OcclusionNCT05737290
Effects of Clear Aligners Versus Fixed Appliances on Occlusion After Treatment of Mild Anterior Crowding
A study testing Clear aligners and Fixed appliances in people with Occlusion, run by Al-Azhar University at 1 site in Egypt.
Trial summary
The aim of this study is to evaluate effects of clear aligners versus fixed appliances on occlusion after treatment of mild anterior crowding a T-scan study. Read more about this study
- Who is it for?
- Ages 14 to 22 yearsHealthy volunteers can take part
- Conditions the study is for
- Occlusion
- What is being tested?
- Clear aligners and Fixed appliances
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteEgypt
- Study dates
- 1 May 2024to 1 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 22 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Patients between the age (14-22 years).
- Fully erupted permanent dentition, 3rd molars excluded.
- Healthy, compliant, and motivated patients who can visit the department regularly.
- Non-extraction treatment.
- Class I with mild anterior crowding lower and/ or upper.
- Good oral and general health.
Who cannot join
- Previous orthodontic treatment.
- Craniofacial abnormalities, congenital syndromes of the craniofacial area.
- Anterior or posterior crossbite.
- Anterior or lateral open bite.
- Poor oral hygiene or periodontally compromised patient.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Clear Aligners Versus Fixed Appliances on Occlusion After Treatment of Mild Anterior Crowding: A T-scan Study.
The aim of this study is to evaluate effects of clear aligners versus fixed appliances on occlusion after treatment of mild anterior crowding a T-scan study.
Read the detailed description
Intervention:
Group 1. Patients treated with clear aligner. Patients with mild anterior crowding will be treated with non-extraction treatment using clear aligners.
Group 2. Patients treated with fixed appliance. Patients with mild anterior crowding will be treated with non-extraction treatment using fixed appliances.
Observations:
Multi-bite closure in centric occlusion using T-Scan® recordings were obtained before and after treatment from each subject to measure the occlusal parameters to be analyzed during this study.
- Conditions
- Occlusion
- Being tested
- Clear aligners, Fixed appliances
- Keywords
- Clear aligners, Fixed appliances, Anterior crowding, Occlusion, T scan
- Medical subject headings
- Bites and Stings
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Clear alignersDevice
Patients with mild anterior crowding will be treated with non-extraction treatment using clear aligners.
Fixed appliancesDevice
Patients with mild anterior crowding will be treated with non-extraction treatment using fixed appliances.
| Study group | Role | What they receive |
|---|---|---|
| Group A | Active comparator | Not described Receives: Device: Clear aligners |
| Group B | Active comparator | Not described Receives: Device: Fixed appliances |
What is being measured
The primary outcome is the main question the study is designed to answer.
Distribution of occlusal forces
Amount of magnitude of occlusal forces after treatment by clear aligners
Measured: 1 Year and 6 Months
Distribution of occlusal forces
Amount of magnitude of occlusal forces after treatment by fixed appliances
Measured: 1 Year and 6 Months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Feb 2023
- Study start1 May 2024
- Primary completion1 Mar 2026
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for OcclusionStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Moaz Hafez Abdelrahman Hafez, Al-Azhar University
- Investigators
- Moaz Hafez Abdelrhman, Master, Principal investigator, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05737290
- Sponsor's protocol ID
- 893/2838
- Status last verified
- May 2026
- First submitted
- 6 Feb 2023
- Last updated
- 13 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The aim of this study is to evaluate effects of clear aligners versus fixed appliances on occlusion after treatment of mild anterior crowding a T-scan study.
Publications
Weir T. Invisalign treatment of lower incisor extraction cases. Aust Orthod J. 2016 May;32(1):82-7.
PubMed 27468595
Study at a glance
From the registry record, last updated by the sponsor on 13 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Clear Aligners Versus Fixed Appliances on Occlusion After Treatment of Mild Anterior Crowding: A T-scan Study.
- ClinicalTrials.gov ID
- NCT05737290
- Acronym / sponsor ID
- 893/2838
- Conditions
- Occlusion
- Keywords
- Clear aligners, Fixed appliances, Anterior crowding, Occlusion, T scan
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 1 Mar 2026 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 21 Feb 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate effects of clear aligners versus fixed appliances on occlusion after treatment of mild anterior crowding a T-scan study.
Detailed description
Intervention:
Group 1. Patients treated with clear aligner. Patients with mild anterior crowding will be treated with non-extraction treatment using clear aligners.
Group 2. Patients treated with fixed appliance. Patients with mild anterior crowding will be treated with non-extraction treatment using fixed appliances.
Observations:
Multi-bite closure in centric occlusion using T-Scan® recordings were obtained before and after treatment from each subject to measure the occlusal parameters to be analyzed during this study.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A | Active comparator | Device: Clear aligners |
| Group B | Active comparator | Device: Fixed appliances |
Who may qualify
- Ages
- 14 to 22 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (6 listed)
- Patients between the age (14-22 years).
- Fully erupted permanent dentition, 3rd molars excluded.
- Healthy, compliant, and motivated patients who can visit the department regularly.
- Non-extraction treatment.
- Class I with mild anterior crowding lower and/ or upper.
Key exclusion criteria (5 listed)
- Previous orthodontic treatment.
- Craniofacial abnormalities, congenital syndromes of the craniofacial area.
- Anterior or posterior crossbite.
- Anterior or lateral open bite.
- Poor oral hygiene or periodontally compromised patient.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Clear alignersPatients with mild anterior crowding will be treated with non-extraction treatment using clear aligners. | Device | Group A |
| Fixed appliancesPatients with mild anterior crowding will be treated with non-extraction treatment using fixed appliances. | Device | Group B |
Primary outcome
Distribution of occlusal forces
Time frame: 1 Year and 6 Months
Amount of magnitude of occlusal forces after treatment by clear aligners
Distribution of occlusal forces
Time frame: 1 Year and 6 Months
Amount of magnitude of occlusal forces after treatment by fixed appliances
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 May 2026.
- Background: PubMed 27468595Weir T. Invisalign treatment of lower incisor extraction cases. Aust Orthod J. 2016 May;32(1):82-7.
- Individual participant dataSharing planned: Yes. The aim of this study is to evaluate effects of clear aligners versus fixed appliances on occlusion after treatment of mild anterior crowding a T-scan study.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Moaz Hafez Abdelrhman, Master principal investigator
Al-Azhar University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Clear aligners and Fixed appliances in people with Occlusion, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Distribution of occlusal forces (time frame: 1 Year and 6 Months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05737290, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2026.