HealthyNCT05985382
Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity
A study testing Lower Body Resistance Exercise and Upper Body Resistance Exercise in people with Healthy, run by University of Central Florida at 1 site in United States.
Trial summary
Resistance exercise may immediately lessen the perception of pain. The purpose of this study is compare the effects of an upper body exercise to a lower body exercise on the perception of pain (pressure pain threshold). Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Lower Body Resistance Exercise and Upper Body Resistance Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Aug 2023to 16 Oct 2023
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- pain free
Who cannot join
- non-English speaking
- regular use of prescription pain medications
- current or history of chronic pain condition
- currently taking blood-thinning medication
- any blood clotting disorder
- medical conditions known to affect sensation, such as: uncontrolled diabetes or neurological conditions
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- any contraindication to the application of ice, including: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
- not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
- surgery, injury, or fracture within the past 6 months
- unable to perform exercise portions of the study
- unable to attend three sessions
- pregnant
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Central Florida
Orlando, Florida, 32765
About this study
Resistance exercise may immediately lessen the perception of pain. The purpose of this study is compare the effects of an upper body exercise to a lower body exercise on the perception of pain (pressure pain threshold).
- Conditions
- Healthy
- Being tested
- Lower Body Resistance Exercise, Upper Body Resistance Exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lower Body Resistance ExerciseOther
Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions.
Upper Body Resistance ExerciseOther
Participants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions.
| Study group | Role | What they receive |
|---|---|---|
| Lower Body Resistance Exercise | Experimental | Participants will perform a leg extension exercise with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Receives: Other: Lower Body Resistance Exercise |
| Upper Body Resistance Exercise | Experimental | Participants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. Receives: Other: Upper Body Resistance Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lower Body Resistance Exercise
For pressure pain threshold, an algometer was gradually increased until the sensation changed from pressure to pain. Pressure at threshold was recorded in kilopascals.
Measured: Pressure pain threshold will be applied to the quadriceps immediately after each exercise.
Secondary outcomes (1)
Heat Pain Threshold
All participants completed Heat Pain Threshold. For heat pain threshold, a thermode will gradually warm up from 32 degrees Celsius until the participant reports the sensation changes from comfortable warmth to slightly unpleasant pain. The temperature at threshold will be recorded.
Measured: Heat Pain Threshold will be applied over the quadriceps before and after the exercise.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2023
- Study start29 Aug 2023
- Primary completion16 Oct 2023
- Study completion16 Oct 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Central Florida
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abigail Wilson, University of Central Florida
- Investigators
- Abigail Wilson, PT, DPT, PhD, Principal investigator, University of Central Florida
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05985382
- Sponsor's protocol ID
- 5
- Status last verified
- Feb 2025
- First submitted
- 26 Jul 2023
- Last updated
- 4 Mar 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 4 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity
- ClinicalTrials.gov ID
- NCT05985382
- Acronym / sponsor ID
- 5
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- University of Central FloridaUniversity, hospital or other
- Study start
- 29 Aug 2023 (actual)
- Primary completion
- 16 Oct 2023 (actual)
- Study completion
- 16 Oct 2023 (actual)
- First posted
- 14 Aug 2023 (actual)
- Results
- Posted 4 Mar 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Resistance exercise may immediately lessen the perception of pain. The purpose of this study is compare the effects of an upper body exercise to a lower body exercise on the perception of pain (pressure pain threshold).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Lower Body Resistance Exercise | Experimental | Other: Lower Body Resistance ExerciseParticipants will perform a leg extension exercise with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. |
| Upper Body Resistance Exercise | Experimental | Other: Upper Body Resistance ExerciseParticipants will perform a shoulder press with weight that is 75% of their estimated 1-repetition maximum (1-RM) for 3 sets of 10 repetitions. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- pain free
Key exclusion criteria (12 listed)
- non-English speaking
- regular use of prescription pain medications
- current or history of chronic pain condition
- currently taking blood-thinning medication
- any blood clotting disorder
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Lower Body Resistance ExerciseParticipants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions. | Other | Lower Body Resistance Exercise |
| Upper Body Resistance ExerciseParticipants will complete a leg extension exercise with weight equivalent to 75% of their estimated 1-repetition maximum 3 sets, 10 repetitions. | Other | Upper Body Resistance Exercise |
Primary outcome
Lower Body Resistance Exercise
Time frame: Pressure pain threshold will be applied to the quadriceps immediately after each exercise.
For pressure pain threshold, an algometer was gradually increased until the sensation changed from pressure to pain. Pressure at threshold was recorded in kilopascals.
1 secondary outcome
Heat Pain Threshold
Time frame: Heat Pain Threshold will be applied over the quadriceps before and after the exercise.
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Mar 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Abigail Wilson, PT, DPT, PhD principal investigator
University of Central Florida
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Lower Body Resistance Exercise and Upper Body Resistance Exercise in people with Healthy, run by University of Central Florida at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 4 Mar 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lower Body Resistance Exercise (time frame: Pressure pain threshold will be applied to the quadriceps immediately after each exercise.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Mar 2025.