Spinal Cord InjuriesKREHA-ParAthNCT05777941
Strength Training With Eccentric Arm-cranking in Para-athletes
A study testing eccentric arm-cranking training in people with Spinal Cord Injuries, run by Swiss Paraplegic Research, Nottwil at 1 site in Switzerland.
Trial summary
The new training device, the eccentric arm-crank, will be examined for its training effects in athletes with a spinal cord injury (SCI) by this project. That the training device can be used in patients with paraplegia in the future, the so-called "testing of the applicability of this concept" will be carried out… Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Spinal Cord Injuries
- What is being tested?
- eccentric arm-cranking training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteSwitzerland
- Study dates
- 3 Aug 2022to 9 Oct 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- male or female with traumatic or disease-related SCI
- age between 18 and 50 years
- experience in strength training
- Squad status or at least 4h per week training
- Biceps/triceps function
- healthy(study physician)
- adequately informed and confirmed per signature
Who cannot join
- findings during anamnesis of study physician
- pregnancy
Trial locations and contacts
1 site in 1 country.
Switzerland1 site
Swiss Paraplegic Centre
Nottwil, Canton of Lucerne, 6207
About this study
The new training device, the eccentric arm-crank, will be examined for its training effects in athletes with a spinal cord injury (SCI) by this project. That the training device can be used in patients with paraplegia in the future, the so-called "testing of the applicability of this concept" will be carried out during this study. Fourteen volunteer, healthy athletes with SCI are first tested for their upper body performance, followed by a training phase over 20 trainings and at the end the performance data is collected again. The training intensity and duration is continuously increased during the training phase.
Read the detailed description
At the beginning, the study design includes a familiarisation appointment with performance tests and training on the eccentric arm-crank device (KREHA). At least one week later, the first test sequence including a maximum strength test (bench press) and a test to determine the anaerobic performance (Wingate test) is conducted. The second test sequence takes place one to three days later. This includes a handgrip strength test, an aerobic endurance test (ramp test on the arm crank ergometer with ergospirometry) and a further familiarisation training on the KREHA. The training phase starts within two weeks after the pre-tests have been completed. There are two to a maximum of three trainings per week. These take 30 to 45 minutes and take place on the KREHA device under the supervision of the study staff. The training phase lasts a maximum of twelve weeks (20 training sessions). The first test sequence is repeated five to eight days after the last workout. The second test sequence takes place at the same time interval as in the pre-tests.
- Conditions
- Spinal Cord Injuries
- Being tested
- eccentric arm-cranking training
- Keywords
- eccentric, strength training
- Medical subject headings
- Spinal Cord Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
eccentric arm-cranking trainingOther
Over the twenty training sessions, able-bodied participants will exercise on the KREHA device. An arm-crank has to be decelerated, which will be rotated by a prematurely defined revolution rate and training duration. During this intervention a certain power has to be applied. During the whole time of training a continous progression in power and training duration is applied.
| Study group | Role | What they receive |
|---|---|---|
| Eccentric Training | Experimental | This Group will train on the KREHA for 20 Trainings Receives: Other: eccentric arm-cranking training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Upper body Performance
Peak Power - maximal reached power, generated during the 30sec Wingate arm-crank test
Measured: through study completion, an average of 20 weeks
Secondary outcomes (10)
Endurance Oxygen consumption
VO2peak [ml/min/kg] - Basic Endurance test (Ergospirometry, arm-crank)
Measured: through study completion, an average of 20 weeks
Maximal Workload
Wmax [W] - Basic Endurance test (Ergospirometry, arm-crank)
Measured: through study completion, an average of 20 weeks
Upper body Mean Power
Mean Power [W] - Wingate Test (arm-crank)
Measured: through study completion, an average of 20 weeks
Upper body Power - Time to Peak
Time to Peak [s] - Wingate Test (arm-crank)
Measured: through study completion, an average of 20 weeks
Upper body Fatigue Index
Fatigue Index [%]- Wingate Test (arm-crank)
Measured: through study completion, an average of 20 weeks
Upper body Fatigue Slope
Fatigue Slope [W/s] - Wingate Test (arm-crank)
Measured: through study completion, an average of 20 weeks
1RM bench press
One Repetition Maximum (1RM) [kg]- bench press
Measured: through study completion, an average of 20 weeks
Grip Strength
Maximal Force that can be generated by pressing hand towards a fist [N]
Measured: through study completion, an average of 20 weeks
Upper Arm Circumference
Circumference of the upper arm is measured with measuring tape
Measured: through study completion, an average of 20 weeks
Lower Arm Circumference
Circumference of the lower arm is measured with measuring tape
Measured: through study completion, an average of 20 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Mar 2023
- Study start3 Aug 2022
- Primary completion20 Sep 2024
- Study completion9 Oct 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Spinal Cord InjuriesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Swiss Paraplegic Research, Nottwil
- Sponsor type
- Research network
- Responsible party
- Sponsor
- Investigators
- Fabian Ammann, MSc, Principal investigator, SPZ
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05777941
- Sponsor's protocol ID
- 2022-06
- Acronym
- KREHA-ParAth
- Status last verified
- Sep 2026
- First submitted
- 8 Mar 2023
- Last updated
- 30 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Strength Training With Eccentric Arm-cranking in Para-athletes
- ClinicalTrials.gov ID
- NCT05777941
- Acronym / sponsor ID
- KREHA-ParAth / 2022-06
- Conditions
- Spinal Cord Injuries
- Keywords
- eccentric, strength training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Swiss Paraplegic Research, NottwilResearch network
- Study start
- 3 Aug 2022 (actual)
- Primary completion
- 20 Sep 2024 (actual)
- Study completion
- 9 Oct 2024 (actual)
- First posted
- 21 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The new training device, the eccentric arm-crank, will be examined for its training effects in athletes with a spinal cord injury (SCI) by this project. That the training device can be used in patients with paraplegia in the future, the so-called "testing of the applicability of this concept" will be carried out during this study. Fourteen volunteer, healthy athletes with SCI are first tested for their upper body performance, followed by a training phase over 20 trainings and at the end the performance data is collected again. The training intensity and duration is continuously increased during the training phase.
Detailed description
At the beginning, the study design includes a familiarisation appointment with performance tests and training on the eccentric arm-crank device (KREHA). At least one week later, the first test sequence including a maximum strength test (bench press) and a test to determine the anaerobic performance (Wingate test) is conducted. The second test sequence takes place one to three days later. This includes a handgrip strength test, an aerobic endurance test (ramp test on the arm crank ergometer with ergospirometry) and a further familiarisation training on the KREHA. The training phase starts within two weeks after the pre-tests have been completed. There are two to a maximum of three trainings per week. These take 30 to 45 minutes and take place on the KREHA device under the supervision of the study staff. The training phase lasts a maximum of twelve weeks (20 training sessions). The first test sequence is repeated five to eight days after the last workout. The second test sequence takes place at the same time interval as in the pre-tests.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Eccentric Training | Experimental | Other: eccentric arm-cranking trainingThis Group will train on the KREHA for 20 Trainings |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- male or female with traumatic or disease-related SCI
- age between 18 and 50 years
- experience in strength training
- Squad status or at least 4h per week training
- Biceps/triceps function
Key exclusion criteria (2 listed)
- findings during anamnesis of study physician
- pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| eccentric arm-cranking trainingOver the twenty training sessions, able-bodied participants will exercise on the KREHA device. An arm-crank has to be decelerated, which will be rotated by a prematurely defined revolution rate and training duration. During this intervention a certain power has to be applied. During the whole time of training a continous progression in power and training duration is applied. | Other | Eccentric Training |
Primary outcome
Upper body Performance
Time frame: through study completion, an average of 20 weeks
Peak Power - maximal reached power, generated during the 30sec Wingate arm-crank test
10 secondary outcomes
Endurance Oxygen consumption
Time frame: through study completion, an average of 20 weeks
Maximal Workload
Time frame: through study completion, an average of 20 weeks
Upper body Mean Power
Time frame: through study completion, an average of 20 weeks
Upper body Power - Time to Peak
Time frame: through study completion, an average of 20 weeks
Upper body Fatigue Index
Time frame: through study completion, an average of 20 weeks
Upper body Fatigue Slope
Time frame: through study completion, an average of 20 weeks
1RM bench press
Time frame: through study completion, an average of 20 weeks
Grip Strength
Time frame: through study completion, an average of 20 weeks
Upper Arm Circumference
Time frame: through study completion, an average of 20 weeks
Lower Arm Circumference
Time frame: through study completion, an average of 20 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Fabian Ammann, MSc principal investigator
SPZ
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing eccentric arm-cranking training in people with Spinal Cord Injuries, run by Swiss Paraplegic Research, Nottwil at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Upper body Performance (time frame: through study completion, an average of 20 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.