HemiplegiaNCT05990413

Periscapular Muscle Activation During Open and Closed Kinetic Chain in Stroke

An observational study of Hemiplegia, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Who is it for?: Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for: Hemiplegia
How many people: 30 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 1 Jun 2024to 31 Jul 2025
How long will I take part?: 1 Day
Phase: Observational
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
Healthy volunteers accepted
Adult, Older adult

Study population: The total number of participants participating in the study is planned to be twenty. It is planned that ten of those twenty participants will be healthy as the controls and ten of them will be individuals with hemiplegia as cases.

Who may be able to join

Stroke patients will be considered eligible for participation if they:
were at least 6 weeks after stroke (hemorrhagic or ischemic);
had mild to moderate upper limb motor impairment (score of ≥30 on the Fugl-Meyer upper limb motor part;
had a negative Neer impingement test;
could sit or stand up independently at least 10 minutes.
Healthy controls will be considered eligible for participation if they:
had no self-reported shoulder pain;
had a negative Neer impingement test.

Who cannot join

Participants will be excluded according to these criteria:
being involuntary to participate and unable to follow the instructions;
being younger than 18 years old;
body mass index equal or higher than 30;
shoulder and/or neck pain in the last six months;
known history of shoulder dislocation, fracture or surgery;
other systemic and/or neurologic diseases. -

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Istinye University Physiotherapy and Rehabilitation Reasearch and Application Center
Istanbul

Other trials in Turkey (Türkiye)

About this study

Official title: Comparison of Activity Levels of Periscapular Muscles During Open and Closed Kinetic Chain Activities in Individuals With Stroke

The goal of this observational study is to compare the activity levels of the periscapular (levator scapula, serratus anterior, infraspinatus, upper, middle and lower trapezius) muscles during open and closed kinetic chain activities in individuals with stroke. It is also aimed to reveal the relationship between the timing and percentage of scapular muscle activation, the viscoelastic properties of these muscles, motor performance and capacity. The main questions it aims to answer are:

The activation timing, percentage and viscoelastic properties of the periscapular muscles of stroke individuals compared to healthy individuals;
The activation timing and percentages of periscapular muscles during closed kinetic chain and open kinetic chain activities in stroke individuals;
The relationship between muscle activation timing, muscle activation percentage, viscoelastic properties, upper extremity motor performance and capacity.

The study will include both hemiplegic (n=10) and healthy (n=10) participants. All of the participants will be assessed in terms of scapular muscle activation timing and percentage (with superficial electromyography) during both open kinetic chain and closed kinetic chain activities.

viscoelastic properties of muscles (Miyoton) will be evaluated. Upper extremity movement frequency and quality (MAG-28) and functional performance (Fugl-Meyer) will be evaluated to reveal the status of stroke individuals.

In the study, it is also aimed to reveal the relationship between the timing and percentage of scapular muscle activation, the viscoelastic properties of these muscles, motor performance and capacity. 10 healthy and 10 hemiplegic individuals are planned to participate in the study.

Conditions: Hemiplegia
Keywords: Hemiplegia, Scapular muscles, Muscle timing, Muscle activation, Kinetic chain
Medical subject headings: Hemiplegia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT05990413
Study group	Role	What they receive
Hemiplegic Participants		Participants will be evaluated in terms of inclusion criteria, and fugl-meyer upper extremity performance assessment will be applied to eligible patients and it will be clarified whether they can be included. Participants who may be included in the study will fill in the patient demographic information form prepared by the researchers as a face-to-face interview. This form will take approximately 5 minutes, during which time the muscles will be rested. Then, the viscoelastic properties of the determined muscles of the participants will be evaluated. Finally, the participants will be evaluated in terms of the activation timing and percentages of the muscles determined during an open and closed kinetic chain activity. Half of the participants will do the open kinetic chain activity before the closed kinetic chain activity with a five-minute resting period between activities. The others will start with the closed kinetic chain activity first and then the open kinetic chain activity.
Healthy Participants		Participants will be evaluated in terms of inclusion criteria. Eligable participants will fill in the patient demographic information form prepared by the researchers as a face-to-face interview. This form will take approximately 5 minutes, during which time the muscles will be rested. Then, the viscoelastic properties of the determined muscles of the participants will be evaluated. Finally, the participants will be evaluated in terms of the activation timing and percentages of the muscles determined during an open and closed kinetic chain activity. Half of the participants will do the open kinetic chain activity before the closed kinetic chain activity with a five-minute resting period between activities. The others will start with the closed kinetic chain activity first and then the open kinetic chain activity.

What is being measured

The primary outcome is the main question the study is designed to answer.

Muscle activation timing and percentage
Noraxon Surface Electromyography System will be used to assess muscle activation timing and percentage of upper, middle and lower trapezius, serratus anterior, infraspinatus, levator scapulae of all participants. The placement of electrodes will be done according to SENIAM's European Recommendations for Surface Electromyography. Synchronized video capture will be used to determine the phases of the scapular motion during the open and closed kinetic chain exercises (OKC and CKC, respectively). To take the measurement during OKC, participants will be seated in a chair that will support the waist and back, with the feet in contact with the ground. They will be asked to cross the fingers of both hands and to raise both arms overhead as high as they can. For CKC, they will be asked to stand next to a table at level of SIAS and place their forearms on table with the elbows flexed. They will be asked to extend the elbow of the non-measuring arm while shifting body weight to the other side.
Measured: 1 day
Viscoelastic properties
Myoton®PRO Digital Palpation Device will be used to measure the muscle tone, stiffness, and elasticity of muscles below. The patient will be seated with the flexed elbow supported by a pillow next to the body. Measurements will be repeated 3 times.
- Upper Trapezius: the end-points of a line connecting the spinous process of C7 and the acromion, distally, from the mid-point of the muscle belly
- Middle Trapezius: the mid-point of a line connecting T4 spinous process to the medial border of spina scapula
- Lower Trapezius: The mid-point of a line connecting the spinous process of T6 to the medial border of spina scapula
- Serratus anterior: a- Over the fourth rib, at the midpoint between the latissimus dorsi and the pectoralis major; b- Over the seventh rib, in the midline of the axilla
- Infraspinatus: Two fingers breadth below the center spine of the scapula
- Levator Scapulae: Between the posterior margin of SCM and anterior margin of the UT, at level of C4/5
Measured: 1 day

Secondary outcomes (1)

Upper extremity motor performance
The Fugl-Meyer Assessment (FMA) is a stroke-specific, performance-based impairment index. It is designed to assess motor functioning, balance, sensation and joint functioning in patients with post-stroke hemiplegia. It will be used for the participants only with hemiplegia.
Measured: 1 day

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Jun 202431 Jul 2025

First posted14 Aug 2023
Study start1 Jun 2024
Primary completion31 Jul 2025
Study completion31 Jul 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for HemiplegiaStudies of the same condition, open and under way.
More trials run by Istanbul University - CerrahpasaThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Observational
Observational model: Case-control
Time perspective: Cross-sectional
Enrolment: 30 participants (actual)
Target duration: 1 Day

IDs, dates and publications

ClinicalTrials.gov ID: NCT05990413
Sponsor's protocol ID: 26032023
Status last verified: Sep 2025
First submitted: 4 Aug 2023
Last updated: 10 Sep 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Not yet recruiting
Effects of Upper Extremity Physiotherapy and Home Exercises on Functional Outcomes in Individuals With Stroke
Stroke
Recruiting
Task-Oriented Training Versus High-Intensity Gait Training in People With Chronic Stroke
Stroke, Hemiplegia
Active, not recruitingObservational study
Studies of the Variable Phenotypic Presentations of Rapid-Onset Dystonia Parkinsonism and Other Movement Disorders
Dystonia, Parkinsonism
RecruitingObservational study
Post-Stroke Apraxia, Motor Function, Balance, and Gait
Stroke, Ideomotor Apraxia
RecruitingObservational study
Ideomotor Apraxia and Robotic Gait Rehabilitation Outcomes After Stroke
Stroke, Ideomotor Apraxia

All Hemiplegia trials

Study at a glance

From the registry record, last updated by the sponsor on 10 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Comparison of Activity Levels of Periscapular Muscles During Open and Closed Kinetic Chain Activities in Individuals With Stroke
ClinicalTrials.gov ID: NCT05990413
Acronym / sponsor ID: 26032023
Conditions: Hemiplegia
Keywords: Hemiplegia, Scapular muscles, Muscle timing, Muscle activation, Kinetic chain
Study type: Observational
Recruitment status: Completed
Enrolment: 30 participants (actual)
Lead sponsor: Istanbul University - CerrahpasaUniversity, hospital or other
Study start: 1 Jun 2024 (actual)
Primary completion: 31 Jul 2025 (actual)
Study completion: 31 Jul 2025 (actual)
First posted: 14 Aug 2023 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

The activation timing, percentage and viscoelastic properties of the periscapular muscles of stroke individuals compared to healthy individuals;
The activation timing and percentages of periscapular muscles during closed kinetic chain and open kinetic chain activities in stroke individuals;
The relationship between muscle activation timing, muscle activation percentage, viscoelastic properties, upper extremity motor performance and capacity.

Study design

Observational model: Case-control
Time perspective: Cross-sectional
Target follow-up: 1 Day
Number of arms: 2

Arm	Type	Receives
Hemiplegic Participants	–	–Participants will be evaluated in terms of inclusion criteria, and fugl-meyer upper extremity performance assessment will be applied to eligible patients and it will be clarified whether they can be included. Participants who may be included in the study will fill in the patient demographic information form prepared by the researchers as a face-to-face interview. This form will take approximately 5 minutes, during which time the muscles will be rested. Then, the viscoelastic properties of the determined muscles of the participants will be evaluated. Finally, the participants will be evaluated in terms of the activation timing and percentages of the muscles determined during an open and closed kinetic chain activity. Half of the participants will do the open kinetic chain activity before the closed kinetic chain activity with a five-minute resting period between activities. The others will start with the closed kinetic chain activity first and then the open kinetic chain activity.
Healthy Participants	–	–Participants will be evaluated in terms of inclusion criteria. Eligable participants will fill in the patient demographic information form prepared by the researchers as a face-to-face interview. This form will take approximately 5 minutes, during which time the muscles will be rested. Then, the viscoelastic properties of the determined muscles of the participants will be evaluated. Finally, the participants will be evaluated in terms of the activation timing and percentages of the muscles determined during an open and closed kinetic chain activity. Half of the participants will do the open kinetic chain activity before the closed kinetic chain activity with a five-minute resting period between activities. The others will start with the closed kinetic chain activity first and then the open kinetic chain activity.

Who may qualify

Ages: 18 years and older
Sex: All
Healthy volunteers: Accepted
Age groups: Adult, Older adult
Study population: The total number of participants participating in the study is planned to be twenty. It is planned that ten of those twenty participants will be healthy as the controls and ten of them will be individuals with hemiplegia as cases.

Key inclusion criteria (8 listed)

were at least 6 weeks after stroke (hemorrhagic or ischemic);
had mild to moderate upper limb motor impairment (score of ≥30 on the Fugl-Meyer upper limb motor part;
had a negative Neer impingement test;
could sit or stand up independently at least 10 minutes.
had no self-reported shoulder pain;

Key exclusion criteria (7 listed)

being involuntary to participate and unable to follow the instructions;
being younger than 18 years old;
body mass index equal or higher than 30;
shoulder and/or neck pain in the last six months;
known history of shoulder dislocation, fracture or surgery;

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Primary outcome

Muscle activation timing and percentage
Time frame: 1 day
Noraxon Surface Electromyography System will be used to assess muscle activation timing and percentage of upper, middle and lower trapezius, serratus anterior, infraspinatus, levator scapulae of all participants. The placement of electrodes will be done according to SENIAM's European Recommendations for Surface Electromyography. Synchronized video capture will be used to determine the phases of the scapular motion during the open and closed kinetic chain exercises (OKC and CKC, respectively). To take the measurement during OKC, participants will be seated in a chair that will support the waist and back, with the feet in contact with the ground. They will be asked to cross the fingers of both hands and to raise both arms overhead as high as they can. For CKC, they will be asked to stand next to a table at level of SIAS and place their forearms on table with the elbows flexed. They will be asked to extend the elbow of the non-measuring arm while shifting body weight to the other side.
Viscoelastic properties
Time frame: 1 day
Myoton®PRO Digital Palpation Device will be used to measure the muscle tone, stiffness, and elasticity of muscles below. The patient will be seated with the flexed elbow supported by a pillow next to the body. Measurements will be repeated 3 times. * Upper Trapezius: the end-points of a line connecting the spinous process of C7 and the acromion, distally, from the mid-point of the muscle belly * Middle Trapezius: the mid-point of a line connecting T4 spinous process to the medial border of spina scapula * Lower Trapezius: The mid-point of a line connecting the spinous process of T6 to the medial border of spina scapula * Serratus anterior: a- Over the fourth rib, at the midpoint between the latissimus dorsi and the pectoralis major; b- Over the seventh rib, in the midline of the axilla * Infraspinatus: Two fingers breadth below the center spine of the scapula * Levator Scapulae: Between the posterior margin of SCM and anterior margin of the UT, at level of C4/5

1 secondary outcome

Upper extremity motor performance
Time frame: 1 day

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2025.

Related trials for Hemiplegia

Not yet recruiting
Effects of Upper Extremity Physiotherapy and Home Exercises on Functional Outcomes in Individuals With Stroke
Stroke
Recruiting
Task-Oriented Training Versus High-Intensity Gait Training in People With Chronic Stroke
Stroke, Hemiplegia
Active, not recruitingObservational study
Studies of the Variable Phenotypic Presentations of Rapid-Onset Dystonia Parkinsonism and Other Movement Disorders
Dystonia, Parkinsonism
RecruitingObservational study
Post-Stroke Apraxia, Motor Function, Balance, and Gait
Stroke, Ideomotor Apraxia
RecruitingObservational study
Ideomotor Apraxia and Robotic Gait Rehabilitation Outcomes After Stroke
Stroke, Ideomotor Apraxia

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Kubra Kardeş, PT,MSc,PhD-c study chair

Istinye University

Çiçek Günday, PT,MSc,PhD-c principal investigator

Istanbul University - Cerrahpasa

Ayse Zengin Alpözgen, PT,MSc,PhD study director

Istanbul University - Cerrahpasa

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

An observational study of Hemiplegia, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 10 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Muscle activation timing and percentage (time frame: 1 day). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05990413.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2025.