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AzTrials

Coronary Microvascular DysfunctionNCT05960474

Coronary Microvascular Disease (CMD) Registry

An observational study of Coronary Microvascular Dysfunction, run by Medstar Health Research Institute at 3 sites in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of a database of patients with coronary microvascular disease (CMD). Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Coronary Microvascular Dysfunction
What is being tested?
Outcomes for Patients with CMD
How many people
1,000 participants
Where
3 sitesUnited States
Study dates
1 Feb 2023to Jan 2033
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Adult, Older adult

Study population: Subjects to be enrolled in either objective for this registry includes patients, 18 years or older, with coronary microvascular disease.

Who may be able to join

  • Those with Coronary Microvascular Disease

Who cannot join

None listed.

Trial locations and contacts

3 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Kassandra Lopez contact

202-877-2452

kassandra.lopez@medstar.net

United States3 sites, 3 recruiting

  • MedStar Southern Maryland

    Clinton, Maryland, 20735

    Vijoli Cermak, Vijoli.I.Cermak@Medstar.net

    Brian Case, MD

    Recruiting

  • Memorial Regional Hospital

    Hollywood, Florida, 33021

    Pamela Shaw, PamShaw@mhs.net

    Elisa Serantes, ElSerantes@mhs.net

    Recruiting

  • Medstar Washington Hospital Center

    Washington D.C., District of Columbia, 20010

    Tolga Ozturk, Sevket.T.Ozturk@Medstar.net

    Ron Waksman, MD

    Recruiting

Other trials in United States

About this study

The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of a database of patients with coronary microvascular disease (CMD). This protocol will outline the process for identification and capture of data, storage, as well as data use and sharing internally and externally for research purposes.

Being tested
Outcomes for Patients with CMD

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Outcomes for Patients with CMDOther

    Our objective is to perform a retrospective/prospective descriptive study on the short term to longterm (up to 5 years of follow-up) outcomes of patients with coronary microvascular disease diagnosis invasively

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Establish a Registry of CMD patients

    Measured: 10 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Jul 2023
  2. Study start1 Feb 2023
  3. Primary completionJan 2033 (estimated)
  4. Study completionJan 2033 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Other
Time perspective
Cross-sectional
Enrolment
1,000 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05960474
Sponsor's protocol ID
CMDR
Status last verified
Jun 2024
First submitted
17 Jul 2023
Last updated
7 Jun 2024
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Hill AP, Wallace RL, Chaturvedi A, Frisancho FT, Cellamare M, Sawant V, Ozturk S, Cermak V, Zhang C, Waksman R, Hashim HD, Case BC. Comparative Visual Analysis of Coronary Slow Flow and Myocardial Blush Grade in Relation to Invasive Testing for Coronary Microvascular Dysfunction. Catheter Cardiovasc Interv. 2025 Dec;106(7):3953-3958. doi: 10.1002/ccd.70246. Epub 2025 Oct 23.

    PubMed 41128690

  • Al Qaraghuli A, Chitturi KR, Kumar S, Cellamare M, Ozturk S, Sawant V, Zhang C, Verma BR, Galo J, Chaturvedi A, Ben-Dor I, Satler L, Rogers T, Waksman R, Hashim H, Case BC. Exploring the impact of age on microvascular function: Insights from the Coronary Microvascular Disease Registry. Int J Cardiol. 2026 Jan 1;442:133858. doi: 10.1016/j.ijcard.2025.133858. Epub 2025 Sep 2.

    PubMed 40907829

  • Chitturi KR, Kumar S, Verma BR, Abusnina W, Cellamare M, Merdler I, Ozturk ST, Cermak V, Sawant V, Ben-Dor I, Waksman R, Hashim HD, Case BC. The incremental diagnostic value of microvascular resistance reserve in the assessment of coronary microvascular dysfunction. Cardiovasc Revasc Med. 2025 Jul;76:35-39. doi: 10.1016/j.carrev.2025.06.009. Epub 2025 Jun 18.

    PubMed 40562606

  • Abusnina W, Merdler I, Cellamare M, Chitturi KR, Chaturvedi A, Feuerstein IM, Zhang C, Ozturk ST, Deksissa T, Sawant V, Lopez K, Lupu L, Haberman D, Ben-Dor I, Satler LF, Waksman R, Hashim HD, Case BC. Epicardial Fat Tissue: A Potential Marker for Coronary Microvascular Dysfunction. J Am Heart Assoc. 2025 Feb 4;14(3):e038484. doi: 10.1161/JAHA.124.038484. Epub 2025 Feb 3.

    PubMed 39895522

  • Chitturi KR, Kumar S, Frisancho FT, Rahman S, Verma BR, Cellamare M, Merdler I, Ozturk ST, Cermak V, Sawant V, Zhang C, Ben-Dor I, Waksman R, Hashim HD, Case BC. The Prevalence of Coronary Microvascular Dysfunction in Patients With Type 2 Diabetes Mellitus. Catheter Cardiovasc Interv. 2025 Apr;105(5):1120-1123. doi: 10.1002/ccd.31429. Epub 2025 Jan 29.

    PubMed 39888248

  • Chitturi KR, Kumar S, Hill AP, Lorente-Ros M, Cellamare M, Merdler I, Abusnina W, Haberman D, Lupu L, Chaturvedi A, Ozturk ST, Cermak V, Sawant V, Zhang C, Ben-Dor I, Tsimploulis A, Waksman R, Hashim HD, Case BC. Prevalence of Arrhythmias in Patients With Coronary Microvascular Dysfunction. Catheter Cardiovasc Interv. 2025 Feb;105(2):483-490. doi: 10.1002/ccd.31324. Epub 2024 Dec 11.

    PubMed 39660783

  • Merdler I, Chitturi KR, Chaturvedi A, Li J, Cellamare M, Ozturk ST, Sawant V, Ben-Dor I, Waksman R, Case BC, Hashim HD. Coronary microvascular dysfunction and inflammation: Insights from the Coronary Microvascular Disease Registry. Cardiovasc Revasc Med. 2024 Dec;69:30-34. doi: 10.1016/j.carrev.2024.05.020. Epub 2024 May 11.

    PubMed 38789342

  • Merdler I, Chitturi KR, Chaturvedi A, Rahman S, Cellamare M, Ozturk ST, Sawant V, Ben-Dor I, Waksman R, Hashim HD, Case BC. Exploring the interplay between coronary microvascular dysfunction and mental health. Cardiovasc Revasc Med. 2024 Dec;69:25-29. doi: 10.1016/j.carrev.2024.05.019. Epub 2024 May 11.

    PubMed 38789341

  • Merdler I, Bazarbashi N, Medranda GA, Zhang C, Ozturk ST, Sawant V, Ben-Dor I, Waksman R, Hashim HD, Case BC. Comparing planned versus ad hoc coronary microvascular assessment: Early findings from the Coronary Microvascular Disease Registry. Cardiovasc Revasc Med. 2024 Oct;67:69-74. doi: 10.1016/j.carrev.2024.04.017. Epub 2024 Apr 12.

    PubMed 38724408

  • Merdler I, Wallace R, Hill AP, Chitturi KR, Medranda GA, Reddy P, Zhang C, Ozturk ST, Sawant V, Weintraub WS, Lopez K, Ben-Dor I, Waksman R, Hashim HD, Case BC. From chest pain to coronary functional testing: Clinical and economic impact of coronary microvascular dysfunction. Cardiovasc Revasc Med. 2024 Sep;66:56-60. doi: 10.1016/j.carrev.2024.03.026. Epub 2024 Mar 28.

    PubMed 38637194

  • Case BC, Merdler I, Medranda GA, Zhang C, Ozturk ST, Sawant V, Garcia-Garcia HM, Satler LF, Ben-Dor I, Hashim HD, Waksman R. Coronary Microvascular Disease Registry (CMDR): Study design and rationale. Cardiovasc Revasc Med. 2024 Sep;66:63-67. doi: 10.1016/j.carrev.2024.03.021. Epub 2024 Mar 27.

    PubMed 38631936

  • Merdler I, Wallace R, Banerjee A, Medranda GA, Reddy P, Cellamare M, Zhang C, Ozturk ST, Sawant V, Lopez K, Ben-Dor I, Waksman R, Case BC, Hashim HD. Coronary microvascular dysfunction assessment: A comparative analysis of procedural aspects. Catheter Cardiovasc Interv. 2024 Apr;103(5):703-709. doi: 10.1002/ccd.30990. Epub 2024 Mar 23.

    PubMed 38520176

Questions about this trial

What is this clinical trial studying?

An observational study of Coronary Microvascular Dysfunction, run by Medstar Health Research Institute at 3 sites in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 7 Jun 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 3 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Kassandra Lopez (202-877-2452, kassandra.lopez@medstar.net), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Establish a Registry of CMD patients (time frame: 10 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05960474, which also lists 12 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jun 2024.

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