DepressionNCT05755165
Adolescent Depression: Video Ads on Instagram
A study testing Depression and Depression, adjusted in people with Depression and Stigmatization, run by Yale University at 2 sites in United States.
Trial summary
The purposes of this study are to test among adolescent viewers the utility of different types of selfie short video-based messaging to: 1. Reduce stigma and self-stigma related to depression, and 2. Increase treatment-seeking intentions. Read more about this study
- Who is it for?
- Ages 14 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Depression, Stigmatization
- What is being tested?
- Depression and Depression, adjusted
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1,235 participants
- Where
- 2 sitesUnited States
- Study dates
- 1 Aug 2024to 1 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- English-speaking
- Living in the US
- Ages 14 - 18
Who cannot join
- None
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Yale Child Center
New Haven, Connecticut, 06510
Yale Child Study Center
New Haven, Connecticut, 06510
About this study
Official title: Reducing Depression-related Stigma and Increasing Help-seeking Intentions: a Randomized Trial of Video Ads on Instagram
The purposes of this study are to test among adolescent viewers the utility of different types of selfie short video-based messaging to:
- Reduce stigma and self-stigma related to depression, and
- Increase treatment-seeking intentions.
Read the detailed description
Intervention videos will each be self-recorded videos (of ~90-second duration) featuring the same underage professional (ages 16) acting as simulated participant. The investigators will post three brief videos ('video Ads') to achieve similar exposure among Instagram users, 14-18-year-old. The videos are: (a) depression video; (b) depression video adjusted to race experiences, and (c) control videos. All videos will feature by the same Black adolescent girl.
The investigators intend to assign ~10,000 individuals aged 14-18 in a randomized way, in equal proportions, and stratified by sex and race, to view one of the three videos.
Outcomes will include:
- Primary outcome: engagement (a composite of likes, shares, comments, and views)
- Secondary outcome: clicks on a designated link at the end of the video ad.
- Conditions
- Depression, Stigmatization
- Being tested
- Depression, Depression, adjusted, Control
- Medical subject headings
- Depression, Stereotyping
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
DepressionBehavioural
~90-second selfie video of an adolescent discussing her history of depression, treatment, and recovery
Depression, adjustedBehavioural
~90-second selfie video of an adolescent discussing her history of depression, treatment, and recovery - and including explicit reference to the role of anti-Black racism as a contributing factor
ControlBehavioural
~90-second selfie video of an adolescent discussing everyday activities and interests, with no reference to depression or racism.
| Study group | Role | What they receive |
|---|---|---|
| Depression | Active comparator | Adolescent depression Receives: Behavioral: Depression |
| Depression, adjusted | Active comparator | Adolescent depression, impacted by racism Receives: Behavioral: Depression, adjusted |
| Control | Active comparator | Control condition Receives: Behavioral: Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Engagement composite
A sum of views, likes, shares, and comments on Instagram.
The composite is an ordinal number ranging from 0 to n; higher values indicate greater engagement with the Instagram add.
Measured: Day 1: within 10 minutes of viewing the ad
Secondary outcomes (1)
Clicks on designated link
The number of clicks on a designated link at the end of the video ad.
Clicks are an ordinal number ranging from 0 to n; higher values indicate greater engagement with the Instagram add.
Measured: Day 1: within 10 minutes of viewing the ad
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2023
- Study start1 Aug 2024
- Primary completion1 Sep 2024
- Study completion1 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for DepressionStudies of the same condition, open and under way.
- More trials run by Yale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 1,235 participants (actual)
Sponsor and investigators
- Lead sponsor
- Yale University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05755165
- Sponsor's protocol ID
- 2000028980_e
- Other IDs
- No NIH funding
- Status last verified
- Nov 2024
- First submitted
- 15 Feb 2023
- Last updated
- 8 Nov 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Martin A, Calhoun A, Paez J, Amsalem D. Destigmatizing perceptions about Black adolescent depression: randomized controlled trial of brief social contact-based video interventions. J Child Psychol Psychiatry. 2022 Nov;63(11):1270-1278. doi: 10.1111/jcpp.13570. Epub 2022 Jan 23.
PubMed 35066880Amsalem D, Martin A. Reducing depression-related stigma and increasing treatment seeking among adolescents: randomized controlled trial of a brief video intervention. J Child Psychol Psychiatry. 2022 Feb;63(2):210-217. doi: 10.1111/jcpp.13427. Epub 2021 Apr 6.
PubMed 33821507Amsalem D, Halloran J, Penque B, Celentano J, Martin A. Effect of a Brief Social Contact Video on Transphobia and Depression-Related Stigma Among Adolescents: A Randomized Clinical Trial. JAMA Netw Open. 2022 Feb 1;5(2):e220376. doi: 10.1001/jamanetworkopen.2022.0376.
PubMed 35212749
Study at a glance
From the registry record, last updated by the sponsor on 8 Nov 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Reducing Depression-related Stigma and Increasing Help-seeking Intentions: a Randomized Trial of Video Ads on Instagram
- ClinicalTrials.gov ID
- NCT05755165
- Acronym / sponsor ID
- 2000028980_e
- Conditions
- Depression, Stigmatization
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 1,235 participants (actual)
- Lead sponsor
- Yale UniversityUniversity, hospital or other
- Study start
- 1 Aug 2024 (actual)
- Primary completion
- 1 Sep 2024 (actual)
- Study completion
- 1 Sep 2024 (actual)
- First posted
- 6 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purposes of this study are to test among adolescent viewers the utility of different types of selfie short video-based messaging to:
- Reduce stigma and self-stigma related to depression, and
- Increase treatment-seeking intentions.
Detailed description
Intervention videos will each be self-recorded videos (of ~90-second duration) featuring the same underage professional (ages 16) acting as simulated participant. The investigators will post three brief videos ('video Ads') to achieve similar exposure among Instagram users, 14-18-year-old. The videos are: (a) depression video; (b) depression video adjusted to race experiences, and (c) control videos. All videos will feature by the same Black adolescent girl.
The investigators intend to assign ~10,000 individuals aged 14-18 in a randomized way, in equal proportions, and stratified by sex and race, to view one of the three videos.
Outcomes will include:
- Primary outcome: engagement (a composite of likes, shares, comments, and views)
- Secondary outcome: clicks on a designated link at the end of the video ad.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Depression | Active comparator | Behavioral: DepressionAdolescent depression |
| Depression, adjusted | Active comparator | Behavioral: Depression, adjustedAdolescent depression, impacted by racism |
| Control | Active comparator | Behavioral: ControlControl condition |
Who may qualify
- Ages
- 14 to 18 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (3 listed)
- English-speaking
- Living in the US
- Ages 14 - 18
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Depression~90-second selfie video of an adolescent discussing her history of depression, treatment, and recovery | Behavioural | Depression |
| Depression, adjusted~90-second selfie video of an adolescent discussing her history of depression, treatment, and recovery - and including explicit reference to the role of anti-Black racism as a contributing factor | Behavioural | Depression, adjusted |
| Control~90-second selfie video of an adolescent discussing everyday activities and interests, with no reference to depression or racism. | Behavioural | Control |
Primary outcome
Engagement composite
Time frame: Day 1: within 10 minutes of viewing the ad
A sum of views, likes, shares, and comments on Instagram. The composite is an ordinal number ranging from 0 to n; higher values indicate greater engagement with the Instagram add.
1 secondary outcome
Clicks on designated link
Time frame: Day 1: within 10 minutes of viewing the ad
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Nov 2024.
- Background: PubMed 35066880Martin A, Calhoun A, Paez J, Amsalem D. Destigmatizing perceptions about Black adolescent depression: randomized controlled trial of brief social contact-based video interventions. J Child Psychol Psychiatry. 2022 Nov;63(11):1270-1278. doi: 10.1111/jcpp.13570. Epub 2022 Jan 23.
- Background: PubMed 33821507Amsalem D, Martin A. Reducing depression-related stigma and increasing treatment seeking among adolescents: randomized controlled trial of a brief video intervention. J Child Psychol Psychiatry. 2022 Feb;63(2):210-217. doi: 10.1111/jcpp.13427. Epub 2021 Apr 6.
- Background: PubMed 35212749Amsalem D, Halloran J, Penque B, Celentano J, Martin A. Effect of a Brief Social Contact Video on Transphobia and Depression-Related Stigma Among Adolescents: A Randomized Clinical Trial. JAMA Netw Open. 2022 Feb 1;5(2):e220376. doi: 10.1001/jamanetworkopen.2022.0376.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Depression and Depression, adjusted in people with Depression and Stigmatization, run by Yale University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Nov 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Engagement composite (time frame: Day 1: within 10 minutes of viewing the ad). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05755165, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Nov 2024.