Human HealthNCT05773794

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

A study testing Soymilk, green tea, or blueberry in people with Human Health and Reactive Carbonyl Species, run by North Carolina Agriculture & Technical State University at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids. Read more about this study

Who is it for?: Ages 25 to 70 yearsHealthy volunteers can take part
Conditions the study is for: Human Health, Reactive Carbonyl Species, Polyphenols
What is being tested?: Soymilk, green tea, or blueberry
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 48 participants
Where: 1 siteUnited States
Study dates: 6 Feb 2023to 19 Dec 2023
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 25 to 70 years
All sexes
Healthy volunteers accepted
Adult, Older adult

Who may be able to join

Age 25-70 years
BMI between 18 and 30
Have no known allergy to soy milk
Be not taking antibiotics for six months
Be not currently taking medication
No taking any prescription drugs

Show all 15Show fewer

If supplements were taken, flavonoid-enriched supplements (see list below) should be avoided.
Major brands Notes: All flavonoid-enriched supplements should be avoided. Soy Isoflavones/ tea/blueberry Lipo-Flavonoid Citrus Bioflavonoids Complex Super Flavonoids Super Antioxidants Quercetin Supplement Essential-C and flavonoids Milk Thistle Other flavonoids supplements, including but not limited: Luteolin, Rutin, etc
No any drugs or supplements within three weeks of the experiment
Be nonsmoking
Have no alcoholic intoxication
No alcoholic addiction
< 3-4 drinks per week (less than 2 glasses (300 mL) per drink)
No alcohol within 3 three weeks of the experiment
Have no extended exposure to industrial wastes

Who cannot join

Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders
Cancer patients
Currently diagnosed cancer patients will be excluded;
Medication free for >2 years could be considered;

Trial locations and contacts

1 site in 1 country.

United States1 site

North Carolina Agriculture and Technical State University
Kannapolis, North Carolina, 28081

Other trials in United States

About this study

Official title: Scavenging of Reactive Carbonyl Species by Dietary Flavonoids From Soymilk, Green Tea, and Blueberry in Humans

Read the detailed description

A crossover design was used. Sixteen healthy volunteers (16 for each study, in total 48) were recruited and asked to avoid the consumption of any soymilk, green tea, and blueberry products starting 1 week before intervention and continuing throughout the entire study for a total of 3 weeks.

On week 2, each of the eight participants received 460 ml of soymilk, green tea, and blueberry in a single dose, and afterward, urine and blood samples at different time points over 24 h and fecal samples at different time points over 48 h were collected. Meanwhile, the other eight participants received breakfast (without any soymilk, green tea, and blueberry) at different time points over 48 h were collected.

On the contrary, on week 3, eight participants who received regular milk or water on week 2 received breakfast only, and eight participants who were used as a control on week 2 received soymilk, green tea, and blueberry. And urine and blood samples at different time points over 24 h, and fecal samples at different time points over 48 h for both groups were collected.

Samples will be analyzed by LC-MS/MS. The Pharmacokinetics of conjugates will be investigated.

Conditions: Human Health, Reactive Carbonyl Species, Polyphenols
Being tested: Soymilk, green tea, or blueberry, Control group
Keywords: dietary flavonoids, Pharmacokinetics, Reactive Carbonyl Species, Polyphenols

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Soymilk, green tea, or blueberryDietary supplement
One dose of soymilk, green tea, or blueberry blends (460mL) with breakfast.
Control groupDietary supplement
Breakfast with milk or water, without soymilk, green tea, or blueberry blends.

Study groups in NCT05773794
Study group	Role	What they receive
Dietary flavonoids (soymilk) consumption	Experimental	Week 1: Sixteen healthy volunteers were recruited and instructed to avoid consuming soymilk, green tea, and blueberry products starting one week before the intervention and continuing throughout the entire 3-week study period. Week 2: Participants consumed a breakfast including 460 mL of soymilk (or milk) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Week 3: Participants consumed a breakfast including 460 mL of milk (or soymilk) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Receives: Dietary Supplement: Soymilk, green tea, or blueberry; Dietary Supplement: Control group
Dietary flavonoids (blueberry) consumption	Experimental	Week 1: Sixteen healthy volunteers were recruited and instructed to avoid consuming soymilk, green tea, and blueberry products starting one week before the intervention and continuing throughout the entire 3-week study period. Week 2: Participants consumed a breakfast including 460 mL of blueberry water (or placebo sweet water) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Week 3: Participants consumed a breakfast including 460 mL of placebo sweet water (or blueberry water) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Receives: Dietary Supplement: Soymilk, green tea, or blueberry; Dietary Supplement: Control group
Dietary flavonoids (green tea) consumption	Experimental	Week 1: Sixteen healthy volunteers were recruited and instructed to avoid consuming soymilk, green tea, and blueberry products starting one week before the intervention and continuing throughout the entire 3-week study period. Week 2: Participants consumed a breakfast including 460 mL of green tea (or water) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Week 3: Participants consumed a breakfast including 460 mL of water (or green tea) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Receives: Dietary Supplement: Soymilk, green tea, or blueberry; Dietary Supplement: Control group

What is being measured

The primary outcome is the main question the study is designed to answer.

Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.
Major RCS in urine will be outlined using Liquid chromatography-tandem mass spectrometry (LC-MS). The urinary levels of major RCS over 8 h after one single dose of soymilk, green tea, or blueberry consumption will be quantified using LC-MS.
Measured: assessed at 0-2 hours, 2-4 hours, 4-6 hours, and 6-8 hours post-dose
Change in Plasma Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 4 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.
Major RCS in plasma will be outlined using liquid chromatography-tandem mass spectrometry (LC-MS). The major RCS levels in plasma over 4 h after one single dose of soymilk, green tea, or blueberry consumption will be quantified using LC-MS.
Measured: assessed at 0 hour, 0.5 hour, 1 hour, 1.5 hours, 2 hours, 3 hours, and 4 hours post-dose
Change in Urinary Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.
Major RCS conjugates of polyphenols in urine after soymilk, green tea, or blueberry consumption will be profiled using liquid chromatography-tandem mass spectrometry (LC-MS). The levels of major RCS conjugates in urine over 24 h after soymilk, green tea, or blueberry consumption will be quantified using LC-MS.
Measured: 0-2 hours, 2-4 hours, 4-6 hours,6-8 hours, 8-12 hours, and 12-24 hours post-dose

Secondary outcomes (2)

Change in Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols in Feces Over 48 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.
Major RCS adducts in fecal samples after soymilk, green tea, or blueberry consumption will be profiled. Liquid chromatography-tandem mass spectrometry will be utilized to assess RCS adducts of soymilk, green tea, or blueberry polyphenols in fecal samples.
Measured: 0 hour, 24 hours, and 48 hours post-dose
Change in Plasma Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.
Liquid chromatography-tandem mass spectrometry will be utilized to assess RCS adducts of soymilk, green tea, or blueberry polyphenols in plasma over 24 hours after one single dose of soymilk, green tea, or blueberry consumption.
Measured: 0 hour, 0.5 hour, 1 hour, 1.5 hours, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, and 24 hours pose dose

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

6 Feb 202319 Dec 2023

First posted17 Mar 2023
Study start6 Feb 2023
Primary completion19 Dec 2023
Study completion19 Dec 2023

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Other trials for Human HealthStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Crossover
Masking: Double blind
Who is masked: Participant, Investigator
Enrolment: 48 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT05773794
Sponsor's protocol ID: 22-0093
Status last verified: May 2025
First submitted: 23 Feb 2023
Last updated: 2 Jun 2026
Results posted: Yes, on ClinicalTrials.gov
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

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Study at a glance

From the registry record, last updated by the sponsor on 2 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Scavenging of Reactive Carbonyl Species by Dietary Flavonoids From Soymilk, Green Tea, and Blueberry in Humans
ClinicalTrials.gov ID: NCT05773794
Acronym / sponsor ID: 22-0093
Conditions: Human Health, Reactive Carbonyl Species, Polyphenols
Keywords: dietary flavonoids, Pharmacokinetics, Reactive Carbonyl Species, Polyphenols
Study type: Interventional
Recruitment status: Completed
Enrolment: 48 participants (actual)
Lead sponsor: North Carolina Agriculture & Technical State UniversityUniversity, hospital or other
Study start: 6 Feb 2023 (actual)
Primary completion: 19 Dec 2023 (actual)
Study completion: 19 Dec 2023 (actual)
First posted: 17 Mar 2023 (actual)
Results: Posted 25 May 2025

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Samples will be analyzed by LC-MS/MS. The Pharmacokinetics of conjugates will be investigated.

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Crossover
Masking: Double blind (participant, investigator)
Number of arms: 3

Arm	Type	Receives
Dietary flavonoids (soymilk) consumption	Experimental	Dietary Supplement: Soymilk, green tea, or blueberry, Dietary Supplement: Control groupWeek 1: Sixteen healthy volunteers were recruited and instructed to avoid consuming soymilk, green tea, and blueberry products starting one week before the intervention and continuing throughout the entire 3-week study period. Week 2: Participants consumed a breakfast including 460 mL of soymilk (or milk) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Week 3: Participants consumed a breakfast including 460 mL of milk (or soymilk) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours.
Dietary flavonoids (blueberry) consumption	Experimental	Dietary Supplement: Soymilk, green tea, or blueberry, Dietary Supplement: Control groupWeek 1: Sixteen healthy volunteers were recruited and instructed to avoid consuming soymilk, green tea, and blueberry products starting one week before the intervention and continuing throughout the entire 3-week study period. Week 2: Participants consumed a breakfast including 460 mL of blueberry water (or placebo sweet water) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Week 3: Participants consumed a breakfast including 460 mL of placebo sweet water (or blueberry water) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours.
Dietary flavonoids (green tea) consumption	Experimental	Dietary Supplement: Soymilk, green tea, or blueberry, Dietary Supplement: Control groupWeek 1: Sixteen healthy volunteers were recruited and instructed to avoid consuming soymilk, green tea, and blueberry products starting one week before the intervention and continuing throughout the entire 3-week study period. Week 2: Participants consumed a breakfast including 460 mL of green tea (or water) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours. Week 3: Participants consumed a breakfast including 460 mL of water (or green tea) in a single dose. Urine and blood samples were collected at multiple time points over 24 hours, and fecal samples were collected at different time points over 48 hours.

Who may qualify

Ages: 25 to 70 years
Sex: All
Healthy volunteers: Accepted
Age groups: Adult, Older adult

Key inclusion criteria (15 listed)

Age 25-70 years
BMI between 18 and 30
Have no known allergy to soy milk
Be not taking antibiotics for six months
Be not currently taking medication

Key exclusion criteria (4 listed)

Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders
Cancer patients

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Soymilk, green tea, or blueberryOne dose of soymilk, green tea, or blueberry blends (460mL) with breakfast.	Dietary supplement	Dietary flavonoids (blueberry) consumption, Dietary flavonoids (green tea) consumption, Dietary flavonoids (soymilk) consumption
Control groupBreakfast with milk or water, without soymilk, green tea, or blueberry blends.	Dietary supplement	Dietary flavonoids (blueberry) consumption, Dietary flavonoids (green tea) consumption, Dietary flavonoids (soymilk) consumption

Primary outcome

Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.
Time frame: assessed at 0-2 hours, 2-4 hours, 4-6 hours, and 6-8 hours post-dose
Major RCS in urine will be outlined using Liquid chromatography-tandem mass spectrometry (LC-MS). The urinary levels of major RCS over 8 h after one single dose of soymilk, green tea, or blueberry consumption will be quantified using LC-MS.
Change in Plasma Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 4 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.
Time frame: assessed at 0 hour, 0.5 hour, 1 hour, 1.5 hours, 2 hours, 3 hours, and 4 hours post-dose
Major RCS in plasma will be outlined using liquid chromatography-tandem mass spectrometry (LC-MS). The major RCS levels in plasma over 4 h after one single dose of soymilk, green tea, or blueberry consumption will be quantified using LC-MS.
Change in Urinary Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.
Time frame: 0-2 hours, 2-4 hours, 4-6 hours,6-8 hours, 8-12 hours, and 12-24 hours post-dose
Major RCS conjugates of polyphenols in urine after soymilk, green tea, or blueberry consumption will be profiled using liquid chromatography-tandem mass spectrometry (LC-MS). The levels of major RCS conjugates in urine over 24 h after soymilk, green tea, or blueberry consumption will be quantified using LC-MS.

2 secondary outcomes

Change in Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols in Feces Over 48 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.
Time frame: 0 hour, 24 hours, and 48 hours post-dose
Change in Plasma Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.
Time frame: 0 hour, 0.5 hour, 1 hour, 1.5 hours, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, and 24 hours pose dose

Results and safety

Results posted to the registry on 25 May 2025, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
Soymilk Consumption First, Then Placebo	8	8
Placebo First, Then Soymilk Consumption	8	8
Green Tea Consumption First, Then Placebo	7	7
Placebo First, Then Green Tea Consumption	9	9
Blueberry Consumption First, Then Placebo	8	8
Placebo First, Then Blueberry Consumption	8	8

Primary outcome: Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.

Time frame: assessed at 0-2 hours, 2-4 hours, 4-6 hours, and 6-8 hours post-dose. Mean (Standard Deviation). Unit: nmol/mSmo

Measure	Soymilk Consumption n = 16	Placebo for Soymilk Consumption n = 16	Green Tea Consumption n = 16	Placebo for Green Tea Consumption n = 16	Blueberry Consumption n = 16	Placebo for Blueberry Consumption n = 16
MGO at 0-2 h	3.71 (0.76)	4.70 (3.54)	5.01 (1.40)	4.98 (0.77)	7.38 (2.93)	8.10 (2.72)
MGO at 2-4 h	4.41 (0.80)	3.87 (1.57)	4.49 (1.06)	4.79 (0.63)	7.66 (2.64)	8.11 (2.24)
MGO at 4-6 h	3.37 (0.79)	2.98 (0.71)	4.41 (0.66)	4.60 (0.67)	5.82 (1.94)	6.52 (2.13)
MGO at 6-8 h	3.23 (1.03)	3.15 (0.69)	4.56 (1.14)	5.06 (1.11)	4.77 (1.86)	4.53 (1.17)

Soymilk Consumption vs Placebo for Soymilk Consumption: p = 0.968, t-test, 2 sided
Green Tea Consumption vs Placebo for Green Tea Consumption: p = 0.366, t-test, 2 sided
Blueberry Consumption vs Placebo for Blueberry Consumption: p >0.05, t-test, 2 sided

Primary outcome: Change in Plasma Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 4 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption.

Time frame: assessed at 0 hour, 0.5 hour, 1 hour, 1.5 hours, 2 hours, 3 hours, and 4 hours post-dose. Mean (Standard Deviation). Unit: nM

Measure	Soymilk Consumption n = 16	Placebo for Soymilk Consumption n = 16	Green Tea Consumption n = 16	Placebo for Green Tea Consumption n = 16	Blueberry Consumption n = 16	Placebo for Blueberry Consumption n = 16
MGO at 0 h	388.81 (194.58)	414.10 (211.59)	265.62 (90.11)	266.84 (58.88)	800.22 (145.41)	783.50 (151.67)
MGO at 0.5 h	349.00 (202.39)	579.12 (264.45)	235.66 (99.01)	245.23 (125.26)	680.86 (241.39)	542.16 (184.62)
MGO at 1.0 h	508.52 (113.90)	652.50 (182.36)	397.41 (227.10)	434.22 (197.90)	448.25 (200.51)	488.45 (323.42)
MGO at 1.5 h	281.63 (99.55)	676.58 (255.80)	288.82 (124.72)	276.45 (87.94)	179.23 (60.95)	253.73 (190.67)
MGO at 2.0 h	403.56 (142.80)	531.82 (176.33)	401.58 (193.72)	414.64 (194.55)	499.80 (156.25)	478.71 (152.22)
MGO at 3.0 h	253.72 (317.69)	321.49 (146.08)	326.86 (165.36)	403.98 (203.01)	307.07 (56.13)	307.85 (92.04)
MGO at 4.0 h	252.68 (117.25)	347.67 (139.16)	322.85 (130.64)	342.93 (214.31)	522.59 (126.55)	482.44 (191.36)

Soymilk Consumption vs Placebo for Soymilk Consumption: p = 0.016, t-test, 2 sided
Green Tea Consumption vs Placebo for Green Tea Consumption: p = 0.11, t-test, 2 sided
Blueberry Consumption vs Placebo for Blueberry Consumption: p = 0.59, t-test, 2 sided

Primary outcome: Change in Urinary Levels of Reactive Carbonyl Species (RCS) Adducts of Soymilk, Green Tea, or Blueberry Polyphenols Over 24 Hours After One Single Dose of Soymilk, Green Tea, or Consumption.

Time frame: 0-2 hours, 2-4 hours, 4-6 hours,6-8 hours, 8-12 hours, and 12-24 hours post-dose. Mean (Standard Deviation). Unit: nmol/mSmo

Measure	Soymilk Consumption n = 16	Placebo for Soymilk Consumption n = 16	Green Tea Consumption n = 16	Placebo for Green Tea Consumption n = 16	Blueberry Consumption n = 16	Placebo for Blueberry Consumption n = 16
MGO-EC at 0-2 h	NA (NA)	NA (NA)	0.042 (0.019)	NA (NA)	NA (NA)	NA (NA)
MGO-EC at 2-4 h	NA (NA)	NA (NA)	0.048 (0.021)	NA (NA)	NA (NA)	NA (NA)
MGO-EC at 4-6 h	NA (NA)	NA (NA)	0.033 (0.013)	NA (NA)	NA (NA)	NA (NA)
MGO-EC at 6-8 h	NA (NA)	NA (NA)	0.018 (0.008)	NA (NA)	NA (NA)	NA (NA)
MGO-EC at 8-12 h	NA (NA)	NA (NA)	0.011 (0.008)	0.0012 (0.003)	NA (NA)	NA (NA)
MGO-EC at 12-24 h	NA (NA)	NA (NA)	0.0027 (0.005)	NA (NA)	NA (NA)	NA (NA)

Green Tea Consumption vs Placebo for Green Tea Consumption: p = 0.0196, t-test, 2 sided
Soymilk Consumption vs Placebo for Soymilk Consumption: p >0.05, t-test, 2 sided
Blueberry Consumption vs Placebo for Blueberry Consumption: p >0.05, t-test, 2 sided

2 secondary outcomes are reported in the full results.

Adverse events

Time frame: 17 days for each intervention.. Other adverse events reported at 0% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
Soymilk Consumption	0 of 16 (0%)	0 of 16 (0%)	0 of 16
Placebo for Soymilk Consumption	0 of 16 (0%)	0 of 16 (0%)	0 of 16
Green Tea Consumption	0 of 16 (0%)	0 of 16 (0%)	0 of 16
Placebo for Green Tea Consumption	0 of 16 (0%)	0 of 16 (0%)	0 of 16
Blueberry Consumption	0 of 16 (0%)	0 of 16 (0%)	0 of 16
Placebo for Blueberry Consumption	0 of 16 (0%)	0 of 16 (0%)	0 of 16

Limitations and caveats (from the sponsor): N/A. We successfully enrolled 16 participants for each of the three proposed PK studies, with no dropouts during the trials.

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 2 Jun 2026.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Individual participant dataSharing planned: No

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Shengmin Sang, PhD principal investigator

NC A&T State University

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Soymilk, green tea, or blueberry in people with Human Health and Reactive Carbonyl Species, run by North Carolina Agriculture & Technical State University at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 15 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 2 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 25 May 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry Consumption. (time frame: assessed at 0-2 hours, 2-4 hours, 4-6 hours, and 6-8 hours post-dose). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05773794.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jun 2026.