ThyroidectomyNCT05869058
DCNN Developed for Detection and Assessing the Perfusion of PTG
An observational study of Thyroidectomy, run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University at 1 site in China.
Trial summary
Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Thyroidectomy
- What is being tested?
- a deep convolutional neural network
- How many people
- 300 participants
- Where
- 1 siteChina
- Study dates
- 13 Jun 2023to Oct 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The patients, who choose to undergo endoscopic thyroidectomy due to thyroid diseases and have no history of hyperparathyroidism, hypoparathyroidism, neck surgery and cervical radiotherapy, are candidates of our study.
Who may be able to join
- The patients who undergo endoscopic thyroidectomy
Who cannot join
- hyperparathyroidism
- hypoparathyroidism
- neck surgery history
- cervical radiotherapy history
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, 510000
Peiliang Lin, M.D., +862034071439, linpliang3@mail.sysu.edu.cn
About this study
Official title: Development and Improvement of a Deep Convolutional Neural Network for Detection and Assessing the Perfusion of Parathyroid Gland During Endoscopic Thyroidectomy
Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. We are planning to train a deep convolutional neural network based on a larger sample of endoscopic images to develop a model to assist surgeons in detection of PTG during endoscopic thyroidectomy. Furthermore, we would like to train a DCNN to predict blood perfusion based on endoscopic images comparing to indocyanine green fluorescence angiography as reference standard, and assess the performance of DCNN in predicting postoperative hypoparathyroidism.
Read the detailed description
Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. Resection of the PTG by mistake or interruption of the blood supply may lead to transient or permanent hypoparathyroidism, which would require short-term or lifelong calcium and/or vitamin D supplement. We are planning to train a deep convolutional neural network based on a larger sample of endoscopic images to develop a model to assist surgeons in detection of PTG during endoscopic thyroidectomy. Although several researchers indicated that indocyanine green fluorescence angiography could be used to assess the perfusion of the PTG intraoperatively, it may cause allergic reaction and need repetitive injection. Therefore, we would like to train a DCNN to predict blood perfusion based on endoscopic images comparing to indocyanine green fluorescence angiography as reference standard, and assess the performance of DCNN in predicting postoperative hypoparathyroidism. This research may lead to the development of endoscopic modules in PTG detection and PTG perfusion prediction to reduce postoperative hypoparathyroidism.
- Conditions
- Thyroidectomy
- Being tested
- a deep convolutional neural network
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
a deep convolutional neural networkDiagnostic test
a deep convolutional neural network developed for detection and assessing the perfusion of parathyroid gland during endoscopic thyroidectomy
What is being measured
The primary outcome is the main question the study is designed to answer.
Area Under the Receiver Operating Characteristic Curve
Area Under the Receiver Operating Characteristic Curve
Measured: 3 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2023
- Study start13 Jun 2023
- Primary completionApr 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ThyroidectomyStudies of the same condition, open and under way.
- More trials run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 300 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Peiliang Lin, M.D., Principal investigator, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05869058
- Sponsor's protocol ID
- SYSKY-2022-177-01
- Status last verified
- Nov 2025
- First submitted
- 11 May 2023
- Last updated
- 3 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Development and Improvement of a Deep Convolutional Neural Network for Detection and Assessing the Perfusion of Parathyroid Gland During Endoscopic Thyroidectomy
- ClinicalTrials.gov ID
- NCT05869058
- Acronym / sponsor ID
- SYSKY-2022-177-01
- Conditions
- Thyroidectomy
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityUniversity, hospital or other
- Study start
- 13 Jun 2023 (actual)
- Primary completion
- Apr 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 22 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. We are planning to train a deep convolutional neural network based on a larger sample of endoscopic images to develop a model to assist surgeons in detection of PTG during endoscopic thyroidectomy. Furthermore, we would like to train a DCNN to predict blood perfusion based on endoscopic images comparing to indocyanine green fluorescence angiography as reference standard, and assess the performance of DCNN in predicting postoperative hypoparathyroidism.
Detailed description
Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. Resection of the PTG by mistake or interruption of the blood supply may lead to transient or permanent hypoparathyroidism, which would require short-term or lifelong calcium and/or vitamin D supplement. We are planning to train a deep convolutional neural network based on a larger sample of endoscopic images to develop a model to assist surgeons in detection of PTG during endoscopic thyroidectomy. Although several researchers indicated that indocyanine green fluorescence angiography could be used to assess the perfusion of the PTG intraoperatively, it may cause allergic reaction and need repetitive injection. Therefore, we would like to train a DCNN to predict blood perfusion based on endoscopic images comparing to indocyanine green fluorescence angiography as reference standard, and assess the performance of DCNN in predicting postoperative hypoparathyroidism. This research may lead to the development of endoscopic modules in PTG detection and PTG perfusion prediction to reduce postoperative hypoparathyroidism.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The patients, who choose to undergo endoscopic thyroidectomy due to thyroid diseases and have no history of hyperparathyroidism, hypoparathyroidism, neck surgery and cervical radiotherapy, are candidates of our study.
Key inclusion criteria (1 listed)
- The patients who undergo endoscopic thyroidectomy
Key exclusion criteria (4 listed)
- hyperparathyroidism
- hypoparathyroidism
- neck surgery history
- cervical radiotherapy history
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| a deep convolutional neural networka deep convolutional neural network developed for detection and assessing the perfusion of parathyroid gland during endoscopic thyroidectomy | Diagnostic test | – |
Primary outcome
Area Under the Receiver Operating Characteristic Curve
Time frame: 3 years
Area Under the Receiver Operating Characteristic Curve
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Peiliang Lin, M.D. principal investigator
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Thyroidectomy, run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Peiliang Lin, M.D. (0086-020-34071439, linpliang3@mail.sysu.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Area Under the Receiver Operating Characteristic Curve (time frame: 3 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Dec 2025.