ObesityNCT05838950
HIIT Effects on Cardiometabolic Health
A study testing high-intensity interval training intervention in people with Obesity and Cardiovascular Diseases, run by Syracuse University at 1 site in United States.
Trial summary
The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Read more about this study
- Who is it for?
- Ages 18 to 25 years
- Conditions the study is for
- Obesity, Cardiovascular Diseases, Metabolic Disease
- What is being tested?
- high-intensity interval training intervention
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Sep 2023to 10 Dec 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).
Who cannot join
- Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
- Taking weight loss medication(s)
- Currently enrolled (or within previous 6 months) in a weight loss program;
- An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
- Presence of cardiac pacemaker.
- Current or anticipated participation in another research that would interfere with any of the outcomes.
- Current or anticipated pregnancy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Women's Building
Syracuse, New York, 13244
Departments of Exercise Science, 315-443-2115
About this study
Official title: Detraining Effect of Short-term HIIT on Cardiometabolic Risk in Young Adults With Obesity
The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.
Read the detailed description
Introduction: High-intensity interval training (HIIT) compared with other traditional exercise regimens has shown to be effective in improving cardiometabolic health (as measured by lipids, blood pressure [BP], insulin sensitivity, pulse wave velocity) in overweight and obese adults. By knowing which HIIT protocol is more efficacious in improving markers of cardiometabolic disease, exercise physiologists, researchers and clinicians can properly prescribe exercise medicine to obese young adults and possibly prevent disease progression. Therefore, the primary aim of the present research is to compare the effects of 3 different HIIT protocols compared with a control group on cardiometabolic health improvement in young adults with obesity.
Participants: Participants will be randomly assigned to one of the following three groups : 1) HIIT-A (5:25 s; 1:5 ratio), 2) HIIT-B (10:50 s; 1:5 ratio), 3) HIIT-C (20:100 s; 1:5 ratio), and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of running-based HIIT programs over a 2-week training period. The variables will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the TC (i.e., measure for detraining effect).
High-Intensity Interval Training (six sessions over 2 weeks): Heart rate will be recorded - while performing a sprint running based on the wood court. The HIIT intensity will be set at 90% of the fastest baseline with 40 repetitions of 5-seconds work time, 20 repetitions of 10-seconds work time, or 10 repetitions of 20-seconds work time. All participants will perform one bout of sprint running for 5-, 10-, or 20- seconds followed by 25-second, 50-second, or 100-seconds resting. The supervisor will verbally encourage the running to inspire the sprint at "all-out" intensity. Note that a total of 200-seconds workout time is required per session.
- Being tested
- high-intensity interval training intervention
- Keywords
- HIIT, Detraining effects, Cardiometabolic disease, Obesity, Young adults
- Medical subject headings
- Obesity, Cardiovascular Diseases, Metabolic Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
high-intensity interval training interventionOther
Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.
| Study group | Role | What they receive |
|---|---|---|
| 5s HIIT | Experimental | 5s HIIT group will perform one bout of sprint running for 5-seconds followed by 25-second, resting of total 40 repetition. Receives: Other: high-intensity interval training intervention |
| 10s HIIT | Experimental | 10s HIIT group will perform one bout of sprint running for 10-seconds followed by 50-second, resting of total 20 repetition. Receives: Other: high-intensity interval training intervention |
| 20s HIIT | Experimental | 20s HIIT group will perform one bout of sprint running for 20-seconds followed by 100-second, resting of total 10 repetition. Receives: Other: high-intensity interval training intervention |
| Control | Experimental | Control group Receives: Other: high-intensity interval training intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Height
Height (cm)
Measured: Baseline
Weight
Weight (kg); Change from Baseline weight at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Body mass index
Body mass index (kg/m2); Change from Baseline BMI at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Percentage body fat
Percentage body fat (kg); Change from Baseline percentage body fat at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Fat mass
Fat mass (kg); Change from Baseline fat mass at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Lean mass
Lean mass (kg); Change from Baseline lean mass at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Systolic blood pressure
Systolic blood pressure (SBP, mmHg); Change from Baseline SBP at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Diastolic blood pressure
Diastolic blood pressure (DBP, mmHg); Change from Baseline DBP at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Mean arterial pressure
Mean blood pressure (MAP, mmHg); Change from Baseline MAP at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Flow-mediated dilation
Flow-mediated dilation (FMD, mm); Change from Baseline FMD at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Carotid-femoral Pulse Wave Velocity (cPWV)
cPWV (m/s); Change from Baseline cPWV at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Total cholesterol
Total cholesterol (mg/dl); Change from Baseline TC at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
LDL-C
LDL-C (mg/dl); Change from Baseline LDL-C at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
HDL-C
HDL-C (mg/dl); Change from Baseline HDL-C at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Triglycerides
Triglycerides (TG, mg/dl); Change from Baseline TG at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Glucose
Glucose (mg/dl); Change from Baseline glucose at 2 week and 4 week
Measured: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 May 2023
- Study start29 Sep 2023
- Primary completion23 Aug 2025 (estimated)
- Study completion10 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Syracuse University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Joon Young Kim, Ph.D, Principal investigator, Syracuse University, Departments of Exercise Science
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05838950
- Sponsor's protocol ID
- 22-010
- Status last verified
- Jul 2025
- First submitted
- 13 Feb 2023
- Last updated
- 23 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Detraining Effect of Short-term HIIT on Cardiometabolic Risk in Young Adults With Obesity
- ClinicalTrials.gov ID
- NCT05838950
- Acronym / sponsor ID
- 22-010
- Keywords
- HIIT, Detraining effects, Cardiometabolic disease, Obesity, Young adults
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Syracuse UniversityUniversity, hospital or other
- Study start
- 29 Sep 2023 (actual)
- Primary completion
- 23 Aug 2025 (estimated)
- Study completion
- 10 Dec 2025 (estimated)
- First posted
- 3 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.
Detailed description
Introduction: High-intensity interval training (HIIT) compared with other traditional exercise regimens has shown to be effective in improving cardiometabolic health (as measured by lipids, blood pressure [BP], insulin sensitivity, pulse wave velocity) in overweight and obese adults. By knowing which HIIT protocol is more efficacious in improving markers of cardiometabolic disease, exercise physiologists, researchers and clinicians can properly prescribe exercise medicine to obese young adults and possibly prevent disease progression. Therefore, the primary aim of the present research is to compare the effects of 3 different HIIT protocols compared with a control group on cardiometabolic health improvement in young adults with obesity.
Participants: Participants will be randomly assigned to one of the following three groups : 1) HIIT-A (5:25 s; 1:5 ratio), 2) HIIT-B (10:50 s; 1:5 ratio), 3) HIIT-C (20:100 s; 1:5 ratio), and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of running-based HIIT programs over a 2-week training period. The variables will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the TC (i.e., measure for detraining effect).
High-Intensity Interval Training (six sessions over 2 weeks): Heart rate will be recorded - while performing a sprint running based on the wood court. The HIIT intensity will be set at 90% of the fastest baseline with 40 repetitions of 5-seconds work time, 20 repetitions of 10-seconds work time, or 10 repetitions of 20-seconds work time. All participants will perform one bout of sprint running for 5-, 10-, or 20- seconds followed by 25-second, 50-second, or 100-seconds resting. The supervisor will verbally encourage the running to inspire the sprint at "all-out" intensity. Note that a total of 200-seconds workout time is required per session.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| 5s HIIT | Experimental | Other: high-intensity interval training intervention5s HIIT group will perform one bout of sprint running for 5-seconds followed by 25-second, resting of total 40 repetition. |
| 10s HIIT | Experimental | Other: high-intensity interval training intervention10s HIIT group will perform one bout of sprint running for 10-seconds followed by 50-second, resting of total 20 repetition. |
| 20s HIIT | Experimental | Other: high-intensity interval training intervention20s HIIT group will perform one bout of sprint running for 20-seconds followed by 100-second, resting of total 10 repetition. |
| Control | Experimental | Other: high-intensity interval training interventionControl group |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).
Key exclusion criteria (7 listed)
- Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
- Taking weight loss medication(s)
- Currently enrolled (or within previous 6 months) in a weight loss program;
- An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
- Presence of cardiac pacemaker.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| high-intensity interval training interventionIntervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity. | Other | 10s HIIT, 20s HIIT, 5s HIIT, Control |
Primary outcome
Height
Time frame: Baseline
Height (cm)
Weight
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Weight (kg); Change from Baseline weight at 2 week and 4 week
Body mass index
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Body mass index (kg/m2); Change from Baseline BMI at 2 week and 4 week
Percentage body fat
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Percentage body fat (kg); Change from Baseline percentage body fat at 2 week and 4 week
Fat mass
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Fat mass (kg); Change from Baseline fat mass at 2 week and 4 week
Lean mass
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Lean mass (kg); Change from Baseline lean mass at 2 week and 4 week
Systolic blood pressure
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Systolic blood pressure (SBP, mmHg); Change from Baseline SBP at 2 week and 4 week
Diastolic blood pressure
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Diastolic blood pressure (DBP, mmHg); Change from Baseline DBP at 2 week and 4 week
Mean arterial pressure
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Mean blood pressure (MAP, mmHg); Change from Baseline MAP at 2 week and 4 week
Flow-mediated dilation
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Flow-mediated dilation (FMD, mm); Change from Baseline FMD at 2 week and 4 week
Carotid-femoral Pulse Wave Velocity (cPWV)
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
cPWV (m/s); Change from Baseline cPWV at 2 week and 4 week
Total cholesterol
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Total cholesterol (mg/dl); Change from Baseline TC at 2 week and 4 week
LDL-C
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
LDL-C (mg/dl); Change from Baseline LDL-C at 2 week and 4 week
HDL-C
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
HDL-C (mg/dl); Change from Baseline HDL-C at 2 week and 4 week
Triglycerides
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Triglycerides (TG, mg/dl); Change from Baseline TG at 2 week and 4 week
Glucose
Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
Glucose (mg/dl); Change from Baseline glucose at 2 week and 4 week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jul 2025.
Related trials for Obesity
RecruitingObservational study
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
Obesity
Active, not recruitingPhase 4
Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic Disorders
Metabolic Abnormalities, Obesity & Overweight
Recruiting
Exercise Training and Vitamin D Metabolism
Obesity & Overweight, Vitamin D
Recruiting
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Weight Loss, Bone Density
Active, not recruiting
Effect of Probiotics on Insulin Sensitivity in Overweight and Obese Pregnancy
Obesity & Overweight, Gestational Diabetes Mellitus (GDM)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Joon Young Kim, Ph.D principal investigator
Syracuse University, Departments of Exercise Science
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing high-intensity interval training intervention in people with Obesity and Cardiovascular Diseases, run by Syracuse University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Myong Won Seo, Ph.D (3154012723, mseo04@syr.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Height (time frame: Baseline). The study lists 16 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2025.