Neurocognitive DeficitMMS-R-epNCT05858489
Concordance Between Mini-Mental Stats Examination (MMSE) and an Adapted Version of the MMSE in Reunion Island Population (MMS-Run)
An observational study of Neurocognitive Deficit, run by Centre Hospitalier Universitaire de la Réunion at 1 site in Reunion.
Trial summary
Illeteracy concerns more than 38% of Réunion Island's people older than 65 years old, which makes it an important risk factor for dementia and a limit to neurocognitive test's administration. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Neurocognitive Deficit
- What is being tested?
- Mini-Mental State Examination (MMSE)
- How many people
- 61 participants
- Where
- 1 siteReunion
- Study dates
- 14 Apr 2023to 12 Apr 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Study population: Patients will be selected in geriatric and physical medicine and rehabilitation departments at CHU de La Réunion.
Who may be able to join
- Patient who needs a cognitive evaluation by MMSe/MMS-RUN during usual medical care
- Patient born and living in Réunion Island
- Patient hospitalized in geriatrics department or in the departement of physical medecine and rehabilitation
- Patient who agrees to participate in the study and who does not oppose to the use of his data
Who cannot join
- Patient with hearing and visual disorder that can interfere in cognitive test administration
- Patient with altered state of consciousness (Glasgow score different of 15)
- Patient diagnosed or having symtoms compatible with a psychiatric pathology with psychosis (altered perception of reality)
- Patient with a current and severe addiction to Alcohol or any other drug (smoking excluded)
- Patient deprived of liberty by judicial or administrative decision and patient under curatorship or guardianship
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Concordance Between Mini-Mental Stats Examination (MMSE) and an Adapted Version of the MMSE in Reunion Island Population (MMS-Run) : Preliminary Study
Illeteracy concerns more than 38% of Réunion Island's people older than 65 years old, which makes it an important risk factor for dementia and a limit to neurocognitive test's administration.
The MMSRun is a Mini Mental State Examination's version adapted to illeteracy and Réunionese culture, inspired by Hindi Mental State Examination's work. It allows a way better participation during neurocognitive evaluation, but it has never been validated.
This study is a peliminary study to a validation, where the concordance between scores obtained from MMSRun and from the consensual version of Mini Mental State Examination proposed by GRECO (Groupe de Réflexion sur les Evaluations Cognitives) - the only french version validated - on a hospitalized and eldery population will be analyzed.
- Conditions
- Neurocognitive Deficit
- Being tested
- Mini-Mental State Examination (MMSE)
- Keywords
- Neurocognitive Deficit, Neurocognitive Impairment, Major neurocognitive disorder, Dementia, Geriatric, Senior, Illeteracy : Mini Mental State Examination, Eldery
- Medical subject headings
- Dementia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mini-Mental State Examination (MMSE)Other
Each patient will be evaluated by MMSE then by the adapted version of MMSE
What is being measured
The primary outcome is the main question the study is designed to answer.
Total scoring of MMSE
30 questions, good response to a question = 1, bad response to a question = 0, global scoring between 0 and 30,
Pathological threshold according to the socio-cultural level :
- without diploma : total score <22
- secondary education without the 3rd class : total score <23
- secondary education from 3rd class to the senior year class (without bachelor degree)
- higher education : total score <26
Measured: Day 0
Total scoring of MMS-RUN
30 questions, good response to a question = 1, bad response to a question = 0, total score between 0 and 30,
Pathological threshold according to the socio-cultural level :
- without diploma : total score <22
- secondary education without the 3rd class : total score <23
- secondary education from 3rd class to the senior year class (without bachelor degree)
- higher education : total score <26
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 May 2023
- Study start14 Apr 2023
- Primary completion12 Apr 2024
- Study completion12 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neurocognitive DeficitStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 61 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de la Réunion
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Bénédicte CASALONGA, MD, Principal investigator, CHU de La Réunion
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05858489
- Sponsor's protocol ID
- 2022/CHU/30
- Acronym
- MMS-R-ep
- Status last verified
- Feb 2025
- First submitted
- 25 Apr 2023
- Last updated
- 13 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Concordance Between Mini-Mental Stats Examination (MMSE) and an Adapted Version of the MMSE in Reunion Island Population (MMS-Run) : Preliminary Study
- ClinicalTrials.gov ID
- NCT05858489
- Acronym / sponsor ID
- MMS-R-ep / 2022/CHU/30
- Conditions
- Neurocognitive Deficit
- Keywords
- Neurocognitive Deficit, Neurocognitive Impairment, Major neurocognitive disorder, Dementia, Geriatric, Senior, Illeteracy : Mini Mental State Examination, Eldery
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 61 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de la RéunionUniversity, hospital or other
- Study start
- 14 Apr 2023 (actual)
- Primary completion
- 12 Apr 2024 (actual)
- Study completion
- 12 Apr 2024 (actual)
- First posted
- 15 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Illeteracy concerns more than 38% of Réunion Island's people older than 65 years old, which makes it an important risk factor for dementia and a limit to neurocognitive test's administration.
The MMSRun is a Mini Mental State Examination's version adapted to illeteracy and Réunionese culture, inspired by Hindi Mental State Examination's work. It allows a way better participation during neurocognitive evaluation, but it has never been validated.
This study is a peliminary study to a validation, where the concordance between scores obtained from MMSRun and from the consensual version of Mini Mental State Examination proposed by GRECO (Groupe de Réflexion sur les Evaluations Cognitives) - the only french version validated - on a hospitalized and eldery population will be analyzed.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
- Study population
- Patients will be selected in geriatric and physical medicine and rehabilitation departments at CHU de La Réunion.
Key inclusion criteria (4 listed)
- Patient who needs a cognitive evaluation by MMSe/MMS-RUN during usual medical care
- Patient born and living in Réunion Island
- Patient hospitalized in geriatrics department or in the departement of physical medecine and rehabilitation
- Patient who agrees to participate in the study and who does not oppose to the use of his data
Key exclusion criteria (5 listed)
- Patient with hearing and visual disorder that can interfere in cognitive test administration
- Patient with altered state of consciousness (Glasgow score different of 15)
- Patient diagnosed or having symtoms compatible with a psychiatric pathology with psychosis (altered perception of reality)
- Patient with a current and severe addiction to Alcohol or any other drug (smoking excluded)
- Patient deprived of liberty by judicial or administrative decision and patient under curatorship or guardianship
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mini-Mental State Examination (MMSE)Each patient will be evaluated by MMSE then by the adapted version of MMSE | Other | – |
Primary outcome
Total scoring of MMSE
Time frame: Day 0
30 questions, good response to a question = 1, bad response to a question = 0, global scoring between 0 and 30, Pathological threshold according to the socio-cultural level : * without diploma : total score <22 * secondary education without the 3rd class : total score <23 * secondary education from 3rd class to the senior year class (without bachelor degree) * higher education : total score <26
Total scoring of MMS-RUN
Time frame: Day 1
30 questions, good response to a question = 1, bad response to a question = 0, total score between 0 and 30, Pathological threshold according to the socio-cultural level : * without diploma : total score <22 * secondary education without the 3rd class : total score <23 * secondary education from 3rd class to the senior year class (without bachelor degree) * higher education : total score <26
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Bénédicte CASALONGA, MD principal investigator
CHU de La Réunion
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Neurocognitive Deficit, run by Centre Hospitalier Universitaire de la Réunion at 1 site in Reunion.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Reunion. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total scoring of MMSE (time frame: Day 0). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Mar 2026.