HealthyMEM_MODNCT05946616
Spectral Characteristics of Memory Transformation
A study testing Transcranial alternating current stimulation (tACS) combined with behavioral intervention in people with Healthy, run by Medical University of South Carolina at 1 site in United States.
Trial summary
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Transcranial alternating current stimulation (tACS) combined with behavioral intervention
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jul 2023to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 18 years or older (2/3 of the final sample will be ≥60years of age)
- No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head
- Ability to give consent for study participation
- who have access to a personal computer with internet
Who cannot join
- • Pregnancy
- Inability to use all ten fingers to type on a standard computer keyboard
- Uncorrected vision, hindering perception of visual cues presented on a standard computer screen
- Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;
- Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing
- Presence of neurological or psychiatric disorders
Show all 13Show fewer
- Presence of scalp injury or disease
- Prior history of seizures
- Prior intracranial surgery
- Prior brain radiotherapy
- Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation
- Metal in head or neck
- Contraindications to MRI (such as severe claustrophobia, implanted medical devices)
Trial locations and contacts
1 site in 1 country.
United States1 site
Medical University of South Carolina
Charleston, South Carolina, 29425
About this study
Official title: Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.
- Conditions
- Healthy
- Being tested
- Transcranial alternating current stimulation (tACS) combined with behavioral intervention, Inactive (sham) stimulation combined with behavioral intervention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transcranial alternating current stimulation (tACS) combined with behavioral interventionOther
Transcranial alternating current stimulation (tACS) combined with behavioral intervention (memory interference).
Inactive (sham) stimulation combined with behavioral interventionOther
Inactive (sham) stimulation combined with behavioral intervention (memory interference)
| Study group | Role | What they receive |
|---|---|---|
| Active non-invasive brain stimulation during behavioral memory interference | Experimental | Non-invasive brain stimulation with transcranial alternating current stimulation will be applied during a memory interference intervention. Receives: Other: Transcranial alternating current stimulation (tACS) combined with behavioral intervention |
| Sham stimulation during behavioral memory interference | Sham comparator | Inactive (sham) stimulation will be applied during a memory interference intervention. Receives: Other: Inactive (sham) stimulation combined with behavioral intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Behavioral: interference rate
Change in performance precision of a previously learned sensorimotor skill
Measured: before - after one single intervention (1 hour)
Neural: brain connectivity change
Change in EEG-derived markers of brain activation and connectivity
Measured: before - after one single intervention (1 hour)
Secondary outcomes (2)
Behavioral: interference rate
Change in performance precision of a previously learned sensorimotor skill
Measured: before - after one single intervention (24 hour follow-up)
Neural: brain connectivity change
Change in EEG-derived markers of brain activation and connectivity
Measured: before - after one single intervention (24 hour follow-up)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2023
- Study start1 Jul 2023
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Medical University of South CarolinaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University of South Carolina
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kirstin-Friederike Heise, Medical University of South Carolina
- Investigators
- Kirstin-Friederike Heise, PhD, Principal investigator, Medical University of South Carolina
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05946616
- Sponsor's protocol ID
- 00126392
- Acronym
- MEM_MOD
- Status last verified
- Sep 2026
- First submitted
- 30 Jun 2023
- Last updated
- 15 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior
- ClinicalTrials.gov ID
- NCT05946616
- Acronym / sponsor ID
- MEM_MOD / 00126392
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Medical University of South CarolinaUniversity, hospital or other
- Study start
- 1 Jul 2023 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 14 Jul 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Active non-invasive brain stimulation during behavioral memory interference | Experimental | Other: Transcranial alternating current stimulation (tACS) combined with behavioral interventionNon-invasive brain stimulation with transcranial alternating current stimulation will be applied during a memory interference intervention. |
| Sham stimulation during behavioral memory interference | Sham comparator | Other: Inactive (sham) stimulation combined with behavioral interventionInactive (sham) stimulation will be applied during a memory interference intervention. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age 18 years or older (2/3 of the final sample will be ≥60years of age)
- No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head
- Ability to give consent for study participation
- who have access to a personal computer with internet
Key exclusion criteria (13 listed)
- • Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transcranial alternating current stimulation (tACS) combined with behavioral interventionTranscranial alternating current stimulation (tACS) combined with behavioral intervention (memory interference). | Other | Active non-invasive brain stimulation during behavioral memory interference |
| Inactive (sham) stimulation combined with behavioral interventionInactive (sham) stimulation combined with behavioral intervention (memory interference) | Other | Sham stimulation during behavioral memory interference |
Primary outcome
Behavioral: interference rate
Time frame: before - after one single intervention (1 hour)
Change in performance precision of a previously learned sensorimotor skill
Neural: brain connectivity change
Time frame: before - after one single intervention (1 hour)
Change in EEG-derived markers of brain activation and connectivity
2 secondary outcomes
Behavioral: interference rate
Time frame: before - after one single intervention (24 hour follow-up)
Neural: brain connectivity change
Time frame: before - after one single intervention (24 hour follow-up)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kirstin-Friederike Heise, PhD principal investigator
Medical University of South Carolina
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transcranial alternating current stimulation (tACS) combined with behavioral intervention in people with Healthy, run by Medical University of South Carolina at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 15 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Behavioral: interference rate (time frame: before - after one single intervention (1 hour)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2026.