StrokeNCT05736653
PCMS Task After Moderate-to-severe Stroke
A study testing Task-specific PCMS and PCMS-rest in people with Stroke, run by University of Utah at 1 site in United States.
Trial summary
Researchers at the University of Pittsburgh are conducting a research study to see how combining brain, nerve, and hand stimulation affect hand movement after stroke. The primary purpose of this study is to examine changes in the connection between the brain and the weak hand muscles after the combined brain, nerve… Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Stroke
- What is being tested?
- Task-specific PCMS and PCMS-rest
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 51 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Jun 2023to 21 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18-85 years
- Diagnosis of first-ever subcortical stroke (single cerebrovascular accident)
- Stroke onset of at least six months prior to the time of participation
- A score of at least 1 out of 2 on the spherical grasping item of the Fugl-Meyer Upper Extremity Subscale to allow participants to grasp the ball
- Cognitive skills to actively participate, as indicated by scores of > 23 on the Mini-Mental Status Examination
- English speaking
Who cannot join
- Inability to elicit a motor evoked potential (MEP) in the EDC muscle even with a 20% background muscle contraction
- Presence of severe aphasia
- Excessive spasticity of the wrist and finger muscles, defined as a Modified Ashworth Score >2
- Diagnosis of neurological disorders other than stroke
- History of seizure or epilepsy
- Orthopedic/musculoskeletal conditions (e.g., arthritis) affecting the upper extremity
Show all 16Show fewer
- Presence of metallic implants in the head or neck
- Currently or planning to become pregnant
- Difficulty maintaining alertness or remaining still
- Ferromagnetic metallic implants, pacemakers, other implanted devices, or ventilators for magnetic resonance imaging (MRI)
- Bodyweight > 300 lbs due to MRI scanner dimensions (for subjects also undergoing MRI)
- Psychiatric diagnosis according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-V), or who are on psychotropic medication
- Life expectancy less than the duration of the study
- Excessive pain in the paretic hand, defined as a Visual Analog Scale Score >4
- Participation in concurrent occupational therapy
- Current use of recreational drugs and stimulants like cocaine and methylenedioxymethamphetamine (MDMA)
Trial locations and contacts
1 site in 1 country.
United States1 site
Neural Plasticity Rehabilitation and Movement Dynamics Lab
Salt Lake City, Utah, 84108
About this study
Official title: Strengthening Task Specific Activation of Paretic Hand Muscles After moderate-to- Severe Chronic Stroke
Researchers at the University of Pittsburgh are conducting a research study to see how combining brain, nerve, and hand stimulation affect hand movement after stroke. The primary purpose of this study is to examine changes in the connection between the brain and the weak hand muscles after the combined brain, nerve, and hand stimulation. The primary hypothesis is that the combined brain, nerve, and hand stimulation will increase the the connection between the brain and the weak hand muscles. The secondary purpose of this study is to examine changes in weak hand's movement and function after the combined brain, nerve, and hand stimulation. The secondary hypothesis is that the combined brain, nerve, and hand stimulation will increase weak hand movement and function.
Read the detailed description
A total of 40 participants will be enrolled in this study. During the intervention sessions, Participants will receive three combinations of the brain, hand, and nerve stimulations.
Each participant will complete three intervention sessions for the short-term effect of the intervention. The time between sessions is 3-7 days. After data collection is completed for the short-term effect part of the study, 5 out of 40 participants will be randomly chosen to enroll in the long-term effect part of the intervention. Those participants will take part in 18 intervention sessions. The sessions will be administered three times a week for six weeks.
In the short-term effect part of the study, participants will complete the following three sessions:
- Repeated brain, hand, and nerve stimulations while practicing a task. In this session, participants will receive 120 pairs of brain, hand, and nerve stimulation while repeatedly grasp and release a ball with the weak hand. The hand stimulation will help participants to release the ball.
- Repeated brain and nerve stimulations during rest. In this session, participants will receive 120 pairs of brain and nerve stimulation while the weak hand is resting (or not performing a task).
- Hand stimulation while practicing a task. In this session, participants will practice grasping and releasing the task 120 times with hand stimulation. The hand stimulation will help participants to release the ball.
In the long-term effect part of the study, participants will complete the following session (3/week for 6 weeks):
During the intervention, participants will receive repeated brain, hand, and nerve stimulations while practicing a task. They will receive 120 pairs of brain, hand, and nerve stimulation while repeatedly grasp and release a ball with the weak hand. The hand stimulation will help participants to release the ball. We will give rest breaks during the practice of the task.
- Conditions
- Stroke
- Being tested
- Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest
- Keywords
- Stroke, Hand, Brain stimulation
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Task-specific PCMSDevice
120 pairs of TMS and PNS volleys will be administered during electromyography-triggered functional electrical stimulation (FES)-assisted task-specific training (task-specific PCMS). In the task-specific PCMS, participants will first grasp a spherical ball when prompted by an auditory 'Ready' cue, and upon seeing a visual 'Go' cue will voluntarily extend the wrist and fingers to release the ball. After the 'Go cue', our customized stimulation delivery algorithm triggers the TMS and PNS only when the extensor digitorum communis (EDC) muscle activity exceeds a pre-determined threshold. The algorithm will then trigger FES to EDC after detecting EDC activity (~2 ms after PNS) for the next 2 seconds, allowing the pairing of PCMS (TMS and PNS) with the voluntary movement of EDC without the confounding effects of FES.
Task-specific sham-PCMSDevice
120 pairs of sham-PCMS stimuli will be administered during task-specific practice. The TMS coil will be placed ~10 cm behind the participant's head, and PNS electrodes will be placed in the same position as for task-specific PCMS, but no stimulation will be delivered. Like the task-specific PCMS condition, participants will perform the same grasp and release a ball task in an identical manner. FES will be delivered after detecting voluntary EDC activity, similar to the task-specific PCMS condition.
PCMS-restDevice
120 pairs of TMS and PNS volleys will be administered with the EDC muscle at rest every 10 s (~20 min, 0.1 Hz). TMS will be used to elicit motor-evoked potentials (MEPs). Antidromic activation of spinal motor neurons will be elicited by supramaximal peripheral nerve stimulation (PNS) applied to the radial nerve near the elbow. Volleys will be timed to arrive in the spinal cord based on central and peripheral conduction times calculated for each subject so that the pre-synaptic terminal is depolarized via TMS ~1-2 ms before spinal motor neurons are depolarized via PNS at a pulse duration of 200us. We will also perform stimulation of the cervical roots (C-root) by placing the coil behind the neck and stimulating the C-root (C6 and C7 vertebrae), which innervate the finger extensor muscles. Conduction times will be calculated from latencies of the primary motor area (M1) MEP, C-root, and M-wave.
| Study group | Role | What they receive |
|---|---|---|
| Task-specific PCMS, PCMS-rest, Task-specific sham-PCMS | Experimental | During Task-specific paired corticospinal-motor neuronal stimulation (PCMS) participants will receive PCMS [Transcranial Magnetic Stimulation (TMS) + Peripheral Nerve Stimulation (PNS)] with task-specific practice.
During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.
During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). Receives: Device: Task-specific PCMS; Device: Task-specific sham-PCMS; Device: PCMS-rest |
| Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest | Experimental | During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.
During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.
During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). Receives: Device: Task-specific PCMS; Device: Task-specific sham-PCMS; Device: PCMS-rest |
| PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS | Experimental | During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.
During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.
During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). Receives: Device: Task-specific PCMS; Device: Task-specific sham-PCMS; Device: PCMS-rest |
| PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS | Experimental | During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.
During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.
During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). Receives: Device: Task-specific PCMS; Device: Task-specific sham-PCMS; Device: PCMS-rest |
| Task-specific sham-PCMS, Task-specific PCMS, PCMS-rest | Experimental | During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.
During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.
During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). Receives: Device: Task-specific PCMS; Device: Task-specific sham-PCMS; Device: PCMS-rest |
| Task-specific sham-PCMS, PCMS-rest, Task-specific PCMS | Experimental | During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.
During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.
During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). Receives: Device: Task-specific PCMS; Device: Task-specific sham-PCMS; Device: PCMS-rest |
What is being measured
The primary outcome is the main question the study is designed to answer.
Transcranial magnetic stimulation to evaluate corticospinal transmission
Corticospinal transmission will be assessed by examining the percent change of the peak-to-peak motor evoked potential (MEP) amplitude relative to baseline.
Measured: Change from baseline up to 30-minutes post intervention
Secondary outcomes (4)
Voluntary force production to evaluate motor performance
We will measure force production of the wrist and finger extensors (EDC) to evaluate motor performance using load cells embedded in cushioned customized platforms. Participants will perform isometric wrist and finger extension movements against load cells. We will calculate the percent change of maximum force output.
Measured: Change from baseline up to 30-minutes post intervention
Maximum finger excursions to evaluate motor performance
Three-dimensional biomechanical data will be collected to evaluate motor performance using a motion capture system. Reflective markers will be placed on the participant's paretic forearm, hand, and fingers to track wrist and finger movements during a maximum hand opening task. Hand biomechanics will be evaluated by computing the percent change of maximum finger excursions during the hand opening task.
Measured: Change from baseline up to 30-minutes post intervention
Maximum finger spread to evaluate motor performance
Three-dimensional biomechanical data will be collected to evaluate motor performance using a motion capture system. Reflective markers will be placed on the participant's paretic forearm, hand, and fingers to track wrist and finger movements during a maximum hand opening task. Hand biomechanics will be evaluated by computing the percent change of maximum finger spread during the hand opening task.
Measured: Change from baseline up to 30-minutes post intervention
Box and Block Test
The Box and Block Test (BBT) measures unilateral gross manual dexterity and the ability to release objects. We will calculate the percent change of the total number of blocks transferred in one minute.
Measured: Change from baseline up to 30-minutes post intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Feb 2023
- Study start29 Jun 2023
- Primary completion21 Dec 2025
- Study completion21 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- We will employ a single group pre-post design.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 51 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Utah
- Sponsor type
- University, hospital or other
- Collaborators
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Responsible party
- Principal investigator, Amit Sethi, University of Utah
- Investigators
- Amit Sethi, PhD, Principal investigator, University of Utah
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05736653
- Sponsor's protocol ID
- 00179089
- Other IDs
- R21HD108462
- Status last verified
- May 2026
- First submitted
- 10 Feb 2023
- Last updated
- 27 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Strengthening Task Specific Activation of Paretic Hand Muscles After moderate-to- Severe Chronic Stroke
- ClinicalTrials.gov ID
- NCT05736653
- Acronym / sponsor ID
- 00179089
- Conditions
- Stroke
- Keywords
- Stroke, Hand, Brain stimulation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 51 participants (actual)
- Lead sponsor
- University of UtahUniversity, hospital or other
- Collaborators
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Study start
- 29 Jun 2023 (actual)
- Primary completion
- 21 Dec 2025 (actual)
- Study completion
- 21 Dec 2025 (actual)
- First posted
- 21 Feb 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Researchers at the University of Pittsburgh are conducting a research study to see how combining brain, nerve, and hand stimulation affect hand movement after stroke. The primary purpose of this study is to examine changes in the connection between the brain and the weak hand muscles after the combined brain, nerve, and hand stimulation. The primary hypothesis is that the combined brain, nerve, and hand stimulation will increase the the connection between the brain and the weak hand muscles. The secondary purpose of this study is to examine changes in weak hand's movement and function after the combined brain, nerve, and hand stimulation. The secondary hypothesis is that the combined brain, nerve, and hand stimulation will increase weak hand movement and function.
Detailed description
A total of 40 participants will be enrolled in this study. During the intervention sessions, Participants will receive three combinations of the brain, hand, and nerve stimulations.
Each participant will complete three intervention sessions for the short-term effect of the intervention. The time between sessions is 3-7 days. After data collection is completed for the short-term effect part of the study, 5 out of 40 participants will be randomly chosen to enroll in the long-term effect part of the intervention. Those participants will take part in 18 intervention sessions. The sessions will be administered three times a week for six weeks.
In the short-term effect part of the study, participants will complete the following three sessions:
- Repeated brain, hand, and nerve stimulations while practicing a task. In this session, participants will receive 120 pairs of brain, hand, and nerve stimulation while repeatedly grasp and release a ball with the weak hand. The hand stimulation will help participants to release the ball.
- Repeated brain and nerve stimulations during rest. In this session, participants will receive 120 pairs of brain and nerve stimulation while the weak hand is resting (or not performing a task).
- Hand stimulation while practicing a task. In this session, participants will practice grasping and releasing the task 120 times with hand stimulation. The hand stimulation will help participants to release the ball.
In the long-term effect part of the study, participants will complete the following session (3/week for 6 weeks):
During the intervention, participants will receive repeated brain, hand, and nerve stimulations while practicing a task. They will receive 120 pairs of brain, hand, and nerve stimulation while repeatedly grasp and release a ball with the weak hand. The hand stimulation will help participants to release the ball. We will give rest breaks during the practice of the task.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind (participant)
- Number of arms
- 6
- Model description
- We will employ a single group pre-post design.
| Arm | Type | Receives |
|---|---|---|
| Task-specific PCMS, PCMS-rest, Task-specific sham-PCMS | Experimental | Device: Task-specific PCMS, Device: Task-specific sham-PCMS, Device: PCMS-restDuring Task-specific paired corticospinal-motor neuronal stimulation (PCMS) participants will receive PCMS [Transcranial Magnetic Stimulation (TMS) + Peripheral Nerve Stimulation (PNS)] with task-specific practice. During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice. During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). |
| Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest | Experimental | Device: Task-specific PCMS, Device: Task-specific sham-PCMS, Device: PCMS-restDuring Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice. During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice. During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). |
| PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS | Experimental | Device: Task-specific PCMS, Device: Task-specific sham-PCMS, Device: PCMS-restDuring Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice. During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice. During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). |
| PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS | Experimental | Device: Task-specific PCMS, Device: Task-specific sham-PCMS, Device: PCMS-restDuring Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice. During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice. During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). |
| Task-specific sham-PCMS, Task-specific PCMS, PCMS-rest | Experimental | Device: Task-specific PCMS, Device: Task-specific sham-PCMS, Device: PCMS-restDuring Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice. During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice. During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). |
| Task-specific sham-PCMS, PCMS-rest, Task-specific PCMS | Experimental | Device: Task-specific PCMS, Device: Task-specific sham-PCMS, Device: PCMS-restDuring Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice. During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice. During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS). |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age between 18-85 years
- Diagnosis of first-ever subcortical stroke (single cerebrovascular accident)
- Stroke onset of at least six months prior to the time of participation
- A score of at least 1 out of 2 on the spherical grasping item of the Fugl-Meyer Upper Extremity Subscale to allow participants to grasp the ball
- Cognitive skills to actively participate, as indicated by scores of > 23 on the Mini-Mental Status Examination
Key exclusion criteria (16 listed)
- Inability to elicit a motor evoked potential (MEP) in the EDC muscle even with a 20% background muscle contraction
- Presence of severe aphasia
- Excessive spasticity of the wrist and finger muscles, defined as a Modified Ashworth Score >2
- Diagnosis of neurological disorders other than stroke
- History of seizure or epilepsy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Task-specific PCMS120 pairs of TMS and PNS volleys will be administered during electromyography-triggered functional electrical stimulation (FES)-assisted task-specific training (task-specific PCMS). In the task-specific PCMS, participants will first grasp a spherical ball when prompted by an auditory 'Ready' cue, and upon seeing a visual 'Go' cue will voluntarily extend the wrist and fingers to release the ball. After the 'Go cue', our customized stimulation delivery algorithm triggers the TMS and PNS only when the extensor digitorum communis (EDC) muscle activity exceeds a pre-determined threshold. The algorithm will then trigger FES to EDC after detecting EDC activity (~2 ms after PNS) for the next 2 seconds, allowing the pairing of PCMS (TMS and PNS) with the voluntary movement of EDC without the confounding effects of FES. | Device | PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS, Task-specific PCMS, PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest, Task-specific sham-PCMS, PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS, Task-specific PCMS, PCMS-rest |
| Task-specific sham-PCMS120 pairs of sham-PCMS stimuli will be administered during task-specific practice. The TMS coil will be placed ~10 cm behind the participant's head, and PNS electrodes will be placed in the same position as for task-specific PCMS, but no stimulation will be delivered. Like the task-specific PCMS condition, participants will perform the same grasp and release a ball task in an identical manner. FES will be delivered after detecting voluntary EDC activity, similar to the task-specific PCMS condition. | Device | PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS, Task-specific PCMS, PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest, Task-specific sham-PCMS, PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS, Task-specific PCMS, PCMS-rest |
| PCMS-rest120 pairs of TMS and PNS volleys will be administered with the EDC muscle at rest every 10 s (~20 min, 0.1 Hz). TMS will be used to elicit motor-evoked potentials (MEPs). Antidromic activation of spinal motor neurons will be elicited by supramaximal peripheral nerve stimulation (PNS) applied to the radial nerve near the elbow. Volleys will be timed to arrive in the spinal cord based on central and peripheral conduction times calculated for each subject so that the pre-synaptic terminal is depolarized via TMS ~1-2 ms before spinal motor neurons are depolarized via PNS at a pulse duration of 200us. We will also perform stimulation of the cervical roots (C-root) by placing the coil behind the neck and stimulating the C-root (C6 and C7 vertebrae), which innervate the finger extensor muscles. Conduction times will be calculated from latencies of the primary motor area (M1) MEP, C-root, and M-wave. | Device | PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS, Task-specific PCMS, PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest, Task-specific sham-PCMS, PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS, Task-specific PCMS, PCMS-rest |
Primary outcome
Transcranial magnetic stimulation to evaluate corticospinal transmission
Time frame: Change from baseline up to 30-minutes post intervention
Corticospinal transmission will be assessed by examining the percent change of the peak-to-peak motor evoked potential (MEP) amplitude relative to baseline.
4 secondary outcomes
Voluntary force production to evaluate motor performance
Time frame: Change from baseline up to 30-minutes post intervention
Maximum finger excursions to evaluate motor performance
Time frame: Change from baseline up to 30-minutes post intervention
Maximum finger spread to evaluate motor performance
Time frame: Change from baseline up to 30-minutes post intervention
Box and Block Test
Time frame: Change from baseline up to 30-minutes post intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Amit Sethi, PhD principal investigator
University of Utah
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Task-specific PCMS and PCMS-rest in people with Stroke, run by University of Utah at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Transcranial magnetic stimulation to evaluate corticospinal transmission (time frame: Change from baseline up to 30-minutes post intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.