Persistent AsthmaIAQNCT05843045
Indoor Air Quality Asthma Study: The Effect of Indoor Air Quality and Mitigation of Same on Persistent Asthma
A study testing Indoor Air Quality Mitigation in people with Persistent Asthma, run by Dayton Children's Hospital at 1 site in United States.
Trial summary
The primary objective is to determine whether continuous sensing, control and mitigation of home indoor air quality influences the frequency of asthma related symptoms, as measured by Serum IgE, Spirometry with exhaled Nitric Oxide, missed school and workdays, need for pharmacologic intervention (albuterol, oral… Read more about this study
- Who is it for?
- Ages 5 to 15 years
- Conditions the study is for
- Persistent Asthma
- What is being tested?
- Indoor Air Quality Mitigation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteUnited States
- Study dates
- 18 Aug 2023to 9 Jan 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 to 15 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Child aged 5.0-15.9 years at the time of informed consent with mild, moderate, or severe persistent asthma diagnosis. In addition, participants
- Agree to attend visits as outlined by protocol
- Agree to respond to Asthma Control Test (ACT) and asthma control questions as outlined in protocol by telephone call, text, or email.
- Are willing to comply with asthma treatment plan prescribed by physician.
- Are willing to practice an acceptable form of birth control to avoid pregnancy. Acceptable forms of birth control include: true abstinence, male or female condom with or without spermicide, female barrier contraception (such as diaphragm, cervical cap, or sponge) with spermicide, continuous use of an intrauterine device throughout the study, hormonal contraceptives (including oral, patch, implanted, or injected), if used consistently and correctly throughout the study.
- Reside in single-family dwellings and must either be homeowners or have written permission from their landlords to participate in the study.
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- In order to participate in the study, homes of participants must
- have working ducted forced air HVAC systems
- a 4-wire thermostat that is determined by Emerson technician to be capable of communicating with Sensi Touch Smart Thermostat
- a bathroom fan switch with neutral wire and wall plate, controlling a bathroom fan that is vented to the outdoors
- access to the internet with a modem or router.
- A smartphone capable of pairing with the Atmotube Pro wearable sensor
Who cannot join
- Exclusion criteria: Age <5.0 or >15.9 years at the time of informed consent, inability to commit to being in the same home for the length of the study, and/or not meeting the above inclusion criteria.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Indoor Air Quality Asthma Study: A Cooperative Study Between Coepland LP, Cairify, and Dayton Children's Hospital to Determine the Effect of Indoor Air Quality and Mitigation of Indoor Air Quality on Persistent Asthma
The primary objective is to determine whether continuous sensing, control and mitigation of home indoor air quality influences the frequency of asthma related symptoms, as measured by Serum IgE, Spirometry with exhaled Nitric Oxide, missed school and workdays, need for pharmacologic intervention (albuterol, oral steroids), frequency of sick visits to pulmonologist or primary care provider (PCP), urgent care / emergency department visits, and hospitalizations
Read the detailed description
Participants will be in the research study for approximately 2 years. There will be 11 visits to the clinic for monitoring of asthma symptoms and pulmonary function and 16 interval contacts with research staff made by either telephone or email to monitor asthma symptoms. There will also be 5 visits to participants' homes by technicians from Emerson Climate Technologies and/or an electrician in cooperation with Emerson. During these visits Emerson employees will assess participants' homes to determine if they qualify for the study and install study equipment to monitor air quality for the first half of the study and monitor and mitigate air quality for the second half of the study. At the end of the study, the technicians and/or electrician from Emerson will reset the study equipment or replace participants' original equipment, if that is their wish.
Participants will be enrolled in the research study for approximately 2 years. The first year, technicians from the study sponsor will install indoor air quality monitoring equipment in the participants' homes and information about the air quality in their home as well as baseline health and asthma information will be collected. This will be done through continuous sensing via an Atmocube air quality sensor, and a portable air quality sensor, the Atmotube. Beginning in the second half of the study, mitigation strategies of a smart home thermostat, the Sensi Touch Smart Thermostat, a smart bath fan control, the Enbrighten Z-wave Switch, and high quality furnace filter, 3M Filtrete MPR 2800 Ultrafine Particle Reduction Air Filter, will be employed. Information about the participants' asthma, health status, and air quality in the homes will continue to be collected.
- Conditions
- Persistent Asthma
- Being tested
- Indoor Air Quality Mitigation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Indoor Air Quality MitigationDevice
Also called Sensi Touch Smart Thermostat, Enbrighten Z-Wave Switch, 3M Filtrete MPR 2800 Ultrafine Particle Reduction Air Filters
Mitigation of indoor air quality with use of smart thermostat, smart bath fan control, and high quality furnace filters
| Study group | Role | What they receive |
|---|---|---|
| Pre-mitigation | No intervention | Information will be collected from participants about their health status and asthma symptoms. Information about the air quality inside the participants' homes will also be collected. |
| Indoor Air Quality Mitigation | Experimental | Indoor air quality mitigation strategies of a smart home thermostat, smart bath fan switch, and a high-quality furnace filter will be employed within the participants' homes. Information will continue to be collected about participants' health status and asthma symptoms as well as the air quality inside their homes. Receives: Device: Indoor Air Quality Mitigation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Asthma Control Test questionnaire
Monthly Asthma Control Test by History. Possible scores ranging from 0 (worst control)-27 (best control) for patients ages 6-11 or 0 (worst control)- 25 (best control) for patients ages 12-16.
Measured: Through study completion, approximately 2 years
Secondary outcomes (13)
Number of asthma related visits to Primary Care Physician, Emergency Department or Urgent Care
Sick Visits due to asthma
Measured: Through study completion, approximately 2 years
Number of missed school and work days
Number of missed school and work days due to asthma symptoms
Measured: Through study completion, approximately 2 years
Frequency of asthma Medication Use
Use of asthma rescue inhaler and systemic steroids
Measured: Through study completion, approximately 2 years
Spirometry with exhaled nitric oxide
measurement of Forced Expiratory Volume in 1 second measured quarterly
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
Physical examination
head, eyes, ears, nose, throat (HEENT), lungs, cardiovascular, abdominal, neurologic, and musculoskeletal exam by a licensed physician.
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
Mini Paediatric Asthma Quality of Life Questionnaire (MiniPAQLQ)
Questionnaire assessing quality of life for patients with asthma. Possible scores range from 13 (worst quality of life)- 91 (best quality of life)
Measured: Weeks 1, 49, 53, 105
Concentration in serum of immunoglobulin E (IgE)
blood test measuring IgE
Measured: Weeks 1, 53, 105
height
standing height in centimeters without shoes
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
weight
weight in kilograms without shoes
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
heart rate
heart beats per minute
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
respiratory rate
number of breaths per one minute
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
blood pressure
systolic over diastolic blood pressure measured in mm/Hg
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
oxygen saturation
percent of hemoglobin saturated by oxygen in blood
Measured: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2023
- Study start18 Aug 2023
- Primary completion9 Jan 2024
- Study completion9 Jan 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Persistent AsthmaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Model description
- The study will consist of two phases with each participant acting as their own control. Data will be collected from participants and their homes for approximately 1 year without mitigation and compared to a second period of approximately 1 year with mitigation.
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dayton Children's Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Cairify LLC, Copeland LP
- Responsible party
- Principal investigator, Daniel Evans, MD, Dayton Children's Hospital
- Investigators
- Daniel A. Evans, MD, Principal investigator, Dayton Children's Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05843045
- Sponsor's protocol ID
- 22-039
- Acronym
- IAQ
- Status last verified
- Oct 2026
- First submitted
- 6 Mar 2023
- Last updated
- 29 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Indoor Air Quality Asthma Study: A Cooperative Study Between Coepland LP, Cairify, and Dayton Children's Hospital to Determine the Effect of Indoor Air Quality and Mitigation of Indoor Air Quality on Persistent Asthma
- ClinicalTrials.gov ID
- NCT05843045
- Acronym / sponsor ID
- IAQ / 22-039
- Conditions
- Persistent Asthma
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- Dayton Children's HospitalUniversity, hospital or other
- Collaborators
- Cairify LLC, Copeland LP
- Study start
- 18 Aug 2023 (actual)
- Primary completion
- 9 Jan 2024 (actual)
- Study completion
- 9 Jan 2024 (actual)
- First posted
- 6 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary objective is to determine whether continuous sensing, control and mitigation of home indoor air quality influences the frequency of asthma related symptoms, as measured by Serum IgE, Spirometry with exhaled Nitric Oxide, missed school and workdays, need for pharmacologic intervention (albuterol, oral steroids), frequency of sick visits to pulmonologist or primary care provider (PCP), urgent care / emergency department visits, and hospitalizations
Detailed description
Participants will be in the research study for approximately 2 years. There will be 11 visits to the clinic for monitoring of asthma symptoms and pulmonary function and 16 interval contacts with research staff made by either telephone or email to monitor asthma symptoms. There will also be 5 visits to participants' homes by technicians from Emerson Climate Technologies and/or an electrician in cooperation with Emerson. During these visits Emerson employees will assess participants' homes to determine if they qualify for the study and install study equipment to monitor air quality for the first half of the study and monitor and mitigate air quality for the second half of the study. At the end of the study, the technicians and/or electrician from Emerson will reset the study equipment or replace participants' original equipment, if that is their wish.
Participants will be enrolled in the research study for approximately 2 years. The first year, technicians from the study sponsor will install indoor air quality monitoring equipment in the participants' homes and information about the air quality in their home as well as baseline health and asthma information will be collected. This will be done through continuous sensing via an Atmocube air quality sensor, and a portable air quality sensor, the Atmotube. Beginning in the second half of the study, mitigation strategies of a smart home thermostat, the Sensi Touch Smart Thermostat, a smart bath fan control, the Enbrighten Z-wave Switch, and high quality furnace filter, 3M Filtrete MPR 2800 Ultrafine Particle Reduction Air Filter, will be employed. Information about the participants' asthma, health status, and air quality in the homes will continue to be collected.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 2
- Model description
- The study will consist of two phases with each participant acting as their own control. Data will be collected from participants and their homes for approximately 1 year without mitigation and compared to a second period of approximately 1 year with mitigation.
| Arm | Type | Receives |
|---|---|---|
| Pre-mitigation | No intervention | –Information will be collected from participants about their health status and asthma symptoms. Information about the air quality inside the participants' homes will also be collected. |
| Indoor Air Quality Mitigation | Experimental | Device: Indoor Air Quality MitigationIndoor air quality mitigation strategies of a smart home thermostat, smart bath fan switch, and a high-quality furnace filter will be employed within the participants' homes. Information will continue to be collected about participants' health status and asthma symptoms as well as the air quality inside their homes. |
Who may qualify
- Ages
- 5 to 15 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (12 listed)
- Child aged 5.0-15.9 years at the time of informed consent with mild, moderate, or severe persistent asthma diagnosis. In addition, participants
- Agree to attend visits as outlined by protocol
- Agree to respond to Asthma Control Test (ACT) and asthma control questions as outlined in protocol by telephone call, text, or email.
- Are willing to comply with asthma treatment plan prescribed by physician.
- Are willing to practice an acceptable form of birth control to avoid pregnancy. Acceptable forms of birth control include: true abstinence, male or female condom with or without spermicide, female barrier contraception (such as diaphragm, cervical cap, or sponge) with spermicide, continuous use of an intrauterine device throughout the study, hormonal contraceptives (including oral, patch, implanted, or injected), if used consistently and correctly throughout the study.
Key exclusion criteria (1 listed)
- Exclusion criteria: Age <5.0 or >15.9 years at the time of informed consent, inability to commit to being in the same home for the length of the study, and/or not meeting the above inclusion criteria.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Indoor Air Quality MitigationAlso: Sensi Touch Smart Thermostat, Enbrighten Z-Wave Switch, 3M Filtrete MPR 2800 Ultrafine Particle Reduction Air FiltersMitigation of indoor air quality with use of smart thermostat, smart bath fan control, and high quality furnace filters | Device | Indoor Air Quality Mitigation |
Primary outcome
Asthma Control Test questionnaire
Time frame: Through study completion, approximately 2 years
Monthly Asthma Control Test by History. Possible scores ranging from 0 (worst control)-27 (best control) for patients ages 6-11 or 0 (worst control)- 25 (best control) for patients ages 12-16.
13 secondary outcomes
Number of asthma related visits to Primary Care Physician, Emergency Department or Urgent Care
Time frame: Through study completion, approximately 2 years
Number of missed school and work days
Time frame: Through study completion, approximately 2 years
Frequency of asthma Medication Use
Time frame: Through study completion, approximately 2 years
Spirometry with exhaled nitric oxide
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
Physical examination
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
Mini Paediatric Asthma Quality of Life Questionnaire (MiniPAQLQ)
Time frame: Weeks 1, 49, 53, 105
Concentration in serum of immunoglobulin E (IgE)
Time frame: Weeks 1, 53, 105
height
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
weight
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
heart rate
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
respiratory rate
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
blood pressure
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
oxygen saturation
Time frame: Weeks 1, 13, 25, 37, 49, 53, 65, 77, 89, 101, 105
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Daniel A. Evans, MD principal investigator
Dayton Children's Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Indoor Air Quality Mitigation in people with Persistent Asthma, run by Dayton Children's Hospital at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Asthma Control Test questionnaire (time frame: Through study completion, approximately 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026.