HypertrophyKIPLINGNCT05774444
Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism
A study testing Krill oil, Krill protein and Vegetable oil in people with Hypertrophy, run by University of Glasgow at 1 site in United Kingdom.
Trial summary
The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance… Read more about this study
- Who is it for?
- Ages 60 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Hypertrophy
- What is being tested?
- Krill oil, Krill protein and Vegetable oil
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 52 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 May 2023to 25 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Be 60 years old or older
- Have a BMI of less than 35kg/m2
- Be participating in structured exercise for less than 2h per week
Who cannot join
- Diabetes
- Severe cardiovascular disease
- Seizure disorders,
- Uncontrolled hypertension (>150/90mmHg at baseline measurement)
- Cancer or cancer that has been in remission <5 years
- Ambulatory impairments which would limit ability to perform assessments of muscle function
Show all 12Show fewer
- Dementia
- Taking medication known to affect muscle (e.g., steroids)
- Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
- Anticoagulant therapy
- Allergies to seafood
- Regular consumption of more than 1 portion of oily fish per week.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial
The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.
- Conditions
- Hypertrophy
- Being tested
- Krill oil, Krill protein, Vegetable oil, Carbohydrate
- Keywords
- Omega-3, Krill oil, Protein, Exercise
- Medical subject headings
- Hypertrophy, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Krill oilDietary supplement
Krill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation.
Krill proteinDietary supplement
Krill protein will be given to the participant following a resistance exercise bout.
Vegetable oilDietary supplement
This will be the control against the Krill oil
CarbohydrateDietary supplement
This will be the control for the Krill protein
| Study group | Role | What they receive |
|---|---|---|
| Vegetable oil + Carbohydrate | Placebo comparator | The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) Receives: Dietary Supplement: Vegetable oil; Dietary Supplement: Carbohydrate |
| Vegetable oil + Krill protein | Experimental | The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g) Receives: Dietary Supplement: Krill protein; Dietary Supplement: Vegetable oil |
| Krill oil + Carbohydrate | Experimental | The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) Receives: Dietary Supplement: Krill oil; Dietary Supplement: Carbohydrate |
| Krill oil + Krill protein | Experimental | Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g) Receives: Dietary Supplement: Krill oil; Dietary Supplement: Krill protein |
What is being measured
The primary outcome is the main question the study is designed to answer.
Post-exercise muscle protein synthesis
Muscle protein synthesis measured 3-7h after a single bout of resistance exercise
Measured: 3-7 hours
Secondary outcomes (10)
Change in Muscle thickness
Vastus lateralis muscle thickness measured by ultrasound
Measured: Change from baseline to 8 weeks
Change in grip strength
Grip strength measured with a Jamar dynamometer
Measured: Change from baseline to 8 weeks
Change in fat mass
Whole body fat mass measured by BIA
Measured: Change from baseline to 8 weeks
Change in lean mass
Whole body lean mass measured by BIA
Measured: Change from baseline to 8 weeks
Change in muscle strength
Knee extensor muscle strength measured isometrically
Measured: Change from baseline to 8 weeks
Change in Chair rise time
Time taken to get up and down from a chair 5 times
Measured: Change from baseline to 8 weeks
Change in balance
Ability to stand for 10 seconds in full tandem, semi-tandem and feet together
Measured: Change from baseline to 8 weeks
Change in gait speed
Time taken to walk 4 metres at a normal walking pace
Measured: Change from baseline to 8 weeks
Basal muscle protein synthesis
Muscle protein synthesis measured from 0-3h after an overnight fast
Measured: 0-3 hours
Change in Erythrocyte fatty acid profile
Erythrocyte fatty acid profile
Measured: Change from baseline to 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Mar 2023
- Study start1 May 2023
- Primary completion25 May 2025
- Study completion25 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HypertrophyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Parallel 2x2 factorial design
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Glasgow
- Sponsor type
- University, hospital or other
- Collaborators
- Aker BioMarine
- Responsible party
- Principal investigator, Stuart Gray, University of Glasgow
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05774444
- Sponsor's protocol ID
- KIPLING
- Acronym
- KIPLING
- Status last verified
- Apr 2026
- First submitted
- 7 Mar 2023
- Last updated
- 29 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT05774444
- Acronym / sponsor ID
- KIPLING / KIPLING
- Conditions
- Hypertrophy
- Keywords
- Omega-3, Krill oil, Protein, Exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- University of GlasgowUniversity, hospital or other
- Collaborators
- Aker BioMarine
- Study start
- 1 May 2023 (actual)
- Primary completion
- 25 May 2025 (actual)
- Study completion
- 25 May 2025 (actual)
- First posted
- 17 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 4
- Model description
- Parallel 2x2 factorial design
| Arm | Type | Receives |
|---|---|---|
| Vegetable oil + Carbohydrate | Placebo comparator | Dietary Supplement: Vegetable oil, Dietary Supplement: CarbohydrateThe vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) |
| Vegetable oil + Krill protein | Experimental | Dietary Supplement: Krill protein, Dietary Supplement: Vegetable oilThe vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g) |
| Krill oil + Carbohydrate | Experimental | Dietary Supplement: Krill oil, Dietary Supplement: CarbohydrateThe Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g) |
| Krill oil + Krill protein | Experimental | Dietary Supplement: Krill oil, Dietary Supplement: Krill proteinBoth the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g) |
Who may qualify
- Ages
- 60 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Be 60 years old or older
- Have a BMI of less than 35kg/m2
- Be participating in structured exercise for less than 2h per week
Key exclusion criteria (12 listed)
- Diabetes
- Severe cardiovascular disease
- Seizure disorders,
- Uncontrolled hypertension (>150/90mmHg at baseline measurement)
- Cancer or cancer that has been in remission <5 years
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Krill oilKrill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation. | Dietary supplement | Krill oil + Carbohydrate, Krill oil + Krill protein |
| Krill proteinKrill protein will be given to the participant following a resistance exercise bout. | Dietary supplement | Krill oil + Krill protein, Vegetable oil + Krill protein |
| Vegetable oilThis will be the control against the Krill oil | Dietary supplement | Vegetable oil + Carbohydrate, Vegetable oil + Krill protein |
| CarbohydrateThis will be the control for the Krill protein | Dietary supplement | Krill oil + Carbohydrate, Vegetable oil + Carbohydrate |
Primary outcome
Post-exercise muscle protein synthesis
Time frame: 3-7 hours
Muscle protein synthesis measured 3-7h after a single bout of resistance exercise
10 secondary outcomes
Change in Muscle thickness
Time frame: Change from baseline to 8 weeks
Change in grip strength
Time frame: Change from baseline to 8 weeks
Change in fat mass
Time frame: Change from baseline to 8 weeks
Change in lean mass
Time frame: Change from baseline to 8 weeks
Change in muscle strength
Time frame: Change from baseline to 8 weeks
Change in Chair rise time
Time frame: Change from baseline to 8 weeks
Change in balance
Time frame: Change from baseline to 8 weeks
Change in gait speed
Time frame: Change from baseline to 8 weeks
Basal muscle protein synthesis
Time frame: 0-3 hours
Change in Erythrocyte fatty acid profile
Time frame: Change from baseline to 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2026.
- Individual participant dataSharing planned: No
Related trials for Hypertrophy
Not yet recruiting
Human Experimental Models of Pain (HEMP)
Acute Pain
Not yet recruiting
Pilot Study Evaluating Catheter Directed Thrombolysis Device in Acute Intermediate Risk Pulmonary Embolism
Pulmonary Embolism (PE), Pulmonary Embolism With Right Ventricle Enlargement
Not yet recruiting
NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices
Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction
Active, not recruitingEarly Phase 1
Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma
B-ALL, DLBCL
RecruitingObservational study
Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
Familial Mediterranean Fever (FMF), Autoinflammation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Krill oil, Krill protein and Vegetable oil in people with Hypertrophy, run by University of Glasgow at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Post-exercise muscle protein synthesis (time frame: 3-7 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026.