Menopause SyndromeNCT05988242
Effect of Lavender Versus Primrose Oil on Menopause Symptom
A study testing Primrose oil, Lavender oil and placcebo in people with Menopause Syndrome, run by Cairo University at 1 site in Egypt.
Trial summary
there is a scanty of researches which integrate to investigate the comparing effect of evening primrose oil and lavender as the essential oil that affects on menopausal vasomotor symptoms especially hot flashes and night sweet Therefore, the current study is expected to contribute to the knowledge and practice… Read more about this study
- Who is it for?
- Ages 40 to 65 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Menopause Syndrome
- What is being tested?
- Primrose oil, Lavender oil and placcebo
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 3 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Mar 2022to 20 Jul 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- can read and write
- experienced amenorrhea for > 6 months
- mild or moderate-to-severe hot flashes at least twice daily
- normal blood pressure
- normal kidney and liver function
- no abnormal vaginal bleeding
- no sensitivity to herbal substances
Who cannot join
- Women with serious disease such as kidney, liver, seizure and allerg
- use of hormonal medications or herbal treatment in the preceding 2 months for treatment of hot flushes or night sweet
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Primrose Oil Versus Lavender Oil on Hot Flashes and Night Sweats Among Menopausal Women
there is a scanty of researches which integrate to investigate the comparing effect of evening primrose oil and lavender as the essential oil that affects on menopausal vasomotor symptoms especially hot flashes and night sweet Therefore, the current study is expected to contribute to the knowledge and practice regarding the effect of lavender versus primrose oil on hot flashes and night sweat in menopausal women.
Read the detailed description
The aim of this study is to assess the efficacy of primrose oil versus lavender oil on hot flashes and night sweats among menopausal women
Research Hypotheses To fulfill the aim of this study the following research hypotheses will be formulated H1: Menopausal women who will receive evening primrose oil may show decrease in frequency and severity of hot flashes and night sweat as compared to those who will receive routine care H2: Menopausal women who will receive lavender oil may show decrease in frequency and severity of hot flashes and night sweat as compared to those who will receive routine care H3: There is a difference between menopausal women who will receive evening primrose oil versus lavender oil in relation to frequency and severity of hot flashes and night sweat Outcome measures
Sample A total of (150) menopausal women who will attend the out patient gynaecological clinic at Obstetrics and Gynecological hospital in Cairo university hospitals, Kasr El Ainy will be recruited for this study and randomly assigned to either group who will receive primrose oil (50) women, the other group who will receive lavender oil (50) women, the placebo group (50) who will take package of oil but dosnt contain the active substance .
Tools for Data Collection To fulfill the aim of the study fourth tools will be utilized for data collection. The first one the interviewing questionnaire which was designed by the researcher through extensive review of literature; the second tool is Daily hot flash / night sweets diaries; the third tool is Hot-flush/ night sweet problem-rating (HFNS Problem Rating) and the fourth tool is Hot Flash Related Daily Interference Scale (HFRDIS).
Tools used in the Randomized Control Trail:
First tool: Interviewing Questionnaires Schedule (Appendix A) This tool designed by the researcher after extensive literature review which constituted of four parts; first part data related to demographic characteristics such as age, level of education, residence and occupation. Second part data related to menstrual history and menopausal status.
Second tool: Daily hot flash / night sweets diaries Daily Hot Flash Diary: It is a selfreport dairy , in which participants recorded how many hot flashes they experienced on a daily basis as well as the severity of each hot flash on a scale of 1-3 (1 being mild, 2 moderate, and 3 severe). Hot flashes throughout a 7-day period were added to produce a weekly hot flash frequency score. While the number of hot flashes reported in each severity level was used to calculate the daily severity score, the total number of daily severity scores over the course of seven days was used to determine the hot flash severity index The hot flash severity score for each day was calculated as the sum of the number of hot flashes within each severity category, multiplied by the severity score for that category, with the resulting sum divided by the total number of hot flashes Third tool: Hot-flush/ night sweet problem-rating (HFNS Problem Rating) This tool is standardized tool to measure the extent to which HFNS are a problem, it is a subscale of the Hot Flush Rating Scale (HFRS) this validated self-report measure has three questions using 10-point Likert scales to rate the extent to which HFNS are problematic, distressing, and the cause of interference in daily life. Problem rating is calculated as the mean of the three questions, with higher scores indicating more problematic. This tool has significant correlations with diary recordings for hot flushes (r=0.97, p<0.001) and night sweats (r=0.94, p<0.001). HFRS has good test-retest reliability (r=0.8) and internal consistency (alpha=0.87); the internal reliability alpha coefficients 0.84. it is significantly associated (r=0.61-0.85 p<0.001) .
Fourth tool: Hot Flash Related Daily Interference Scale (HFRDIS) It is a 10-item scale to assess the degree to which hot flashes interfere with women's daily life activities. The first nine items assess the quality of daily life activities including work, social activities, leisure activities, sleep, mood, concentration, relationships with others, sexuality, and enjoyment of life and the tenth item assesses the overall quality of life. On a scale of 0 (do not interfere) to 10 (totally interfere), Women rate the extent to which hot flashes interfered with each item throughout the previous week. A total score is calculated by summing items. Higher scores reflect more interference from hot flashes and a greater impact on quality of life. The total score ranges from 0-100. This score was interpreted to the Mild interference 0-33•corresponding daily interference as follows: Moderate interference 34-67• Severe interference 68-100• Validity and reliability
Tools of data collection are standardized tool..UN standardized tools were submitted to 3 experts in the field of maternity nursing to test content validity, clarity of sentences and an appropriateness of content. Modifications were carried out according to the expert judgment before seeking the acceptance of ethical committee.
Ethical consideration An official approval to conduct the proposed study will be obtained from the Research Ethics Committee at faculty of nursing - Cairo University. As well, an official permission will be taken from the administrative personnel in the recommended settings. Also, each woman will be informed orally about the purpose of the trial and its importance. In addition, informed written consent will be obtained from women who will be willing to participate in the trial after ensuring that their participation in the trial will be voluntary and can be withdrawing at any time. As well as the anonymity, confidentiality and privacy of the information will be maintained.
- Conditions
- Menopause Syndrome
- Being tested
- Primrose oil, Lavender oil, placcebo
- Keywords
- Hot Flashes, Sweat, Menopause, Lavandula, Primula
- Medical subject headings
- Hot Flashes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Primrose oilOther
group A will take primrose oil
Lavender oilOther
group B will take lavender oil
placceboOther
this is the comparator group who will take the same bottle of oil which dosnt contain the active substances but have the sampe shape, same oder, same color
| Study group | Role | What they receive |
|---|---|---|
| primrose oil | Experimental | primrose oil Receives: Other: Primrose oil |
| lavender oil | Experimental | lavender oil Receives: Other: Lavender oil |
| the placebo group | Placebo comparator | took the same bottle of oil which didn't contain the active substances but have the same shape, same oder, same color. Receives: Other: placcebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
frequency of hot flashes among menopausal women.
it will be assessed by Daily Hot Flash Diary: It is a selfreport dairy in which participants recorded how many hot flashes they experienced on a daily basis. Hot flashes throughout a 7-day period were added to produce a weekly hot flash frequency score
Measured: Before intervention, 4 week after intervention, 8 week after intervention
severity of hot flashes among menopausal women
it will be assessed by Daily Hot Flash Diaryas well as the severity of each hot flash on a scale of 1-3 (1 being mild, 2 moderate, and 3 severe). the number of hot flashes reported in each severity level was used to calculate the daily severity score, the total number of daily severity scores over the course of seven days was used to determine the hot flash severity index.
The hot flash severity score for each day was calculated as the sum of the number of hot flashes within each severity category, multiplied by the severity score for that category, with the resulting sum divided by the total number of hot flashes
Measured: Before intervention, 4 week after intervention, 8 week after intervention
to To what extent hot flash and night sweet are a problem
This tool is standardized tool to measure the extent to which hot flash and night sweet are a problem, it is a subscale of the Hot Flush Rating Scale (HFRS) this validated self-report measure has three questions using 10-point Likert scales to rate the extent to which HFNS are problematic, distressing, and the cause of interference in daily life. Problem rating is calculated as the mean of the three questions, with higher scores indicating more problematic
Measured: Before intervention, 4 week after intervention, 8 week after intervention
Secondary outcomes (1)
Hot Flash Related Daily Interference
It is a 10-item scale developed by Carpenter, (2001) to assess the degree to which hot flashes interfere with women's daily life activities. The first nine items assess the quality of daily life activities including work, social activities, leisure activities, sleep, mood, concentration, relationships with others, sexuality, and enjoyment of life and the tenth item assesses the overall quality of life. On a scale of 0 (do not interfere) to 10 (totally interfere), Women rate the extent to which hot flashes interfered with each item throughout the previous week. A total score is calculated by summing items. Higher scores reflect more interference from hot flashes and a greater impact on quality of life. The total score ranges from 0-100. This score was interpreted to the Mild interference 0-33•corresponding daily interference as follows: Moderate interference 34-67• Severe interference 68-100•
Measured: Before intervention, 4 week after intervention, 8 week after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2023
- Study start20 Mar 2022
- Primary completion21 Apr 2023
- Study completion20 Jul 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for Menopause SyndromeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Parallel randomized controlled trial will be used to fulfill the aim of proposed study. The randomized control trial (RCT) is a trial in which subjects are randomly assigned to one of two or more groups: the intervention (group A) who will receive evening primrose oil, the intervention (group B) who will receive lavender oil, the third group ( C) who will receive placebo (Spieth et al, 2016).
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 3 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Fatma Zaghloul, Cairo University
- Investigators
- Lamiaa Saad, lecturer, Study chair, faculty of nursing
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05988242
- Sponsor's protocol ID
- Lavender and Primrose
- Status last verified
- Aug 2023
- First submitted
- 20 Jul 2023
- Last updated
- 15 Aug 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: the data will be shared online
Publications
Kazemi F, Masoumi SZ, Shayan A, Oshvandi K. The Effect of Evening Primrose Oil Capsule on Hot Flashes and Night Sweats in Postmenopausal Women: A Single-Blind Randomized Controlled Trial. J Menopausal Med. 2021 Apr;27(1):8-14. doi: 10.6118/jmm.20033.
PubMed 33942584Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Arch Gynecol Obstet. 2013 Nov;288(5):1075-9. doi: 10.1007/s00404-013-2852-6. Epub 2013 Apr 27.
PubMed 23625331Reddi KK. Human granulocyte ribonuclease. Biochem Biophys Res Commun. 1976 Feb 23;68(4):1119-25. doi: 10.1016/0006-291x(76)90312-0. No abstract available.
PubMed 5077Baker FC, Lampio L, Saaresranta T, Polo-Kantola P. Sleep and Sleep Disorders in the Menopausal Transition. Sleep Med Clin. 2018 Sep;13(3):443-456. doi: 10.1016/j.jsmc.2018.04.011.
PubMed 30098758Carreiras M, Seghier ML, Baquero S, Estevez A, Lozano A, Devlin JT, Price CJ. An anatomical signature for literacy. Nature. 2009 Oct 15;461(7266):983-6. doi: 10.1038/nature08461.
PubMed 19829380Mehrpooya M, Rabiee S, Larki-Harchegani A, Fallahian AM, Moradi A, Ataei S, Javad MT. A comparative study on the effect of "black cohosh" and "evening primrose oil" on menopausal hot flashes. J Educ Health Promot. 2018 Mar 1;7:36. doi: 10.4103/jehp.jehp_81_17. eCollection 2018.
PubMed 29619387Green MR, Pastewka JV. The cationic carbocyanine dyes Stains-all DBTC, and Ethyl-Stains-all, DBTC-3,3',9 triethyl. J Histochem Cytochem. 1979 Mar;27(3):797-9. doi: 10.1177/27.3.90067.
PubMed 90067Tsai J, Chung YC, Chen FP, Yeh ML. [Effect of Aromatherapy on Menopausal Symptoms, Heart Rate Variability, and Sleep Quality in Women]. Hu Li Za Zhi. 2020 Feb;67(1):44-54. doi: 10.6224/JN.202002_67(1).07. Chinese.
PubMed 31960396Kazemzadeh R, Nikjou R, Rostamnegad M, Norouzi H. Effect of lavender aromatherapy on menopause hot flushing: A crossover randomized clinical trial. J Chin Med Assoc. 2016 Sep;79(9):489-92. doi: 10.1016/j.jcma.2016.01.020. Epub 2016 Jul 4.
PubMed 27388435
Study at a glance
From the registry record, last updated by the sponsor on 15 Aug 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Primrose Oil Versus Lavender Oil on Hot Flashes and Night Sweats Among Menopausal Women
- ClinicalTrials.gov ID
- NCT05988242
- Acronym / sponsor ID
- Lavender and Primrose
- Conditions
- Menopause Syndrome
- Keywords
- Hot Flashes, Sweat, Menopause, Lavandula, Primula
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 3 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 20 Mar 2022 (actual)
- Primary completion
- 21 Apr 2023 (actual)
- Study completion
- 20 Jul 2023 (actual)
- First posted
- 14 Aug 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
there is a scanty of researches which integrate to investigate the comparing effect of evening primrose oil and lavender as the essential oil that affects on menopausal vasomotor symptoms especially hot flashes and night sweet Therefore, the current study is expected to contribute to the knowledge and practice regarding the effect of lavender versus primrose oil on hot flashes and night sweat in menopausal women.
Detailed description
The aim of this study is to assess the efficacy of primrose oil versus lavender oil on hot flashes and night sweats among menopausal women
Research Hypotheses To fulfill the aim of this study the following research hypotheses will be formulated H1: Menopausal women who will receive evening primrose oil may show decrease in frequency and severity of hot flashes and night sweat as compared to those who will receive routine care H2: Menopausal women who will receive lavender oil may show decrease in frequency and severity of hot flashes and night sweat as compared to those who will receive routine care H3: There is a difference between menopausal women who will receive evening primrose oil versus lavender oil in relation to frequency and severity of hot flashes and night sweat Outcome measures
Sample A total of (150) menopausal women who will attend the out patient gynaecological clinic at Obstetrics and Gynecological hospital in Cairo university hospitals, Kasr El Ainy will be recruited for this study and randomly assigned to either group who will receive primrose oil (50) women, the other group who will receive lavender oil (50) women, the placebo group (50) who will take package of oil but dosnt contain the active substance .
Tools for Data Collection To fulfill the aim of the study fourth tools will be utilized for data collection. The first one the interviewing questionnaire which was designed by the researcher through extensive review of literature; the second tool is Daily hot flash / night sweets diaries; the third tool is Hot-flush/ night sweet problem-rating (HFNS Problem Rating) and the fourth tool is Hot Flash Related Daily Interference Scale (HFRDIS).
Tools used in the Randomized Control Trail:
First tool: Interviewing Questionnaires Schedule (Appendix A) This tool designed by the researcher after extensive literature review which constituted of four parts; first part data related to demographic characteristics such as age, level of education, residence and occupation. Second part data related to menstrual history and menopausal status.
Second tool: Daily hot flash / night sweets diaries Daily Hot Flash Diary: It is a selfreport dairy , in which participants recorded how many hot flashes they experienced on a daily basis as well as the severity of each hot flash on a scale of 1-3 (1 being mild, 2 moderate, and 3 severe). Hot flashes throughout a 7-day period were added to produce a weekly hot flash frequency score. While the number of hot flashes reported in each severity level was used to calculate the daily severity score, the total number of daily severity scores over the course of seven days was used to determine the hot flash severity index The hot flash severity score for each day was calculated as the sum of the number of hot flashes within each severity category, multiplied by the severity score for that category, with the resulting sum divided by the total number of hot flashes Third tool: Hot-flush/ night sweet problem-rating (HFNS Problem Rating) This tool is standardized tool to measure the extent to which HFNS are a problem, it is a subscale of the Hot Flush Rating Scale (HFRS) this validated self-report measure has three questions using 10-point Likert scales to rate the extent to which HFNS are problematic, distressing, and the cause of interference in daily life. Problem rating is calculated as the mean of the three questions, with higher scores indicating more problematic. This tool has significant correlations with diary recordings for hot flushes (r=0.97, p<0.001) and night sweats (r=0.94, p<0.001). HFRS has good test-retest reliability (r=0.8) and internal consistency (alpha=0.87); the internal reliability alpha coefficients 0.84. it is significantly associated (r=0.61-0.85 p<0.001) .
Fourth tool: Hot Flash Related Daily Interference Scale (HFRDIS) It is a 10-item scale to assess the degree to which hot flashes interfere with women's daily life activities. The first nine items assess the quality of daily life activities including work, social activities, leisure activities, sleep, mood, concentration, relationships with others, sexuality, and enjoyment of life and the tenth item assesses the overall quality of life. On a scale of 0 (do not interfere) to 10 (totally interfere), Women rate the extent to which hot flashes interfered with each item throughout the previous week. A total score is calculated by summing items. Higher scores reflect more interference from hot flashes and a greater impact on quality of life. The total score ranges from 0-100. This score was interpreted to the Mild interference 0-33•corresponding daily interference as follows: Moderate interference 34-67• Severe interference 68-100• Validity and reliability
Tools of data collection are standardized tool..UN standardized tools were submitted to 3 experts in the field of maternity nursing to test content validity, clarity of sentences and an appropriateness of content. Modifications were carried out according to the expert judgment before seeking the acceptance of ethical committee.
Ethical consideration An official approval to conduct the proposed study will be obtained from the Research Ethics Committee at faculty of nursing - Cairo University. As well, an official permission will be taken from the administrative personnel in the recommended settings. Also, each woman will be informed orally about the purpose of the trial and its importance. In addition, informed written consent will be obtained from women who will be willing to participate in the trial after ensuring that their participation in the trial will be voluntary and can be withdrawing at any time. As well as the anonymity, confidentiality and privacy of the information will be maintained.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
- Model description
- Parallel randomized controlled trial will be used to fulfill the aim of proposed study. The randomized control trial (RCT) is a trial in which subjects are randomly assigned to one of two or more groups: the intervention (group A) who will receive evening primrose oil, the intervention (group B) who will receive lavender oil, the third group ( C) who will receive placebo (Spieth et al, 2016).
| Arm | Type | Receives |
|---|---|---|
| primrose oil | Experimental | Other: Primrose oilprimrose oil |
| lavender oil | Experimental | Other: Lavender oillavender oil |
| the placebo group | Placebo comparator | Other: placcebotook the same bottle of oil which didn't contain the active substances but have the same shape, same oder, same color. |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- can read and write
- experienced amenorrhea for > 6 months
- mild or moderate-to-severe hot flashes at least twice daily
- normal blood pressure
- normal kidney and liver function
Key exclusion criteria (2 listed)
- Women with serious disease such as kidney, liver, seizure and allerg
- use of hormonal medications or herbal treatment in the preceding 2 months for treatment of hot flushes or night sweet
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Primrose oilgroup A will take primrose oil | Other | primrose oil |
| Lavender oilgroup B will take lavender oil | Other | lavender oil |
| placcebothis is the comparator group who will take the same bottle of oil which dosnt contain the active substances but have the sampe shape, same oder, same color | Other | the placebo group |
Primary outcome
frequency of hot flashes among menopausal women.
Time frame: Before intervention, 4 week after intervention, 8 week after intervention
it will be assessed by Daily Hot Flash Diary: It is a selfreport dairy in which participants recorded how many hot flashes they experienced on a daily basis. Hot flashes throughout a 7-day period were added to produce a weekly hot flash frequency score
severity of hot flashes among menopausal women
Time frame: Before intervention, 4 week after intervention, 8 week after intervention
it will be assessed by Daily Hot Flash Diaryas well as the severity of each hot flash on a scale of 1-3 (1 being mild, 2 moderate, and 3 severe). the number of hot flashes reported in each severity level was used to calculate the daily severity score, the total number of daily severity scores over the course of seven days was used to determine the hot flash severity index. The hot flash severity score for each day was calculated as the sum of the number of hot flashes within each severity category, multiplied by the severity score for that category, with the resulting sum divided by the total number of hot flashes
to To what extent hot flash and night sweet are a problem
Time frame: Before intervention, 4 week after intervention, 8 week after intervention
This tool is standardized tool to measure the extent to which hot flash and night sweet are a problem, it is a subscale of the Hot Flush Rating Scale (HFRS) this validated self-report measure has three questions using 10-point Likert scales to rate the extent to which HFNS are problematic, distressing, and the cause of interference in daily life. Problem rating is calculated as the mean of the three questions, with higher scores indicating more problematic
1 secondary outcome
Hot Flash Related Daily Interference
Time frame: Before intervention, 4 week after intervention, 8 week after intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Aug 2023.
- Background: PubMed 33942584Kazemi F, Masoumi SZ, Shayan A, Oshvandi K. The Effect of Evening Primrose Oil Capsule on Hot Flashes and Night Sweats in Postmenopausal Women: A Single-Blind Randomized Controlled Trial. J Menopausal Med. 2021 Apr;27(1):8-14. doi: 10.6118/jmm.20033.
- Background: PubMed 23625331Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Arch Gynecol Obstet. 2013 Nov;288(5):1075-9. doi: 10.1007/s00404-013-2852-6. Epub 2013 Apr 27.
- Background: PubMed 5077Reddi KK. Human granulocyte ribonuclease. Biochem Biophys Res Commun. 1976 Feb 23;68(4):1119-25. doi: 10.1016/0006-291x(76)90312-0. No abstract available.
- Background: PubMed 30098758Baker FC, Lampio L, Saaresranta T, Polo-Kantola P. Sleep and Sleep Disorders in the Menopausal Transition. Sleep Med Clin. 2018 Sep;13(3):443-456. doi: 10.1016/j.jsmc.2018.04.011.
- Background: PubMed 19829380Carreiras M, Seghier ML, Baquero S, Estevez A, Lozano A, Devlin JT, Price CJ. An anatomical signature for literacy. Nature. 2009 Oct 15;461(7266):983-6. doi: 10.1038/nature08461.
- Background: PubMed 29619387Mehrpooya M, Rabiee S, Larki-Harchegani A, Fallahian AM, Moradi A, Ataei S, Javad MT. A comparative study on the effect of "black cohosh" and "evening primrose oil" on menopausal hot flashes. J Educ Health Promot. 2018 Mar 1;7:36. doi: 10.4103/jehp.jehp_81_17. eCollection 2018.
- Background: PubMed 90067Green MR, Pastewka JV. The cationic carbocyanine dyes Stains-all DBTC, and Ethyl-Stains-all, DBTC-3,3',9 triethyl. J Histochem Cytochem. 1979 Mar;27(3):797-9. doi: 10.1177/27.3.90067.
- Results publication: PubMed 31960396Tsai J, Chung YC, Chen FP, Yeh ML. [Effect of Aromatherapy on Menopausal Symptoms, Heart Rate Variability, and Sleep Quality in Women]. Hu Li Za Zhi. 2020 Feb;67(1):44-54. doi: 10.6224/JN.202002_67(1).07. Chinese.
- Results publication: PubMed 27388435Kazemzadeh R, Nikjou R, Rostamnegad M, Norouzi H. Effect of lavender aromatherapy on menopause hot flushing: A crossover randomized clinical trial. J Chin Med Assoc. 2016 Sep;79(9):489-92. doi: 10.1016/j.jcma.2016.01.020. Epub 2016 Jul 4.
- Individual participant dataSharing planned: Yes. the data will be shared online
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lamiaa Saad, lecturer study chair
faculty of nursing
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Primrose oil, Lavender oil and placcebo in people with Menopause Syndrome, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Aug 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
frequency of hot flashes among menopausal women. (time frame: Before intervention, 4 week after intervention, 8 week after intervention). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05988242, which also lists 9 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Aug 2023.