Cannabis UseNCT05824754

An App to Reduce Cannabis Use Among Emerging Adults

A study testing Just-In-Time-Adaptive-Intervention (JITAI) in people with Cannabis Use, run by University of Michigan at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This study is being completed to pilot prevention methods to promote wellness and reduce risky behaviors, including the use of substances such as cannabis. This study will help researchers learn about ways of delivering this information that is both appealing and helpful to young adults who use mobile apps. Read more about this study

Who is it for?: Ages 18 to 25 years
Conditions the study is for: Cannabis Use
What is being tested?: Just-In-Time-Adaptive-Intervention (JITAI)
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 122 participants
Where: 1 siteUnited States
Study dates: 21 Feb 2024to 28 May 2024
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 25 years
All sexes
No healthy volunteers
Adult

Who may be able to join

Reside in the US
Speak and read English
Have a smartphone on which the app can be downloaded
Screen positive for cannabis use 3 or more times each week over the past month
Report motivation to change cannabis as 1 or higher (using scale of 0-10)
Meet Study verification criteria (i.e., use of CAPTCHA, IP address checks)

Who cannot join

Use of Medical Cannabis
Failure to meet study verification criteria

Trial locations and contacts

1 site in 1 country.

United States1 site

University of Michigan
Ann Arbor, Michigan, 48109

Other trials in United States

About this study

Official title: Pilot Project 1. Feasibility Pilot of a JITAI to Reduce Cannabis Use Among Emerging Adults

Conditions: Cannabis Use
Being tested: Just-In-Time-Adaptive-Intervention (JITAI)
Keywords: Cannabis Use, Marijuana, Substance-Related Disorders, Mental Disorders
Medical subject headings: Marijuana Abuse, Substance-Related Disorders, Mental Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Just-In-Time-Adaptive-Intervention (JITAI)Other
Behavioral: MiWaves behavioral messages
Participants will be using the MiWaves mobile app for 30 days. When a participant is assigned to receive a message, a message will be randomly selected from a pool of intervention message sets. Messages are based in motivational interviewing and include affect management and behavioral economic strategies.

Study groups in NCT05824754
Study group	Role	What they receive
JITAI	Experimental	Experimental: Within-participant micro-randomization Twice daily in the study, a participant is assigned to receive a message or no message. The micro-randomization will be performed by a reinforcement learning algorithm based on the participant's engagement with the intervention. Receives: Other: Just-In-Time-Adaptive-Intervention (JITAI)

What is being measured

The primary outcome is the main question the study is designed to answer.

App Feasibility
% of participants who consented to the study who download the MiWaves app.
Measured: 1 month
App Acceptability
Participants will complete acceptability ratings for the MiWaves app within their post-test assessment (percent with positive rating).
Measured: 1 month

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

21 Feb 202428 May 2024

First posted24 Apr 2023
Study start21 Feb 2024
Primary completion28 May 2024
Study completion28 May 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Publications (1)Papers the sponsor has linked to this study.
Other trials for Cannabis UseStudies of the same condition, open and under way.
More trials run by University of MichiganThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Other
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Enrolment: 122 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT05824754
Sponsor's protocol ID: HUM00222194
Other IDs: 5P50DA054039-02
Status last verified: Jun 2025
First submitted: 6 Apr 2023
Last updated: 27 Oct 2026
Results posted: Yes, on ClinicalTrials.gov
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Publications

Coughlin LN, Campbell M, Wheeler T, Rodriguez C, Florimbio AR, Ghosh S, Guo Y, Hung PY, Newman MW, Pan H, Zhang KW, Zimmermann L, Bonar EE, Walton M, Murphy S, Nahum-Shani I. A mobile health intervention for emerging adults with regular cannabis use: A micro-randomized pilot trial design protocol. Contemp Clin Trials. 2024 Oct;145:107667. doi: 10.1016/j.cct.2024.107667. Epub 2024 Aug 17.
PubMed 39159806

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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All Cannabis Use trials

Study at a glance

From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Pilot Project 1. Feasibility Pilot of a JITAI to Reduce Cannabis Use Among Emerging Adults
ClinicalTrials.gov ID: NCT05824754
Acronym / sponsor ID: HUM00222194
Conditions: Cannabis Use
Keywords: Cannabis Use, Marijuana, Substance-Related Disorders, Mental Disorders
Study type: Interventional
Recruitment status: Completed
Enrolment: 122 participants (actual)
Lead sponsor: University of MichiganUniversity, hospital or other
Collaborators: National Institute on Drug Abuse (NIDA)
Study start: 21 Feb 2024 (actual)
Primary completion: 28 May 2024 (actual)
Study completion: 28 May 2024 (actual)
First posted: 24 Apr 2023 (actual)
Results: Posted 12 Jun 2025

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Other
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Number of arms: 1

Arm	Type	Receives
JITAI	Experimental	Other: Just-In-Time-Adaptive-Intervention (JITAI)Experimental: Within-participant micro-randomization Twice daily in the study, a participant is assigned to receive a message or no message. The micro-randomization will be performed by a reinforcement learning algorithm based on the participant's engagement with the intervention.

Who may qualify

Ages: 18 to 25 years
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult

Key inclusion criteria (6 listed)

Reside in the US
Speak and read English
Have a smartphone on which the app can be downloaded
Screen positive for cannabis use 3 or more times each week over the past month
Report motivation to change cannabis as 1 or higher (using scale of 0-10)

Key exclusion criteria (2 listed)

Use of Medical Cannabis
Failure to meet study verification criteria

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Just-In-Time-Adaptive-Intervention (JITAI)Behavioral: MiWaves behavioral messages Participants will be using the MiWaves mobile app for 30 days. When a participant is assigned to receive a message, a message will be randomly selected from a pool of intervention message sets. Messages are based in motivational interviewing and include affect management and behavioral economic strategies.	Other	JITAI

Primary outcome

App Feasibility
Time frame: 1 month
% of participants who consented to the study who download the MiWaves app.
App Acceptability
Time frame: 1 month
Participants will complete acceptability ratings for the MiWaves app within their post-test assessment (percent with positive rating).

Results and safety

Results posted to the registry on 12 Jun 2025, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
JITAI	122	122

Primary outcome: App Feasibility

Time frame: 1 month. Count of participants. Unit: Participants

Measure	JITAI n = 137
Value	122

Population analysed: App feasibility outcome is operationalized as % of participants who consented to the study who download the MiWaves app. Not all that consented to the study were included in study flow since not all that consented downloaded the app. Therefore, the number analyzed for app feasibility is greater than the number in the participant flow.

Primary outcome: App Acceptability

Time frame: 1 month. Count of participants. Unit: Participants

Measure	JITAI n = 112
Value	90

Adverse events

Time frame: Up to 2.5 months. After enrollment, participants were followed for AEs until either: a) The participant completes the follow-up survey (2-months post enrollment) b) The window for completing the follow-up survey passed (2 weeks after sending follow-up survey) Therefore, the maximum amount of time a participant would be followed for AEs is 2.5 months post-enrollment.. Other adverse events reported at 0% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
JITAI	0 of 122 (0%)	0 of 122 (0%)	0 of 122

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Derived from this study: PubMed 39159806Coughlin LN, Campbell M, Wheeler T, Rodriguez C, Florimbio AR, Ghosh S, Guo Y, Hung PY, Newman MW, Pan H, Zhang KW, Zimmermann L, Bonar EE, Walton M, Murphy S, Nahum-Shani I. A mobile health intervention for emerging adults with regular cannabis use: A micro-randomized pilot trial design protocol. Contemp Clin Trials. 2024 Oct;145:107667. doi: 10.1016/j.cct.2024.107667. Epub 2024 Aug 17.
Individual participant dataSharing planned: No

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RecruitingObservational study
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Not yet recruitingEarly Phase 1
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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Just-In-Time-Adaptive-Intervention (JITAI) in people with Cannabis Use, run by University of Michigan at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 12 Jun 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

App Feasibility (time frame: 1 month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05824754, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.