliated Hospital of Chengdu Medical College

    Chengdu, 610500

  • Chenzhou No.1 People's Hospital

    Chenzhou, 432000

  • PLA Army Characteristic Medical Center

    Chongqing, 400042

  • Affiliated Zhongshan Hospital of Dalian University

    Dalian, 116001

  • Dalian Municipal Central Hospital

    Dalian, 116021

  • Dazhou Central Hospital

    Dazhou, 635000

  • People's Hospital of Deyang City

    Deyang, 618000

  • Dongguan People s Hospital

    Dongguan, 523059

  • Jiangxi Ganzhou Peoples Hospital

    Ganzhou, 341000

  • Guangdong Provincial People's Hospital

    Guangzhou, 510080

  • Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

    Guangzhou, 510120

  • Guangzhou First Municipal People's Hospital

    Guangzhou, 510180

  • Guangdong Second Provincial General Hospital

    Guangzhou, 510317

  • The Affiliated Hospital of Hangzhou Normal University

    Hangzhou, 310000

  • Zhejiang Provincial People's Hospital

    Hangzhou, 310000

  • Zhejiang Hospital

    Hangzhou, 310007

  • Inner Mongolia People's Hospital

    Hohhot, 010017

  • Qilu Hospital of Shandong University

    Jinan, 250012

  • Shandong First medical university

    Jinan, 250014

  • Jingdezhen No.1 People's Hospital

    Jingdezhen, 333000

  • Shandong Jining No.1 People's Hospital

    Jining, 272011

  • The No.2 Hospital affiliated to Guizhou Medical college

    Kaili, 556000

  • First Peoples Hospital of Yunnan Province

    Kunming, 650032

  • The First Hospital of Lanzhou University

    Lanzhou, 730000

  • The Second People's Hospital of Lianyungang

    Lianyungang, 222006

  • Liaocheng People s Hospital

    Liaocheng, 252000

  • Linfen Central Hospital

    Linfen, 041000

  • Linyi City People Hospital

    Linyi, 276000

  • Liuzhou people's Hospital

    Liuzhou, 545006

  • No. 2 Hospital Affiliated to Henan Technical University

    Luoyang, 471000

  • The First Affiliated Hospital of NanChang University

    Nanchang, 330006

  • Nanchong Central Hospital

    Nanchong, 637000

  • Zhongda Hospital Southeast University

    Nanjing, 210000

  • Jiangsu Province Hospital

    Nanjing, 210029

  • Nanyang Central Hospital

    Nanyang, 473000

  • Nanshi Hospital of Nanyang

    Nanyang, 473065

  • Pingxiang People's Hospital

    Pingxiang, 337055

  • Qingdao Municipal Hospital

    Qingdao, 266011

  • The First Hospital of Qiqihar

    Qiqihar, 161005

  • Shanghai Seventh People's Hospital

    Shanghai, 200137

  • The First Affiliated Hospital of Shantou University Medical

    Shantou, 515041

  • Shengjing Hospital Of China Medical University

    Shenyang, 110004

  • The first people's hospital of Shenyang

    Shenyang, 110041

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, 050000

  • Second Affiliated Hospital of Soochow University

    Suzhou, 215004

  • Tai An City Center Hospital

    Taian, 271000

  • Shanxi Cardiovascular Hospital

    Taiyuan, 030013

  • Shanxi Provincial People's Hospital

    Taiyuan, 30012

  • Taizhou Peoples Hospital

    Taizhou, 225300

  • Tianjin Medical University General Hospital

    Tianjin, 300052

  • Tonghua Central Hospital

    Tonghua

  • The first affiliated hospital of Xinjiang medical university

    Ürümqi, 830054

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000

  • Ruian People's Hospital

    Wenzhou, 325200

  • The Central Hospital of Wuhan

    Wuhan, 430014

  • Wuxi 2nd Peoples Hospital

    Wuxi, 214002

  • The First Affiliated Hospital of Xian Jiaotong University

    Xi'an, 710061

  • Zhongshan Hospital, Xiamen University

    Xiamen, 361004

  • Xiangtan Central Hospital

    Xiangtan, 411100

  • Xuancheng People s Hospital

    Xuancheng, 242099

  • The Affiliated Hospital of Xuzhou Medical College

    Xuzhou

  • Affiliated Hospital of Yangzhou University

    Yangzhou, 225012

  • Yanbian University Hospital

    Yanji, 133000

  • Yantai Yuhuangding Hospital

    Yantai, 264000

  • Yichang Central Pepole's Hospital

    Yichang, 443003

  • Affiliated Hospital Of Guangdong Medical University

    Zhanjiang, 524000

Other trials in China

Japan71 sites
  • Funabashi Municipal Medical Center

    Chiba, 273 8588

  • Fukuoka University Chikushi Hospital

    Chikushino-shi, 818-8502

  • Steel Memorial Yawata Hospital

    Fukuoka, 805-0050

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, 810 8563

  • Saiseikai Fukuoka General Hospital

    Fukuoka, 810-0001

  • Fukuoka Neurosurgical Hospital

    Fukuoka, 811-1313

  • Japanese Red Cross Fukuoka Hospital

    Fukuoka, 815-8555

  • Japanese Red Cross Takayama Hospital

    Gifu, 506-0025

  • Tokai University Hachioji Hospital

    Hachiōji, 192-0032

  • Seirei Hamamatsu General Hospital

    Hamamatsu, 430-8558

  • JA Hiroshima General Hospital

    Hatsukaichi, 738-8503

  • Saitama Medical University International Medical Center

    Hidaka, 350-1298

  • Higashihiroshima Medical Center

    Higashihiroshima-shi, 739-0041

  • Hyogo Prefectural Harima-Himeji General Medical Center

    Himeji-shi, 670-8560

  • Hiroshima City Hiroshima Citizens Hospital

    Hiroshima, 730-8518

  • Hiroshima City Asa Citizens Hospital

    Hiroshima, 731-0293

  • Hiroshima Prefectural Hospital

    Hiroshima, 734-8530

  • Ja Toride Medical Center

    Ibaraki, 302-0022

  • Ina Central Hospital

    Ina-shi, 396-8555

  • National Hospital Organization Kanazawa Medical Center

    Ishikawa, 920 8650

  • National Hospital Organization Kagoshima Medical Center

    Kagoshima, 892-0853

  • Fukuoka Tokushukai Hospital

    Kasuga-shi, 816-0864

  • Nagoya Tokushukai General Hospital

    Kasugai-shi, 487-0016

  • St Marianna University Hospital

    Kawasaki, 216 8511

  • Kokura Memorial Hospital

    Kitakyushu-shi, 802-8555

  • Hospital of the University of Occupational and Environmental Health

    Kitakyushu-shi, 807-8556

  • Kobe City Medical Center General Hospital

    Kobe, 650-0047

  • National Hospital Organization Fukuoka Higashi Medical Center

    Koga, 811-3195

  • Asama Nanroku Komoro Medical Center

    Komoro-shi, 384-8588

  • Japanese Red Cross Kumamoto Hospital

    Kumamoto, 861 8520

  • Chugoku Rosai Hospital

    Kure, 737-0193

  • Shinkoga Clinic

    Kurume-shi, 830-8577

  • Koseikai Takeda Hospital

    Kyoto, 600-8558

  • Kyoto University Hospital

    Kyoto, 606-8507

  • Maebashi Red Cross Hospital

    Maebashi, 371-0811

  • Matsubara Tokushukai Hospital

    Matsubara-shi, 580-0032

  • Nagasaki University Hospital

    Nagasaki, 852-8501

  • NHO Nagoya Medical Center

    Nagoya, 460-0001

  • Hyogo Medical University Hospital

    Nishinomiya Shi, 663 8501

  • Okayama City General Medical Center Okayama City Hospital

    Okayama, 700-8557

  • Omuta City Hospital

    Omuta-Shi, 836-0861

  • National Hospital Organization Osaka National Hospital

    Osaka, 540-0006

  • Osaka Metropolitan University Hospital

    Osaka, 545 8586

  • Osaka General Medical Center

    Osaka, 558-8558

  • Osaka University Hospital

    Osaka, 565-0871

  • Rinku General Medical Center

    Osaka, 598-8577

  • Jinikai Makita General Hospital

    Ōta-ku, 144-8501

  • Saga University Hospital

    Saga, 849-8501

  • Kyoyukai Sainokuni Higashi Omiya Medical Center

    Saitama-shi, 331-8577

  • Ijinkai Nakamura Memorial Hospital

    Sapporo, 060-8570

  • Sendai City Hospital

    Sendai, 982-8502

  • Kohnan Hospital

    Sendai, 982-8523

  • Shimonoseki City Hospital

    Shimonoseki-shi, 7500061

  • Kanmon Medical Center

    Shimonoseki-shi, 752-8510

  • Jichi Medical University Hospital

    Shimotsuke, 329-0498

  • Keio University Hospital

    Shinjuku-ku, 160-8582

  • Shizuoka City Shizuoka Hospital

    Shizuoka Aoi-ku, 420-8630

  • National Cerebral and Cardiovascular Center 1

    Suita-Shi, 564-8565

  • National Cerebral and Cardiovascular Center

    Suita-Shi, 564-8565

  • Nippon Medical School Hospital

    Tokyo, 113 8603

  • NTT Medical Center Tokyo

    Tokyo, 141-8625

  • Nihon University Itabashi Hospital

    Tokyo, 173 8610

  • Kyorin University Hospital

    Tokyo, 181-8611

  • Tokyo Medical University Hachioji Medical Center

    Tokyo, 193-0998

  • Fujita Health University Hospital

    Toyoake, 470-1192

  • National Hospital Organization Toyohashi Medical Center

    Toyohasi-shi, 440-8510

  • Toyota Memorial Hospital

    Toyota-shi, 471-8513

  • University of Tsukuba Hospital

    Tsukuba, 305 8576

  • Juntendo University Hospital Urayasu

    Urayasu-shi, 279-0021

  • Uwajima City Hospital

    Uwajima-shi, 798-8510

  • Sanyudo Hospital

    Yonezawa-shi, 992-0045

Other trials in Japan

India54 sites
  • NHL Medical College (SVP Hospital IMSR)

    Ahmedabad, 380006

  • J L N Medical College and Attached Hospitals

    Ajmer, 305001

  • Shree Krishna Hospital and Medical Research Center

    Anand, 388325

  • Bangalore Medical College and Research Institute

    Bangalore, 560002

  • KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC)

    Belagavi, 590010

  • SUM Ultimate Medicare

    Bhubaneswar, 751003

  • Apollo Hospitals

    Bhubaneswar, 751005

  • S.P.Medical College & AG of Hospitals

    Bikaner, 334003

  • Stanley Medical College

    Chennai, 600001

  • Tamil Nadu Government Multi Super Speciality Hospital

    Chennai, 600002

  • SIMS Multispecialty Hospital

    Chennai, 600026

  • K.G. Hospital and PG Medical Institute

    Coimbatore, 641018

  • ESIC Medical College and Hospital

    Faridabad, 121001

  • Guru Gobind Singh Medical College and Hospital

    Farīdkot, 151203

  • Paras Hospital

    Gūrgaon, 122002

  • Institute of Neurological Sciences GNRC

    Guwahati, 781006

  • Gauhati Medical College and Hospital

    Guwahati, 781032

  • Nizams Institute of Medical Sciences

    Hyderabad, 500082

  • Yashoda Super Speciality Hospitals

    Hyderabad, 500082

  • Care Hospitals

    Hyderbad, 500034

  • Shalby Hospital

    Jaipur, 302021

  • Institute of Neurosciences Kolkata

    Kolkata, 700017

  • Bangur Institute of Neurosciences and Psychiatry

    Kolkata, 700025

  • Baby Memorial Hospital

    Kozhikode, 673004

  • King Georges Medical University

    Lucknow, 226003

  • Dayanand Medical College & Hospital, Tagore Nagar, Civil Lines

    Ludhiana, 141001

  • Christian Medical College

    Ludhiana, 141008

  • Mallikatta Neurocentre

    Mangalore, 575002

  • B. Y. L. Nair Charitable Hospital & Topiwala National Medical College

    Mumbai, 400008

  • Seth G S Medical College and KEM Hospital

    Mumbai, 400012

  • JSS Hospital

    Mysuru, 570004

  • Chopda Medicare & Research Centre

    Nashik, 422005

  • Siddhi Hospital

    Nashik, 422007

  • BLK Super Specialty Hospital

    New Delhi, 110005

  • Sir Ganga Ram Hospital

    New Delhi, 110060

  • Ruby Hall Clinic

    Pune, 411001

  • Sahyadri Speciality Hospital 1

    Pune, 411004

  • Sahyadri Speciality Hospital 2

    Pune, 411004

  • Sahyadri Speciality Hospital

    Pune, 411014

  • Synergy Superspeciality Hospital

    Rajkot, 360005

  • All India Institute of Medical Sciences

    Sumthāna, 441108

  • Institute of Neuroscience

    Surat, 395001

  • Kiran Super Multispecialty Hospital

    Surat, 395004

  • Bhaktivedanta Hospital & Research Institute

    Thane, 411107

  • Government Medical College

    Thiruvananthapuram, 695011

  • City Neurology Centre

    Varanasi, 221002

  • Banaras Hindu University

    Varanasi, 221005

  • Galaxy Life Care Services Pvt. Ltd

    Varanasi, 221010

  • Christian Medical College 1

    Vellore, 632004

  • Government Siddhartha Medical College

    Vijayawada, 520008

  • King George Hospital

    Visakhapatnam, 530002

  • Visakha Institute of Medical Sciences

    Visakhapatnam, 530040

  • Government Medical College Vizianagaram

    Vizianagaram, 535002

  • Mahatma Gandhi Memorial Hospital

    Warangal, 506002

Other trials in India

Germany38 sites
  • Universitätsklinikum Aachen

    Aachen, 52074

  • Klinikum Altenburger Land GmbH

    Altenburg, 04600

  • Neurologische Klinik Bad Neustadt Saale

    Bad Neustadt an der Saale, 97616

  • Vivantes Auguste Viktoria Klinikum

    Berlin, 12157

  • Charite Campus Benjamin Franklin

    Berlin, 12203

  • Vivantes Klinikum Neukoelln

    Berlin, 12351

  • Vivantes Humboldt Klinikum

    Berlin, 13509

  • Klinikum Dortmund gGmbH

    Dortmund, 44137

  • Staedtisches Klinikum Dresden Standort Dresden Friedrichstadt

    Dresden, 01067

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    Dresden, 01307

  • Universitatsklinikum Erlangen

    Erlangen, 91054

  • Alfried Krupp Krankenhaus Ruettenscheid

    Essen, 45131

  • Universitaetsklinikum Essen

    Essen, 45147

  • Universitaetsklinikum Frankfurt Goethe Universitaet

    Frankfurt, 60528

  • Klinikum Frankfurt Hoechst GmbH

    Frankfurt, 65929

  • Klinikum Friedrichshafen GmbH

    Friedrichshafen, 88048

  • Philipps Universitaet Marburg Klinikum Fulda GAG

    Fulda, 36043

  • Universitaetsklinikum Giessen und Marburg GmbH

    Giessen, 35392

  • Universitatsmedizin Gottingen

    Göttingen, 37075

  • Universitaetsklinikum Hamburg Eppendorf

    Hamburg, 20246

  • Asklepios Klinik Wandsbeck

    Hamburg, 22043

  • Asklepios Klinik Nord - Heidberg

    Hamburg, 22417

  • Asklepios Klinik Altona

    Hamburg, 22763

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120

  • Universitaetsklinikum Schleswig Holstein Campus Kiel

    Kiel, 24105

  • Universitaetsklinikum Leipzig

    Leipzig, 04103

  • Klinikum Main Spessart

    Lohr a. Main, 97816

  • Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

    Lübeck, 23538

  • Medizinisches Zentrum Klinikum Lueneburg

    Lüneburg, 21339

  • Johannes Wesling Klinikum Minden

    Minden, 32429

  • Institut fuer Schlaganfall- und Demenzforschung

    München, 81377

  • Universitaetsklinikum Muenster

    Münster, 48149

  • Klinikum Ernst von Bergmann gGmbH

    Potsdam, 14467

  • Nordwest Krankenhaus Sanderbusch

    Sande, 26452

  • Helios Klinikum Schleswig

    Schleswig, 24837

  • Universitaetsklinikum Tuebingen

    Tübingen, 72074

  • Universitaetsklinikum Ulm

    Ulm, 89081

  • Universitaetsklinikum Wuerzburg

    Würzburg, 97080

Other trials in Germany

South Korea32 sites
  • Hallym University Sacred Heart Hospital

    Anyang-si, 431-796

  • Pusan National University Hospital

    Busan, 49241

  • Dong-A University Hospital

    Busan, 602 812

  • Kyungpook National University Hospital

    Daegu, 41944

  • Yeungnam University Hospital

    Daegu, 42415

  • Keimyung University Dongsan Hospital

    Daegu, 42601

  • Chungnam National University Hospital 1

    Daejeon, 35015

  • Inje University Ilsan Paik Hospital

    Goyang-si, 10380

  • Chosun university hospital

    Gwangju, 61453

  • Chonnam National University Hospital

    Gwangju, 61469

  • Gachon University Gil Medical Center

    Incheon, 21565

  • Inha University Hospital

    Incheon, 22322

  • Catholic Kwandong University International ST Marys Hospital

    Incheon, 22711

  • Jeju National University Hospital

    Jeju Special, 63241

  • Chungnam National University Hospital

    Sejong-si, 30099

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620

  • Nowon Eulji Medical Center, Eulji University

    Seoul, 01830

  • Korea University Anam Hospital

    Seoul, 02841

  • Severance Hospital Yonsei University Health System

    Seoul, 03722

  • Hanyang University Medical Center

    Seoul, 04763

  • Asan Medical Center

    Seoul, 05505

  • Samsung Medical Center

    Seoul, 06351

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591

  • Seoul National University Boramae Hospital

    Seoul, 07061

  • Ewha Woman's University Seoul Hospital

    Seoul, 07804

  • Kyung Hee University Hospital

    Seoul, 130-872

  • Soon Chun Hyang Univ.Hospital

    Seoul, 140-743

  • Seoul National University Hospital

    Seoul, 3080

  • Korea University Guro Hospital

    Seoul, 8308

  • Uijeongbu Eulji Medical Center Eulji University

    Uijeongbu-si, 11759

  • Ulsan University Hospital

    Ulsan, 44033

  • Yongin Severance Hospital

    Yongin-si, 16995

Other trials in South Korea

Spain32 sites
  • Hosp Univ A Coruna

    A Coruña, 15006

  • Hosp. Gral. de Albacete

    Albacete, 02008

  • Hosp. Gral. Univ. de Alicante

    Alicante, 03010

  • Hosp. Univ. Germans Trias I Pujol

    Badalona, 08916

  • Hosp. Univ. de Cruces

    Barakaldo, 48903

  • Hosp. Del Mar

    Barcelona, 08003

  • Hosp Univ Vall D Hebron

    Barcelona, 08035

  • Hosp. de La Santa Creu I Sant Pau

    Barcelona, 08041

  • Hosp Reina Sofia

    Córdoba, 14004

  • Hosp. Univ. Dr. Josep Trueta

    Girona, 17007

  • Hosp. Univ. de Bellvitge

    L'Hospitalet de Llobregat, 08907

  • Hosp. Univ. Arnau de Vilanova de Lleida

    Lleida, 25198

  • Complejo Hosp Ruber Juan Bravo

    Madrid, 28006

  • Hosp. Univ. de La Princesa

    Madrid, 28006

  • Hosp. Univ. Ramon Y Cajal

    Madrid, 28034

  • Hosp. Clinico San Carlos

    Madrid, 28040

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041

  • Hosp. Univ. de La Paz

    Madrid, 28046

  • Hosp Regional Univ de Malaga

    Málaga, 29010

  • Hosp. Puerta Del Sur

    Móstoles, 28938

  • Hosp. Univ. Son Espases

    Palma de Mallorca, 07120

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007

  • Hosp. Clinico Univ. de Santiago

    Santiago de Compostela, 15706

  • Hosp. Virgen Macarena

    Seville, 41009

  • Hosp. Virgen Del Rocio

    Seville, 41013

  • Hosp Univ de Tarragona Joan Xxiii

    Tarragona, 43005

  • Hosp. Mutua Terrassa

    Terrassa, 08221

  • Hosp. Clinico Univ. de Valencia

    Valencia, 46010

  • Hosp. Univ. I Politecni La Fe

    Valencia, 46026

  • Hosp. Clinico Univ. de Valladolid

    Valladolid, 470003

  • Hosp. Alvaro Cunqueiro

    Vigo, 36213

  • Hosp. Univ. Miguel Servet

    Zaragoza, 50009

Other trials in Spain

United Kingdom29 sites
  • Aberdeen Royal Infirmary

    Aberdeen, AB25 2ZN

  • University Hospital Monklands

    Airdrie, ML6 0JS

  • Royal United Hospital

    Bath, BA1 3NG

  • Bury Care Organisation

    Bury

  • Cheltenham General Hospital

    Cheltenham, GL53 7AN

  • Darent Valley Hospital

    Dartford, DA2 8DA

  • Doncaster Royal Infirmary

    Doncaster, DN2 5LT

  • Ninewells Hospital

    Dundee, DD1 9SY

  • Hairmyres Hospital

    East Kilbride, G75 8RG

  • Royal Devon and Exeter Hospital(Wonford)

    Exeter, EX2 5DW

  • Queen Elizabeth University Hospital

    Glasgow, G51 4TF

  • Calderdale Royal Hospital

    Halifax, HX3 0PW

  • Hull Royal Infirmary

    Hull, HU3 2JZ

  • Leicester General Hospital

    Leicester, LE5 4PW

  • Lincoln County Hospital

    Lincoln, LN2 5QY

  • Royal London Hospital

    London, E1 1BB

  • Kings College Hospital

    London, SE5 8EF

  • Luton and Dunstable Hospital

    Luton, LU4 0DZ

  • Arrowe Park Hospital

    Metropolitan Borough of Wirral, CH49 5PE

  • Nottingham University Hospitals

    Nottingham, NG5 1PB

  • Derriford Hospital

    Plymouth, PL6 8DH

  • Royal Preston Hospital

    Preston, PR2 9HT

  • Royal Hallamshire Hospital

    Sheffield, S10 2JF

  • Royal Stoke University Hospital

    Stoke-on-Trent, ST4 6QG

  • Musgrove Park Hospital

    Taunton, TA1 5DA

  • Royal Cornwall Hospital

    Truro, TR1 3LQ

  • Pinderfields General Hospital - Dept. of Neurology

    Wakefield, WF1 4DG

  • Watford General Hospital

    Watford, WD18 0HB

  • York Hospital

    York, YO31 8HE

Other trials in United Kingdom

France27 sites
  • Centre Hospitalier du Pays d'Aix Service de Neurologie

    Aix-en-Provence, 13616

  • CHRU Besancon Hopital Jean Minjoz

    Besançon, 25030

  • Groupe Hospitalier Pellegrin CHU de Bordeaux

    Bordeaux, 33076

  • CHU Bourg en Bresse

    Bourg-en-Bresse, 01012

  • CHU de Brest - Hopital de la Cavale Blanche

    Brest, 29609

  • Hopital Neurologique Pierre Wertheimer

    Bron, 69677

  • Centre Hospitalier de Chartres

    Chartres, 28018

  • CHU Clermont-Ferrand - Hopital Gabriel Montpied

    Clermont-Ferrand, 63003

  • CHU Dijon

    Dijon, 21033

  • Hopital Raymond Poincare

    Garches, 92380

  • Centre Hospitalier

    La Roche-sur-Yon, 85925

  • CHR Metz Thionville Hopital de Mercy

    Laquenexy, 57530

  • Hopital Roger Salengro - CHU Lille

    Lille, 59037

  • CHU de Limoges Hopital Dupuytren

    Limoges, 87000

  • Hopital de la Timone

    Marseille, 13385

  • Centre Hospitalier Annecy Genevois

    Metz-Tessy, 74374

  • Hopital Gui de Chauliac

    Montpellier, 34295

  • Centre Hospitalier Universitaire de Nancy - Hôpital Central

    Nancy, 54035

  • Hopital Lariboisiere

    Paris, 75010

  • Hopital Saint Joseph

    Paris, 75014

  • Hôpital Bichat - Claude Bernard

    Paris, 75018

  • Fondation Adolphe de Rothschild Hospital

    Paris, 75019

  • Centre Hospitalier De Perpignan - Hopital Marechal Joffre

    Perpignan, 66046

  • CHU Poitiers - Hopital la Miletrie

    Poitiers, 86000

  • CHU Rouen Hopital Charles Nicolle

    Rouen, 76031

  • Hopital Pierre Paul Riquet - Purpan

    Toulouse, 31059

  • CHU Tours - Hopital Bretonneau - Maladies Infectieuses

    Tours, 37044

Other trials in France

Brazil26 sites
  • Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

    Belo Horizonte, 30380-090

  • Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu)

    Botucatu, 18618-686

  • Hospital Brasilia

    Brasília, 71.681-603

  • Sociedade Hospitalar Angelina Caron

    Campina Grande do Sul, 83430-000

  • Hospital das Clínicas da Faculdade de Medicina da UNICAMP

    Campinas, 13083-888

  • Hospital do Rocio

    Campo Largo, 83606-177

  • Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose

    Criciúma, 88811-508

  • Universidade Federal do Parana - Hospital de Clínicas

    Curitiba, 80060-900

  • Instituto Presbiteriano Mackenzie - Hospital Universitario Evangelico Mackenzie

    Curitiba, 80730-150

  • HGF - Hospital Geral de Fortaleza

    Fortaleza, 60155-290

  • Associacao Hospital de Caridade Ijui

    Ijuí, 98700-000

  • Clinica Neurologica e Neurocirurgica de Joinville

    Joinville, 89202-165

  • Complexo Hospitalar de Niteroi

    Niterói, 24030-103

  • Instituto Mederi de Pesquisa e Saude

    Passo Fundo, 99010-120

  • Associacao Hospitalar Moinhos de Vento

    Porto Alegre, 90035-001

  • Hospital das Clinicas de Porto Alegre

    Porto Alegre, 90035-903

  • IMV Pesquisa Neurológica

    Porto Alegre, 90110-000

  • Associacao Educadora Sao Carlos AESC Hospital Mae De Deus

    Porto Alegre, 90470-340

  • Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP

    Ribeirão Preto, 14098-900

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base

    São José do Rio Preto, 15090-000

  • Irmandade Santa Casa de Misericordia de Sao Paulo

    São Paulo, 01221-020

  • Hospital Alemao Oswaldo Cruz

    São Paulo, 01323-903

  • Hospital Nove de Julho

    São Paulo, 01409902

  • Casa de Saude Santa Marcelina - Hospital Santa Marcelina

    São Paulo, 08270-070

  • HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro

    Uberaba

  • Hospital Estadual Central

    Vitória, 29018-140

Other trials in Brazil

Italy25 sites
  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Presidio Spedali Civili

    Brescia, 25123

  • Azienda Ospedaliera Istituti Ospitalieri di Cremona

    Cremona, 26100

  • Nuovo Ospedale San Giovanni Battista

    Foligno, 06034

  • Ospedale Policlinico San Martino IRCCS 1

    Genova, 16132

  • Ospedale Policlinico San Martino IRCCS

    Genova, 16132

  • Azienda Sanitaria Locale 1 Umbria - Ospedale di Gubbio e Gualdo Tadino

    Gubbio, 06024

  • Ospedale San Salvatore

    L’Aquila, 67100

  • Ospedale Vito Fazzi

    Lecce, 73100

  • Azienda Ospedaliera della Provincia di Lecco_Presidio Ospedaliero 'A. Manzoni' - S.C.di Cardiologia

    Lecco, 23900

  • Ospedale Apuane

    Massa, 54100

  • Ospedale San Raffaele

    Milan, 20132

  • Nuovo Ospedale Civile S.Agostino - Estense

    Modena, 41126

  • Fondazione Istituto Neurologico Casimiro Mondino

    Pavia, 27100

  • Azienda Unita Sanitaria Locale Umbria 1 Ospedale di Citta di Castello

    Perugia, 06012

  • Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia

    Perugia, 06156

  • Azienda Ospedaliera Ospedale Santa Corona

    Pietra Ligure, 17027

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126

  • Arcispedale S Maria Nuova (Civic Hospital)

    Reggio Emilia, 42100

  • Ospedale S. Eugenio

    Roma, 00144

  • Azienda Ospedaliera San Camillo-Forlanini

    Roma, 00152

  • Policlinico Umberto I

    Roma, 00161

  • Policlinico Universitario Agostino Gemelli

    Roma, 00168

  • Azienda sanitaria universitaria Giuliano Isontina ASU GI

    Trieste, 34149

  • ASUI Santa Maria della Misericordia di Udine

    Udine, 33100

  • Azienda Ospedaliera Universitaria Integrata Verona

    Verona, 37126

Other trials in Italy

Argentina22 sites
  • Fundacion Favaloro

    Buenos Aires, 1093

  • Hospital Aleman

    Buenos Aires, C1118AAT

  • Sanatorio Finochietto

    Buenos Aires, C1187AAN

  • Hospital Britanico de Buenos Aires

    Buenos Aires, C1280AEB

  • Sanatorio Los Arcos

    Buenos Aires, C1425FSD

  • Sanatorio Guemes

    CABA, C1180AAX

  • Sanatorio Mater Dei

    Ciudad Autonoma Buenos Aires, C1425DND

  • Hospital Gral Agudos Ignacio Pirovano

    Ciudad Autonoma Buenos Aires, C1430BKC

  • Clinica Adventista Belgrano

    Ciudad Autonoma Buenos Aires, C1430EGF

  • Clinica Privada Velez Sarsfield

    Córdoba, 5000

  • Clínica Colombo

    Córdoba, 5000

  • Hospital San Roque

    Córdoba, 5000

  • Clínica Chutro

    Córdoba, X5000EPU

  • Sanatorio Allende

    Córdoba, X5000JHQ

  • Sanatorio de la Canada

    Córdoba, X5000

  • Hospital Cordoba

    Córdoba, X5004CDT

  • Hospital Municipal Dr Raul Alfredo Caccavo

    Coronel Suárez, B7540GHD

  • Hospital General de Agudos Dr. J. M. Ramos Mejia

    Federal, 1221

  • Sanatorio Parque

    Rosario, S2000SDV

  • Hospital Interzonal General de Agudos Eva Perón

    San Martin, B1650 NBN

  • Clinica Mayo de UMCB

    San Miguel de Tucumán, 4000

  • Estudios Clinicos de los Arroyos

    San Nicolás, 2900

Other trials in Argentina

Australia21 sites
  • Royal Adelaide Hospital

    Adelaide, 5000

  • Flinders Medical Centre

    Adelaide, 5042

  • Box Hill Hospital

    Box Hill, 3128

  • Campbelltown Hospital

    Campbelltown, 2560

  • Royal Prince Alfred Hospital

    Camperdown, 2050

  • Monash Medical Centre

    Clayton, 3168

  • St Vincent's Hospital - Melbourne

    Fitzroy, 3065

  • Austin Health

    Heidelberg, 3084

  • Royal Brisbane and Women's Hospital

    Herston, 4029

  • Launceston General Hospital

    Launceston, 7250

  • Liverpool Hospital

    Liverpool, 2170

  • The Alfred Hospital

    Melbourne, 3004

  • Fiona Stanley Hospital

    Murdoch, 6150

  • John Hunter Hospital

    New Lambton Heights, 2305

  • Royal Melbourne Hospital

    Parkville, 3050

  • Prince Of Wales Hospital

    Randwick, 2031

  • Mater Hospital Brisbane

    South Brisbane, 4101

  • Gold Coast University Hospital

    Southport, 4215

  • Royal Darwin Hospital

    Tiwi, 0810

  • Latrobe Regional Hospital

    Traralgon, 3844

  • Princess Alexandra Hospital

    Woolloongabba, 4102

Other trials in Australia

Bulgaria21 sites
  • Multiprofile Hospital for Active Treatment Puls

    Blagoevgrad, 2700

  • MHAT Botevgrad EOOD

    Botevgrad, 2140

  • MHAT Sveti Ivan Rilski 1

    Dupnitsa

  • MHAT Sveti Ivan Rilski

    Gorna Oryahovitsa, 5100

  • Multiprofile Hospital for Active Treatment - Haskovo

    Haskovo, 6300

  • Mhat Sveti Georgi

    Montana, 3400

  • MHAT - Pazardzhik AD

    Pazardzhik, 4400

  • MHAT Avis - Medica OOD

    Pleven, 5800

  • UMHAT 'Dr. Georgi Stranski', EAD

    Pleven, 5800

  • UMHAT Kaspela

    Plovdiv, 4001

  • UMHAT Sveti Georgi

    Plovdiv, 4002

  • UMHAT 'Kanev' EAD

    Rousse, 7002

  • MHAT Southwest hospital OOD

    Sandanski, 2800

  • MHAT Hadzhi Dimitar

    Sliven, 8800

  • Medical Center St. Naum

    Sofia, 1113

  • University First MHAT-Sofia St Joan Krastitel EAD

    Sofia, 1142

  • Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead

    Sofia, 1309

  • Acibadem City Clinic Tokuda Hospital

    Sofia, 1407

  • University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD

    Sofia, 1527

  • UMHATEM N I Pirogov

    Sofia, 1606

  • University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD

    Sofia, 1750

Other trials in Bulgaria

Poland21 sites
  • Uniwersytecki Szpital Kliniczny w Bialymstoku

    Bialystok, 15 276

  • Szpital Sw Lukasza w Boleslawcu Centrum Profilaktyki I leczenia udarow Mozgu

    Bolesławiec, 59 700

  • Szpital Uniwersytecki NR 1 IM Dr Antoniego Jurasza

    Bydgoszcz, 85 096

  • Samodzielny Publiczny Wojewodzki Szpital Specjalistyczny w Chelmie

    Chelmie, 22-100

  • Samodzielny Publiczny ZOZ w Dzialdowie

    Działdowo, 13-200

  • SP Specjalistyczny Szpital Zachodni im. Jana Pawla II

    Grodzisk Mazowiecki, 05-825

  • Samodzielny Publiczny Zespol Zakladow Opieki Zdrowotnej Medicam Gryfice

    Gryfice, 72-300

  • Uniwersyteckie Centrum Kliniczne im prof K Gibinskiego SUM

    Katowice, 40 752

  • SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im Prof Leszka Gieca

    Katowice Ochojec, 40635

  • Oddzial Ortopedii i Traumatologii Narzadu Ruchu Szpital Specjalistyczny im Ludwika Rydygiera

    Krakow, 31 637

  • Wojewodzki Szpital Zespolony w Lesznie Oddzial Neurologiczny z Pododzialem udarowym

    Leszno, 64-100

  • Uniwersytecki Szpital Kliniczny nr 1 im. N. Barlickiego

    Lodz, 90-153

  • III Szpital Miejski im. Dr. K. Jonschera w Lodzi

    Lodz, 93-113

  • 1 Wojskowy Szpital Kliniczny Z Poliklinika SPZOZ W Lublinie

    Lublin, 20 049

  • Wojewodzki Szpital Specjalistyczny w Olsztynie

    Olsztyn, 10 561

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny nr 3 w Rybniku

    Rybnik, 44 200

  • Zespol Opieki Zdrowotnej w Skarzysku-Kamiennej Szpital Powiatowy im. M.Curie-Sklodowskiej

    Skarżysko-Kamienna, 26-110

  • KO-MED Centra Kliniczne Staszow

    Staszów, 28 200

  • Specjalistyczny Szpital Miejski im. M.Kopernika

    Torun, 87-100

  • Uniwersyteckie Centrum Kliniczne

    Warsaw, 02 097

  • Szpital Specjalistyczny im. F. Ceynowy Szpitale Pomorskie

    Wejherowo, 84-200

Other trials in Poland

Canada19 sites
  • Brandon Regional Health Centre

    Brandon, Manitoba, R7A 2B3

  • University of Calgary

    Calgary, Alberta, T2N 4Z6

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2B7

  • Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1

  • CISSS de la Monteregie Centre

    Greenfield Park, Quebec, J4V 2H1

  • QEII Health Sciences Centre

    Halifax, Nova Scotia, B3H1V7

  • Hamilton General Hospital

    Hamilton, Ontario, L8L 2X2

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7

  • Lethbridge Regional Hospital

    Lethbridge, Alberta, T1J 1W8

  • Medicine Hat Regional Hospital - Medical Arts Clinic

    Medicine Hat, Alberta, T1A 8M7

  • Trillium Health Partners

    Mississauga, Ontario, L5B 1B8

  • Royal Columbian Hospital

    New Westminster, British Columbia, V3L 3W4

  • Niagara Health System - Greater Niagara General Site

    Niagara Falls, Ontario, L2E 6X2

  • CHU de Quebec - Hôpital de l' Enfant Jésus

    Québec, Quebec, G1J 1Z4

  • CHUS

    Sherbrooke, Quebec, J1H 5N4

  • Unity Health Toronto

    Toronto, Ontario, M5B 1W8

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9

  • Windsor Regional Hospital

    Windsor, Ontario, N8X 5A6

  • Health Sciences Centre Winnipeg

    Winnipeg, Manitoba, R3P 1W7

Other trials in Canada

Turkey (Türkiye)17 sites
  • Ankara University

    Ankara, 06800

  • Hacettepe Universitesi Hastanesi

    Ankara, 6230

  • Gazi University Medical Faculty

    Ankara, 6500

  • Bursa Yuksek Ihtisas Training and Research Hospital

    Bursa, 16330

  • Dicle University Medical Faculty

    Diyarbakır, 21280

  • Firat University Hospital

    Elâzığ, 23119

  • Erciyes University Medical Faculty

    Erciyes, 38039

  • Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurology Hospital

    Istanbul, 34147

  • Bakirkoy Training and Research Hospital

    Istanbul, 34147

  • Sisli Etfal Research Training Hospital

    Istanbul, 34371

  • Kartal Dr Lutfi Kirdar Egitim ve Arastirma Hastanesi

    Istanbul, 34890

  • Ege University Medical Faculty

    Izmir, 35100

  • Dokuz Eylul University Medical Faculty

    Izmir, 35340

  • Necmettin Erbakan University Meram Medical Faculty

    Konya, 42090

  • Sakarya University Training and Research Hospital

    Sakarya, 54100

  • Ondokuz Mayis University

    Samsun, 55139

  • Izmir Katip Celebi University Ataturk Training and Research Hospital

    Turkey, 35360

Other trials in Turkey (Türkiye)

Hungary16 sites
  • Péterfy Sándor utcai Kórház

    Budapest, 1076

  • Semmelweis Egyetem

    Budapest, 1083

  • Bajcsy-Zsilinszky Kórház és Rendelőintézet

    Budapest, 1106

  • Esza-Kozep-budai Centrum, Uj Szent Janos Korhaz es Szakrendelo

    Budapest, 1125

  • Magyar Honvedseg Egeszsegugyi Kozpont

    Budapest, 1134

  • Semmelweis Egyetem 1

    Budapest, 1145

  • Debreceni Egyetem Klinikai Központ,Infektológiai Klinika

    Debrecen, 4031

  • Szent Pantaleon Kórház-Rendelointézet Dunaújváros

    Dunaújváros, 2600

  • Markhot Ferenc Oktatokorhaz es Rendelointezet

    Eger, 3300

  • Petz Aladar Megyei Oktato Korhaz

    Győr, 9023

  • Pest Megyei Flor Ferenc Korhaz

    Kistarcsa, 2143

  • Szent Damjan Gorogkatolikus Korhaz

    Kisvárda, 4600

  • Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz

    Miskolc, 3526

  • Szent Lazar Megyei Korhaz

    Salgótarján, 3100

  • Szent Borbala Hospital Tatabanya

    Tatabánya, 2800

  • Javorszky Odon Korhaz

    Vác, 2600

Other trials in Hungary

Philippines14 sites
  • Cebu Doctors University Hospital

    Cebu, 6000

  • Davao Doctors Hospital

    Davao City, 8000

  • St.Paul's Hospital-Iloilo

    Iloilo City, 5000

  • West Visayas State University Medical Center

    Iloilo City, 5000

  • Mary Mediatrix Medical Center

    Lipa City, 4217

  • Manila Doctors Hospital

    Manila, 1000

  • Chinese General Hospital & Medical Center

    Manila, 1003

  • Metropolitan Medical Center

    Manila, 1003

  • Amang Rodriguez Memorial Medical Center

    Marikina City, 1800

  • San Juan de Dios Educational Foundation, Inc (Hospital)

    Pasay, 1300

  • The Medical City

    Pasig, 1605

  • St. Luke's Medical Center

    Quezon, 1102

  • Capitol Medical Center Inc.

    Quezon City, 1100

  • GreenCity Medical Center

    San Fernando City, 2000

Other trials in Philippines

Taiwan14 sites
  • Changhua Christian Hospital

    Changhua, 50006

  • Chia-Yi Christian Hospital

    Chia-Yi City, 600

  • Chang Gung Memorial Hospital, Chiayi Branch

    Chiayi City, 613

  • National Taiwan University Hospital 1

    Douliu, 640

  • Hualien Tzu Chi Hospital

    Hualien City, 97002

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301

  • Chang Gung Medical Foundation

    Keelung, 20401

  • Taipei Medical University Shuang Ho Hospital

    New Taipei City, 23561

  • En Chu Kong Hospital

    New Taipei City, 237

  • China Medical University Hospital

    Taichung, 404327

  • National Cheng Kung University Hospital

    Tainan, 70403

  • National Taiwan University Hospital

    Taipei, 10002

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Chang Gung Memorial Hospital- Linkou

    Taoyuan County, 33305

Other trials in Taiwan

Slovakia13 sites
  • FNsP F. D. Roosevelta Banska Bystrica

    Banská Bystrica, 97517

  • Univerzitna nemocnica Bratislava

    Bratislava, 82601

  • Univerzitna nemocnica L. Pasteura Kosice

    Košice, 04011

  • Nemocnica AGEL Levice, s.r.o.

    Levice, 93401

  • Nemocnica S Poliklinikou SV. Barbory

    Lučenec, 98401

  • Univerzitná nemocnica Martin

    Martin, 036 59

  • Fakultna nemocnica s poliklinikou Nove Zamky

    Nové Zámky, 940 34

  • Centrum Intervencnej Neuroradiologie a Endovaskularnej Liecby CINRE

    Petržalka, 85105

  • Nemocnica s poliklinikou Spisska Nova Ves, a.s.

    Spišská Nová Ves, 05201

  • Nemocnica Trebisov

    Trebišov, 07501

  • FN Trencin

    Trenčín, 91101

  • Fakultna nemocnica Trnava

    Trnava, 917 75

  • Fakultna nemocnica s poliklinikou v Ziline

    Žilina, 1207

Other trials in Slovakia

Belgium12 sites
  • ZNA Middelheim

    Antwerp, 2020

  • Centre Hospitalier EPICURA Ath-Baudour-Hornu

    Ath, 7800

  • Imeldaziekenhuis

    Bonheiden, 2820

  • C.H.U. Brugmann

    Brussels, 1020

  • Cliniques Universitaires Saint Luc

    Brussels, 1200

  • AZ Sint-Blasius

    Dendermonde, 9200

  • UZA

    Edegem, 2650

  • Az Groeninge

    Kortrijk, 8500

  • Chu Tivoli

    La Louvière, 7100

  • UZ Leuven

    Leuven, 3000

  • CHC MontLegia

    Liège, 4000

  • CHU Ambroise Pare

    Mons, 7000

Other trials in Belgium

Greece12 sites
  • Uni General Hospital of Alexandroupolis

    Alexandroupoli, 68100

  • Laiko General Hospital of Athens

    Athens, 11527

  • Alexandra General Hospital of Athens

    Athens, 11528

  • General Hospital of Athens Attikon

    Athens, 12462

  • Tzanio General Hospital of Piraeus

    Athens, 18536

  • University General Hospital of Ioannina

    Ioannina, 45500

  • University Hospital Of Larissa 1

    Larissa, 41110

  • University Hospital Of Larissa

    Larissa, 41110

  • Ahepa University General Hospital of Thessaloniki

    Thessaloniki, 54636

  • Hippokration Hospital

    Thessaloniki, 54642

  • Papageorgiou General Hospital

    Thessaloniki, 56429

  • G Papanikolaou Hospital of Thessaloniki

    Thessaloniki, 57010

Other trials in Greece

Portugal12 sites
  • Hospital de Braga

    Braga, 4710-243

  • Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra

    Coimbra, 3040-278

  • Centro Hospitalar Cova da Beira, E.P.E.

    Covilha, 6200-502

  • Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes

    Guimarães, 4835 044

  • Centro Hospitalar de Lisboa Central

    Lisbon, 1150-199

  • Uls Lisboa Ocidental - Hosp. Egas Moniz

    Lisbon, 1349-019

  • Centro Hospitalar de Lisboa Norte Hospital Santa Maria

    Lisbon, 1649-035

  • H. Santo António - Centro Hospitalar do Porto

    Porto, 4099-001

  • Hospital Garcia de Orta, EPE

    Pragal, 2808-267

  • Centro Hospitalar de Entre o Douro e Vouga, E.P.E

    Santa Maria da Feira, 4520-211

  • Centro Hospitalar de Vila Nova de Gaia Espinho E P E

    Vila Nova de Gaia, 4434-502

  • Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE - Unidade de Vila Real

    Vila Real, 5000-508

Other trials in Portugal

Czechia11 sites
  • Fakultni nemocnice Brno

    Brno, 636 00

  • Fakultni nemocnice u sv. Anny v Brne

    Brno, 656 91

  • Nemocnice Jihlava

    Jihlava, 586 33

  • Fakultni nemocnice Olomouc

    Olomouc, 775 20

  • Nemocnice AGEL Ostrava Vitkovice a s

    Ostrava - Vitkovice, 703 84

  • Nemocnice Pisek, a.s.

    Písek, 397 23

  • Fakultni Nemocnice Ostrava

    Poruba, 708 52

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 21

  • Fakultni nemocnice v Motole

    Prague, 150 06

  • Ustredni vojenske nemocnice Praha

    Prague, 169 02

Other trials in Czechia

South Africa10 sites
  • Iatros International

    Bloemfontein, 9324

  • Tread Research

    Cape Town, 7500

  • Naidoo A

    Durban, 4319

  • Synergy Biomed Research Institute (SBRI)

    East London, 5241

  • TASK Central

    George, 06530

  • Garda, RA

    Johannesburg, 2192

  • Into Research

    Pretoria, 0181

  • Dr J.M. Engelbrecht Trial Site

    Somerset West, 7130

  • Drs Sarvan and Moodley

    Tongaat, 4399

  • Clinical Projects Research SA (PTY) LTD

    Worcester, 6850

Other trials in South Africa

Israel9 sites
  • Soroka University Medical Center

    Beersheba, 151

  • Rambam Health Care Campus

    Haifa, 31096

  • Carmel Medical Center

    Haifa, 3436212

  • Shaare Zedek Medical Center

    Jerusalem, 9103102

  • Health Corporation of Galilee Medical Center

    Naharya, 2633737

  • Rabin Medical Center

    Petah Tikva, 49100

  • Chaim Sheba Medical Center

    Ramat Gan, 52621

  • Ziv Medical Center

    Safed, 13100

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239

Other trials in Israel

Vietnam9 sites
  • Da Nang General Hospital

    Da Nang, 00000

  • Bach Mai Hospital

    Hanoi, 100000

  • 103 Military Hospital

    Hanoi

  • Hanoi Medical University Hospital

    Hanoi

  • People's Hospital 115

    Ho Chi Minh City, 700000

  • Thong Nhat HOSPITAL

    Ho Chi Minh City, 700000

  • University Medical Center Ho Chi Minh city

    Ho Chi Minh City, 748806

  • Gia Dinh People Hospital

    Ho Chi Minh City

  • Nguyen Tri Phuong Hospital

    Ho Chi Minh City

Other trials in Vietnam

Croatia8 sites
  • Opca bolnica Bjelovar

    Bjelovar, 43000

  • Clinic hospital Osijek

    Osijek, 31000

  • Clinical Hospital Centre Rijeka

    Rijeka, 51000

  • Clinical Hospital Center Split

    Split, 21000

  • OB Varazdin

    Varaždin, 42000

  • Clinical Hospital Centre Zagreb

    Zagreb, 10000

  • Clinical Hospital Sestre Milosrdnice

    Zagreb, 10000

  • University Hospital Sveti Duh

    Zagreb, 10000

Other trials in Croatia

Malaysia8 sites
  • Hospital Raja Permaisuri Bainun

    Ipoh, 30990

  • Hospital Tengku Ampuan Rahimah

    Klang, 41200

  • Hospital University Sains Malaysia

    Kota Bharu, 15200

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586

  • University Kebangsaan Malaysia Medical Centre

    Kuala Lumpur, 56000

  • Sarawak General Hospital

    Kuching, 93200

  • Hospital Seberang Jaya

    Seberang Jaya, 13700

  • Hospital Sungai Buloh

    Sungai Buloh, 47000

Other trials in Malaysia

Serbia8 sites
  • Special Hospital for Cerebrovascular Disease Sveti Sava

    Belgrade, 11000

  • University Clinical Center of Serbia

    Belgrade, 11000

  • University Clinical Center Kragujevac

    Kragujevac, 34000

  • Clinical Center Nis

    Niš, 18000

  • Clinical Center of Vojvodina

    Novi Sad, 21000

  • General Hospital 'Dr Radivoj Simonovic'

    Sombor, 25101

  • Health Center Subotica

    Subotica, 24000

  • General Hospital Uzice

    Užice, 31000

Other trials in Serbia

Thailand8 sites
  • Phramongkutklao Hospital and Medical College

    Bangkok, 10400

  • Ramathibodi Hospital

    Bangkok, 10400

  • Siriraj Hospital

    Bangkoknoi, 10700

  • Maharaj Nakorn Chiang Mai hospital Faculty of Medicine

    Chiang Mai, 50200

  • Lampang Hospital

    Muang, 52000

  • Srinagarind Hospital

    Nai Mueang Subdistrict Mueang, 40000

  • King Chulalongkorn Memorial Hospital

    Pathum Wan, 10330

  • Prasat Neurological Institute

    Rajathevi, 10400

Other trials in Thailand

Denmark6 sites
  • Aarhus Universitetshospital

    Aarhus, 8200

  • Bispebjerg Og Frederiksberg Hospital

    Copenhagen NV, 2400

  • Aalborg Universitetshospital

    Gistrup, 9260

  • Rigshospitalet

    Glostrup Municipality, 2600

  • Herlev Hospital

    Herlev, 2730

  • Herning Regional Hospital

    Herning, 7400

Other trials in Denmark

Mexico6 sites
  • Hospital Cardiologica Aguascalientes

    Aguascalientes, 20230

  • Centenario Hospital Miguel Hidalgo

    Aguascalientes, 20259

  • Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

    Distrito Federal, 14269

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

    Mexico City, 14080

  • Centro de Investigacion Clinica Chapultepec S.A. de C.V.

    Morelia, 58260

  • PRISMA Neurociencias A.C.

    San Luis Potosí City, 78216

Other trials in Mexico

New Zealand6 sites
  • Auckland City Hospital

    Auckland, 1023

  • Hawkes Bay Hospital

    Hastings, 4120

  • Middlemore Hospital

    Otahuhu, 2025

  • Rotorua Hospital

    Rotorua, 3010

  • Tauranga Hospital

    Tauranga, 3143

  • Wellington Hospital

    Wellington, 6021

Other trials in New Zealand

Romania6 sites
  • Spitalul Clinic Judetean de Urgenta Arad

    Arad, 310037

  • Spitalul de Psihiatrie si Neurologie Brasov

    Brasov, 500123

  • Institutul National de Neurologie si Boli Neurovasculare Bucuresti

    Bucharest, 077160

  • Emergency Clinical County Hospital Constanta

    Constanța, 900591

  • Spitalul Clinic Judetean de Urgenta Targu Mures

    Târgu Mureş, RO540136

  • Spitalul Clinic Judetean de Urgenta Pius Brinzeu

    Timișoara, 300723

Other trials in Romania

Switzerland5 sites
  • Kantonsspital Aarau

    Aarau, 5001

  • Universitatsspital Basel

    Basel, 4031

  • Inselspital Universitatsspital Bern

    Bern, 3010

  • Centre Hospitalier Universitaire Vaudois CHUV

    Lausanne, CH-1011

  • Kantonsspital St Gallen

    Sankt Gallen, CH-9007

Other trials in Switzerland

Chile4 sites
  • Hospital Base de Osorno

    Osorno, 5290000

  • Clinica Alemana de Santiago S.A.

    Santiago

  • Hospital Dipreca

    Santiago

  • Hospital Clinico Vina del Mar

    Viña del Mar, 2520612

Other trials in Chile

Sweden4 sites
  • Sahlgrenska University Hospital

    Gothenburg, 41345

  • Hässleholms sjukhus

    Hässleholm, 28138

  • Skanes universitetssjukhus

    Malmö, 205 02

  • Skaraborgs sjukhus Skövde

    Skövde, 54142

Other trials in Sweden

Finland3 sites
  • Helsinki University Hospital

    HUS, 00029

  • Turun yliopistollinen keskussairaala

    Turku, 20520

  • Vaasa Central Hospital

    Vaasa, 65130

Other trials in Finland

Hong Kong3 sites
  • The University of Hong Kong

    Hong Kong

  • The Chinese University of Hong Kong

    N T

  • North District Hospital

    New Territories

Other trials in Hong Kong

Netherlands3 sites
  • Amphia Ziekenhuis

    Breda, 4818 CK

  • Reinier de Graaf Gasthuis

    Delft, 2625 AD

  • Bernhoven Uden

    Uden, 5406 PT

Other trials in Netherlands

Singapore3 sites
  • National University Hospital

    Singapore, 119074

  • Singapore General Hospital

    Singapore, 169608

  • National Neuroscience Institute

    Singapore, 308433

Other trials in Singapore

Austria2 sites
  • Klinikum Klagenfurt am Worthersee

    Klagenfurt, 9020

  • Klinikum Wels Grieskirchen

    Wels, 4600

Other trials in Austria

Latvia2 sites
  • Riga East Clinical University Hospital

    Riga, LV-1038

  • Pauls Stradins Clinical University Hospital

    Riga, LV1002

Other trials in Latvia

Lithuania2 sites
  • Vilnius University Hospital Santariskiu Clinic, Public Institution

    Vilnius, LT-08661

  • Republican Vilnius University Hospital, Public Institution

    Vilnius, LT04130

Other trials in Lithuania

Estonia1 site
  • West Tallinn Central Hospital

    Tallinn, 10617

Other trials in Estonia

About this study

Official title: A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack

The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.

Being tested
Milvexian, Placebo
Medical subject headings
Ischemic Stroke

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • MilvexianDrug

    Also called JNJ-70033093, BMS-986177

    Milvexian will be administered orally.

  • PlaceboDrug

    Placebo will be administered orally

Study groups in NCT05702034
Study groupRoleWhat they receive
MilvexianExperimentalParticipants after an acute ischemic stroke or high-risk transient ischemic attack (TIA) who are receiving antiplatelet therapy standard-of-care (SAPT [single antiplatelet therapy] or DAPT [dual antiplatelet therapy]) will receive milvexian 25 milligrams (mg), orally, twice daily.
Receives: Drug: Milvexian
PlaceboPlacebo comparatorParticipants after an acute ischemic stroke or high-risk TIA who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) will receive placebo orally twice daily.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of Ischemic Stroke

    Time to first occurrence of ischemic stroke will be reported.

    Measured: Up to global targeted endpoint date (approximately 41 months)

Secondary outcomes (3)
  1. Time to First Occurrence of any Component of the Composite of Cardiovascular Death (CVD), Myocardial Infraction (MI), or Ischemic Stroke

    Time to first occurrence of any component of the composite of CVD, MI, or ischemic stroke will be reported.

    Measured: Up to global targeted endpoint date (approximately 41 months)

  2. Time to First Occurrence of Ischemic Stroke

    Time to first occurrence of ischemic stroke in the first 90 days will be reported.

    Measured: Up to Day 90

  3. Time to First Occurrence of any Component of Major Adverse Vascular Events (MAVE)

    Time to first occurrence of any component of MAVE will be reported. MAVE is a composite of (CVD), myocardial infarction (MI), ischemic stroke, major adverse limb events (MALE), symptomatic pulmonary embolism (PE) or deep vein thrombosis (DVT).

    Measured: Up to global targeted endpoint date (approximately 41 months)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Jan 2023
  2. Study start15 Feb 2023
  3. Primary completion15 Oct 2026 (estimated)
  4. Study completion15 Oct 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
12,523 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05702034
Sponsor's protocol ID
CR109231
Other IDs
70033093STR3001, 2022-501176-26-00
Acronym
LIBREXIA-STROK
Status last verified
Sep 2026
First submitted
19 Jan 2023
Last updated
25 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu

Publications

  • Weitz JI, Harrington RA; LIBREXIA Program Executive Council. Rationale for the milvexian dosing in the phase 3 LIBREXIA program. J Thromb Haemost. 2026 Jun;24(6):2158-2169. doi: 10.1016/j.jtha.2026.02.020. Epub 2026 Mar 4.

    PubMed 41791675

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Milvexian in people with Ischemic Stroke; Ischemic Attack, Transient, run by Janssen Research & Development, LLC at 880 sites in 47 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 880 sites in United States, China, Japan, India, Germany and 42 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of Ischemic Stroke (time frame: Up to global targeted endpoint date (approximately 41 months)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05702034, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in