HealthyNCT05863039
Resistance Training With Blood Flow Restriction
A study testing Blood flow restriction, Regular training type 1 and Regular training type 2 in people with Healthy, run by University of Oklahoma at 1 site in United States.
Trial summary
Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Blood flow restriction, Regular training type 1 and Regular training type 2
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 8 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Nov 2022to 27 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
None listed.
Who cannot join
- presence of neurological diseases,
- presence of metal implants or joint replacement
- any restriction to perform physical activity
- pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Resistance Training With Blood Flow Restriction for the Lower Extremity Muscles
Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.
Read the detailed description
The purpose of this study is to determine alterations in motor unit behavior of the tibialis anterior muscles after a resistance exercise program associated with blood flow restriction. Our working hypothesis is that blood flow restriction to working muscles will induce greater changes in muscle activation, lean mass and muscle size compared with a training at same intensity without blood flow restriction.
- Conditions
- Healthy
- Being tested
- Blood flow restriction, Regular training type 1, Regular training type 2
- Keywords
- resistance training, strength training, blood flow restriction, motor units, body composition
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Blood flow restrictionOther
Strength training of the lower leg muscles using blood flow restriction
Regular training type 1Other
Strength training of the lower leg muscles using high loads
Regular training type 2Other
Strength training of the lower leg muscles using low loads
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Experimental | Strength training associated with blood flow restriction Receives: Other: Blood flow restriction |
| Group 2 | Experimental | Conventional strength training using high loads Receives: Other: Regular training type 1 |
| Group 3 | Experimental | Conventional strength training using low loads Receives: Other: Regular training type 2 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Force
Force of the lower leg muscles using a custom made ergometer
Measured: 10 sessions (up to 6 weeks)
Secondary outcomes (1)
Body composition
dual x-ray absorptiometry (DEXA) will be used to assess body composition
Measured: Start and end of the protocol
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 May 2023
- Study start1 Nov 2022
- Primary completion31 May 2025
- Study completion27 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 8 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Oklahoma
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Hugo Pereira, PhD, Principal investigator, University of Oklahoma
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05863039
- Sponsor's protocol ID
- 14083P
- Status last verified
- Apr 2026
- First submitted
- 17 Apr 2023
- Last updated
- 1 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: deidentified information can be shared according to instructions of the local institutional review board that reviewed the study
Study at a glance
From the registry record, last updated by the sponsor on 1 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Resistance Training With Blood Flow Restriction for the Lower Extremity Muscles
- ClinicalTrials.gov ID
- NCT05863039
- Acronym / sponsor ID
- 14083P
- Conditions
- Healthy
- Keywords
- resistance training, strength training, blood flow restriction, motor units, body composition
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 8 participants (actual)
- Lead sponsor
- University of OklahomaUniversity, hospital or other
- Study start
- 1 Nov 2022 (actual)
- Primary completion
- 31 May 2025 (actual)
- Study completion
- 27 Apr 2026 (actual)
- First posted
- 17 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.
Detailed description
The purpose of this study is to determine alterations in motor unit behavior of the tibialis anterior muscles after a resistance exercise program associated with blood flow restriction. Our working hypothesis is that blood flow restriction to working muscles will induce greater changes in muscle activation, lean mass and muscle size compared with a training at same intensity without blood flow restriction.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Experimental | Other: Blood flow restrictionStrength training associated with blood flow restriction |
| Group 2 | Experimental | Other: Regular training type 1Conventional strength training using high loads |
| Group 3 | Experimental | Other: Regular training type 2Conventional strength training using low loads |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (0 listed)
Key exclusion criteria (4 listed)
- presence of neurological diseases,
- presence of metal implants or joint replacement
- any restriction to perform physical activity
- pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Blood flow restrictionStrength training of the lower leg muscles using blood flow restriction | Other | Group 1 |
| Regular training type 1Strength training of the lower leg muscles using high loads | Other | Group 2 |
| Regular training type 2Strength training of the lower leg muscles using low loads | Other | Group 3 |
Primary outcome
Force
Time frame: 10 sessions (up to 6 weeks)
Force of the lower leg muscles using a custom made ergometer
1 secondary outcome
Body composition
Time frame: Start and end of the protocol
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 May 2026.
- Individual participant dataSharing planned: Yes. deidentified information can be shared according to instructions of the local institutional review board that reviewed the study
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hugo Pereira, PhD principal investigator
University of Oklahoma
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Blood flow restriction, Regular training type 1 and Regular training type 2 in people with Healthy, run by University of Oklahoma at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Force (time frame: 10 sessions (up to 6 weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 May 2026.