Osteo Arthritis KneeNUMOQUANCT05955300
Nutrition and Movement to Improve Quality of Life With Knee Osteoarthritis
A study testing Training program and Nutrition therapy in people with Osteo Arthritis Knee, run by St. Pölten University of Applied Sciences at 2 sites in Austria.
Trial summary
This project aims to evaluate the effects of an evidence-based training program in combination with an antiinflammatory dietetic intervention on quality of life for patients with knee osteoarthritis Read more about this study
- Who is it for?
- Ages 50 to 75 years
- Conditions the study is for
- Osteo Arthritis Knee
- What is being tested?
- Training program and Nutrition therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 2 sitesAustria
- Study dates
- 11 Nov 2022to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Mild to moderate knee osteoarthritis
Who cannot join
- Musculosceletal disorders which obviates a participation in the training program
- kognitive deficits
- internal, neurological and mental diseases
- drug and/or alcohol abuse
Trial locations and contacts
2 sites in 1 country.
Austria2 sites
Sankt Pölten University of Applied Sciences
Sankt Pölten, Lower Austria, 3100
St. Poelten University of Applied Sciences
Sankt Pölten, 3100
About this study
Official title: Evidence Based Training Program Combined With Nutrition Therapy for Patients With Knee Osteoarthritis
This project aims to evaluate the effects of an evidence-based training program in combination with an antiinflammatory dietetic intervention on quality of life for patients with knee osteoarthritis
Read the detailed description
Osteoarthritis (OA) is the most prevalent arthritic disease worldwide characterized by pain, effusion and stiffness leading to functional decline and reduced quality of life (QL). It has been long considered as a degenerative disease of cartilage resulting from bodily wear and tear that affect the entire joint structure. However, there is accumulating evidence that inflammation plays a key role in the OA pathogenesis. Triggered from tissue damage and by metabolic dysfunction, inflammatory processes within the joint may trigger the development of chronic low-grade inflammation.
Factors that contribute to chronic low-grade inflammation include a nutrient overload, a metabolic surplus, pro-inflammatory cytokines and adipokines. Knee OA is the most common form of OA with prevalence rising with age peaked at around 50 years of age affecting more than 250 million people worldwide. Exercise therapy (ET) is an effective component of early treatment and is therefore recommended as a first line treatment. Good Life with osteoArthritis in Denmark (GLA:D®) represents an evidence-based treatment plan for knee OA and optimizes the implementation of ET. However, ET mainly addresses physical and functional deficits in patients with knee OA, but not the inflammatory processes. Due to the association of chronic low-grad inflammation with dietary patterns, nutrition plays a significant role in inflammation-related diseases. A plant-based, anti-oxidative and anti-inflammatory therapeutic diet helps to improve symptoms leading to improved quality of life. When implementing a therapeutic diet, it should be attractive for patients and regional needs should be considered. This might increase adherence to therapeutic diet and will have an environmental impact - the New Nordic Diet (NND) seems to fulfil these requirements. To our knowledge no study has examined the influence of NND on symptoms and QL in OA. Further, there is a lack of knowledge concerning the impact of exercise therapy AND nutrition therapy on symptoms and QL in patients with knee OA.
Aims
- To evaluate the effect of a nutrition therapy combined with exercise therapy on QL in patients knee OA
- To investigate the impact of a nutrition therapy combined with exercise therapy on symptoms, nutrition and inflammation status and joint function in patients with knee OA
- Conditions
- Osteo Arthritis Knee
- Being tested
- Training program, Nutrition therapy
- Keywords
- Knee, Osteoarthritis, Exercise therapy, Nutrition, Quality of life
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Training programOther
The GLAD training program consists of neuromuscular exercises for the core, the knee and the hip muscles and patient education. The New Nordic Diet is a plant-based nutrition thats aims to reduce systematic low-grad inflammation.
Nutrition therapyOther
Nutrition therapy based on the New Nordic Diet
| Study group | Role | What they receive |
|---|---|---|
| Training program and nutrition therapy | Experimental | The intervention group receive the GLA:D® training program for 6 weeks and a nutrition therapy for 9 months. Receives: Other: Training program; Other: Nutrition therapy |
| Training program | Active comparator | The control group receive GLA:D® training program for 6 weeks and general information regarding a healthy life style for 9 months. Receives: Other: Training program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Knee Injury and Osteoarthritis Outcome Score (Quality of Life)
Patient reported outcome measurement, Max: 100, Min: 0, Max is the best that can be achieved
Measured: 9 Month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2023
- Study start11 Nov 2022
- Primary completion5 Feb 2025
- Study completion30 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Osteo Arthritis KneeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Clinical trial with 2 groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- St. Pölten University of Applied Sciences
- Sponsor type
- University, hospital or other
- Collaborators
- University of Vienna, Danube University Krems
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05955300
- Sponsor's protocol ID
- NUMOQUA
- Acronym
- NUMOQUA
- Status last verified
- May 2025
- First submitted
- 5 Jul 2023
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Chmelar S, Trubswasser U, Aubram T, Leitner G, Haas A, Neubauer O, Wagner KH, Wondrasch B, Hold E. Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study. Front Nutr. 2026 Mar 13;13:1743219. doi: 10.3389/fnut.2026.1743219. eCollection 2026.
PubMed 41909038Hold E, Chmelar S, Aubram T, Leitner G, Nehrer S, Neubauer O, Wagner KH, Wondrasch B. Nutrition and movement to improve quality of life in patients with knee osteoarthritis: the NUMOQUA study protocol for a randomised controlled trial. Trials. 2024 Apr 9;25(1):245. doi: 10.1186/s13063-024-08048-2.
PubMed 38594710
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evidence Based Training Program Combined With Nutrition Therapy for Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT05955300
- Acronym / sponsor ID
- NUMOQUA / NUMOQUA
- Conditions
- Osteo Arthritis Knee
- Keywords
- Knee, Osteoarthritis, Exercise therapy, Nutrition, Quality of life
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- St. Pölten University of Applied SciencesUniversity, hospital or other
- Collaborators
- University of Vienna, Danube University Krems
- Study start
- 11 Nov 2022 (actual)
- Primary completion
- 5 Feb 2025 (actual)
- Study completion
- 30 Jun 2026 (estimated)
- First posted
- 21 Jul 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This project aims to evaluate the effects of an evidence-based training program in combination with an antiinflammatory dietetic intervention on quality of life for patients with knee osteoarthritis
Detailed description
Osteoarthritis (OA) is the most prevalent arthritic disease worldwide characterized by pain, effusion and stiffness leading to functional decline and reduced quality of life (QL). It has been long considered as a degenerative disease of cartilage resulting from bodily wear and tear that affect the entire joint structure. However, there is accumulating evidence that inflammation plays a key role in the OA pathogenesis. Triggered from tissue damage and by metabolic dysfunction, inflammatory processes within the joint may trigger the development of chronic low-grade inflammation.
Factors that contribute to chronic low-grade inflammation include a nutrient overload, a metabolic surplus, pro-inflammatory cytokines and adipokines. Knee OA is the most common form of OA with prevalence rising with age peaked at around 50 years of age affecting more than 250 million people worldwide. Exercise therapy (ET) is an effective component of early treatment and is therefore recommended as a first line treatment. Good Life with osteoArthritis in Denmark (GLA:D®) represents an evidence-based treatment plan for knee OA and optimizes the implementation of ET. However, ET mainly addresses physical and functional deficits in patients with knee OA, but not the inflammatory processes. Due to the association of chronic low-grad inflammation with dietary patterns, nutrition plays a significant role in inflammation-related diseases. A plant-based, anti-oxidative and anti-inflammatory therapeutic diet helps to improve symptoms leading to improved quality of life. When implementing a therapeutic diet, it should be attractive for patients and regional needs should be considered. This might increase adherence to therapeutic diet and will have an environmental impact - the New Nordic Diet (NND) seems to fulfil these requirements. To our knowledge no study has examined the influence of NND on symptoms and QL in OA. Further, there is a lack of knowledge concerning the impact of exercise therapy AND nutrition therapy on symptoms and QL in patients with knee OA.
Aims
- To evaluate the effect of a nutrition therapy combined with exercise therapy on QL in patients knee OA
- To investigate the impact of a nutrition therapy combined with exercise therapy on symptoms, nutrition and inflammation status and joint function in patients with knee OA
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Clinical trial with 2 groups
| Arm | Type | Receives |
|---|---|---|
| Training program and nutrition therapy | Experimental | Other: Training program, Other: Nutrition therapyThe intervention group receive the GLA:D® training program for 6 weeks and a nutrition therapy for 9 months. |
| Training program | Active comparator | Other: Training programThe control group receive GLA:D® training program for 6 weeks and general information regarding a healthy life style for 9 months. |
Who may qualify
- Ages
- 50 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Mild to moderate knee osteoarthritis
Key exclusion criteria (4 listed)
- Musculosceletal disorders which obviates a participation in the training program
- kognitive deficits
- internal, neurological and mental diseases
- drug and/or alcohol abuse
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Training programThe GLAD training program consists of neuromuscular exercises for the core, the knee and the hip muscles and patient education. The New Nordic Diet is a plant-based nutrition thats aims to reduce systematic low-grad inflammation. | Other | Training program, Training program and nutrition therapy |
| Nutrition therapyNutrition therapy based on the New Nordic Diet | Other | Training program and nutrition therapy |
Primary outcome
Knee Injury and Osteoarthritis Outcome Score (Quality of Life)
Time frame: 9 Month
Patient reported outcome measurement, Max: 100, Min: 0, Max is the best that can be achieved
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Derived from this study: PubMed 41909038Chmelar S, Trubswasser U, Aubram T, Leitner G, Haas A, Neubauer O, Wagner KH, Wondrasch B, Hold E. Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study. Front Nutr. 2026 Mar 13;13:1743219. doi: 10.3389/fnut.2026.1743219. eCollection 2026.
- Derived from this study: PubMed 38594710Hold E, Chmelar S, Aubram T, Leitner G, Nehrer S, Neubauer O, Wagner KH, Wondrasch B. Nutrition and movement to improve quality of life in patients with knee osteoarthritis: the NUMOQUA study protocol for a randomised controlled trial. Trials. 2024 Apr 9;25(1):245. doi: 10.1186/s13063-024-08048-2.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Training program and Nutrition therapy in people with Osteo Arthritis Knee, run by St. Pölten University of Applied Sciences at 2 sites in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Knee Injury and Osteoarthritis Outcome Score (Quality of Life) (time frame: 9 Month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05955300, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026.