COVID-19NCT05778344
Teletechnology-assisted Home-based Exercise Program for Severe COVID-19
A study testing Teletechnology-assisted home-based pulmonary rehabilitation in people with COVID-19 and Telerehabilitation, run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
The aim of this study was to investigate the efficacy of a home-based pulmonary rehabilitation program with the support of teletechnology in COVID-19 survivors. The main questions it aims to answer were: The change of six-minute walk distance The change of time of one-minute sit-to-stand test The change of maximal… Read more about this study
- Who is it for?
- Ages 20 years and older
- Conditions the study is for
- COVID-19, Telerehabilitation
- What is being tested?
- Teletechnology-assisted home-based pulmonary rehabilitation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteTaiwan
- Study dates
- 12 Apr 2023to 24 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients are 20 years or more with severe (severe pneumonia) to critical (acute respiratory distress syndrome, sepsis, or septic shock) COVID-19 during hospitalization after deisolation.
- Patients are 65 years or more, or ever receiving oral antiviral treatment after deisolation.
- Patient have the ability to ambulate on level surface without direct contact of another person, have telecommunication device(s), and provide consent to receive teletechnology-assisted rehabilitation.
Who cannot join
- Patients are pregnant or planning for pregnancy.
- Patients have cognitive dysfunction, learning disability, uncontrolled arrhythmia or hypertension, or any medical diagnosis other than COVID-19 that would prominently influence their ability to follow instructions and perform exercise.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Efficacy of Teletechnology-assisted Home-based Exercise Program for Severe COVID-19
The aim of this study was to investigate the efficacy of a home-based pulmonary rehabilitation program with the support of teletechnology in COVID-19 survivors. The main questions it aims to answer were:
- The change of six-minute walk distance
- The change of time of one-minute sit-to-stand test
- The change of maximal strength of upper-limb, lower-limb and respiratory muscle
- The change of quality of life Participants in the home-based pulmonary rehabilitation group received teletechnology-assisted consultations (either by videotelephony or telephone calls) for every 1-2 weeks during the intervention period, and participants in the usual care group did not receive teletechnology-assisted consultations during the intervention period.
- Conditions
- COVID-19, Telerehabilitation
- Being tested
- Teletechnology-assisted home-based pulmonary rehabilitation
- Keywords
- Pulmonary Rehabilitation
- Medical subject headings
- COVID-19
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Teletechnology-assisted home-based pulmonary rehabilitationBehavioural
The accuracy and safety of home-based pulmonary rehabilitation will be checked regularly through technology devices such as smart watch and via videotelephony (or telephone calls if indicated).
| Study group | Role | What they receive |
|---|---|---|
| Home-based pulmonary rehabilitation group | Experimental | The home-based pulmonary rehabilitation group received breathing exercise instructions using online learning materials soon after randomization. The participants received a home-based exercise plan, which comprised aerobic exercise and resistance exercise with instruction sheets. Teletechnology was incorporated into home-based pulmonary rehabilitation via videotelephony (or telephone calls if indicated). Time points for these teletechnology-assisted consultations were at day 7, day 14 after randomization and every 2 weeks after that until the completion of the study (week 12). Receives: Behavioral: Teletechnology-assisted home-based pulmonary rehabilitation |
| Usual care group | Active comparator | The usual care group will receive breathing exercise instructions using online learning materials soon after randomization. The participants will also receive general exercise education and exercise safety principles but not any consultation about their physical activity/exercise during the study period. Receives: Behavioral: Teletechnology-assisted home-based pulmonary rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Six-minute walk distance
The distance of six-minute walk test
Measured: Week 0
Six-minute walk distance
The distance of six-minute walk test
Measured: Week 4
Six-minute walk distance
The distance of six-minute walk test
Measured: Week 8
Six-minute walk distance
The distance of six-minute walk test
Measured: Week 12
Six-minute walk distance
The distance of six-minute walk test
Measured: Week 24
Secondary outcomes (20)
Maximal upper limb strength
Hand grip strength
Measured: Week 0
Maximal upper limb strength
Hand grip strength
Measured: Week 4
Maximal upper limb strength
Hand grip strength
Measured: Week 8
Maximal upper limb strength
Hand grip strength
Measured: Week 12
Maximal upper limb strength
Hand grip strength
Measured: Week 24
Maximal lower limb strength
Leg press strength
Measured: Week 0
Maximal lower limb strength
Leg press strength
Measured: Week 4
Maximal lower limb strength
Leg press strength
Measured: Week 8
Maximal lower limb strength
Leg press strength
Measured: Week 12
Maximal lower limb strength
Leg press strength
Measured: Week 24
Maximal respiratory muscle strength
Inspiratory and expiratory pressure of respiratory muscle
Measured: Week 0
Maximal respiratory muscle strength
Inspiratory and expiratory pressure of respiratory muscle
Measured: Week 4
Maximal respiratory muscle strength
Inspiratory and expiratory pressure of respiratory muscle
Measured: Week 8
Maximal respiratory muscle strength
Inspiratory and expiratory pressure of respiratory muscle
Measured: Week 12
Maximal respiratory muscle strength
Inspiratory and expiratory pressure of respiratory muscle
Measured: Week 24
Quality of life score
Quality of life assessed by Short-form 12 questionnaire
Measured: Week 0
Quality of life score
Quality of life assessed by Short-form 12 questionnaire
Measured: Week 4
Quality of life score
Quality of life assessed by Short-form 12 questionnaire
Measured: Week 8
Quality of life score
Quality of life assessed by Short-form 12 questionnaire
Measured: Week 12
Quality of life score
Quality of life assessed by Short-form 12 questionnaire
Measured: Week 24
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Mar 2023
- Study start12 Apr 2023
- Primary completion24 May 2024
- Study completion24 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for COVID-19Studies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, National Taiwan University Clinical Trial Center, National Taiwan University Hospital
- Investigators
- Ping-Lun Hsieh, Principal investigator, National Taiwan University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05778344
- Sponsor's protocol ID
- 202106133RIND
- Status last verified
- Sep 2025
- First submitted
- 13 Mar 2023
- Last updated
- 11 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Felten-Barentsz KM, van Oorsouw R, Klooster E, Koenders N, Driehuis F, Hulzebos EHJ, van der Schaaf M, Hoogeboom TJ, van der Wees PJ. Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19. Phys Ther. 2020 Aug 31;100(9):1444-1457. doi: 10.1093/ptj/pzaa114.
PubMed 32556323Gloeckl R, Leitl D, Jarosch I, Schneeberger T, Nell C, Stenzel N, Vogelmeier CF, Kenn K, Koczulla AR. Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study. ERJ Open Res. 2021 May 31;7(2):00108-2021. doi: 10.1183/23120541.00108-2021. eCollection 2021 Apr.
PubMed 34095290Betschart M, Rezek S, Unger I, Beyer S, Gisi D, Shannon H, Sieber C. Feasibility of an Outpatient Training Program after COVID-19. Int J Environ Res Public Health. 2021 Apr 9;18(8):3978. doi: 10.3390/ijerph18083978.
PubMed 33918887
Study at a glance
From the registry record, last updated by the sponsor on 11 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy of Teletechnology-assisted Home-based Exercise Program for Severe COVID-19
- ClinicalTrials.gov ID
- NCT05778344
- Acronym / sponsor ID
- 202106133RIND
- Conditions
- COVID-19, Telerehabilitation
- Keywords
- Pulmonary Rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 12 Apr 2023 (actual)
- Primary completion
- 24 May 2024 (actual)
- Study completion
- 24 May 2024 (actual)
- First posted
- 21 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to investigate the efficacy of a home-based pulmonary rehabilitation program with the support of teletechnology in COVID-19 survivors. The main questions it aims to answer were:
- The change of six-minute walk distance
- The change of time of one-minute sit-to-stand test
- The change of maximal strength of upper-limb, lower-limb and respiratory muscle
- The change of quality of life Participants in the home-based pulmonary rehabilitation group received teletechnology-assisted consultations (either by videotelephony or telephone calls) for every 1-2 weeks during the intervention period, and participants in the usual care group did not receive teletechnology-assisted consultations during the intervention period.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Home-based pulmonary rehabilitation group | Experimental | Behavioral: Teletechnology-assisted home-based pulmonary rehabilitationThe home-based pulmonary rehabilitation group received breathing exercise instructions using online learning materials soon after randomization. The participants received a home-based exercise plan, which comprised aerobic exercise and resistance exercise with instruction sheets. Teletechnology was incorporated into home-based pulmonary rehabilitation via videotelephony (or telephone calls if indicated). Time points for these teletechnology-assisted consultations were at day 7, day 14 after randomization and every 2 weeks after that until the completion of the study (week 12). |
| Usual care group | Active comparator | Behavioral: Teletechnology-assisted home-based pulmonary rehabilitationThe usual care group will receive breathing exercise instructions using online learning materials soon after randomization. The participants will also receive general exercise education and exercise safety principles but not any consultation about their physical activity/exercise during the study period. |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients are 20 years or more with severe (severe pneumonia) to critical (acute respiratory distress syndrome, sepsis, or septic shock) COVID-19 during hospitalization after deisolation.
- Patients are 65 years or more, or ever receiving oral antiviral treatment after deisolation.
- Patient have the ability to ambulate on level surface without direct contact of another person, have telecommunication device(s), and provide consent to receive teletechnology-assisted rehabilitation.
Key exclusion criteria (2 listed)
- Patients are pregnant or planning for pregnancy.
- Patients have cognitive dysfunction, learning disability, uncontrolled arrhythmia or hypertension, or any medical diagnosis other than COVID-19 that would prominently influence their ability to follow instructions and perform exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Teletechnology-assisted home-based pulmonary rehabilitationThe accuracy and safety of home-based pulmonary rehabilitation will be checked regularly through technology devices such as smart watch and via videotelephony (or telephone calls if indicated). | Behavioural | Home-based pulmonary rehabilitation group, Usual care group |
Primary outcome
Six-minute walk distance
Time frame: Week 0
The distance of six-minute walk test
Six-minute walk distance
Time frame: Week 4
The distance of six-minute walk test
Six-minute walk distance
Time frame: Week 8
The distance of six-minute walk test
Six-minute walk distance
Time frame: Week 12
The distance of six-minute walk test
Six-minute walk distance
Time frame: Week 24
The distance of six-minute walk test
20 secondary outcomes
Maximal upper limb strength
Time frame: Week 0
Maximal upper limb strength
Time frame: Week 4
Maximal upper limb strength
Time frame: Week 8
Maximal upper limb strength
Time frame: Week 12
Maximal upper limb strength
Time frame: Week 24
Maximal lower limb strength
Time frame: Week 0
Maximal lower limb strength
Time frame: Week 4
Maximal lower limb strength
Time frame: Week 8
Maximal lower limb strength
Time frame: Week 12
Maximal lower limb strength
Time frame: Week 24
Maximal respiratory muscle strength
Time frame: Week 0
Maximal respiratory muscle strength
Time frame: Week 4
Maximal respiratory muscle strength
Time frame: Week 8
Maximal respiratory muscle strength
Time frame: Week 12
Maximal respiratory muscle strength
Time frame: Week 24
Quality of life score
Time frame: Week 0
Quality of life score
Time frame: Week 4
Quality of life score
Time frame: Week 8
Quality of life score
Time frame: Week 12
Quality of life score
Time frame: Week 24
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Sep 2025.
- Background: PubMed 32556323Felten-Barentsz KM, van Oorsouw R, Klooster E, Koenders N, Driehuis F, Hulzebos EHJ, van der Schaaf M, Hoogeboom TJ, van der Wees PJ. Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19. Phys Ther. 2020 Aug 31;100(9):1444-1457. doi: 10.1093/ptj/pzaa114.
- Background: PubMed 34095290Gloeckl R, Leitl D, Jarosch I, Schneeberger T, Nell C, Stenzel N, Vogelmeier CF, Kenn K, Koczulla AR. Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study. ERJ Open Res. 2021 May 31;7(2):00108-2021. doi: 10.1183/23120541.00108-2021. eCollection 2021 Apr.
- Background: PubMed 33918887Betschart M, Rezek S, Unger I, Beyer S, Gisi D, Shannon H, Sieber C. Feasibility of an Outpatient Training Program after COVID-19. Int J Environ Res Public Health. 2021 Apr 9;18(8):3978. doi: 10.3390/ijerph18083978.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ping-Lun Hsieh principal investigator
National Taiwan University Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Teletechnology-assisted home-based pulmonary rehabilitation in people with COVID-19 and Telerehabilitation, run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Six-minute walk distance (time frame: Week 0). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05778344, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Sep 2025.