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NeoplasmsNCT06001723

A Feasibility Study to Determine Whether the Botanical Garden Become a Region of Forest Therapy for Cancer Survivors

A study testing Forest Therapy in people with Neoplasms and Cancer, run by Taipei City Hospital at 1 site in Taiwan.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The forest healing system is an important topic of alternative therapy in recent years. To investigates forest therapy's effectiveness in alleviating negative emotions among post-cancer patients. It compares therapy outcomes at Taipei Botanical Garden and Fushan Botanical Garden. Read more about this study

Who is it for?
Ages 36 to 82 years
Conditions the study is for
Neoplasms, Cancer, Mental Health Disorder
What is being tested?
Forest Therapy
Could I receive a placebo?
No, everyone receives an active treatment
How many people
50 participants
Where
1 siteTaiwan
Study dates
4 Aug 2022to 20 Jan 2023
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 36 to 82 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Over 20 year-old
  • Cancer patients finished cancer treatments more than 6 months (regardless hormone therapy)
  • Voluntary attendance

Who cannot join

  • People who unable to walk for at least 120 minutes
  • People who still smoking, chewing betel nut or drinking alcohol (over five standard cups in any situation)
  • People who addicted to medicine
  • People who attend another clinical trial at the same time or in the follow-up period of an interventional trial
  • Pregnant women or breast feeding
  • Other conditions that participants unable to cooperate with

Trial locations and contacts

1 site in 1 country.

Taiwan1 site
  • Taipei city hospital

    Taipei, Taipei, 10845

Other trials in Taiwan

About this study

The forest healing system is an important topic of alternative therapy in recent years. To investigates forest therapy's effectiveness in alleviating negative emotions among post-cancer patients. It compares therapy outcomes at Taipei Botanical Garden and Fushan Botanical Garden. Utilizing a pretest-posttest experimental design, a two-hour guided forest healing activity serves as the intervention method. Data collection involves instrumental tests and saliva samples.

Read the detailed description

Introduction:

Cancer's global impact persists, ranking among the top three causes of death in Taiwan. Despite improved survival rates after cancer surgery, negative emotions among patients remain a challenge. Post-cancer depression adversely affects treatment outcomes and overall quality of life. Forest therapy, a natural healing approach, has gained attention for its potential to reduce stress, mitigate negative emotions, and enhance well-being.

Objectives:

This study investigates forest therapy's effectiveness in alleviating negative emotions among post-cancer patients. It compares therapy outcomes at Taipei Botanical Garden and Fushan Botanical Garden. Additionally, the study explores the lasting emotional benefits of forest therapy.

Methods:

Utilizing a pretest-posttest experimental design, this study is conducted at the Botanical Garden in Fushan, Taipei. Participants are cancer patients who are six months post-treatment. A two-hour guided forest healing activity serves as the intervention method. Data collection involves instrumental tests and saliva samples. A comparable location adjacent to Taipei Botanical Garden, excluding urban areas, is selected for comparison activities. Portable heart rhythm monitors track data, and saliva samples are analyzed for salivary α-amylase enzyme kinetics and cortisol concentrations. The study employs questionnaires including the Profile of Mood States 2nd Edition-Adult short (POMS2-A short), Beck Depression Inventory-Second edition (BDI-II), Beck Anxiety Inventory (BAI), and the abbreviated Taiwan version of the World Health Organization Quality of Life-Brief (WHOQOL-BREF).

Being tested
Forest Therapy
Keywords
Forest therapy, Forest healing, Cancer Survivors, Mental Health Disorder
Medical subject headings
Neoplasms, Mental Disorders, Depression

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Forest TherapyBehavioural

    Forest healing activities are guided by professionals, allowing participants to engage in a two-hour sensory experience within the forest environment. This includes activities such as stacking leaves and stones, closing their eyes to listen to sounds, engaging in physical stretches, blindfolded tree identification, connecting with tree companions, creating earth mandalas, and partaking in tea ceremonies and sharing insights.

Study groups in NCT06001723
Study groupRoleWhat they receive
Forest TherapyExperimentalThis is a pretest-posttest designed experiment. A two-hour guided forest healing activity was used as an intervention method. For the purpose of comparison, an urban area adjacent to the Taipei Botanical Garden, specifically the Wanhua district, was selected. This choice ensures the exclusion of extensive green spaces commonly used for walking.
Receives: Behavioral: Forest Therapy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. questionnaire: POMS2-A short (Fushan botanical garden)

    Change of the Profile of Mood States 2nd Edition-Adult short at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  2. questionnaire: POMS2-A short (Taipei botanical garden)

    Change of the Profile of Mood States 2nd Edition-Adult short at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  3. questionnaire: POMS2-A short (urban region)

    Change of the Profile of Mood States 2nd Edition-Adult short at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  4. questionnaire: BAI (Fushan botanical garden)

    Change of The Beck Anxiety Inventory at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  5. questionnaire: BAI (Taipei botanical garden)

    Change of The Beck Anxiety Inventory at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  6. questionnaire: BAI (urban region)

    Change of The Beck Anxiety Inventory at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  7. questionnaire: BDI-II (Fushan botanical garden)

    Change of The Beck Depression Inventory II at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  8. questionnaire: BDI-II (Taipei botanical garden)

    Change of baseline The Beck Depression Inventory II at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  9. questionnaire: BDI-II (urban region)

    Change of baseline The Beck Depression Inventory II at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  10. questionnaire: WHOQOL-BREF (Fushan botanical garden)

    Change of World Health Organization Quality of Life-Brief (Taiwan version) at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  11. questionnaire: WHOQOL-BREF (Taipei botanical garden)

    Change of World Health Organization Quality of Life-Brief (Taiwan version) at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  12. questionnaire: WHOQOL-BREF (urban region)

    Change of World Health Organization Quality of Life-Brief (Taiwan version) at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  13. physiological indicator: alpha-amylase activity in salivary (Fushan botanical garden)

    Change of alpha-amylase activity in salivary by using commercial kits (Salimetrics®) at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  14. physiological indicator: alpha-amylase activity in salivary (Taipei botanical garden)

    Change of alpha-amylase activity in salivary by using commercial kits (Salimetrics®) at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  15. physiological indicator: alpha-amylase activity in salivary (urban region)

    Change of alpha-amylase activity in salivary by using commercial kits (Salimetrics®) at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  16. physiological indicator: cortisol concentration in salivary (Fushan botanical garden)

    Change of cortisol concentration in salivary by using commercial kits (Salimetrics®) at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  17. physiological indicator: cortisol concentration in salivary (Taipei botanical garden)

    Change of cortisol concentration in salivary by using commercial kits (Salimetrics®) at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  18. physiological indicator: cortisol concentration in salivary (urban region)

    Change of cortisol concentration in salivary by using commercial kits (Salimetrics®) at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  19. physiological indicator: HRV (Heart Rate Variability) (Fushan botanical garden)

    Change of HRV by using wrist monitors (ANSWatch®) to measure heart rate, heart rate variability (related to activities of the autonomic nervous system ANS), irregular heartbeats (IRRHB), and 5-minute continuous pulse wave at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  20. physiological indicator: HRV (Heart Rate Variability) (Taipei botanical garden)

    Change of HRV by using wrist monitors (ANSWatch®) to measure heart rate, heart rate variability (related to activities of the autonomic nervous system ANS), irregular heartbeats (IRRHB), and 5-minute continuous pulse wave at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  21. physiological indicator: HRV (Heart Rate Variability) (urban region)

    Change of HRV by using wrist monitors (ANSWatch®) to measure heart rate, heart rate variability (related to activities of the autonomic nervous system ANS), irregular heartbeats (IRRHB), and 5-minute continuous pulse wave at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

  22. physiological indicator: blood pressures (systolic and diastolic) (Fushan botanical garden)

    Change of blood pressures by using wrist monitors (ANSWatch®) to measure blood pressures (systolic and diastolic) at Fushan botanical garden

    Measured: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention

  23. physiological indicator: blood pressures (systolic and diastolic) (Taipei botanical garden)

    Change of blood pressures by using wrist monitors (ANSWatch®) to measure blood pressures (systolic and diastolic) at Taipei botanical garden

    Measured: per-test → 2 hours intervention at Taipei botanical garden → post-test immediately after the intervention

  24. physiological indicator: blood pressures (systolic and diastolic) (urban region)

    Change of blood pressures by using wrist monitors (ANSWatch®) to measure blood pressures (systolic and diastolic) at urban region

    Measured: per-test → 2 hours intervention at urban region → post-test immediately after the intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted21 Aug 2023
  2. Study start4 Aug 2022
  3. Primary completion20 Jan 2023
  4. Study completion20 Jan 2023

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Supportive care
Allocation
Not applicable
Intervention model
Sequential
Masking
None (open label)
Enrolment
50 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06001723
Sponsor's protocol ID
TCHIRB-11104010
Status last verified
May 2025
First submitted
14 Aug 2023
Last updated
4 Jun 2025
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Wei RS, Chu YS, Hong MY, Li MY, Fan SW, Tung GS, Hsu CH. A comprehensive evaluation of the health benefits of forest therapy for cancer survivors. Environ Health Prev Med. 2026;31:7. doi: 10.1265/ehpm.25-00333.

    PubMed 41605676

Questions about this trial

What is this clinical trial studying?

A study testing Forest Therapy in people with Neoplasms and Cancer, run by Taipei City Hospital at 1 site in Taiwan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 4 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

questionnaire: POMS2-A short (Fushan botanical garden) (time frame: per-test → 2 hours intervention at Fushan botanical garden → post-test immediately after the intervention). The study lists 24 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06001723, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jun 2025.

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Clinical Trial NCT06001723 | AzTrials