AzTrials
AzTrials

Atopic DermatitisPhase 3ROCKET-ASCENDNCT05882877

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

A Phase 3 study testing Rocatinlimab in people with Atopic Dermatitis, run by Amgen at 547 sites in 42 countries.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
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Trial summary

The primary objective of this study is to describe the long-term safety and tolerability of rocatinlimab in participants with moderate-to-severe AD. Read more about this study

Who is it for?
Ages 12 to 100 years
Conditions the study is for
Atopic Dermatitis
What is being tested?
Rocatinlimab
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
2,621 participants
Where
547 sitesin 42 countries
Study dates
31 May 2023to 1 Jul 2026
Phase
Phase 3
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 12 to 100 years
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Who may be able to join

  • Completion of an end of treatment duration visit (Week 24 or Week 52 visit for adult or adolescent studies, respectively) in a rocatinlimab parent study (ROCKET-IGNITE, ROCKET-HORIZON, ROCKET-SHUTTLE, ROCKET-ASTRO, ROCKET-ORBIT, OR ROCKET-VOYAGER) within the past 28 days.
  • Participants from the parent study ROCKET-ORBIT must achieve an improvement in EASI score at week 52 of at least 60% compared to parent study baseline (EASI 60).

Who cannot join

  • Permanent investigational product discontinuation due to safety-related reasons, protocol-defined stopping rules or conditions/reasons unrelated to efficacy during the rocatinlimab parent study (ROCKET-IGNITE, ROCKET-HORIZON, ROCKET-SHUTTLE, ROCKET-ASTRO, ROCKET-ORBIT, OR ROCKET-VOYAGER), or at the time of Screening or Day 1.

Trial locations and contacts

547 sites in 42 countries.

547 sites in 42 countries

United States136 sites

  • Albuquerque Clinical Trials Incorporated

    Albuquerque, New Mexico, 87102

  • Atlanta Dermatology, Vein and Research Center, PC

    Alpharetta, Georgia, 30022

  • University of Michigan

    Ann Arbor, Michigan, 48109

  • US Dermatology Partners Jollyville

    Austin, Texas, 78759

  • Kern Research Inc

    Bakersfield, California, 93301

  • Bellaire Dermatology Associates

    Bellaire, Texas, 77401

  • Bexley Dermatology Research

    Bexley, Ohio, 43209

  • Cahaba Dermatology and Skin Health Center

    Birmingham, Alabama, 35244

  • Skin Care Research Incorporated

    Boca Raton, Florida, 33486

  • Treasure Valley Medical Research

    Boise, Idaho, 83706

  • MetroBoston Clinical Partners

    Brighton, Massachusetts, 02135

  • Dermatology Trial Associates

    Bryant, Arkansas, 72022

  • Best Skin Research

    Camp Hill, Pennsylvania, 17011

  • Hope Clinical Research LLC

    Canoga Park, California, 91303

  • Renaissance Research and Medical Group

    Cape Coral, Florida, 33991

  • US Dermatology Partners Cedar Park

    Cedar Park, Texas, 78613

  • IMMUNOe Research Centers

    Centennial, Colorado, 80112

  • Medical University of South Carolina

    Charleston, South Carolina, 29425

  • DJL Clinical Research PLLC

    Charlotte, North Carolina, 28211

  • Foxhall Research Center

    Chevy Chase, Maryland, 20815

  • Institute for Asthma and Allergy

    Chevy Chase, Maryland, 20815

  • DeNova Research

    Chicago, Illinois, 60602

  • Bernstein Clinical Research Center LLC

    Cincinnati, Ohio, 45236

  • DS Research

    Clarksville, Indiana, 47129

  • Driven Research LLC

    Coral Gables, Florida, 33134

  • Corazon United States of America, LLC doing business as Life Clinical Trials

    Coral Springs, Florida, 33071

  • Driscoll Childrens Hospital

    Corpus Christi, Texas, 78411

  • Alina Clinical Trials, LLC

    Dallas, Texas, 75225

  • Dermatology Treatment and Research Center PA

    Dallas, Texas, 75230

  • Zenos Clinical Research

    Dallas, Texas, 75230

  • Texas Dermatology Research Center

    Dallas, Texas, 75246

  • Henry Ford Medical Center - New Center One

    Detroit, Michigan, 48202

  • D and H Doral Research Centers

    Doral, Florida, 33122

  • Saint Jude Clinical Research

    Doral, Florida, 33172

  • West Coast Research LLC

    Dublin, California, 94568

  • Newco 3A Research LLC

    El Paso, Texas, 79925

  • California Dermatology and Clinical Research Institute

    Encinitas, California, 92024

  • First Georgia Physicians Group

    Fayetteville, Georgia, 30214

  • Onyx Clinical Research

    Flint, Michigan, 48532

  • Education and Research Foundation Inc

    Forest, Virginia, 24551

  • First OC Dermatology

    Fountain Valley, California, 92708

  • The Ohio State University

    Gahanna, Ohio, 43230

  • Cumberland Skin Center

    Hermitage, Tennessee, 37076

  • Direct Helpers Research Center

    Hialeah, Florida, 33012

  • Global Research Solutions

    Homestead, Florida, 33030

  • Nexus Clinical Research

    Homestead, Florida, 33033

  • Burke Pharmaceutical Research

    Hot Springs, Arkansas, 71913

  • Center For Clinical Studies PLLC

    Houston, Texas, 77004

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana, 46250

  • Sante Clinical Research

    Kerrville, Texas, 78028

  • Forest Hills Dermatology Group

    Kew Gardens, New York, 11415

  • Antelope Valley Clinical Trials

    Lancaster, California, 93534

  • Chemidox Clinical Trials Incorporated

    Lancaster, California, 93534

  • Jubilee Clinical Research Inc

    Las Vegas, Nevada, 89106

  • Excel Clinical Research

    Las Vegas, Nevada, 89109

  • Dermatology and Skin Cancer Center Leawood

    Leawood, Kansas, 66211

  • Dermatology and Skin Cancer Center of Lees Summit

    Lee's Summit, Missouri, 64064

  • Somnos Clinical Research

    Lincoln, Nebraska, 68505

  • Long Beach Research Institute

    Long Beach, California, 90805

  • University of California Los Angeles

    Los Angeles, California, 90024

  • Dermatology Research Associates

    Los Angeles, California, 90045

  • Wallace Medical Group Inc

    Los Angeles, California, 90056

  • DS Research

    Louisville, Kentucky, 40241

  • Long and Harris Dermatology

    Lubbock, Texas, 79424

  • Glick Skin Institute

    Margate, Florida, 33063

  • Apex Clinical Research Center LLC

    Mayfield Heights, Ohio, 44124

  • Velocity Clinical Research Medford

    Medford, Oregon, 97504

  • Sms Clinical Research Limited Liability Company

    Mesquite, Texas, 75149

  • ara Professionals Limited Liability Corporation

    Miami, Florida, 33155

  • Gold Coast Health Research Center

    Miami, Florida, 33155

  • Miami Clinical Research

    Miami, Florida, 33155

  • Healthy Life Research

    Miami, Florida, 33175

  • Anchor Medical Research

    Miami, Florida, 33176

  • Meridian International Research

    Miami Gardens, Florida, 33014

  • Savin Medical Group LLC

    Miami Lakes, Florida, 33014

  • Stride Clinical Research LLC

    Missouri City, Texas, 77459

  • Kentucky Advanced Medical Research LLC

    Murray, Kentucky, 42071

  • Tanner Clinic

    Murray, Utah, 84107

  • University of Utah MidValley Dermatology

    Murray, Utah, 84107

  • Southern Indiana Clinical Trials

    New Albany, Indiana, 47150

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029

  • Sadick Research Group

    New York, New York, 10075

  • OptiSkin Medical

    New York, New York, 10128

  • Virginia Dermatology and Skin Cancer Center

    Norfolk, Virginia, 23502

  • Eastern Virginia Medical School

    Norfolk, Virginia, 23507

  • Sneeze, Wheeze, and Itch Associates, LLC

    Normal, Illinois, 61761

  • Las Vegas Clinical Trials

    North Las Vegas, Nevada, 89030

  • Arkansas Research Trials, LLC

    North Little Rock, Arkansas, 72117

  • Northridge Clinical Trials

    Northridge, California, 91325

  • Unity Clinical Research

    Oklahoma City, Oklahoma, 73118

  • University of California Irvine

    Orange, California, 92868

  • Clinical Associates of Orlando Limited Liability Company

    Orlando, Florida, 32819

  • Innovation Medical Research Center Inc

    Palmetto Bay, Florida, 33157

  • Havana Research Institute Inc

    Pasadena, California, 91105

  • Paddington Testing Company Inc

    Philadelphia, Pennsylvania, 19103

  • Medical Dermatology Specialists

    Phoenix, Arizona, 85006

  • Alliance Dermatology and Mohs Center

    Phoenix, Arizona, 85032

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213

  • The Indiana Clinical Trials Center PC

    Plainfield, Indiana, 46168

  • Oregon Medical Research Center

    Portland, Oregon, 97201

  • Oregon Dermatology and Research Center

    Portland, Oregon, 97210

  • Health Concepts

    Rapid City, South Dakota, 57702

  • Skin Cancer and Dermatology Institute

    Reno, Nevada, 89509

  • Integrative Skin Science and Research

    Sacramento, California, 95815

  • University of California at Davis Medical Center

    Sacramento, California, 95816

  • Kaiser Permanente South Sacramento Medical Center

    Sacramento, California, 95823

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas, 78218

  • Dermatology Clinical Research Center of San Antonio

    San Antonio, Texas, 78229

  • Alliance Clinical Research

    San Diego, California, 92120

  • Kaiser Permanente Medical Center - Oakland

    San Francisco, California, 94118

  • Kaiser Permanente Medical Center - San Francisco

    San Francisco, California, 94118

  • Advanced Medical Research PC

    Sandy Springs, Georgia, 30328

  • Wolverine Clinical Trials

    Santa Ana, California, 92706

  • Clinical Science Institute

    Santa Monica, California, 90404

  • Affiliated Dermatology

    Scottsdale, Arizona, 85255

  • Scottsdale Clinical Trials

    Scottsdale, Arizona, 85260

  • Endeavor Health Clinical Trials Center

    Skokie, Illinois, 60077

  • Stryde Research Epiphany Dermatology

    Southlake, Texas, 76092

  • MultiCare Institute for Research and Innovation

    Spokane, Washington, 99202

  • Dermatologist of Central States Clinical Research - Springfield

    Springfield, Ohio, 45505

  • Saint Louis University

    St Louis, Missouri, 63110

  • University of South Florida

    Tampa, Florida, 33612

  • Olympian Clinical Research - Tampa

    Tampa, Florida, 33615

  • Chear Center LLC

    The Bronx, New York, 10455

  • The Woodlands Dermatology Associates

    The Woodlands, Texas, 77380

  • Continental Clinical Solutions, LLC

    Towson, Maryland, 21204

  • Revival Research Institute LLC

    Troy, Michigan, 48084

  • Somerset Skin Centre

    Troy, Michigan, 48084

  • Dermatology Research Center of Oklahoma, PLLC

    Tulsa, Oklahoma, 74132

  • Essential Medical Research LLC

    Tulsa, Oklahoma, 74145

  • Dundee Dermatology

    West Dundee, Illinois, 60118

  • Options Research Group LLC

    West Lafayette, Indiana, 47906

  • Wilmington Dermatology Center

    Wilmington, North Carolina, 28405

  • Accellacare of Wilmington

    Wilmington, North Carolina, 28411

  • The Skin Surgery Center for Clinical Research

    Winston-Salem, North Carolina, 27103

Other trials in United States

Japan51 sites

  • Mildix Skin Clinic

    Adachi-ku, Tokyo, 120-0034

  • Yoshimura Child Clinic

    Akashi-shi, Hyōgo, 674-0068

  • Asahikawa City Hospital

    Asahikawa-shi, Hokkaido, 070-8610

  • Ekihigashi Dermatology Allergy Clinic

    Fukuoka, Fukuoka, 812-0013

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180

  • Matsuo Clinic

    Fukuoka, Fukuoka, 819-0373

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1295

  • Osaka Habikino Medical Center

    Habikino-shi, Osaka, 583-8588

  • JA Shizuoka Kohseiren Enshu Hospital

    Hamamatsu, Shizuoka, 430-0929

  • Hamamatsu University Hospital

    Hamamatsu, Shizuoka, 431-3192

  • Tokyo Medical University Ibaraki Medical Center

    Inashiki-gun, Ibaraki, 300-0395

  • Teikyo University Hospital

    Itabashi-ku, Tokyo, 173-8606

  • Nihon University Itabashi Hospital

    Itabashi-ku, Tokyo, 173-8610

  • Mochida Dermatology Clinic

    Izumiotsu-shi, Osaka, 595-0025

  • Katahira Dermatology Urology Clinic

    Kagoshima, Kagoshima-ken, 890-0063

  • Kosugi Dermatology Clinic

    Kawasaki-shi, Kanagawa, 211-0063

  • Nippon Medical School Musashikosugi Hospital

    Kawasaki-shi, Kanagawa, 211-8533

  • St Marianna University Hospital

    Kawasaki-shi, Kanagawa, 216-8511

  • Kobe University Hospital

    Kobe, Hyōgo, 650-0017

  • Jouzan Hihuka Hinyoukika Clinic

    Kumamoto, Kumamoto, 860-0066

  • Suizenji Dermatology Clinic

    Kumamoto, Kumamoto, 862-0950

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, Kyoto, 602-8566

  • Rakuwakai Otowa Hospital

    Kyoto, Kyoto, 607-8062

  • Takeoka Dermatology Clinic

    Marugame-shi, Kagawa-ken, 763-0074

  • Miyata Dermatology Clinic

    Matsudo-shi, Chiba, 271-0092

  • Mita Dermatology Clinic

    Minato-ku, Tokyo, 108-0014

  • Iwate Medical University Uchimaru Medical Center

    Morioka, Iwate, 020-8505

  • Aichi Medical University Hospital

    Nagakute-shi, Aichi-ken, 480-1195

  • Nagasaki University Hospital

    Nagasaki, Nagasaki, 852-8501

  • Fukui Dermatology Clinic

    Nagoya, Aichi-ken, 454-0803

  • Japan Community Healthcare Organization Chukyo Hospital

    Nagoya, Aichi-ken, 457-8510

  • Central Clinic

    Nagoya, Aichi-ken, 464-0821

  • Nagoya City University Hospital

    Nagoya, Aichi-ken, 467-8602

  • International University of Health and Welfare Narita Hospital

    Narita-shi, Chiba, 286-8520

  • Yoshioka Dermatology Clinic

    Neyagawa, Osaka, 572-0838

  • Kaji Dermatology Clinic

    Nonoichi-shi, Ishikawa-ken, 921-8801

  • Takagi Dermatological Clinic

    Obihiro-shi, Hokkaido, 080-0013

  • National Hospital Organization Sagamihara National Hospital

    Sagamihara-shi, Kanagawa, 252-0392

  • Dermatology and Ophthalmology Kume Clinic

    Sakai-shi, Osaka, 593-8324

  • Medical Corporation Kojinkai Sapporo Skin Clinic

    Sapporo, Hokkaido, 060-0063

  • Naoko Dermatology Clinic

    Setagaya-ku, Tokyo, 158-0097

  • Dokkyo Medical University Hospital

    Shimotsuga-gun, Tochigi, 321-0293

  • NTT Medical Center Tokyo

    Shinagawa-ku, Tokyo, 141-8625

  • Showa Medical University Hospital

    Shinagawa-ku, Tokyo, 142-8666

  • Seibo International Catholic Hospital

    Shinjuku-ku, Tokyo, 161-8521

  • Yamate Dermatology Clinic

    Shinjuku-ku, Tokyo, 169-0075

  • Shirasaki Dermatology Clinic

    Takaoka-shi, Toyama, 933-0871

  • Sugamo Kobayashi Derma Clinic

    Toshima-ku, Tokyo, 170-0002

  • Nomura Dermatology Clinic

    Yokohama, Kanagawa, 221-0825

  • Showa Medical University Northern Yokohama Hospital

    Yokohama, Kanagawa, 224-8503

  • Yokohama City Minato Red Cross Hospital

    Yokohama, Kanagawa, 231-8682

Other trials in Japan

Canada50 sites

  • CCA Medical Research Corp

    Ajax, Ontario, L1S 7K8

  • SimcoDerm Medical and Surgical Dermatology Centre

    Barrie, Ontario, L4M 7G1

  • Halton Pediatric Allergy

    Burlington, Ontario, L7L 6W6

  • Dermatology Research Institute Incorporated

    Calgary, Alberta, T2J 7E1

  • Beacon Dermatology

    Calgary, Alberta, T3E 0B2

  • Rejuvenation Dermatology Laser Calgary North

    Calgary, Alberta, T3K 6B8

  • SKiN Health

    Coburg, Ontario, K9A 0Z4

  • Laser Rejuvenation Clinics Edmonton D T Incorporated

    Edmonton, Alberta, T5J 3S9

  • Stratica Dermatology

    Edmonton, Alberta, T5K 1X3

  • Alberta Derma Surgery Centre

    Edmonton, Alberta, T6G 1C3

  • Vida Clinical Research

    Edmonton, Alberta, T6H 4J8

  • Skin Physicians Dermatology

    Edmonton, Alberta, T6W 4V4

  • Kingsway Clinical Research

    Etobicoke, Ontario, M8X 1Y9

  • Guelph Dermatology Research

    Guelph, Ontario, N1L 0B7

  • LEADER Research

    Hamilton, Ontario, L8L 3C3

  • Triple A Lab

    Hamilton, Ontario, L8S 1G5

  • Interior Dermatology Centre

    Kelowna, British Columbia, V1W 4V5

  • Centricity Research London Victoria

    London, Ontario, N6A 2C2

  • Lynderm Research Inc

    Markham, Ontario, L3P 1X3

  • DermEdge Research Incorporated

    Mississauga, Ontario, L4Y 4C5

  • Clinique de Dermatologie Rosemont

    Montreal, Quebec, H1Y 3L1

  • Innovaderm Research Inc

    Montreal, Quebec, H2X 2V1

  • Ryan Clinical Research Incorporated

    Newmarket, Ontario, L3Y 5G8

  • Allergy Research Canada Incorporated

    Niagara Falls, Ontario, L2H 1H5

  • North Bay Dermatology Centre

    North Bay, Ontario, P1B 3Z7

  • Canadian Dermatology Centre

    North York, Ontario, M3B 0A7

  • The Centre for Clinical Trials Inc

    Oakville, Ontario, L6J 7W5

  • JRB Research Incorporated

    Ottawa, Ontario, K1K 4L2

  • Dermatology Ottawa Research Centre

    Ottawa, Ontario, K2C 3N2

  • SKiN Centre for Dermatology

    Peterborough, Ontario, K9J 5K2

  • Recherche Clinique Sigma Incorporated

    Québec, Quebec, G1G 3Y8

  • Centre de Recherche Dermatologique du Quebec Metropolitain

    Québec, Quebec, G1V 4X7

  • Clinique Medicale Saint Louis

    Québec, Quebec, G1W 4R4

  • The Centre for Dermatology

    Richmond Hill, Ontario, L4B 1A5

  • York Dermatology Clinic and Research Centre

    Richmond Hill, Ontario, L4B 1L1

  • Oak Ridges Aesthetics Centre

    Richmond Hill, Ontario, L4E 4L6

  • Skinsense Medical Research

    Saskatoon, Saskatchewan, S7K 2C1

  • Saskatoon Dermatology Centre

    Saskatoon, Saskatchewan, S7T 0G3

  • Karma Clinical Trials

    St. John's, Newfoundland and Labrador, A1A 4Y3

  • Doctor Chih-Ho Hong Medical Incorporated

    Surrey, British Columbia, V3R 6A7

  • Enverus Medical Research

    Surrey, British Columbia, V3V 0C6

  • North York Research Incorporated

    Toronto, Ontario, M2N 3A6

  • Toronto Research Centre Inc

    Toronto, Ontario, M3H 5Y8

  • FACET Dermatology

    Toronto, Ontario, M4E 1R7

  • Research Toronto

    Toronto, Ontario, M4W 2N4

  • Evidence Based Medical Educator Inc

    Toronto, Ontario, M5G 1E2

  • Alliance Clinical Trials

    Waterloo, Ontario, N2J 1C4

  • XLR8 Medical Research, Incorporated

    Windsor, Ontario, N8T 1E6

  • Winnipeg Clinic Dermatology Research

    Winnipeg, Manitoba, R3C 0N2

  • Wiseman Dermatology Research Incorporated

    Winnipeg, Manitoba, R3M 3Z4

Other trials in Canada

China33 sites

  • Peking University Peoples Hospital

    Beijing, Beijing Municipality, 100044

  • Beijing Childrens Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100045

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191

  • The First Bethune Hospital of Jilin University

    Changchun, Jilin, 130021

  • Hunan Childrens Hospital

    Changsha, Hunan, 410007

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011

  • Chengdu Second Peoples Hospital

    Chengdu, Sichuan, 610021

  • Childrens Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400014

  • The First Affiliated Hospital of Fujian Medical University

    Fuzhou, Fujian, 350005

  • The First Affiliated Hospital Sun-Yat Sen University

    Guangzhou, Guangdong, 510080

  • Dermatology Hospital of Southern Medical University

    Guangzhou, Guangdong, 510091

  • Sun Yat-sen Memorial Hospital Sun Yat-sen University

    Guangzhou, Guangdong, 510120

  • Zhejiang Provincial Peoples Hospital

    Hangzhou, Zhejiang, 310014

  • Affiliated Hangzhou First Peoples Hospital School of Medicine Westlake University

    Hangzhou, Zhejiang, 310020

  • Kunming Childrens Hospital

    Kunming, Yunnan, 650103

  • Dermatology Hospital of Jiangxi Province

    Nanchang, Jiangxi, 330000

  • Nanyang First Peoples Hospital

    Nanyang, Henan, 473002

  • Ningbo NO 2 Hospital

    Ningbo, Zhejiang, 315010

  • The First Affiliation Hospital Of Ningbo University

    Ningbo, Zhejiang, 315010

  • Sanmenxia Central Hospital

    Sanmenxia, Henan, 472099

  • Shanghai Skin Disease Hospital

    Shanghai, Shanghai Municipality, 200443

  • The Fist Affiliated Hospital of Shantou University Medical College

    Shantou, Guangdong, 515041

  • The First Hospital of China Medical University

    Shenyang, Liaoning, 110001

  • Shenzhen Childrens Hospital

    Shenzhen, Guangdong, 518038

  • The First Hospital Of Hebei Medical University

    Shijiazhuang, Hebei, 050000

  • Suining Central Hospital

    Suining, Sichuan, 629099

  • Taizhou Central Hospital

    Taizhou, Zhejiang, 318000

  • The Central Hospital of Wuhan

    Wuhan, Hubei, 430014

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430022

  • Wuxi Second Peoples Hospital

    Wuxi, Jiangsu, 214001

  • Wuxi Peoples Hospital

    Wuxi, Jiangsu, 241023

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, 750004

Other trials in China

Poland27 sites

  • ClinicMed Daniluk Nowak Spolka komandytowa

    Bialystok, 15-879

  • Dermapolis Medical Dermatology Center dr n med Edyta Gebska

    Chorzów, 41-500

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214

  • AKK Medical Spolka z ograniczona odpowiedzialnoscia Centrum Medyczne Tu sie leczy

    Gdansk, 80-280

  • GynCentrum Spzoo NZOZ Holsamed - Oddzial Libero

    Katowice, 40-600

  • Centrum Medyczne Angelius Provita

    Katowice, 40-611

  • Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski Pawel Brzewski SpCywilna

    Krakow, 30-002

  • Diamond Clinic Spolka z Ograniczona Odpowiedzialnoscia Diamond Medical Center

    Krakow, 31-559

  • Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna

    Lodz, 90-338

  • AppleTreeClinics Network Spzoo

    Lodz, 90-349

  • Ip Clinic Sp zoo

    Lodz, 90-752

  • Amicare Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa Amicare Centrum Medyczne

    Lodz, 91-495

  • Clinical Best Solutions Sp zoo Spolka Komandytowa

    Lublin, 20-011

  • Centrum Zdrowia i Urody Maxxmed

    Lublin, 20-080

  • Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Spzoo

    Malbork, 82-200

  • Twoja przychodnia Ncm

    Nowa Sól, 67-100

  • Twoja przychodnia Pcm

    Poznan, 60-324

  • Centrum Zdrowia Dziecka i Rodziny Im Jana Pawla II w Sosnowcu Osrodek Badan Klinicznych

    Sosnowiec, 41-200

  • Twoja Przychodnia Scm

    Szczecin, 71-500

  • Alergo-Med Osrodek Badan Klinicznych sp zoo

    Tarnów, 33-100

  • Klinika Osipowicz and Turkowski Sp zoo

    Warsaw, 00-716

  • High Med Przychodnia Specjalistyczna

    Warsaw, 01-817

  • Evimed sp zoo centrum medyczne evimed

    Warsaw, 02-625

  • Klinika Ambroziak Dermatologia

    Warsaw, 02-953

  • Royalderm Agnieszka Nawrocka

    Warsaw, 02-962

  • DermMedica Spzoo Centrum Columbus

    Wroclaw, 51-503

  • Dermaceum Spolka z Ograniczona Odpowiedzialnoscia Dermaceum Centrum Medyczne

    Wroclaw, 53-613

Other trials in Poland

Germany25 sites

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455

  • Charite - Universitaetsmedizin Berlin, Campus Mitte

    Berlin, 10117

  • Clinical Research Services Berlin GmbH

    Berlin, 13672

  • Hautarztpraxis Dr Niesmann und Dr Othlinghaus

    Bochum, 44793

  • Rosenpark Research GmbH

    Darmstadt, 64283

  • Universitaetsklinikum Dresden

    Dresden, 01307

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60590

  • Universitaetsmedizin Goettingen - Georg-August-Universitaet

    Göttingen, 37075

  • Institute for Health Services Research in Dermatology and Nursing

    Hamburg, 20246

  • Hautaerzte Zentrum Hannover

    Hanover, 30159

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120

  • Universitaetsklinikum Schleswig-Holstein - Kiel

    Kiel, 24105

  • Velocity Clinical Research

    Leipzig, 04177

  • Dermatologische Gemeinschaftspraxis-Mahlow

    Mahlow, 15831

  • Universitaetsmedizin Mainz

    Mainz, 55101

  • Beldio Research GmbH

    Memmingen, 87700

  • Hautmedizin Saar

    Merzing, 66663

  • Klinikum rechts der Isar der TUM

    München, 80802

  • Universitaetsklinikum Muenster

    Münster, 48149

  • KliFOs Klinische Forschung Osnabrueck

    Osnabrück, 49074

  • Hautarztpraxis Mortazawi

    Remscheid, 42897

  • Hautarztpraxis Dres Leitz und Kollegen

    Stuttgart, 70178

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076

  • Helios Klinikum Wuppertal

    Wuppertal, 42283

  • CentroDerm GmbH

    Wuppertal, 42287

Other trials in Germany

Spain20 sites

  • Hospital General Universitario de Alicante

    Alicante, Valencia, 03010

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Catalonia, 08916

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalonia, 08025

  • Hospital Universitario Basurto

    Bilbao, Basque Country, 48013

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, Catalonia, 08907

  • Hospital Universitario de Gran Canaria Doctor Negrin

    Las Palmas de Gran Canaria, Canary Islands, 35010

  • Hospital Universitario de La Princesa

    Madrid, 28006

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007

  • Hospital Universitario Infanta Leonor

    Madrid, 28031

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

  • Hospital Universitario La Paz

    Madrid, 28046

  • Hospital de Manises

    Manises, Valencia, 46940

  • Clinica Universidad de Navarra

    Pamplona, Navarre, 31008

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, Madrid, 28223

  • Hospital Clinico Universitario de Santiago

    Santiago de Compostela, Galicia, 15706

  • Hospital Universitario Virgen Macarena

    Seville, Andalusia, 41009

  • Hospital Arnau de Vilanova de Valencia

    Valencia, Valencia, 46015

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009

Other trials in Spain

Brazil19 sites

  • Alergoalfa Nucleo Diagnostico Tratamento e Pesquisa Clinica em Alergia

    Barueri, São Paulo, 06454-010

  • Centro de Pesquisa Clínica da Universidade de Belo Horizonte - Unibh

    Belo Horizonte, Minas Gerais, 30575-180

  • Ceti Centro Est Terap Inovadoras

    Curitiba, Paraná, 80030-110

  • Universidade Federal do Parana

    Curitiba, Paraná, 80060-240

  • Cecip Centro Est Clin Int Paulista

    Jaú, São Paulo, 17201-130

  • Irmandade da Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90020-090

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Hospital Ernesto Dornelles

    Porto Alegre, Rio Grande do Sul, 90160-093

  • IBPClin Instituto Brasil de Pesquisa Clinica

    Rio de Janeiro, 20241-180

  • Clinica Instituto Bahiano de Imunoterapia - Medicina, Reumatologia e Dermatologia ltda

    Salvador, Estado de Bahia, 41820-020

  • Fundacao Abc - Centro Univ Fmabc

    Santo André, São Paulo, 09060-870

  • Cemec Centro Multidisciplinar Estudos Clinicos

    São Bernardo do Campo, São Paulo, 09715-090

  • Hospital de Base de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

  • Ispem - Instituto Sao Jose dos Campos em Pesquisas Medicas

    São José dos Campos, São Paulo, 12243-280

  • Instituto Pesquisa e Ensino em Saúde Infantil

    São Paulo, São Paulo, 01228-200

  • Sociedade Beneficente de Senhoras Hospital Sirio Libanes

    São Paulo, São Paulo, 01308-050

  • Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

    São Paulo, São Paulo, 05403-002

  • Consultoria Medica e Pesquisa Clinica Cmpc

    Sorocaba, São Paulo, 18040-425

  • Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo

    Vitória, Espírito Santo, 29055-450

Other trials in Brazil

South Korea19 sites

  • Korea University Ansan Hospital

    Ansansi, Gyeonggido, 15355

  • SoonChunHyang University Hospital Bucheon

    Bucheon-si, Gyeonggi-do, 14584

  • Chosun University Hospital

    Gwangju, 61453

  • The Catholic University of Korea Incheon St Marys Hospital

    Incheon, 21431

  • Inha University Hospital

    Incheon, 22332

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620

  • Korea University Anam Hospital

    Seoul, 02841

  • Seoul National University Hospital

    Seoul, 03080

  • Severance Hospital Yonsei University Health System

    Seoul, 03722

  • National Medical Center

    Seoul, 04564

  • Konkuk University Medical Center

    Seoul, 05030

  • Kyung Hee University Hospital at Gangdong

    Seoul, 05278

  • Asan Medical Center

    Seoul, 05505

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591

  • Chung-Ang University Hospital

    Seoul, 06973

  • Hallym University Kangnam Sacred Heart Hospital

    Seoul, 07441

  • Ewha Womans University Seoul Hospital

    Seoul, 07804

  • Korea University Guro Hospital

    Seoul, 08308

  • Ajou University Hospital

    Suwon-si, Gyeonggi-do, 16499

Other trials in South Korea

Argentina14 sites

  • Buenos Aires Skin SA

    Buenos Aires, Distrito Federal, 1054

  • Fundacion Cidea

    Buenos Aires, Distrito Federal, 1121

  • Care- Centro de Alergia y Enfermedades Respiratorias

    Buenos Aires, Distrito Federal, 1414

  • Instituto de Neumonologia y Dermatologia

    Buenos Aires, Distrito Federal, 1425

  • Psoriahue Medicina Interdisciplinaria SRL

    Buenos Aires, Distrito Federal, 1425

  • Conexa Investigacion Clinica SA

    CABA, Buenos Aires, C1012AAY

  • InAER - Investigaciones en Alergia y Enfermedades Respiratorias

    CABA, Distrito Federal, 1425

  • Cinme - Centro de Investigaciones Metabolicas

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056ABI

  • Fundacion Respirar

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1426ABP

  • Hospital Universitario Austral

    Derqui, Pilar, Buenos Aires, B1629ODT

  • Framingham Centro Medico

    La Plata, Buenos Aires, B1902COS

  • Centro de Investigaciones Clinicas Instituto Especialidades De La Salud De Rosario

    Rosario, Santa Fe Province, 2000

  • Fundacion Estudios Clinicos

    Rosario, Santa Fe Province, 2000

  • Instituto de Diagnostico abc

    Rosario, Santa Fe Province, 2000

Other trials in Argentina

Australia14 sites

  • The Skin Centre

    Benowa, Queensland, 4217

  • Box Hill Hospital

    Box Hill, Victoria, 3128

  • Emeritus Research Camberwell

    Camberwell, Victoria, 3124

  • Skin Health Institute

    Carlton, Victoria, 3053

  • Monash Childrens Hospital

    Clayton, Victoria, 3168

  • Premier Specialists

    Kogarah, New South Wales, 2217

  • St George Dermatology and Skin Cancer Centre

    Kogarah, New South Wales, 2217

  • Liverpool Hospital

    Liverpool, New South Wales, 2170

  • The Alfred Hospital

    Melbourne, Victoria, 3004

  • Institute for Skin Health and Immunity

    Mitcham, Victoria, 3132

  • The Royal Melbourne Hospital

    Parkville, Victoria, 3050

  • Princess Alexandra Hospital

    South Brisbane, Queensland, 4101

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065

  • Veracity Clinical Research

    Woolloongabba, Queensland, 4102

Other trials in Australia

Czechia14 sites

  • Kozni ambulance Kutna Hora sro

    Kutná Hora, 284 01

  • Dermamedica, sro

    Náchod, 547 01

  • Nemocnice Novy Jicin as

    Nový Jičín, 741 01

  • CCR Ostrava sro

    Ostrava, 702 00

  • Pratia Pardubice as

    Pardubice, 530 02

  • Fakultni nemocnice Plzen

    Pilsen, 305 99

  • Clintrial sro

    Prague, 100 00

  • Dermamedest sro

    Prague, 120 00

  • Pratia Prague sro

    Prague, 130 00

  • Kozni ambulance Fialova sro

    Prague, 160 00

  • Fakultni nemocnice Bulovka

    Prague, 180 81

  • Praglandia sro

    Praha 5 - Smichov, 150 00

  • Dermatologicka ambulance MUDr Petr Trestik

    Svitavy, 568 02

  • Krajska zdravotni as - Masarykova nemocnice Usti nad Labem oz

    Ústí nad Labem, 401 13

Other trials in Czechia

Hungary11 sites

  • Trial Pharma Kft

    Békéscsaba, 5600

  • Csalogany Orvosi Kozpont

    Budapest, 1027

  • Clinexpert Kft

    Budapest, 1033

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • Gyongyosi Bugat Pal Korhaz

    Gyöngyös, 3200

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz

    Kaposvár, 7400

  • DermaMed Research Kft

    Orosháza, 5900

  • Allergo-Derm Bakos Kft

    Szolnok, 5000

  • Medmare Bt

    Veszprém, 8200

  • Obudai Egeszsegugyi Centrum Kft

    Zalaegerszeg, 8900

Other trials in Hungary

France10 sites

  • Hopital Prive d Antony

    Antony, 92160

  • Polyclinique de Courlancy

    Bezannes, 51430

  • Centre Hospitalier Regional Universitaire de Brest - Hopital Morvan

    Brest, 29200

  • Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez

    Lille, 59037

  • Centre Hospitalier de Bretagne Sud - Hopital du Scorff

    Lorient, 56322

  • Cabinet du Docteur Ruer-Mulard Mireille

    Martigues, 13500

  • Centre Hospitalier Universitaire Archet 2

    Nice, 06202

  • Hopital Saint Louis

    Paris, 75475

  • Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

    Rennes, 35033

  • Centre Hospitalier Universitaire de Rouen - Hopital Charles Nicolle

    Rouen, 76000

Other trials in France

Turkey (Türkiye)9 sites

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800

  • Gaziantep Universitesi Tip Fakultesi Hastanesi

    Gaziantep, 27310

  • Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi

    Istanbul, 34390

  • Acibadem Altunizade Hastanesi

    Istanbul, 34662

  • Marmara Universitesi Tip Fakultesi Hastanesi

    Istanbul, 34899

  • Bakircay Universitesi Cigli Egitim ve Arastirma Hastanesi

    Izmir, 35620

  • Erciyes Universitesi Tip Fakultesi Hastanesi

    Kayseri, 38030

  • Kocaeli Universitesi Tip Fakultesi Hastanesi

    Kocaeli, 41380

  • Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi

    Samsun, 55200

Other trials in Turkey (Türkiye)

Italy8 sites

  • Universita degli Studi Gabriele D Annunzio di Chieti e Pescara

    Chieti, 66100

  • Ospedale San Salvatore

    LAquila, 67100

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, 20122

  • Azienda Ospedaliera Universitaria Luigi Vanvitelli

    Naples, 80131

  • Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia

    Perugia, 06156

  • Azienda Ospedaliera Policlinico Umberto I

    Roma, 00161

  • IRCCS Istituto Clinico Humanitas

    Rozzano MI, 20089

  • Azienda Ospedaliera Citta della Salute e della Scienza di Torino

    Torino, 10126

Other trials in Italy

Belgium7 sites

  • Universite Catholique de Louvain Cliniques Universitaires Saint Luc

    Brussels, 1200

  • Grand Hopital de Charleroi - Site des Viviers

    Charleroi, 6060

  • Universitair Ziekenhuis Gent

    Ghent, 9000

  • Clinique Andre Renard

    Herstal, 4040

  • Dermatologie Handelskaai

    Kortrijk, 8500

  • Centre Hospitalier Universitaire de Liege - Sart Tilman

    Liège, 4000

  • Dermatologie Maldegem

    Maldegem, 9990

Other trials in Belgium

Greece7 sites

  • University General Hospital Attikon

    Athens, 12462

  • Andreas Syngros Hospital Of Venereal And Dermatological Diseases

    Athens, 16121

  • University General Hospital of Ioannina

    Ioannina, 45500

  • General University Hospital of Larissa

    Larissa, 41110

  • General Hospital Of Nea Ionia Konstantopouleio Patision

    Nea Ionia, 14233

  • Geniko Nosokomeio Peiraia Tzaneio

    Piraeus, 18536

  • Papageorgiou General Hospital

    Thessaloniki, 56429

Other trials in Greece

Slovakia6 sites

  • Fakultna Nemocnica s poliklinikou F D Roosevelta Banska Bystrica

    Banská Bystrica, 975 17

  • Maxderm, sro

    Bardejov, 085 01

  • Univerzitna nemocnica Bratislava - Nemocnica Stare Mesto

    Bratislava, 813 69

  • Derma therapy, spol s ro

    Bratislava, 851 01

  • Sanare spol sro

    Svidník, 089 01

  • Kaderma Majtan, sro

    Topoľčany, 955 01

Other trials in Slovakia

Taiwan6 sites

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301

  • National Cheng Kung University Hospital

    Tainan, 70403

  • National Taiwan University Hospital

    Taipei, 10002

  • Mackay Memorial Hospital Taipei Branch

    Taipei, 10449

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Linkou Chang Gung Memorial Hospital

    Taoyuan, 33305

Other trials in Taiwan

United Kingdom6 sites

  • Alder Hey Childrens Hospital

    Liverpool, L12 2AP

  • Whipps Cross University Hospital

    London, E11 1NR

  • The Royal Free Hospital

    London, NW3 2PF

  • Guys Hospital

    London, SE1 9RT

  • Salford Care Organisation

    Salford, M6 8HD

  • Accellacare Yorkshire

    Shipley, BD18 3SA

Other trials in United Kingdom

Bulgaria5 sites

  • Medical Center Asklepii OOD

    Dupnitsa, 2600

  • Medical Center Medconsult Pleven OOD

    Pleven, 5800

  • Medical Center Excelsior OOD

    Sofia, 1407

  • Diagnostic-Consultative Center Alexandrovska EOOD

    Sofia, 1431

  • Diagnostic-Consultative Center - Fokus-5 - Medical Institution for Outpatient Care OOD

    Sofia, 1463

Other trials in Bulgaria

Chile5 sites

  • Hospital Base San Jose de Osorno

    Osorno, 5311523

  • Centro Medico Skinmed Spa

    Santiago, 7580206

  • Clinica Dermacross SA

    Santiago, 7640881

  • Fundacion Innovacion Cardiovascular Clinica Ensenada

    Santiago, 8380465

  • Centro Internacional de Estudios Clinicos

    Santiago

Other trials in Chile

Portugal5 sites

  • Unidade de Saude Local de Almada-Seixal, EPE - Hospital Garcia de Orta

    Almada, 2801-951

  • Unidade Local de Saude de Coimbra, EPE

    Coimbra, 3000-075

  • Hospital Cuf Descobertas

    Lisbon, 1998-018

  • Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio

    Porto, 4099-001

  • Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao

    Porto, 4200-319

Other trials in Portugal

Malaysia4 sites

  • Hospital Pulau Pinang

    George Town, Pulau Pinang, 10990

  • Hospital Raja Permaisuri Bainun

    Ipoh, Perak, 30450

  • Hospital Sultan Ismail

    Johor Bahru, Johor, 81100

  • University Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100

Other trials in Malaysia

Thailand4 sites

  • King Chulalongkorn Memorial Hospital

    Bangkok, 10330

  • Siriraj Hospital

    Bangkok, 10700

  • Maharaj Nakorn Chiang Mai Hospital

    Chiang Mai, 50200

  • Thammasat University Hospital

    Pathum Thani, 12120

Other trials in Thailand

Croatia3 sites

  • Special Hospital for Medical Rehabilitation Naftalan

    Ivanić-Grad, 10310

  • Children s Hospital Zagreb

    Zagreb, 10000

  • University Hospital Centre Zagreb

    Zagreb, 10000

Other trials in Croatia

Finland3 sites

  • Clinical Research Services Helsinki

    Helsinki, 00180

  • Oulun Yliopistollinen sairaala

    Oulu, 90029

  • Terveystalo Tampere

    Tampere, 33100

Other trials in Finland

Latvia3 sites

  • Outpatient clinic Veselibas Centrs 4

    Riga, 1003

  • Outpatient clinic Veselibascentrs 4

    Riga, LV-1013

  • Smite Aija practice in dermatology and venerology

    Talsi, 3201

Other trials in Latvia

Netherlands3 sites

  • Bravis Ziekenhuis

    Bergen op Zoom, 4624 VT

  • Universitair Medisch Centrum Groningen

    Groningen, 9700 RB

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX

Other trials in Netherlands

Singapore3 sites

  • National University Hospital

    Singapore, 119074

  • Singapore General Hospital

    Singapore, 168753

  • National Skin Centre

    Singapore, 308205

Other trials in Singapore

Switzerland3 sites

  • Inselspital Bern

    Bern, 3010

  • Centre Hospitalier Universitaire Vaudois

    Lausanne, 1011

  • Universitaetsspital Zuerich

    Zurich, 8091

Other trials in Switzerland

Austria2 sites

  • Medizinische Universitaet Graz

    Graz, 8036

  • Landeskrankenhaus Salzburg

    Salzburg, 5020

Other trials in Austria

Estonia2 sites

  • North Estonia Medical Centre

    Tallinn, 13419

  • Clinical Research Centre

    Tartu, 50106

Other trials in Estonia

Mexico2 sites

  • Phylasis Clinical Research

    Cuautitlán Izcalli, 54750

  • Clínica de Enfermedades Crónicas y de Procedimientos Especiales

    Morelia, Michoacán, 58249

Other trials in Mexico

Slovenia2 sites

  • Univerzitetni klinicni center Ljubljana

    Ljubljana, 1000

  • Univerzitetni Klinicni Center Maribor

    Maribor, 2000

Other trials in Slovenia

Denmark1 site

  • Gentofte Hospital

    Hellerup, 2900

Other trials in Denmark

Hong Kong1 site

  • Queen Mary Hospital, The University of Hong Kong

    Hong Kong

Other trials in Hong Kong

Israel1 site

  • Sheba Medical Center

    Ramat Gan, 5262000

Other trials in Israel

Puerto Rico1 site

  • Gcm Medical Group, Psc

    San Juan, 00917

Other trials in Puerto Rico

Romania1 site

  • Derma Cluj

    Cluj-Napoca, 400105

Other trials in Romania

South Africa1 site

  • Hiway Medical Centre

    Westville, Durban, KwaZulu-Natal, 3630

Other trials in South Africa

About this study

Official title: A Phase 3, Multicenter, Double-blind Maintenance Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-ASCEND)

The primary objective of this study is to describe the long-term safety and tolerability of rocatinlimab in participants with moderate-to-severe AD.

Being tested
Rocatinlimab, Placebo
Keywords
Atopic Dermatitis, Rocatinlimab, AMG 451, Eczema
Medical subject headings
Dermatitis, Atopic, Eczema

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • RocatinlimabDrug

    Also called AMG 451, KHK4083

    Subcutaneous (SC) injection

  • PlaceboOther

    SC injection

Study groups in NCT05882877
Study groupRoleWhat they receive
ARM A: Dose 1 to Dose 1ExperimentalParticipants from parent Rocatinlimab studies ROCKET-Ignite, ROCKET-Horizon, ROCKET-SHUTTLE, or ROCKET-ASTRO who received Dose 1 will be randomized or assigned to receive Dose 1 Every 4 Weeks (Q4W) or Every 8 Weeks (Q8W). Participants from parent Rocatinlimab study ROCKET-VOYAGER who received Dose 1 will be assigned to receive Dose 1 Q4W.
Receives: Drug: Rocatinlimab
ARM B: Dose 2 to Dose 2ExperimentalParticipants from parent Rocatinlimab studies ROCKET-Ignite, ROCKET-SHUTTLE, or ROCKET-ASTRO who received Dose 2 will be randomized or assigned to receive Dose 2 Q4W or Q8W.
Receives: Drug: Rocatinlimab
ARM C: Dose 1 or Dose 2 to PlaceboPlacebo comparatorParticipants from parent Rocatinlimab studies ROCKET-Ignite or ROCKET-Horizon who received Dose 1 will be randomized to receive placebo Q4W. Participants from parent Rocatinlimab study ROCKET-Ignite who received Dose 2 will be randomized to receive placebo Q4W.
Receives: Other: Placebo
ARM D: Placebo to PlaceboPlacebo comparatorParticipants from parent Rocatinlimab studies ROCKET- Ignite, ROCKET-Horizon, ROCKET-SHUTTLE, ROCKET-ASTRO, or ROCKET-VOYAGER who received placebo will be randomized or assigned to receive placebo Q4W.
Receives: Other: Placebo
ARM E: Dose 1, Dose 2, Placebo, or Open-label (OL) to OL Dose 1ExperimentalParticipants from parent Rocatinlimab studies ROCKET- Ignite, ROCKET-Horizon, ROCKET- SHUTTLE, ROCKET-ASTRO, or ROCKET-VOYAGER who received Dose 1, Dose 2, or placebo will be assigned to receive OL Rocatinlimab Dose 1 Q4W. Participants who received OL in parent Rocatinlimab study ROCKET- ASTRO will continue to receive OL Rocatinlimab Dose 1 Q4W. All participants from parent Rocatinlimab study ROCKET-Orbit will continue to receive OL Rocatinlimab Dose 1 Q4W.
Receives: Drug: Rocatinlimab
ARM F GroupNo interventionParticipants in Arm E (OL Rocatinlimab Dose 1 Q4W) who meet defined criteria will have Rocatinlimab withdrawn, but will continue all subsequent study visits.
ARM G GroupExperimentalParticipants from Arm F who meet defined criteria will resume OL Rocatinlimab Dose 1 Q4W.
Receives: Drug: Rocatinlimab

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of Participants With Treatment-emergent Adverse Events

    Measured: Up to 116 weeks

Secondary outcomes (6)

  1. Maintaining Validated Investigator's Global Assessment for Atopic Dermatitis (vIGA-AD™) 0/1 Response at Week 32 Among Participants Achieving vIGA-AD™ 0/1 Response at Day 1

    This outcome measure applies only to participants from parent rocatinlimab studies ROCKET-Ignite and ROCKET-Horizon who entered into the randomized treatment withdrawal cohort.

    Measured: Week 32

  2. Maintaining a Revised IGA (rIGA™) 0/1 Response at Week 32 Among Participants Achieving rIGA™ 0/1 Response at Day 1

    This outcome measure applies only to participants from parent rocatinlimab studies ROCKET-Ignite and ROCKET-Horizon who entered into the randomized treatment withdrawal cohort.

    Measured: Week 32

  3. Maintaining Eczema Area and Severity Index (EASI) 75 Response at Week 32 Among Participants Achieving EASI 75 Response at Day 1

    This outcome measure applies only to participants from parent rocatinlimab studies ROCKET-Ignite and ROCKET-Horizon who entered into the randomized treatment withdrawal cohort.

    Measured: Week 32

  4. Maintaining EASI 90 Response at Week 32 Among Participants Achieving EASI 90 Response at Day 1

    This outcome measure applies only to participants from parent rocatinlimab studies ROCKET-Ignite and ROCKET-Horizon who entered into the randomized treatment withdrawal cohort.

    Measured: Week 32

  5. Maintaining vIGA-AD™ 0/1 Response and EASI 75 Response at Week 32 Among Participants Achieving vIGA-AD™ 0/1 Response and EASI 75 Response at Day 1

    This outcome measure applies only to participants from parent rocatinlimab studies ROCKET-Ignite and ROCKET-Horizon who entered into the randomized treatment withdrawal cohort.

    Measured: Week 32

  6. Maintaining ≥ 4-point Reduction from Parent Study Baseline in Worst Pruritus NRS Score at Week 32 Among Participants Achieving ≥ 4 Point Reduction from Parent Study Baseline in Worst Pruritus NRS Score at Day 1

    This outcome measure applies only to participants from parent rocatinlimab studies ROCKET-Ignite and ROCKET-Horizon who entered into the randomized treatment withdrawal cohort.

    Measured: Week 32

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted31 May 2023
  2. Study start31 May 2023
  3. Primary completion1 Jul 2026
  4. Study completion1 Jul 2026

Why it stopped: Sponsor Decision

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
2,621 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05882877
Sponsor's protocol ID
20210146
Other IDs
2022-501587-17
Acronym
ROCKET-ASCEND
Status last verified
Jul 2026
First submitted
22 May 2023
Last updated
16 Jul 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

Publications

  • Guttman-Yassky E, Simpson E, Bissonnette R, Eichenfield LF, Kabashima K, Luna PC, Hercogova JT, Spelman L, Worm M, Esfandiari E, Arai T, Mano H, Charuworn P, Wang A, Kricorian G. ROCKET: a phase 3 program evaluating the efficacy and safety of rocatinlimab in moderate-to-severe atopic dermatitis. Immunotherapy. 2025 Feb;17(2):83-94. doi: 10.1080/1750743X.2025.2464528. Epub 2025 Feb 26.

    PubMed 40012373

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Rocatinlimab in people with Atopic Dermatitis, run by Amgen at 547 sites in 42 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 16 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 547 sites in United States, Japan, Canada, China, Poland and 37 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study was stopped early (reason given: Sponsor Decision). Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of Participants With Treatment-emergent Adverse Events (time frame: Up to 116 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05882877, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2026.

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ROCKET-ASCEND Clinical Trial NCT05882877 | AzTrials