SchizophreniaNCT05830903
Develop a Novel Occupational Training Program for Schizophrenia Patients Based on Virtual Reality Techniques
A study testing VR-assisted occupational training in people with Schizophrenia and Cognitive Impairment, run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
Establish a novel vocational training program and test its validity in a pilot study. Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Schizophrenia, Cognitive Impairment
- What is being tested?
- VR-assisted occupational training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Jan 2020to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Having a diagnosis of schizophrenia based on the Diagnostic and Statistical Manual of Mental Disorders -5th version
- Aged between 20 and 55 years.
- Motivated to have a job.
- Having a full-scale IQ > 70 on the Wechsler Adult Intelligence Scale-version IV.
- Having a PANSS positive scale < 70, indicating a stable condition during the illness course.
Who cannot join
- Comorbid with other major psychiatric disorders (i.e., bipolar disorders) or neurological diseases.
- Substance abuse within one year.
- Visual impairment and/or hearing impairment that would preclude participation in the VR-based training program.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site, 1 recruiting
- Recruiting
National Taiwan University Hospital
Taipei
Yi Ling Chien, M.D., Ph.D., 886-2-2312-3456 ext. 66013, ylchien@hotmail.com
About this study
Establish a novel vocational training program and test its validity in a pilot study.
Read the detailed description
40 schizophrenia patients will be recruited to join the virtual reality based vocational training program, the training effect will be compared by interview skills and problem solving before and after the training.
- Conditions
- Schizophrenia, Cognitive Impairment
- Being tested
- VR-assisted occupational training
- Medical subject headings
- Schizophrenia, Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
VR-assisted occupational trainingBehavioural
VR-assisted occupational training
| Study group | Role | What they receive |
|---|---|---|
| Mild ED/NS | Experimental | 10 patients with mild or none executive function impairment and mild or none negative symptoms. Receives: Behavioral: VR-assisted occupational training |
| Mild ED/Severe NS | Experimental | 10 patients with mild or none executive function impairment and severe or moderate negative symptoms. Receives: Behavioral: VR-assisted occupational training |
| Severe ED/Mild NS | Experimental | 10 patients with severe or moderate executive function impairment and mild or none negative symptoms. Receives: Behavioral: VR-assisted occupational training |
| Severe ED/NS | Experimental | 10 patients with severe or moderate executive function impairment and severe or moderate negative symptoms. Receives: Behavioral: VR-assisted occupational training |
What is being measured
The primary outcome is the main question the study is designed to answer.
clinical ratings of schizophrenia symptoms
The Positive and Negative Syndrome Scale (PANSS) is a 30-item rating scale completed by trained research staff. Scores for positive, negative, cognitive disorganization, emotional discomfort, and hostility/excitement symptoms were derived from factor-derived scoring published.
- There are 30 different symptoms rated from 1 to 7 (total score of 210). Higher the score, worse the symptoms
Measured: 8 weeks
vocational skills
Job interview role-play performance will be scored across nine domains: conveying oneself as a hard worker, sounding easy to work with, conveying that one behaves professionally, negotiation skills (requesting one day off), sharing things in a positive way, sounding honest, sounding interested in the position, comfort level, and establishing rapport
Measured: 8 weeks
global improvement
Clinical Global Impression Improvement scale (CGI-I) rating scales are commonly used measures of symptom severity, treatment response and the efficacy in treatment studies of patients with mental disorders. It is a 7-point scale that require clinician to assess how much the patient's illness has improved or worsened relative to baseline. "1" meaning very much improved, "7" meaning very much worsen.
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Apr 2023
- Study start1 Jan 2020
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SchizophreniaStudies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Sequential
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Yi Ling Chien, Principal investigator, National Taiwan University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05830903
- Sponsor's protocol ID
- 201904105RINB
- Status last verified
- Feb 2026
- First submitted
- 4 Jul 2019
- Last updated
- 27 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Develop a Novel Occupational Training Program for Schizophrenia Patients Based on Virtual Reality Techniques
- ClinicalTrials.gov ID
- NCT05830903
- Acronym / sponsor ID
- 201904105RINB
- Conditions
- Schizophrenia, Cognitive Impairment
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 1 Jan 2020 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 26 Apr 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Establish a novel vocational training program and test its validity in a pilot study.
Detailed description
40 schizophrenia patients will be recruited to join the virtual reality based vocational training program, the training effect will be compared by interview skills and problem solving before and after the training.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Sequential
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Mild ED/NS | Experimental | Behavioral: VR-assisted occupational training10 patients with mild or none executive function impairment and mild or none negative symptoms. |
| Mild ED/Severe NS | Experimental | Behavioral: VR-assisted occupational training10 patients with mild or none executive function impairment and severe or moderate negative symptoms. |
| Severe ED/Mild NS | Experimental | Behavioral: VR-assisted occupational training10 patients with severe or moderate executive function impairment and mild or none negative symptoms. |
| Severe ED/NS | Experimental | Behavioral: VR-assisted occupational training10 patients with severe or moderate executive function impairment and severe or moderate negative symptoms. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Having a diagnosis of schizophrenia based on the Diagnostic and Statistical Manual of Mental Disorders -5th version
- Aged between 20 and 55 years.
- Motivated to have a job.
- Having a full-scale IQ > 70 on the Wechsler Adult Intelligence Scale-version IV.
- Having a PANSS positive scale < 70, indicating a stable condition during the illness course.
Key exclusion criteria (3 listed)
- Comorbid with other major psychiatric disorders (i.e., bipolar disorders) or neurological diseases.
- Substance abuse within one year.
- Visual impairment and/or hearing impairment that would preclude participation in the VR-based training program.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| VR-assisted occupational trainingVR-assisted occupational training | Behavioural | Mild ED/NS, Mild ED/Severe NS, Severe ED/Mild NS, Severe ED/NS |
Primary outcome
clinical ratings of schizophrenia symptoms
Time frame: 8 weeks
The Positive and Negative Syndrome Scale (PANSS) is a 30-item rating scale completed by trained research staff. Scores for positive, negative, cognitive disorganization, emotional discomfort, and hostility/excitement symptoms were derived from factor-derived scoring published. * There are 30 different symptoms rated from 1 to 7 (total score of 210). Higher the score, worse the symptoms
vocational skills
Time frame: 8 weeks
Job interview role-play performance will be scored across nine domains: conveying oneself as a hard worker, sounding easy to work with, conveying that one behaves professionally, negotiation skills (requesting one day off), sharing things in a positive way, sounding honest, sounding interested in the position, comfort level, and establishing rapport
global improvement
Time frame: 8 weeks
Clinical Global Impression Improvement scale (CGI-I) rating scales are commonly used measures of symptom severity, treatment response and the efficacy in treatment studies of patients with mental disorders. It is a 7-point scale that require clinician to assess how much the patient's illness has improved or worsened relative to baseline. "1" meaning very much improved, "7" meaning very much worsen.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Yi Ling Chien principal investigator
National Taiwan University Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing VR-assisted occupational training in people with Schizophrenia and Cognitive Impairment, run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yi Ling Chien (886-2-2312-3456 ext. 66013, ylchien@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
clinical ratings of schizophrenia symptoms (time frame: 8 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026.