HealthyNCT05729685
Aerobic Adaptations With Various Training Methods
A study testing Interval training and Continuous training in people with Healthy, run by Ilias Smilios at 1 site in Greece.
Trial summary
The goal of this intervention study is to compare the adaptations after a 6-week training period between an intense continuous and a high-intensity interval training program performed under iso-effort conditions on aerobic performance parameters in young healthy adults. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Interval training and Continuous training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteGreece
- Study dates
- 1 Sep 2020to 10 Dec 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- All participants should have been involved in low intensity continuous training,
- All participants should have been training 1-3 times per week for 30-45 min for at least three months.
Who cannot join
- Not familiar with aerobic training
- Any health issues that did not allow participation in regular exercise training.
Trial locations and contacts
1 site in 1 country.
Greece1 site
Department of Physical Education and Sport Science
Komotini, Rodopi, 69100
About this study
Official title: Aerobic Adaptations Following Two Iso-effort Training Programs: An Intense Continuous and a High-intensity Interval
The goal of this intervention study is to compare the adaptations after a 6-week training period between an intense continuous and a high-intensity interval training program performed under iso-effort conditions on aerobic performance parameters in young healthy adults. The main question it aims to answer are if the intense continuous and a high-intensity interval training programs will induce similar adaptations in maximal (VO2max and PTV) and submaximal (critical velocity, lactate threshold parameters and running economy) aerobic performance parameters. Participants will be ere randomly assigned either to an intense continuous training group (CON) or to a high-intensity interval training group (INT). The training program will comprise of 14 training sessions performed over a 6-week period.
Read the detailed description
The aim of this study was to compare the adaptations after a 6-week training period between the intense continuous and the high-intensity interval training methods performed under iso-effort conditions on maximal (VO2max and PTV) and submaximal (critical velocity, lactate threshold parameters and running economy) aerobic performance parameters.
A parallel group research design was used in the present study. Initially, 26 participants (10 males and 16 females), using stratified randomization (gender was the variable of stratification) were randomly assigned (1:1), according to a random-number table, either to an intense continuous training group (CON) or to a high-intensity interval training group (INT).
The INT group trained using the interval method. During the exercise sessions the participants ran each bout at an intensity corresponding to 90% of PTV. PTV was used to prescribe the exercise intensity at the INT group. The duration of the running-bouts was equal to ¼ of the individual time to exhaustion at 90% of PTV (determined during the CV testing) followed by passive rest equal to 2/3 of exercise duration. The duration of the exercise-bouts was individualized based on the time to exhaustion at 90% of PTV to reduce the between subject's variability. The participants terminated each exercise session when an RPE value of 17 was reached. Running bout duration and intensity were adjusted after 7 training sessions (during the 3rd week) following a reassessment of the time to exhaustion at 90% of the "new" PTV achieved during mid-testing as a result of training.
The CONT group trained using the continuous method. During the training sessions the participants ran with an intensity corresponding to -2,5% of CV until they reported a rating of 17 at the 6-20 Borg's scale. Running velocity was adjusted after 7 training sessions (during the 3rd week) after reassessment of CV. CV was used to determine the exercise intensity in the CONT group to ensure that all individuals would ran at the heavy intensity domain and be able to complete at least 15 min of continuous running, and to minimize the high inter-individual variations in endurance time at intensities near the upper limit of the heavy intensity domain. Using PTV to determine the intensity in the CONT group, would increase the possibility for trainees to exercise at different exercise intensity domains.
During the experiment, participants will not perform any other form of training besides of that applied in the current study. VO2max, PTV, oxygen consumptions, heart rates and the velocities corresponding to the 1st and the 2nd lactate thresholds (LT1 and LT2), the velocity at 4 mmol/L of blood lactate concentration (v4mmol), running economy, and critical velocity (CV) will be measured before, after 7 training sessions (3rd week, two days after the 7th training session), and after the completion of training program.
- Conditions
- Healthy
- Being tested
- Interval training, Continuous training
- Keywords
- exercise, maximal oxygen consumption, endurance
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Interval trainingOther
The interval training group trained using the interval method. During the exercise sessions the participants ran each bout at an intensity corresponding to 90% of PTV. PTV was used to prescribe the exercise intensity at the INT group. The duration of the running-bouts was equal to ¼ of the individual time to exhaustion at 90% of PTV (determined during the CV testing) followed by passive rest equal to 2/3 of exercise duration. The duration of the exercise-bouts was individualized based on the time to exhaustion at 90% of PTV to reduce the between subject's variability. The participants terminated each exercise session when an RPE value of 17 was reached. Running bout duration and intensity were adjusted after 7 training sessions (during the 3rd week) following a reassessment of the time to exhaustion at 90% of the "new" PTV achieved during mid-testing as a result of training.
Continuous trainingOther
The continuous group trained using the continuous method. During the training sessions the participants ran with an intensity corresponding to -2,5% of CV until they reported a rating of 17 at the 6-20 Borg's scale. Running velocity was adjusted after 7 training sessions (during the 3rd week) after reassessment of CV. CV was used to determine the exercise intensity in the CONT group to ensure that all individuals would ran at the heavy intensity domain and be able to complete at least 15 min of continuous running, and to minimize the high inter-individual variations in endurance time at intensities near the upper limit of the heavy intensity domain. Using PTV to determine the intensity in the CONT group, would increase the possibility for trainees to exercise at different exercise intensity domains.
| Study group | Role | What they receive |
|---|---|---|
| Interval training | Experimental | The interval group trained using the interval trainining method. Receives: Other: Interval training |
| Continuous training | Experimental | The continuous group trained using the continuous training method. Receives: Other: Continuous training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in maximal oxygen consumption
Maximal oxygen consumption in ml/kg/min
Measured: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Changes in peak treadmill velocity
Peak treadmill velocity using a maximal incremental test to exhaustion on a treadmill in km/h
Measured: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Changes in running velocities at the 1st and the 2nd lactate thresholds
Running velocities (km/h) at the 1st and the 2nd lactate thresholds by measuring the changes in blood lactate concentration during a maximal incremental test to exhaustion on a treadmill.
Measured: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Changes in critical velocity
Critical velocity (km/h) determined by having the participants ran until exhaustion at velocities corresponding to 90, 100, and 110% of peak treadmill velocity. Using linear regression analyses, the relationship between the distance covered at each run and the time to exhaustion was calculated. Τhe slope of the linear regression line was the critical velocity.
Measured: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Secondary outcomes (2)
Changes in running economy
Running economy determined by measuring the oxygen consumption (ml/kg/min) while running for 10 min at a velocity corresponding to 70% of the pre-training peak treadmill velocity
Measured: At the beginning of the training program and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Changes in running velocity at a blood lactate concentration of 4 mmol/L
Running velocity (km/h) at a blood lactate concentration of 4 mmol/L determined by the individual relationship between lactate concentrations and running velocities during an incremental test by applying a nonlinear regression model.
Measured: At the beginning of the training program and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Feb 2023
- Study start1 Sep 2020
- Primary completion10 Dec 2021
- Study completion10 Dec 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- A parallel group research design was used in the present study. Initially, 26 participants (10 males and 16 females), using stratified randomization (gender was the variable of stratification) were randomly assigned (1:1), according to a random-number table, either to an intense continuous training group (CON) or to a high-intensity interval training group (INT).
- Masking
- None (open label)
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ilias Smilios
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ilias Smilios, Democritus University of Thrace
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05729685
- Sponsor's protocol ID
- AERCONINT
- Status last verified
- Feb 2023
- First submitted
- 26 Jan 2023
- Last updated
- 15 Feb 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Feb 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Aerobic Adaptations Following Two Iso-effort Training Programs: An Intense Continuous and a High-intensity Interval
- ClinicalTrials.gov ID
- NCT05729685
- Acronym / sponsor ID
- AERCONINT
- Conditions
- Healthy
- Keywords
- exercise, maximal oxygen consumption, endurance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Ilias SmiliosUniversity, hospital or other
- Study start
- 1 Sep 2020 (actual)
- Primary completion
- 10 Dec 2021 (actual)
- Study completion
- 10 Dec 2021 (actual)
- First posted
- 15 Feb 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this intervention study is to compare the adaptations after a 6-week training period between an intense continuous and a high-intensity interval training program performed under iso-effort conditions on aerobic performance parameters in young healthy adults. The main question it aims to answer are if the intense continuous and a high-intensity interval training programs will induce similar adaptations in maximal (VO2max and PTV) and submaximal (critical velocity, lactate threshold parameters and running economy) aerobic performance parameters. Participants will be ere randomly assigned either to an intense continuous training group (CON) or to a high-intensity interval training group (INT). The training program will comprise of 14 training sessions performed over a 6-week period.
Detailed description
The aim of this study was to compare the adaptations after a 6-week training period between the intense continuous and the high-intensity interval training methods performed under iso-effort conditions on maximal (VO2max and PTV) and submaximal (critical velocity, lactate threshold parameters and running economy) aerobic performance parameters.
A parallel group research design was used in the present study. Initially, 26 participants (10 males and 16 females), using stratified randomization (gender was the variable of stratification) were randomly assigned (1:1), according to a random-number table, either to an intense continuous training group (CON) or to a high-intensity interval training group (INT).
The INT group trained using the interval method. During the exercise sessions the participants ran each bout at an intensity corresponding to 90% of PTV. PTV was used to prescribe the exercise intensity at the INT group. The duration of the running-bouts was equal to ¼ of the individual time to exhaustion at 90% of PTV (determined during the CV testing) followed by passive rest equal to 2/3 of exercise duration. The duration of the exercise-bouts was individualized based on the time to exhaustion at 90% of PTV to reduce the between subject's variability. The participants terminated each exercise session when an RPE value of 17 was reached. Running bout duration and intensity were adjusted after 7 training sessions (during the 3rd week) following a reassessment of the time to exhaustion at 90% of the "new" PTV achieved during mid-testing as a result of training.
The CONT group trained using the continuous method. During the training sessions the participants ran with an intensity corresponding to -2,5% of CV until they reported a rating of 17 at the 6-20 Borg's scale. Running velocity was adjusted after 7 training sessions (during the 3rd week) after reassessment of CV. CV was used to determine the exercise intensity in the CONT group to ensure that all individuals would ran at the heavy intensity domain and be able to complete at least 15 min of continuous running, and to minimize the high inter-individual variations in endurance time at intensities near the upper limit of the heavy intensity domain. Using PTV to determine the intensity in the CONT group, would increase the possibility for trainees to exercise at different exercise intensity domains.
During the experiment, participants will not perform any other form of training besides of that applied in the current study. VO2max, PTV, oxygen consumptions, heart rates and the velocities corresponding to the 1st and the 2nd lactate thresholds (LT1 and LT2), the velocity at 4 mmol/L of blood lactate concentration (v4mmol), running economy, and critical velocity (CV) will be measured before, after 7 training sessions (3rd week, two days after the 7th training session), and after the completion of training program.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- A parallel group research design was used in the present study. Initially, 26 participants (10 males and 16 females), using stratified randomization (gender was the variable of stratification) were randomly assigned (1:1), according to a random-number table, either to an intense continuous training group (CON) or to a high-intensity interval training group (INT).
| Arm | Type | Receives |
|---|---|---|
| Interval training | Experimental | Other: Interval trainingThe interval group trained using the interval trainining method. |
| Continuous training | Experimental | Other: Continuous trainingThe continuous group trained using the continuous training method. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- All participants should have been involved in low intensity continuous training,
- All participants should have been training 1-3 times per week for 30-45 min for at least three months.
Key exclusion criteria (2 listed)
- Not familiar with aerobic training
- Any health issues that did not allow participation in regular exercise training.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Interval trainingThe interval training group trained using the interval method. During the exercise sessions the participants ran each bout at an intensity corresponding to 90% of PTV. PTV was used to prescribe the exercise intensity at the INT group. The duration of the running-bouts was equal to ¼ of the individual time to exhaustion at 90% of PTV (determined during the CV testing) followed by passive rest equal to 2/3 of exercise duration. The duration of the exercise-bouts was individualized based on the time to exhaustion at 90% of PTV to reduce the between subject's variability. The participants terminated each exercise session when an RPE value of 17 was reached. Running bout duration and intensity were adjusted after 7 training sessions (during the 3rd week) following a reassessment of the time to exhaustion at 90% of the "new" PTV achieved during mid-testing as a result of training. | Other | Interval training |
| Continuous trainingThe continuous group trained using the continuous method. During the training sessions the participants ran with an intensity corresponding to -2,5% of CV until they reported a rating of 17 at the 6-20 Borg's scale. Running velocity was adjusted after 7 training sessions (during the 3rd week) after reassessment of CV. CV was used to determine the exercise intensity in the CONT group to ensure that all individuals would ran at the heavy intensity domain and be able to complete at least 15 min of continuous running, and to minimize the high inter-individual variations in endurance time at intensities near the upper limit of the heavy intensity domain. Using PTV to determine the intensity in the CONT group, would increase the possibility for trainees to exercise at different exercise intensity domains. | Other | Continuous training |
Primary outcome
Changes in maximal oxygen consumption
Time frame: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Maximal oxygen consumption in ml/kg/min
Changes in peak treadmill velocity
Time frame: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Peak treadmill velocity using a maximal incremental test to exhaustion on a treadmill in km/h
Changes in running velocities at the 1st and the 2nd lactate thresholds
Time frame: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Running velocities (km/h) at the 1st and the 2nd lactate thresholds by measuring the changes in blood lactate concentration during a maximal incremental test to exhaustion on a treadmill.
Changes in critical velocity
Time frame: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Critical velocity (km/h) determined by having the participants ran until exhaustion at velocities corresponding to 90, 100, and 110% of peak treadmill velocity. Using linear regression analyses, the relationship between the distance covered at each run and the time to exhaustion was calculated. Τhe slope of the linear regression line was the critical velocity.
2 secondary outcomes
Changes in running economy
Time frame: At the beginning of the training program and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Changes in running velocity at a blood lactate concentration of 4 mmol/L
Time frame: At the beginning of the training program and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Feb 2023.
- Individual participant dataSharing planned: No
Related trials for Healthy
Enrolling by invitation
Development and Evaluation of Magnetic Resonance Imaging Acquisition and Analysis Methods
Healthy
RecruitingObservational study
Adaptive Optics Retinal Imaging
Eye Diseases, Healthy Volunteers
RecruitingObservational study
Characterization of Diseases With Salivary Gland Involvement
Healthy Volunteer, Sjogren's Syndrome
Enrolling by invitationObservational study
Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens)
Healthy Volunteer Samples
Not yet recruitingObservational study
Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
Healthy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Interval training and Continuous training in people with Healthy, run by Ilias Smilios at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Feb 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in maximal oxygen consumption (time frame: At the beginning of the training program, the 3rd week of training (after 7 training sessions), and the 7th week after the start of the intervention (after the completion of 6 weeks of training, 14 training sessions)). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Feb 2023; AzTrials last refreshed its copy on 28 Oct 2026.