Out-Of-Hospital Cardiac ArrestEXECT_CPRNCT05907460
EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest
A study testing transesophageal echocardiography examination during cardiopulmonary resuscitation in people with Out-Of-Hospital Cardiac Arrest, run by Far Eastern Memorial Hospital at 1 site in Taiwan.
Trial summary
The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of end-tidal CO2, which represents the quality of cardiopulmonary resuscitation, or not in… Read more about this study
- Who is it for?
- Ages 20 years and older
- Conditions the study is for
- Out-Of-Hospital Cardiac Arrest
- What is being tested?
- transesophageal echocardiography examination during cardiopulmonary resuscitation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 132 participants
- Where
- 1 siteTaiwan
- Study dates
- 29 Jun 2023to 19 Nov 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 20 years-old
- Out-of-hospital cardiac arrest
- Non-trauma
Who cannot join
- Obvious signs of death appears, such as separation of head and body, rigor mortis, livor mortis, cankered corpse......etc.
- Family members clearly express the willing of do not attempt resuscitation or patients who have registered advance care planning not to attempt resuscitation.
- Patients not suitable for transesophageal ultrasound, such as patients with esophageal tumor, those whose probe cannot be placed......etc.
- Received Extracorporeal CPR.
- Achieving sustained ROSC before ED arrival
Trial locations and contacts
1 site in 1 country.
Taiwan1 site
Far Eastern Memorial Hospital
Banqiao District, New Taipei City, 220
About this study
The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of end-tidal CO2, which represents the quality of cardiopulmonary resuscitation, or not in adult patients with non-traumatic out-of-hospital cardiac arrest while comparing to those who don't receive examination of transesophageal echocardiography during cardiopulmonary resuscitation.
- Conditions
- Out-Of-Hospital Cardiac Arrest
- Being tested
- transesophageal echocardiography examination during cardiopulmonary resuscitation
- Keywords
- Out-Of-Hospital Cardiac Arrest, Chest compression site, transesophageal echocardiography, end-tidal CO2
- Medical subject headings
- Out-of-Hospital Cardiac Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
transesophageal echocardiography examination during cardiopulmonary resuscitationDevice
Perform transesophageal echocardiography in patients with out-of-hospital cardiac arrest during cardiopulmonary resuscitation and adjust the chest compression site to compress the left ventricle and avoid left ventricular outflow tract.
| Study group | Role | What they receive |
|---|---|---|
| Control group | No intervention | Perform standard advanced life support. No examination of transesophageal echocardiography during cardiopulmonary resuscitation. |
| Intervention group | Experimental | Perform examination of transesophageal echocardiography during cardiopulmonary resuscitation and adjust the chest compression site to avoid left ventricular outflow tract according to the result of transesophageal echocardiography Receives: Device: transesophageal echocardiography examination during cardiopulmonary resuscitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of sustained return of spontaneous circulation (ROSC)
successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes
Measured: 20 minutes after ROSC
Secondary outcomes (5)
Rate of any return of spontaneous circulation
successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR)
Measured: 1 minutes after ROSC
Rate of survival to ICU admission
Successful restoration and stabilization of a patient's heartbeat and circulation, enabling safe transfer to the ICU.
Measured: 48 hours after ROSC
Rate of survival to discharge
successful restoration and maintenance of a patient's heartbeat and blood circulation and able to complete treatment course till discharge
Measured: 6 months after ROSC
Rate of discharge with favorable neurological outcomes
using cerebral performance category score to measure neurologic outcomes of the patient at the time while patient's discharge. CPC1 and 2 are consider as favorable neurological outcomes, CPC3 and 4 are consider as unfavorable neurological outcomes
Measured: 6 months after ROSC
end-tidal carbon dioxide (EtCO2)
measuring end-tidal carbon dioxide during resuscitation
Measured: During resuscitation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2023
- Study start29 Jun 2023
- Primary completion19 Nov 2023
- Study completion19 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Out-Of-Hospital Cardiac ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 132 participants (actual)
Sponsor and investigators
- Lead sponsor
- Far Eastern Memorial Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Jun-Tang Sun, MD, Msc, Study chair, Attending physician of emergency medicine department
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05907460
- Sponsor's protocol ID
- 109070-F
- Acronym
- EXECT_CPR
- Status last verified
- Feb 2024
- First submitted
- 8 Jun 2023
- Last updated
- 2 Oct 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Chu SE, Cheng CY, Chang CJ, Ho H, Chen HA, Chan CH, Ma MH, Chang CH, Tsai KC, Chiu KM, Chen LW, Chiang WC, Sun JT. Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest: The EXECT-CPR Randomized Clinical Trial. JAMA Intern Med. 2026 May 1;186(5):557-566. doi: 10.1001/jamainternmed.2026.0102.
PubMed 41870444
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest
- ClinicalTrials.gov ID
- NCT05907460
- Acronym / sponsor ID
- EXECT_CPR / 109070-F
- Conditions
- Out-Of-Hospital Cardiac Arrest
- Keywords
- Out-Of-Hospital Cardiac Arrest, Chest compression site, transesophageal echocardiography, end-tidal CO2
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 132 participants (actual)
- Lead sponsor
- Far Eastern Memorial HospitalUniversity, hospital or other
- Study start
- 29 Jun 2023 (actual)
- Primary completion
- 19 Nov 2023 (actual)
- Study completion
- 19 Nov 2023 (actual)
- First posted
- 18 Jun 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of end-tidal CO2, which represents the quality of cardiopulmonary resuscitation, or not in adult patients with non-traumatic out-of-hospital cardiac arrest while comparing to those who don't receive examination of transesophageal echocardiography during cardiopulmonary resuscitation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control group | No intervention | –Perform standard advanced life support. No examination of transesophageal echocardiography during cardiopulmonary resuscitation. |
| Intervention group | Experimental | Device: transesophageal echocardiography examination during cardiopulmonary resuscitationPerform examination of transesophageal echocardiography during cardiopulmonary resuscitation and adjust the chest compression site to avoid left ventricular outflow tract according to the result of transesophageal echocardiography |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age ≥ 20 years-old
- Out-of-hospital cardiac arrest
- Non-trauma
Key exclusion criteria (5 listed)
- Obvious signs of death appears, such as separation of head and body, rigor mortis, livor mortis, cankered corpse......etc.
- Family members clearly express the willing of do not attempt resuscitation or patients who have registered advance care planning not to attempt resuscitation.
- Patients not suitable for transesophageal ultrasound, such as patients with esophageal tumor, those whose probe cannot be placed......etc.
- Received Extracorporeal CPR.
- Achieving sustained ROSC before ED arrival
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| transesophageal echocardiography examination during cardiopulmonary resuscitationPerform transesophageal echocardiography in patients with out-of-hospital cardiac arrest during cardiopulmonary resuscitation and adjust the chest compression site to compress the left ventricle and avoid left ventricular outflow tract. | Device | Intervention group |
Primary outcome
Rate of sustained return of spontaneous circulation (ROSC)
Time frame: 20 minutes after ROSC
successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes
5 secondary outcomes
Rate of any return of spontaneous circulation
Time frame: 1 minutes after ROSC
Rate of survival to ICU admission
Time frame: 48 hours after ROSC
Rate of survival to discharge
Time frame: 6 months after ROSC
Rate of discharge with favorable neurological outcomes
Time frame: 6 months after ROSC
end-tidal carbon dioxide (EtCO2)
Time frame: During resuscitation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2024.
- Derived from this study: PubMed 41870444Chu SE, Cheng CY, Chang CJ, Ho H, Chen HA, Chan CH, Ma MH, Chang CH, Tsai KC, Chiu KM, Chen LW, Chiang WC, Sun JT. Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest: The EXECT-CPR Randomized Clinical Trial. JAMA Intern Med. 2026 May 1;186(5):557-566. doi: 10.1001/jamainternmed.2026.0102.
- Individual participant dataSharing planned: No
Related trials for Out-Of-Hospital Cardiac Arrest
Not yet recruitingObservational study
CAROTID DOPPLER AND CEREBRAL OXIMERY IN POST CARDIAC ARREST ICU PATIENTS
Cardiac Arrest (CA), Carotid Doppler
Active, not recruitingPhase 3
The Danish Out-of-Hospital Cardiac Arrest Study
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Not yet recruiting
Compression-Only Versus Standard Basic Life Support Training in Nursing Students
Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
Not yet recruiting
Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac Arrest
Out-of-hospital Cardiac Arrest (OHCA)
Active, not recruiting
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jun-Tang Sun, MD, Msc study chair
Attending physician of emergency medicine department
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing transesophageal echocardiography examination during cardiopulmonary resuscitation in people with Out-Of-Hospital Cardiac Arrest, run by Far Eastern Memorial Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of sustained return of spontaneous circulation (ROSC) (time frame: 20 minutes after ROSC). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05907460, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2024.