HomeostasisNCT05785221
Energy Metabolism Profiles Over Weight-loss and Eating Responses
A study testing General lifestyle and nutritional education and Personalized nutritional and lifestyle weight reduction intervention in people with Homeostasis and Metabolism and Nutrition Disorder, run by Chinese Academy of Sciences at 1 site in China.
Trial summary
This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese. Twelve weeks of caloric-restriction dietary intervention will be conducted in the overweight or obese participants. Read more about this study
- Who is it for?
- Ages 20 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Homeostasis, Metabolism and Nutrition Disorder, Healthy
- What is being tested?
- General lifestyle and nutritional education and Personalized nutritional and lifestyle weight reduction intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 117 participants
- Where
- 1 siteChina
- Study dates
- 2 Mar 2023to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- 20-70 years of age, inclusive
- BMI ≥ 24kg/m2
- Not in other clinical studies currently or in the past three months
Who cannot join
- Fasting glucose >7.0mmol/L or diagnosed diabetes or taking insulin or other blood glucose-lowering drugs
- Blood pressure > 160/100 mmHg; diagnosed phase II or III hypertension or cannot decrease SBP under 160mmHg after anti-hypertension drugs
- Fasting blood TG≥ 5.7 mmol/L or fasting LDL-C≥ 4.9 mmol/L or cannot control TG < 5.7 mmol/L or LDL-C < 4.9 mmol/L after taking lipid lowering drugs
- Pregnant or lactating
- Attempting to change body weight in the past 3 months
- Use of antibiotic in the preceding 3 months for 3-serial days
Show all 21Show fewer
- Use of estrogen therapy or hormonal drugs in the preceding 6 months
- Smokers
- History of alcohol abuse or other substance abuse (Alcohol abuse is defined as regular alcohol consumption > 40 g/day for females or > 80 g/day for males)
- Severe renal disease or liver disease
- Severe gastrointestinal diseases
- Surgical events preceding 1 year (except appendicitis or hernia surgery)
- Severe cardiovascular or cerebrovascular diseases
- Implantation of heart stent or any device containing metal material
- Cancer or receiving radiotherapy and chemotherapy within 5 years
- Hyperthyroidism or hypothyroidism
- Suffering from AIDS, hepatitis A, hepatitis B and other infectious diseases
- Claustrophobia
- Physical disability
- Any mental disorders or current use of antidepressants
- Cognitive disability
Trial locations and contacts
1 site in 1 country.
China1 site
Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Hangzhou, Zhejiang, 310024
About this study
Official title: Exploratory Personalized Lifestyle Intervention on Metabolic Homeostasis in Overweight or Obese Chinese Population
This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese. Twelve weeks of caloric-restriction dietary intervention will be conducted in the overweight or obese participants. Before and after the 12-week intervention, metabolic health will be characterized by metabolic homeostasis, determined via comprehensive measurements of dynamic postprandial metabolic responses to a standardized mixed macronutrient tolerance test (75 g glucose, 60 g fat, 20 g protein) in a whole-room indirect calorimeter. The objectives of this study are
- to characterize dynamic metabolic response elicited by acute nutritional and acute exercise challenges,
- to elucidate biological mechanisms underlying inter-individual heterogeneity in these responses,
- to predict prospective weight loss over the intervention using heterogeneous metabolic responses to acute challenges
Read the detailed description
The objectives of this study are 1) to characterize dynamic metabolic response elicited by acute nutritional and acute exercise challenges, 2) to elucidate biological mechanisms underlying inter-individual heterogeneity in these responses, and 3) to predict prospective weight loss over the intervention using heterogeneous metabolic responses to acute challenges.
In this study, 84 overweight or obese participants (BMI ≥ 24 kg/m2) and 28 normal weight participants (18.5 ≤ BMI<24 kg/m2) will be recruited and receive 12-week caloric-restriction dietary or weight maintenance interventions. Before and after the 12-week interventions, metabolic homeostasis will be used to characterize metabolic health and to be determined using comprehensive measurements of dynamic changes in postprandial metabolic responses (including energy metabolism, multiple clinical biomarkers, metabolomic signatures, gut microbiota, genetic signatures etc.) after standardized mixed macronutrient tolerance test (75 g glucose, 60 g fat and 20 g protein) in whole room indirect calorimeter under both resting and exercise conditions. In addition, data from dietary intake, anthropometric measurements, body composition, psychosocial measures, behavior questionnaires and 14-day continuous glucose monitoring will also be collected to characterize metabolic homeostasis. During the interventions, participants will receive personalized dietary advice, behavior guidance and nutritional and lifestyle education by dietitian and physicians. APP-connected wearable devices will be utilized to monitor their dietary intakes, physical activities and sleep conditions, and an application-connected scale will be used to monitor their weight changes during interventions. The study's protocol has been approved by the Ethics Committee of Sir Run Run Shaw Hospital.
- Conditions
- Homeostasis, Metabolism and Nutrition Disorder, Healthy, Obesity
- Being tested
- General lifestyle and nutritional education, Personalized nutritional and lifestyle weight reduction intervention
- Keywords
- Metabolic homeostasis, Healthy, Lifestyle intervention
- Medical subject headings
- Nutrition Disorders, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
General lifestyle and nutritional educationBehavioural
Participants will receive general dietary advice, behavior guidance and nutritional and lifestyle education based on dietary guidelines.
Personalized nutritional and lifestyle weight reduction interventionBehavioural
Participants will receive personalized dietary advice, behavior guidance and nutritional and lifestyle education by dietitian and physicians. APP-connected wearable devices will be utilized to monitor their dietary intakes, physical activities and sleep conditions and APP-connected scale will be used to monitor their weight changes during interventions.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Comparators | Placebo comparator | They will receive general lifestyle and nutritional education. Receives: Behavioral: General lifestyle and nutritional education |
| Overweight/Obese Group | Experimental | They will receive personalized nutritional and lifestyle weight reduction intervention including dietary advice, behavior guidance and nutritional and lifestyle education by dietitian and physicians. Receives: Behavioral: Personalized nutritional and lifestyle weight reduction intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fasting and postprandial energy metabolic response at baseline and post-intervention
Energy metabolism is characterized by four primary indicators: energy expenditure (EE), respiratory quotient (RQ), carbohydrate oxidation rate (CarbOx), and fat oxidation rate (FatOx).
EE denotes the rate of energy expenditure per minute (typically expressed in kcal/min).
RQ, defined as the ratio of carbon dioxide produced to oxygen consumed (VCO₂/VO₂), reflects whole-body substrate utilization.
CarbOx and FatOx represent the respective oxidation rates of carbohydrate and fat, quantifying the contribution of each macronutrient to total energy production.
Measured: Baseline and Week 12
Secondary outcomes (22)
Change from Baseline in Body Weight at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Weight will be assessed by Seca-255 (ScalesGalore).
Measured: Baseline and Week 12
Change from Baseline in Body Mass Index at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Weight and height will be assessed by Seca-255 (ScalesGalore).
Measured: Baseline and Week 12
Change from Baseline in Waist Circumference at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Waist circumference will be assessed by Seca-201(ScalesGalore).
Measured: Baseline and Week 12
Change from Baseline in Hip Circumference at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Waist circumference will be assessed by Seca-201(ScalesGalore).
Measured: Baseline and Week 12
Change from Baseline in Blood Pressure at 12 Weeks
The change of systolic and diastolic blood pressures between the baseline and after 12-week lifestyle intervention. Both systolic pressure and diastolic pressure will be assessed using electronic blood pressure monitor (Omron J750).
Measured: Baseline and Week 12
Change from Baseline in Heart Rate at 12 Weeks
The change of systolic and diastolic blood pressures between the baseline and after 12-week lifestyle intervention. Heart rate will be assessed using Omron J750.
Measured: Baseline and Week 12
Change from Baseline in Body Composition at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Body composition will assessed using dual energy x-ray absorptiometry (DXA) (GE).
Measured: Baseline and Week 12
Change from Baseline in Energy Expenditure at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Energy expenditure will be assessed using whole room indirect calorimeter.
Measured: Baseline and Week 12
Change from Baseline in Respiratory Quotient at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Respiratory quotient will be assessed using whole room indirect calorimeter.
Measured: Baseline and Week 12
Change from Baseline in Glucose Homeostasis at 12 Weeks
The change between the baseline and after 12-week lifestyle intervention. Glucose homeostasis will be assessed by Continuous Glucose Monitoring (FreeStyle Libre).
Measured: Baseline and Week 12
Change from Baseline in Glucose at 12 Weeks
The dynamic change of glucose from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in C-peptide at 12 Weeks
The dynamic change of C-peptide from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Insulin Indices at 12 Weeks
The dynamic change of insulin indices from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Lipid Parameters at 12 Weeks
The dynamic change of lipid parameters from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Protein and Amino Acids Metabolites at 12 Weeks
The dynamic change from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Inflammatory Biomarkers and Cytokines at 12 Weeks
The dynamic change from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Gastrointestinal Hormones at 12 Weeks
The dynamic change in gastrointestinal hormones from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Cell Adhesion Molecules at 12 Weeks
The dynamic change in cell adhesion molecules from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Adipokines at 12 Weeks
The dynamic change in adipokines from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention.
Measured: Baseline and Week 12
Change from Baseline in Metabolomics at 12 Weeks
The dynamic change in metabolomics including profiling of free fatty acids and other metabolites from 0 to 30, 60, 120, 180, 240, 300 minutes pre- and post-oral mixed-nutrient dietary challenge between the baseline and after 12-week lifestyle intervention. Metabolomics will be measured by LC-MS.
Measured: Baseline and Week 12
Single nucleotide polymorphism (SNPs)
Mutations at specific sites will be detected by gene chip.
Measured: Baseline
Gut microbiota 16S rDNA sequencing
Gut microbiota 16S rDNA will be sequenced and community composition will be analyzed.
Measured: Baseline and Week 12
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2023
- Study start2 Mar 2023
- Primary completion1 Mar 2025
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HomeostasisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 117 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chinese Academy of Sciences
- Sponsor type
- Other government
- Collaborators
- Sir Run Run Shaw Hospital
- Responsible party
- Principal investigator, Xu Lin, Chinese Academy of Sciences
- Investigators
- Xu Lin, PhD, Principal investigator, Institute for Nutritional Sciecnes, CAS; Hangzhou Institute for Advanced Study, UCAS
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05785221
- Sponsor's protocol ID
- HIAS-LIMH-202302
- Status last verified
- Feb 2026
- First submitted
- 1 Mar 2023
- Last updated
- 9 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exploratory Personalized Lifestyle Intervention on Metabolic Homeostasis in Overweight or Obese Chinese Population
- ClinicalTrials.gov ID
- NCT05785221
- Acronym / sponsor ID
- HIAS-LIMH-202302
- Conditions
- Homeostasis, Metabolism and Nutrition Disorder, Healthy, Obesity
- Keywords
- Metabolic homeostasis, Healthy, Lifestyle intervention
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 117 participants (actual)
- Lead sponsor
- Chinese Academy of SciencesOther government
- Collaborators
- Sir Run Run Shaw Hospital
- Study start
- 2 Mar 2023 (actual)
- Primary completion
- 1 Mar 2025 (actual)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 27 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese. Twelve weeks of caloric-restriction dietary intervention will be conducted in the overweight or obese participants. Before and after the 12-week intervention, metabolic health will be characterized by metabolic homeostasis, determined via comprehensive measurements of dynamic postprandial metabolic responses to a standardized mixed macronutrient tolerance test (75 g glucose, 60 g fat, 20 g protein) in a whole-room indirect calorimeter. The objectives of this study are
- to characterize dynamic metabolic response elicited by acute nutritional and acute exercise challenges,
- to elucidate biological mechanisms underlying inter-individual heterogeneity in these responses,
- to predict prospective weight loss over the intervention using heterogeneous metabolic responses to acute challenges
Detailed description
The objectives of this study are 1) to characterize dynamic metabolic response elicited by acute nutritional and acute exercise challenges, 2) to elucidate biological mechanisms underlying inter-individual heterogeneity in these responses, and 3) to predict prospective weight loss over the intervention using heterogeneous metabolic responses to acute challenges.
In this study, 84 overweight or obese participants (BMI ≥ 24 kg/m2) and 28 normal weight participants (18.5 ≤ BMI<24 kg/m2) will be recruited and receive 12-week caloric-restriction dietary or weight maintenance interventions. Before and after the 12-week interventions, metabolic homeostasis will be used to characterize metabolic health and to be determined using comprehensive measurements of dynamic changes in postprandial metabolic responses (including energy metabolism, multiple clinical biomarkers, metabolomic signatures, gut microbiota, genetic signatures etc.) after standardized mixed macronutrient tolerance test (75 g glucose, 60 g fat and 20 g protein) in whole room indirect calorimeter under both resting and exercise conditions. In addition, data from dietary intake, anthropometric measurements, body composition, psychosocial measures, behavior questionnaires and 14-day continuous glucose monitoring will also be collected to characterize metabolic homeostasis. During the interventions, participants will receive personalized dietary advice, behavior guidance and nutritional and lifestyle education by dietitian and physicians. APP-connected wearable devices will be utilized to monitor their dietary intakes, physical activities and sleep conditions, and an application-connected scale will be used to monitor their weight changes during interventions. The study's protocol has been approved by the Ethics Committee of Sir Run Run Shaw Hospital.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Healthy Comparators | Placebo comparator | Behavioral: General lifestyle and nutritional educationThey will receive general lifestyle and nutritional education. |
| Overweight/Obese Group | Experimental | Behavioral: Personalized nutritional and lifestyle weight reduction interventionThey will receive personalized nutritional and lifestyle weight reduction intervention including dietary advice, behavior guidance and nutritional and lifestyle education by dietitian and physicians. |
Who may qualify
- Ages
- 20 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- 20-70 years of age, inclusive
- BMI ≥ 24kg/m2
- Not in other clinical studies currently or in the past three months
Key exclusion criteria (21 listed)
- Fasting glucose >7.0mmol/L or diagnosed diabetes or taking insulin or other blood glucose-lowering drugs
- Blood pressure > 160/100 mmHg; diagnosed phase II or III hypertension or cannot decrease SBP under 160mmHg after anti-hypertension drugs
- Fasting blood TG≥ 5.7 mmol/L or fasting LDL-C≥ 4.9 mmol/L or cannot control TG < 5.7 mmol/L or LDL-C < 4.9 mmol/L after taking lipid lowering drugs
- Pregnant or lactating
- Attempting to change body weight in the past 3 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| General lifestyle and nutritional educationParticipants will receive general dietary advice, behavior guidance and nutritional and lifestyle education based on dietary guidelines. | Behavioural | Healthy Comparators |
| Personalized nutritional and lifestyle weight reduction interventionParticipants will receive personalized dietary advice, behavior guidance and nutritional and lifestyle education by dietitian and physicians. APP-connected wearable devices will be utilized to monitor their dietary intakes, physical activities and sleep conditions and APP-connected scale will be used to monitor their weight changes during interventions. | Behavioural | Overweight/Obese Group |
Primary outcome
Fasting and postprandial energy metabolic response at baseline and post-intervention
Time frame: Baseline and Week 12
Energy metabolism is characterized by four primary indicators: energy expenditure (EE), respiratory quotient (RQ), carbohydrate oxidation rate (CarbOx), and fat oxidation rate (FatOx). EE denotes the rate of energy expenditure per minute (typically expressed in kcal/min). RQ, defined as the ratio of carbon dioxide produced to oxygen consumed (VCO₂/VO₂), reflects whole-body substrate utilization. CarbOx and FatOx represent the respective oxidation rates of carbohydrate and fat, quantifying the contribution of each macronutrient to total energy production.
22 secondary outcomes
Change from Baseline in Body Weight at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Body Mass Index at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Waist Circumference at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Hip Circumference at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Blood Pressure at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Heart Rate at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Body Composition at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Energy Expenditure at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Respiratory Quotient at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Glucose Homeostasis at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Glucose at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in C-peptide at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Insulin Indices at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Lipid Parameters at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Protein and Amino Acids Metabolites at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Inflammatory Biomarkers and Cytokines at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Gastrointestinal Hormones at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Cell Adhesion Molecules at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Adipokines at 12 Weeks
Time frame: Baseline and Week 12
Change from Baseline in Metabolomics at 12 Weeks
Time frame: Baseline and Week 12
Single nucleotide polymorphism (SNPs)
Time frame: Baseline
Gut microbiota 16S rDNA sequencing
Time frame: Baseline and Week 12
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Xu Lin, PhD principal investigator
Institute for Nutritional Sciecnes, CAS; Hangzhou Institute for Advanced Study, UCAS
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing General lifestyle and nutritional education and Personalized nutritional and lifestyle weight reduction intervention in people with Homeostasis and Metabolism and Nutrition Disorder, run by Chinese Academy of Sciences at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 21 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fasting and postprandial energy metabolic response at baseline and post-intervention (time frame: Baseline and Week 12). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Feb 2026.