Sedentary TimeNCT05942144
Exercise-snacks at Work: Impact on Cardiometabolic Parameters
A study testing Exercise-snacks program in people with Sedentary Time and Overweight and Obesity, run by University of Avignon at 1 site in France.
Trial summary
The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health Read more about this study
- Who is it for?
- Ages 30 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Sedentary Time, Overweight and Obesity, Work-Related Condition
- What is being tested?
- Exercise-snacks program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 23 participants
- Where
- 1 siteFrance
- Study dates
- 16 May 2023to 20 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- administrative staff,
- age between 30 and 60,
- body mass index ≥25kg/m²,
- sedentary time ≥7h/day,
- minimum 3 working days on site,
- no known cardiovascular or metabolic pathology, social security affiliation or benefit,
- ability and willingness to give free, written and informed consent.
Who cannot join
- pregnant or breast-feeding women,
- anti-hypertensive treatment, beta-blockers and anti-diabetics,
- known contraindications to physical activity (articular, cardiac or other),
- exercise-induced asthma,
- lack of motivation of subjects posing problems of compliance and adherence to the exercise program,
- participation in a study in the preceding 3 months, ongoing participation in a clinical trial.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers
The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health
Read the detailed description
Backgrounds: Very short (< 1 minute) and intense exercises, entitled "exercise-snacks", have been reported to be effective 1) in improving physical fitness over 6 weeks and 2) in improving vascular function and lowering blood glucose levels over one day. These studies were all carried out in the laboratory. The question therefore arises as to whether these acute vascular and metabolic benefits, as well as those on physical fitness, are sustainable over time following a chronic "exercise-snacks" program applicable in the professional environment to sedentary, overweight people.
Aims of this project is therefore to measure the effects of an "exercise-snacks" type physical activity program in the workplace of administrative staff on the cardio-metabolic health and sedentary behaviour of staff.
- Being tested
- Exercise-snacks program
- Keywords
- brief intense exercise, vascular function, cardiorespiratory fitness
- Medical subject headings
- Sedentary Behavior, Overweight, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise-snacks programOther
Subjects in the exercise-snacks group will perform 4 "exercise-snacks" sessions per working day for 4 weeks. These sessions will consist of 80 one-to-one walks to be completed as quickly as possible. They will also receive information about their attitudes to physical activity.
| Study group | Role | What they receive |
|---|---|---|
| Exercise-snacks group | Experimental | They will perform a "exercise-snacks" program and receive information about physical activity Receives: Other: Exercise-snacks program |
| Control group | No intervention | They will maintain their usual lifestyle until the end of the study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in aerobic fitness
Aerobic fitness will be assessed via the Chester step test's prediction of VO2max
Measured: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Secondary outcomes (18)
Adherence of staff in the experimental group by analyzing accelerometric data.
Total number of exercise-snacks performed during the 4-week program by analysing accelerometers data
Measured: during the 4-weeks program
Intensity of exercise-snacks
Heart rate during exercise-snacks in % heart rate max
Measured: during the 4-weeks program
Changes in flow mediated dilation of superficial femoral artery
measured by echocardiography (Vivid Q, GE) , in %
Measured: at inclusion, at the end of the 4-weeks program
Changes in peak shear rate of superficial femoral artery
measured by echocardiography (Vivid Q, GE) during hyperemia, in s-1
Measured: at inclusion, at the end of the 4-weeks program
Changes in nitrate mediated dilation of superficial femoral artery
by echocardiography (Vivid Q, GE), in %
Measured: at inclusion, at the end of the 4-weeks program
Changes in superficial femoral artery compliance
by echocardiography (Vivid Q, GE), in mm2 mmHg-1
Measured: at inclusion, at the end of the 4-weeks program
Changes in carotid intima-thickness
by echocardiography (Vivid Q) in mm
Measured: at inclusion, at the end of the 4-weeks program
Changes in carotid compliance
by echocardiography (Vivid Q) in mm2 mmHg-1
Measured: at inclusion, at the end of the 4-weeks program
Changes in carotid-femoral pulse wave velocity
by Sphygmocor, in m.s-1
Measured: at inclusion, at the end of the 4-weeks program
Changes in post-occlusive skin perfusion
by Laser Doppler (Perimed), in perfusion unit, in area under the curve, in time to peak
Measured: at inclusion, at the end of the 4-weeks program
Changes in blood pressure
systolic, diastolic, mean and pulsed
Measured: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Changes in mean amplitude of glycemic excursions
measured by continuous glucose monitoring (FreeStyle), in mmol.L-1
Measured: one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program
Changes in heart rate
Heart rate at rest, at the end of the Chester step test and during exercise
Measured: between the beginning and end of the 4-week exercise program and 4 weeks after the program.
Changes in level of habitual physical activity
Physical Activity questionnaire
Measured: between the start and end of the 4-week exercise program and 4 weeks after the program
Changes in fat mass
measured by InBody, in kg
Measured: between the start and end of the 4-week exercise program and 4 weeks after the program
Changes in lean mass
measured by InBody, in kg
Measured: between the start and end of the 4-week exercise program and 4 weeks after the program
Change in physical activity behaviour at work of staff
Theory of planned behavior questionnaire, score range from 20 to 80 with higher scores mean a better outcome.
Measured: between the start and end of the 4-week exercise program.
Changes in rating of perceived exertion
measured during the Chester test, score range from 7 to 20 with higher scores mean a worse outcome.
Measured: between the start and end of the 4-week exercise program and 4 weeks after the program
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jul 2023
- Study start16 May 2023
- Primary completion30 Jun 2024
- Study completion20 Jul 2024
Why it stopped: Post hoc power analysis results on the primary hypothesis during the preliminary analyses
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sedentary TimeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 23 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Avignon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Agnès VINET, Principal investigator, Avignon University - LaPEC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05942144
- Sponsor's protocol ID
- AU-062023-AVJ
- Status last verified
- Apr 2025
- First submitted
- 19 Jun 2023
- Last updated
- 20 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers
- ClinicalTrials.gov ID
- NCT05942144
- Acronym / sponsor ID
- AU-062023-AVJ
- Keywords
- brief intense exercise, vascular function, cardiorespiratory fitness
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: Post hoc power analysis results on the primary hypothesis during the preliminary analyses
- Enrolment
- 23 participants (actual)
- Lead sponsor
- University of AvignonUniversity, hospital or other
- Study start
- 16 May 2023 (actual)
- Primary completion
- 30 Jun 2024 (actual)
- Study completion
- 20 Jul 2024 (actual)
- First posted
- 12 Jul 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health
Detailed description
Backgrounds: Very short (< 1 minute) and intense exercises, entitled "exercise-snacks", have been reported to be effective 1) in improving physical fitness over 6 weeks and 2) in improving vascular function and lowering blood glucose levels over one day. These studies were all carried out in the laboratory. The question therefore arises as to whether these acute vascular and metabolic benefits, as well as those on physical fitness, are sustainable over time following a chronic "exercise-snacks" program applicable in the professional environment to sedentary, overweight people.
Aims of this project is therefore to measure the effects of an "exercise-snacks" type physical activity program in the workplace of administrative staff on the cardio-metabolic health and sedentary behaviour of staff.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Exercise-snacks group | Experimental | Other: Exercise-snacks programThey will perform a "exercise-snacks" program and receive information about physical activity |
| Control group | No intervention | –They will maintain their usual lifestyle until the end of the study |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- administrative staff,
- age between 30 and 60,
- body mass index ≥25kg/m²,
- sedentary time ≥7h/day,
- minimum 3 working days on site,
Key exclusion criteria (6 listed)
- pregnant or breast-feeding women,
- anti-hypertensive treatment, beta-blockers and anti-diabetics,
- known contraindications to physical activity (articular, cardiac or other),
- exercise-induced asthma,
- lack of motivation of subjects posing problems of compliance and adherence to the exercise program,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise-snacks programSubjects in the exercise-snacks group will perform 4 "exercise-snacks" sessions per working day for 4 weeks. These sessions will consist of 80 one-to-one walks to be completed as quickly as possible. They will also receive information about their attitudes to physical activity. | Other | Exercise-snacks group |
Primary outcome
Changes in aerobic fitness
Time frame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Aerobic fitness will be assessed via the Chester step test's prediction of VO2max
18 secondary outcomes
Adherence of staff in the experimental group by analyzing accelerometric data.
Time frame: during the 4-weeks program
Intensity of exercise-snacks
Time frame: during the 4-weeks program
Changes in flow mediated dilation of superficial femoral artery
Time frame: at inclusion, at the end of the 4-weeks program
Changes in peak shear rate of superficial femoral artery
Time frame: at inclusion, at the end of the 4-weeks program
Changes in nitrate mediated dilation of superficial femoral artery
Time frame: at inclusion, at the end of the 4-weeks program
Changes in superficial femoral artery compliance
Time frame: at inclusion, at the end of the 4-weeks program
Changes in carotid intima-thickness
Time frame: at inclusion, at the end of the 4-weeks program
Changes in carotid compliance
Time frame: at inclusion, at the end of the 4-weeks program
Changes in carotid-femoral pulse wave velocity
Time frame: at inclusion, at the end of the 4-weeks program
Changes in post-occlusive skin perfusion
Time frame: at inclusion, at the end of the 4-weeks program
Changes in blood pressure
Time frame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program
Changes in mean amplitude of glycemic excursions
Time frame: one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program
Changes in heart rate
Time frame: between the beginning and end of the 4-week exercise program and 4 weeks after the program.
Changes in level of habitual physical activity
Time frame: between the start and end of the 4-week exercise program and 4 weeks after the program
Changes in fat mass
Time frame: between the start and end of the 4-week exercise program and 4 weeks after the program
Changes in lean mass
Time frame: between the start and end of the 4-week exercise program and 4 weeks after the program
Change in physical activity behaviour at work of staff
Time frame: between the start and end of the 4-week exercise program.
Changes in rating of perceived exertion
Time frame: between the start and end of the 4-week exercise program and 4 weeks after the program
Results and safety
The study was stopped early (reason given: Post hoc power analysis results on the primary hypothesis during the preliminary analyses). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Apr 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Agnès VINET principal investigator
Avignon University - LaPEC
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise-snacks program in people with Sedentary Time and Overweight and Obesity, run by University of Avignon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 20 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: Post hoc power analysis results on the primary hypothesis during the preliminary analyses). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in aerobic fitness (time frame: at inclusion, at the end of the 4-weeks program and 1 month following the end of the program). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Apr 2025.