Tooth Extraction Status NosPhase 1NCT05816707
The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh
A Phase 1 study testing PRF, Curcuma Longa gel and extraction socket in people with Tooth Extraction Status Nos and Tooth Fracture, run by Rania Farouk Mohamed Abdulmaguid at 1 site in Egypt.
Trial summary
The study will be conducted on 30 patients with split mouth design patients will be divided into curcumin and PRF groups patients will have bilateral tooth extraction one side will receive curcumin/PRF and the other side will be control soft tissue healing and bone quality will be evaluated post-operative Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Tooth Extraction Status Nos, Tooth Fracture
- What is being tested?
- PRF, Curcuma Longa gel and extraction socket
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 May 2024to 1 Mar 2026
- Phase
- Phase 1
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 1. Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
- 2. Patients free from any systemic disease 3. Patients who approved to be included in the trial and signed the informed consent.
- 4. Patients with no signs or symptoms of acute periapical\ periodontal infection.
- 5. Adults aged between 18-50 years old.
Who cannot join
- 1. Patients who are allergic to Curcumin 2. Smoker patient 3. Patients receiving chemotherapy or radiotherapy. 4. Patients who refused to be included in the trial.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh Extraction Sockets; Randomized Controlled Clinical Trial.
The study will be conducted on 30 patients with split mouth design patients will be divided into curcumin and PRF groups patients will have bilateral tooth extraction one side will receive curcumin/PRF and the other side will be control soft tissue healing and bone quality will be evaluated post-operative
Read the detailed description
30 Patients will be collected from the outpatient clinic of the Department of Oral \&Maxillofacial surgery, Faculty of Dentistry, MSA University, Cairo, Egypt
Eligibility criteria:
Inclusion Criteria for participants:
- Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
- Patients free from any systemic disease
- Patients who approved to be included in the trial and signed the informed consent.
- Patients with no signs or symptoms of acute periapical\ periodontal infection.
- Adults aged between 18-50 years old.
Exclusion criteria for participants:
- Patients who are allergic to Curcumin
- Smoker patient
- Patients receiving chemotherapy or radiotherapy.
- Patients who refused to be included in the trial.
Interventions:
- Diagnosis
- All patients will be diagnosed and selected according to inclusion and exclusion criteria.
- Comprehensive clinical examination and understanding of patient's chief complains and needs will be done.
- Standard preoperative intra-oral photographs (occlusal and lateral)
- (Pre-operative orthopantogram* will be taken to ensure absence of any periapical infection)
- Intra-operative procedures: Local anesthesia* will be injected intraoral around selected teeth. Patients will rinse by antiseptic mouthwash** 30 seconds before extraction. Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage. The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group. After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture***
- Postoperative treatment Analgesics **** every 6 hours for 3 days
- Concomitant care None needed.
- Follow up \& Evaluation.
- The extraction site will be inspected clinically after 3 days for signs of infection.
- Soft tissue healing and pain score will be assessed after 7, 14, and 21 days.
- 3 months post-operatively, each patient will undergo radiographic assessment by using Cone Beam Computed Tomography** (CBCT) to evaluate bone healing and bone density.
- Conditions
- Tooth Extraction Status Nos, Tooth Fracture
- Being tested
- PRF, Curcuma Longa gel, extraction socket
- Medical subject headings
- Tooth Fractures
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PRFBiological
Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage.
The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group.
After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture
Curcuma Longa gelBiological
Curcuma Longa gel
extraction socketOther
extraction socket
| Study group | Role | What they receive |
|---|---|---|
| Control | Other | extraction socket . Receives: Other: extraction socket |
| PRF Group | Active comparator | extraction socket and PRF Receives: Biological: PRF; Other: extraction socket |
| Curcuma Longa Group | Active comparator | Extraction Socket and Curcuma Longa Receives: Biological: Curcuma Longa gel; Other: extraction socket |
What is being measured
The primary outcome is the main question the study is designed to answer.
Soft tissue healing
Healing index (change is being assessed)
Measured: 21 days after surgery
Secondary outcomes (1)
Bone Density
CBCT (change is being assessed)
Measured: 3 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Apr 2023
- Study start1 May 2024
- Primary completion1 Feb 2026
- Study completion1 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth Extraction Status NosStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized controlled clinical trial.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rania Farouk Mohamed Abdulmaguid
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Rania Farouk Mohamed Abdulmaguid, October University for Modern Sciences and Arts
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05816707
- Sponsor's protocol ID
- REC-D652-3
- Status last verified
- Mar 2026
- First submitted
- 19 Mar 2023
- Last updated
- 27 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh Extraction Sockets; Randomized Controlled Clinical Trial.
- ClinicalTrials.gov ID
- NCT05816707
- Acronym / sponsor ID
- REC-D652-3
- Conditions
- Tooth Extraction Status Nos, Tooth Fracture
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Rania Farouk Mohamed AbdulmaguidUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 1 Feb 2026 (actual)
- Study completion
- 1 Mar 2026 (actual)
- First posted
- 18 Apr 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study will be conducted on 30 patients with split mouth design patients will be divided into curcumin and PRF groups patients will have bilateral tooth extraction one side will receive curcumin/PRF and the other side will be control soft tissue healing and bone quality will be evaluated post-operative
Detailed description
30 Patients will be collected from the outpatient clinic of the Department of Oral \&Maxillofacial surgery, Faculty of Dentistry, MSA University, Cairo, Egypt
Eligibility criteria:
Inclusion Criteria for participants:
- Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
- Patients free from any systemic disease
- Patients who approved to be included in the trial and signed the informed consent.
- Patients with no signs or symptoms of acute periapical\ periodontal infection.
- Adults aged between 18-50 years old.
Exclusion criteria for participants:
- Patients who are allergic to Curcumin
- Smoker patient
- Patients receiving chemotherapy or radiotherapy.
- Patients who refused to be included in the trial.
Interventions:
- Diagnosis
- All patients will be diagnosed and selected according to inclusion and exclusion criteria.
- Comprehensive clinical examination and understanding of patient's chief complains and needs will be done.
- Standard preoperative intra-oral photographs (occlusal and lateral)
- (Pre-operative orthopantogram* will be taken to ensure absence of any periapical infection)
- Intra-operative procedures: Local anesthesia* will be injected intraoral around selected teeth. Patients will rinse by antiseptic mouthwash** 30 seconds before extraction. Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage. The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group. After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture***
- Postoperative treatment Analgesics **** every 6 hours for 3 days
- Concomitant care None needed.
- Follow up \& Evaluation.
- The extraction site will be inspected clinically after 3 days for signs of infection.
- Soft tissue healing and pain score will be assessed after 7, 14, and 21 days.
- 3 months post-operatively, each patient will undergo radiographic assessment by using Cone Beam Computed Tomography** (CBCT) to evaluate bone healing and bone density.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
- Model description
- Randomized controlled clinical trial.
| Arm | Type | Receives |
|---|---|---|
| Control | Other | Other: extraction socketextraction socket . |
| PRF Group | Active comparator | Biological: PRF, Other: extraction socketextraction socket and PRF |
| Curcuma Longa Group | Active comparator | Biological: Curcuma Longa gel, Other: extraction socketExtraction Socket and Curcuma Longa |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- 1. Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
- 2. Patients free from any systemic disease 3. Patients who approved to be included in the trial and signed the informed consent.
- 4. Patients with no signs or symptoms of acute periapical\ periodontal infection.
- 5. Adults aged between 18-50 years old.
Key exclusion criteria (1 listed)
- 1. Patients who are allergic to Curcumin 2. Smoker patient 3. Patients receiving chemotherapy or radiotherapy. 4. Patients who refused to be included in the trial.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PRFTeeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage. The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group. After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture | Biological | PRF Group |
| Curcuma Longa gelCurcuma Longa gel | Biological | Curcuma Longa Group |
| extraction socketextraction socket | Other | Control, Curcuma Longa Group, PRF Group |
Primary outcome
Soft tissue healing
Time frame: 21 days after surgery
Healing index (change is being assessed)
1 secondary outcome
Bone Density
Time frame: 3 months after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing PRF, Curcuma Longa gel and extraction socket in people with Tooth Extraction Status Nos and Tooth Fracture, run by Rania Farouk Mohamed Abdulmaguid at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Soft tissue healing (time frame: 21 days after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Mar 2026.