AzTrials
AzTrials

ArteriosclerosisPhase 3NCT06008756

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

A Phase 3 study testing Enlicitide Decanoate in people with Arteriosclerosis and Hypercholesterolaemia, run by Merck Sharp & Dohme LLC at 669 sites in 29 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

This is a phase 3, randomized, placebo-controlled study of the efficacy and safety of enlicitide decanoate, an oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, in participants with high cardiovascular risk. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Arteriosclerosis, Hypercholesterolaemia
What is being tested?
Enlicitide Decanoate
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
14,550 participants
Where
669 sitesin 29 countries
Study dates
9 Oct 2023to 29 Nov 2031
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Meets one of the following:
  • Age ≥18 years with a history of a major atherosclerotic cardiovascular disease (ASCVD) event defined as at least 1 of the following: ≥30 days post MI (presumed Type 1 due to plaque rupture or erosion); ≥30 days post ischemic stroke (presumed due to atherosclerosis); or ≥30 days post successful peripheral (carotid or lower extremity) arterial revascularization (surgical or endovascular) or major (ankle or above) amputation due to atherosclerosis; or
  • High risk for first major ASCVD event defined as at least 1 of the following: Age ≥50 years with evidence of coronary artery disease; Age ≥50 years with evidence of atherosclerotic cerebrovascular disease; Age ≥50 years with evidence of peripheral arterial disease; or Age ≥60 years with diabetes mellitus and at least one of the following: microvascular disease or urine albumin-creatinine ratio ≥30 mg/mmol within 6 months before Visit 1, daily insulin use, or diabetes for ≥10 years
  • Has fasted lipid values (evaluated by the Central Laboratory) at Visit 1 (Screening) as follows:
  • History of major ASCVD Event: LDL-C ≥70 mg/dL (1.81 mmol/L) OR non-HDL-C ≥100 mg/dL (2.59 mmol/L)
  • High risk for first major ASCVD Event: LDL-C ≥90 mg/dL (2.33 mmol/L) OR non-HDL-C ≥120 mg/dL (3.11 mmol/L)
  • Is treated with moderate- or high-intensity statin (± nonstatin lipid-lowering therapy [LLT]) at Visit 1
  • Is on a stable dose of all background LLTs (including statin and nonstatin agents) for at least 30 days before Visit 1 (Screening) with no medication or dose changes planned during the participation in the study

Who cannot join

  • Has a history of homozygous familial hypercholesterolemia (FH) based on genetic or clinical criteria, compound heterozygous FH, or double heterozygous FH
  • Has New York Heart Association Class IV heart failure, last known Left Ventricular Ejection Fraction ≤25% by any imaging method, or had a Heart Failure hospitalization within 3 months before Visit 1 (Screening)
  • Has recurrent ventricular tachycardia within 3 months prior to randomization
  • Has a planned arterial revascularization procedure
  • Is undergoing or previously underwent an LDL-C apheresis program within 3 months before Visit 1 (Screening) or plans to initiate an LDL-C apheresis program
  • Was previously treated/is being treated with certain other cholesterol lowering medications, including protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors without adequate washout.
  • Has a fasting triglyceride value ≥400 mg/dL (≥4.52 mmol/L) at Visit 1 (Screening)

Trial locations and contacts

669 sites in 29 countries.

669 sites in 29 countries

United States132 sites

  • New Mexico Clinical Research & Osteoporosis Center ( Site 0005)

    Albuquerque, New Mexico, 87106

  • Advanced Cardiovascular - Alexander City ( Site 0156)

    Alexander City, Alabama, 35010

  • PharmaTex Research, LLC ( Site 0182)

    Amarillo, Texas, 79106

  • Velocity Clinical Research, Anderson ( Site 0022)

    Anderson, South Carolina, 29621

  • University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 0146)

    Aurora, Colorado, 80045

  • Texas Diabetes and Endocrinology, P.A. ( Site 0187)

    Austin, Texas, 78731

  • Northeast Cardiology Associates ( Site 0168)

    Bangor, Maine, 04401

  • National Heart Institute-Research ( Site 0077)

    Beverly Hills, California, 90211

  • Velocity Clinical Research, Binghamton ( Site 0063)

    Binghamton, New York, 13905

  • Central Research Associates ( Site 0118)

    Birmingham, Alabama, 35205

  • St. Vincent's Birmingham Hospital ( Site 0181)

    Birmingham, Alabama, 35205

  • Central Alabama Research ( Site 0109)

    Birmingham, Alabama, 35209

  • Bingham Memorial Hospital ( Site 0195)

    Blackfoot, Idaho, 83221

  • Excel Medical Clinical Trials ( Site 0052)

    Boca Raton, Florida, 33434

  • Brigham and Women's Hospital-Cardiovascular Medicine ( Site 0147)

    Boston, Massachusetts, 02115

  • Boston Clinical Trials ( Site 0029)

    Boston, Massachusetts, 02131

  • Flourish Research - Bowie ( Site 0190)

    Bowie, Maryland, 20715

  • Advanced Heart Care - Bridgewater Route 22 ( Site 0160)

    Bridgewater, New Jersey, 08807

  • Holston Medical Group ( Site 0106)

    Bristol, Tennessee, 37620

  • Burke Internal Medicine and Research ( Site 0035)

    Burke, Virginia, 22015

  • Capital Area Research, LLC ( Site 0139)

    Camp Hill, Pennsylvania, 17011

  • Charlottesville Medical Research ( Site 0030)

    Charlottesville, Virginia, 22911

  • Synexus Clinical Research US, Inc. ( Site 0084)

    Chicago, Illinois, 60602

  • Great Lakes Clinical Trials - Ravenswood ( Site 0056)

    Chicago, Illinois, 60640

  • Velocity Clinical Research, Springdale ( Site 0112)

    Cincinnati, Ohio, 45246

  • Cleveland Clinic Main ( Site 0121)

    Cleveland, Ohio, 44195

  • Centennial Medical Group ( Site 0179)

    Columbia, Maryland, 21045

  • The Ohio State Wexner Medical Center ( Site 0200)

    Columbus, Ohio, 43203

  • Remington-Davis, Inc. ( Site 0183)

    Columbus, Ohio, 43215

  • Avant Research Associates ( Site 0103)

    Crowley, Louisiana, 70526

  • Advanced Pharma Research ( Site 0040)

    Cutler Bay, Florida, 33189

  • Southwest Family Medicine Associates ( Site 0189)

    Dallas, Texas, 75235

  • Alliance for Multispecialty Research, LLC ( Site 0076)

    Daphne, Alabama, 36526

  • Premier Cardiovascular Institute ( Site 0136)

    Dayton, Ohio, 45414

  • Alliance for Multispecialty Research, LLC. ( Site 0171)

    Dearborn, Michigan, 48126

  • Duke University Health System (DUHS) ( Site 0153)

    Durham, North Carolina, 27710

  • Skyline Medical Center/CCT Research ( Site 0148)

    Elkhorn, Nebraska, 68022

  • Alliance for Multispecialty Research - Medisphere Medical Research Center ( Site 0080)

    Evansville, Indiana, 47714

  • Virginia Heart ( Site 0097)

    Falls Church, Virginia, 22042

  • Lillestol Research ( Site 0025)

    Fargo, North Dakota, 58104

  • G&L Research ( Site 0042)

    Foley, Alabama, 36535

  • Alliance for Multispecialty Research, LLC ( Site 0083)

    Fort Myers, Florida, 33912

  • Parkview Research Center at Parkview Regional Medical Center ( Site 0154)

    Fort Wayne, Indiana, 46845

  • NextStage Clinical Research - Phoenix - (01) ( Site 0191)

    Glendale, Arizona, 85306

  • Altru Health System ( Site 0197)

    Grand Forks, North Dakota, 58201

  • Healthy Heart Cardiology ( Site 0113)

    Grand Rapids, Michigan, 49546

  • Velocity Clinical Research, Gulfport ( Site 0038)

    Gulfport, Mississippi, 39503

  • Great Lakes Clinical Trials - Gurnee ( Site 0134)

    Gurnee, Illinois, 60031

  • Healthcare Research Network - St. Louis ( Site 0053)

    Hazelwood, Missouri, 63042

  • Prolato Clinical Research Center ( Site 0108)

    Houston, Texas, 77054

  • Franciscan Physician Network - Indiana Heart Physicians ( Site 0141)

    Indianapolis, Indiana, 46237

  • Westside Center for Clinical Research ( Site 0049)

    Jacksonville, Florida, 32205

  • University of Florida - Jacksonville ( Site 0166)

    Jacksonville, Florida, 32209

  • East Coast Institute for Research, LLC ( Site 0031)

    Jacksonville, Florida, 32216

  • Jacksonville Center for Clinical Research ( Site 0048)

    Jacksonville, Florida, 32216

  • University of Kansas Medical Center ( Site 0004)

    Kansas City, Kansas, 66160

  • Alliance for Multispecialty Research, LLC ( Site 0071)

    Kansas City, Missouri, 64114

  • Holston Medical Group ( Site 0047)

    Kingsport, Tennessee, 37660

  • Alliance for Multispecialty Research, LLC ( Site 0008)

    Knoxville, Tennessee, 37909

  • UCSD - Altman Clinical and Translational Research Institute (ACTRI) ( Site 0130)

    La Jolla, California, 92037

  • East Coast Institute for Research ( Site 0034)

    Lake City, Florida, 32055

  • Chemidox Clinical Trials ( Site 0145)

    Lancaster, California, 93534

  • Excel Clinical Research, LLC ( Site 0123)

    Las Vegas, Nevada, 89109

  • Clinical Research of South Nevada ( Site 0135)

    Las Vegas, Nevada, 89121-4350

  • Alliance for Multispecialty Research, LLC ( Site 0027)

    Lexington, Kentucky, 40509

  • Velocity Clinical Research at The Pioneer Heart Institute, Lincoln ( Site 0078)

    Lincoln, Nebraska, 68510

  • CHI Health Clinic Heart Institute ( Site 0180)

    Lincoln, Nebraska, 68526

  • Medical Investigations Inc. ( Site 0188)

    Little Rock, Arkansas, 72211

  • South Denver Cardiology Associates ( Site 0167)

    Littleton, Colorado, 80120

  • Velocity Clinical Research, Westlake ( Site 0039)

    Los Angeles, California, 90057

  • L-MARC Research Center ( Site 0001)

    Louisville, Kentucky, 40213

  • The Jones Center Clinical Research ( Site 0032)

    Macon, Georgia, 31210

  • Carient Heart & Vascular - Manassas ( Site 0170)

    Manassas, Virginia, 20109

  • Manassas Clinical Research Center ( Site 0007)

    Manassas, Virginia, 20110

  • Central New York Clinical Research ( Site 0044)

    Manlius, New York, 13104

  • Fairview Health Services ( Site 0024)

    Maplewood, Minnesota, 55109

  • Columbus Clinical Services ( Site 0026)

    Miami, Florida, 33125

  • Miami Cardiac & Vascular Institute-Ambulatory Research ( Site 0059)

    Miami, Florida, 33173

  • Inpatient Research Clinic ( Site 0041)

    Miami Lakes, Florida, 33014

  • Abbott Northwestern Hospital ( Site 0199)

    Minneapolis, Minnesota, 55407

  • University of Minnesota, Lillehei Clinical Research Unit ( Site 0193)

    Minneapolis, Minnesota, 55455

  • Eminat ( Site 0082)

    Miramar, Florida, 33027

  • IMA Clinical Research- Monroe- North 18th Street ( Site 0111)

    Monroe, Louisiana, 71201

  • North Shore Diabetes & Endocrine Associates ( Site 0165)

    New Hyde Park, New York, 11042

  • Mid Hudson Medical Research ( Site 0087)

    New Windsor, New York, 12553

  • NYU Langone Health ( Site 0099)

    New York, New York, 10016

  • Health Research of Hampton Roads, Inc. ( Site 0043)

    Newport News, Virginia, 23606

  • Alliance for Multispecialty Research, LLC ( Site 0068)

    Norfolk, Virginia, 23502

  • Coastal Carolina Research Center ( Site 0006)

    North Charleston, South Carolina, 29405

  • Ocala Research Institute - Ocala - Southwest 20th Place ( Site 0079)

    Ocala, Florida, 34471

  • Permian Research Foundation ( Site 0157)

    Odessa, Texas, 79761

  • South Oklahoma Heart Research ( Site 0164)

    Oklahoma City, Oklahoma, 73135

  • Alliance for Multispecialty Research, LLC ( Site 0173)

    Park Ridge, Illinois, 60068

  • Carbon Health - Pasadena ( Site 0149)

    Pasadena, California, 91101

  • LinQ Research ( Site 0101)

    Pearland, Texas, 77584

  • Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0066)

    Phoenix, Arizona, 85020

  • Progressive Medical Research ( Site 0045)

    Port Orange, Florida, 32127

  • Monument Health Clinical Research, a department of Monument -Monument Health Clinical Research, a d ( Site 0009)

    Rapid City, South Dakota, 57701

  • Reid Physician Associates ( Site 0174)

    Richmond, Indiana, 47374

  • Rochester Clinical Research, Inc. ( Site 0098)

    Rochester, New York, 14609

  • Laurelton Heart Specialist PC ( Site 0092)

    Rosedale, New York, 11422

  • St Johns Center for Clinical Research ( Site 0016)

    Saint Augustine, Florida, 32086

  • Synexus Clinical Research US, Inc. ( Site 0086)

    Salt Lake City, Utah, 84106

  • Highland Clinical Research ( Site 0122)

    Salt Lake City, Utah, 84124

  • Northeast Clinical Research of San Antonio ( Site 0011)

    San Antonio, Texas, 78233

  • Discovery Clinical Trials ( Site 0096)

    San Antonio, Texas, 78258

  • Carbon Health - San Mateo - Hillsdale Mall ( Site 0151)

    San Mateo, California, 94403

  • Guthrie Medical Group, P.C. ( Site 0176)

    Sayre, Pennsylvania, 18840

  • Cardiology Associates of Fairfield County, P.C. ( Site 0159)

    Stamford, Connecticut, 06905

  • Centricity Research Suffolk Family Medicine ( Site 0105)

    Suffolk, Virginia, 23435

  • Sugar Lakes Family Practice, PA ( Site 0094)

    Sugar Land, Texas, 77479

  • America Clinical Trials-Research Dept ( Site 0104)

    Tarzana, California, 91356-3551

  • Healthcare Research Network - Chicago ( Site 0051)

    Tinley Park, Illinois, 60477

  • Premiere Medical Center ( Site 0093)

    Toluca Lake, California, 91602

  • LinQ Research - Tomball ( Site 0208)

    Tomball, Texas, 77375

  • Northwest Houston Heart Center-Northwest Houston Clinical Research, PLLC ( Site 0158)

    Tomball, Texas, 77375

  • Cotton O'Neil Clinical Research Center ( Site 0095)

    Topeka, Kansas, 66606

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0058)

    Torrance, California, 90502

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0003)

    Troy, Michigan, 48098

  • Cardiology Associates of North Mississippi ( Site 0169)

    Tupelo, Mississippi, 38801

  • NextStage Clinical Research - Waco ( Site 0196)

    Waco, Texas, 76712

  • Emerson Clinical Research Institute ( Site 0143)

    Washington D.C., District of Columbia, 20009

  • Cardiovascular Associates of the Delaware Valley ( Site 0162)

    Washington Township, New Jersey, 08080

  • Chase Medical Research, LLC ( Site 0046)

    Waterbury, Connecticut, 06708

  • Velocity Clinical Research, Salt Lake City ( Site 0019)

    West Jordan, Utah, 84088

  • AMR Clinical - Wichita ( Site 0116)

    Wichita, Kansas, 67226

  • Wake Forest Baptist Health-Cardiovascular Medicine ( Site 0142)

    Winston-Salem, North Carolina, 27157

  • Clinical Site Partners LLC, dba CSP Orlando ( Site 0067)

    Winter Park, Florida, 32789

  • North Georgia Clinical Research ( Site 0128)

    Woodstock, Georgia, 30189

  • Cardiology Consultants of Philadelphia Yardley ( Site 0072)

    Yardley, Pennsylvania, 19067

  • Trinity Health-Michigan d/b/a Michigan Heart ( Site 0186)

    Ypsilanti, Michigan, 48197

  • Genesis Healthcare System-Pharmacy Research ( Site 0163)

    Zanesville, Ohio, 43701

Other trials in United States

China58 sites

  • Baotou Central Hospital-Cardiology ( Site 3436)

    Baotou, Inner Mongolia, 014040

  • Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 3400)

    Beijing, Beijing Municipality, 100029

  • Beijing Tsinghua Changgung Hospital ( Site 3423)

    Beijing, Beijing Municipality, 102218

  • Jilin Province People's Hospital-Department of Cardiology ( Site 3442)

    Changchun, Jilin, 130021

  • Changsha Central Hospital-Cardiovascular ( Site 3404)

    Changsha, Hunan, 410004

  • The Third Xiangya Hospital of Central South University-Cardiology ( Site 3412)

    Changsha, Hunan, 410013

  • The Third Hospital of Changsha-Cardiovascular department ( Site 3434)

    Changsha, Hunan, 410015

  • Changzhou Second People's Hospital-Cardiology ( Site 3459)

    Changzhou, Jiangsu, 213000

  • The Third People's Hospital of Chengdu (CDTPH) ( Site 3430)

    Chengdu, Sichuan, 610014

  • Chengdu Second Municipal People's Hospital ( Site 3419)

    Chengdu, Sichuan, 610021

  • Chifeng Hospital-Department of Cardiology ( Site 3433)

    Chifeng, Inner Mongolia, 024099

  • The Second Affiliated Hospital of Chongqing Medical University ( Site 3424)

    Chongqing, Chongqing Municipality, 400072

  • Chongqing University Three Gorges Hospital ( Site 3441)

    Chongqing, Chongqing Municipality, 404000

  • Daqing People's Hospital-Cardiology ( Site 3470)

    Daqing, Heilongjiang, 163316

  • The Eighth Affiliated Hospital of Southern Medical University ( Site 3427)

    Foshan, Guangdong, 528399

  • Guangdong Provincial People's Hospital-Cardiology ( Site 3402)

    Guangzhou, Guangdong, 510080

  • Zhujiang Hospital of Southern Medical University ( Site 3415)

    Guangzhou, Guangdong, 510280

  • The Affiliated Hospital of Guizhou Medical University ( Site 3486)

    Guiyang, Guizhou, 550004

  • Hainan General Hospital ( Site 3409)

    Haikou, Hainan, 570311

  • The First Affiliated Hospital, Zhejiang University ( Site 3417)

    Hangzhou, Zhejiang, 310003

  • The first affiliated Hospital of Harbin Medical University-Cardiology ( Site 3406)

    Harbin, Heilongjiang, 150001

  • The Fourth Hospital of Harbin Medical University-Endocrinology department ( Site 3452)

    Harbin, Heilongjiang, 150001

  • Second Affiliated hospital of Anhui Medical University-Cardiology ( Site 3458)

    Hefei, Anhui, 230601

  • Inner Mongolia People's Hospital ( Site 3439)

    Hohhot, Inner Mongolia, 010017

  • Huizhou Municipal Central Hospital ( Site 3467)

    Huizhou, Guangdong, 516001

  • Jiangmen Center Hospital ( Site 3492)

    Jiangmen, Guangdong, 529030

  • The First Affiliated Hospital of Jinzhou Medical University ( Site 3476)

    Jinzhou, Liaoning, 121001

  • Taizhou Hospital of Zhejiang Province-Cardiovascular Department ( Site 3472)

    Linhai, Zhejiang, 317000

  • Linyi People's Hospital ( Site 3468)

    Linyi, Shandong, 276003

  • Lishui Central Hospital ( Site 3455)

    Lishui, Zhejiang, 323030

  • The Third Hospital of Nanchang - Fuhe-cardiology ( Site 3496)

    Nanchang, Jiangxi, 330003

  • The Third Hospital of Nanchang ( Site 3454)

    Nanchang, Jiangxi, 330009

  • The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 3480)

    Nanjing, Jiangsu, 210011

  • Nanyang First People's Hospital ( Site 3469)

    Nanyang, Henan, 473000

  • The Second People's Hospital of Neijiang ( Site 3482)

    Neijiang, Sichuan, 641099

  • Pingxiang People's Hospital-Cardiology ( Site 3473)

    Pingxiang, Jiangxi, 337055

  • The Third Affiliated Hospital of Qiqihar Medical University ( Site 3465)

    Qiqihar, Heilongjiang, 161000

  • Shanghai Tongji Hospital ( Site 3431)

    Shanghai, Shanghai Municipality, 200065

  • Shanghai General Hospital ( Site 3479)

    Shanghai, Shanghai Municipality, 200080

  • Shanghai East Hospital ( Site 3485)

    Shanghai, Shanghai Municipality, 200120

  • The People's Hospital of Liaoning Province-Cardiology ( Site 3453)

    Shenyang, Liaoning, 110016

  • The University of Hong Kong-Shenzhen Hospital-Cardiovascular department ( Site 3414)

    Shenzhen, Guangdong, 518053

  • Siping Central People's Hospital-Cardiovascular Department ( Site 3408)

    Siping, Jilin, 136000

  • Suining Central Hospital ( Site 3487)

    Suining, Sichuan, 629000

  • Shanxi Cardiovascular Hospital ( Site 3462)

    Taiyuan, Shaanxi, 030024

  • Tianjin People' s Hospital-Cardiology ( Site 3425)

    Tianjin, Tianjin Municipality, 300121

  • Tianjin Fourth Centre Hospital-Department of Cardiology ( Site 3456)

    Tianjin, Tianjin Municipality, 300140

  • Pu'ai Hospital of Wuhan City ( Site 3451)

    Wuhan, Hubei, 430030

  • Renmin Hospital of Wuhan University ( Site 3464)

    Wuhan, Hubei, 430060

  • The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3420)

    Xi'an, Shaanxi, 710061

  • Shaanxi provincial people's hospital ( Site 3421)

    Xi'an, Shaanxi, 710068

  • Xianyang Hospital of Yan'an University ( Site 3435)

    Xianyang, Shaanxi, 712000

  • The Affiliated Hospital of Xuzhou Medical College ( Site 3403)

    Xuzhou, Jiangsu, 221000

  • Northern Jiangsu People's Hospital ( Site 3405)

    Yangzhou, Jiangsu, 225001

  • General Hospital of Ningxia Medical University ( Site 3478)

    Yinchuan, Ningxia, 750004

  • The First People's Hospital of Yueyang-Cardiovascular department ( Site 3448)

    Yueyang, Hunan, 414000

  • Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 3481)

    Zhenjiang, Jiangsu, 212001

  • Zibo Municipal Hospital ( Site 3474)

    Zibo, Shandong, 255400

Other trials in China

Japan38 sites

  • Tokyonishi Tokushukai Hospital ( Site 3530)

    Akishima, Tokyo, 196-0003

  • Fujisawa City Hospital ( Site 3522)

    Fujisawa, Kanagawa, 251-8550

  • Saiseikai Fukuoka General Hospital ( Site 3536)

    Fukuoka, 810-0001

  • Fukuoka University Hospital ( Site 3502)

    Fukuoka, 814-0180

  • Japanese Red Cross Fukuoka Hospital ( Site 3528)

    Fukuoka, 815-8555

  • Minamino Cardiovascular Hospital ( Site 3546)

    Hachiōji, Tokyo, 192-0918

  • Hanyu General Hospital ( Site 3504)

    Hanyū, Saitama, 348-8505

  • Affiliated Central Clinic of Higashiyamato Hospital ( Site 3533)

    Higashiyamato, Tokyo, 207-0014

  • Hyogo Prefectural Harima-Himeji General Medical Center ( Site 3514)

    Himeji, Hyōgo, 670-8560

  • Tokai University Hospital ( Site 3500)

    Isehara, Kanagawa, 259-1193

  • Nakamura Cardiovascular Clinic ( Site 3529)

    Itoshima, Fukuoka, 819-1104

  • Shonan Kamakura General Hospital ( Site 3516)

    Kamakura, Kanagawa, 247-8533

  • Fukuoka Tokushukai Hospital ( Site 3511)

    Kasuga, Fukuoka, 816-0864

  • Kokura Memorial Hospital ( Site 3521)

    Kitakyushu, Fukuoka, 802-8555

  • Kumamoto University Hospital ( Site 3501)

    Kumamoto, 860-8556

  • Saiseikai Kumamoto Hospital ( Site 3515)

    Kumamoto, 861-4193

  • Kyoto Okamoto Memorial Hospital ( Site 3524)

    Kuse-gun Kumiyama-cho, Kyoto, 613-0034

  • Kyoto City Hospital ( Site 3542)

    Kyoto, 604-8845

  • Seikeikai Medical Corporation New Tokyo Heart Clinic ( Site 3537)

    Matsudo, Chiba, 271-0077

  • Nagasaki Harbor Medical Center ( Site 3527)

    Nagasaki, 850-8555

  • Nagoya Kyoritsu Hospital ( Site 3531)

    Nagoya, Aichi-ken, 454-0933

  • Chubu Rosai Hospital ( Site 3507)

    Nagoya, Aichi-ken, 455-8530

  • Go Neurosurgical Clinic ( Site 3534)

    Nakagawa, Fukuoka, 811-1244

  • Okayama City General Medical Center Okayama City Hospital ( Site 3508)

    Okayama, 700-8557

  • National Hospital Organization Okayama Medical Center ( Site 3512)

    Okayama, 7011192

  • National Hospital Organization Nagasaki Medical Center ( Site 3505)

    Ōmura, Nagasaki, 856-8562

  • National Hospital Organization Osaka National Hospital ( Site 3503)

    Osaka, 540-0006

  • Saga-Ken Medical Centre Koseikan ( Site 3543)

    Saga, Saga-ken, 840-8571

  • Sanai Hospital - Saitama ( Site 3532)

    Saitama, 332-0012

  • Saitama City Hospital ( Site 3535)

    Saitama, 336-8522

  • Matsuda Cardiovascular Clinic ( Site 3526)

    Sapporo, Hokkaido, 003-0026

  • TAKAMATSU Red Cross Hospital ( Site 3506)

    Takamatsu, Kagawa-ken, 760-0017

  • Kagawa Prefectural Central Hospital ( Site 3538)

    Takamatsu, Kagawa-ken, 760-8557

  • Machida Municipal Hospital ( Site 3545)

    Tokyo, 194-0023

  • Toyota Kosei Hospital ( Site 3519)

    Toyota, Aichi-ken, 470-0396

  • Toyota Memorial Hospital ( Site 3539)

    Toyota, Aichi-ken, 471-8513

  • Tsukuba Medical Center Hospital ( Site 3540)

    Tsukuba, Ibaraki, 305-8558

  • Uji-Tokushukai Medical Center ( Site 3509)

    Uji, Kyoto, 611-0041

Other trials in Japan

Netherlands35 sites

  • Noordwest Ziekenhuisgroep-Research Cardiology ( Site 1914)

    Alkmaar, North Holland, 1815 JD

  • Ziekenhuisgroep Twente, locatie Almelo-Cardioresearch ZGT ( Site 1919)

    Almelo, Overijssel, 7609 PP

  • Meander Medisch Centrum ( Site 1933)

    Amersfoort, Utrecht, 3813 TZ

  • Ziekenhuis Amstelland-Cardiologie ( Site 1920)

    Amstelveen, North Holland, 1186AM

  • Onze Lieve Vrouwe Gasthuis ( Site 1922)

    Amsterdam, North Holland, 1051 AC

  • Amsterdam UMC, locatie AMC-Vascular Medicine Clin Trial Unit ( Site 1926)

    Amsterdam, North Holland, 1105 AZ

  • Gelre Ziekenhuis ( Site 1907)

    Apeldoorn, Gelderland, 7334 DZ

  • Amphia Ziekenhuis, locatie Breda Molengracht-Research cardiology ( Site 1903)

    Breda, North Brabant, 4818 CK

  • Reinier de Graaf Ziekenhuis, locatie Delft-Research Department Cardiology ( Site 1915)

    Delft, South Holland, 2625 AD

  • Slingeland Ziekenhuis ( Site 1941)

    Doetinchem, Gelderland, 7009 BL

  • Albert Schweitzer Ziekenhuis, locatie Dordwijk ( Site 1901)

    Dordrecht, South Holland, 3318 AT

  • Ziekenhuis Gelderse Vallei ( Site 1939)

    Ede, Gelderland, 6716 RP

  • Catharina Ziekenhuis ( Site 1934)

    Eindhoven, North Brabant, 5623 EJ

  • Treant, locatie Scheper Ziekenhuis ( Site 1918)

    Emmen, Drenthe, 7824 AA

  • Admiraal de Ruyter Ziekenhuis, locatie Goes ( Site 1900)

    Goes, Zeeland, 4462 RA

  • Groene Hart Ziekenhuis-Research Cardiologie ( Site 1932)

    Gouda, South Holland, 2803 HH

  • Martini Ziekenhuis ( Site 1940)

    Groningen, 9728 NT

  • Ziekenhuis St. Jansdal ( Site 1917)

    Harderwijk, Gelderland, 3844 DG

  • Elkerliek Ziekenhuis ( Site 1938)

    Helmond, North Brabant, 5707 HA

  • Tergooiziekenhuizen, locatie Hilversum ( Site 1929)

    Hilversum, North Holland, 1213 XZ

  • Treant, locatie Ziekenhuis Bethesda-Bethesda Diabetes Research Center ( Site 1930)

    Hoogeveen, Drenthe, 7909 AA

  • Dijklander Ziekenhuis ( Site 1936)

    Hoorn, North Holland, 1624 NP

  • Medische Centrum Leeuwarden ( Site 1935)

    Leeuwarden, Provincie Friesland, 8934 AD

  • Leids Universitair Medisch Centrum ( Site 1924)

    Leiden, South Holland, 2333 ZA

  • Alrijne Ziekenhuis, locatie Leiderdorp ( Site 1902)

    Leiderdorp, South Holland, 2353 GA

  • Radboudumc-Cardiology ( Site 1925)

    Nijmegen, Gelderland, 6525 GA

  • Bravis Ziekenhuis, locatie Roosendaal ( Site 1905)

    Roosendaal, North Brabant, 4708 AE

  • Erasmus Medisch Centrum, Centrumlocatie ( Site 1943)

    Rotterdam, South Holland, 3015 GD

  • Ikazia Ziekenhuis ( Site 1911)

    Rotterdam, South Holland, 3083 AN

  • Antonius Ziekenhuis, locatie D&A Research and Genetics ( Site 1928)

    Sneek, Provincie Friesland, 8601 ZR

  • Haga Ziekenhuis locatie Leyweg ( Site 1909)

    The Hague, South Holland, 2545 AA

  • Ziekenhuis Rivierenland-Remati ( Site 1916)

    Tiel, Gelderland, 4002 WP

  • VieCuri Medisch Centrum, locatie Venlo-Cardiology ( Site 1923)

    Venlo, Limburg, 5912 BL

  • Zaans Medisch Centrum ( Site 1942)

    Zaandam, North Holland, 1502 DV

  • Gelre Ziekenhuizen ( Site 1908)

    Zutphen, Gelderland, 7207 AE

Other trials in Netherlands

Poland32 sites

  • Trial Medica ( Site 2122)

    Bialystok, Podlaskie Voivodeship, 15-481

  • Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny ( Site 2140)

    Bielsko-Biala, Silesian Voivodeship, 43-316

  • NZOZ Centrum Medyczne KERmed ( Site 2121)

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231

  • Centrum Medyczne Pratia Bydgoszcz-Centrum Medyczne Pratia Bydgoszcz ( Site 2125)

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796

  • Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 2141)

    Chrzanów, Lesser Poland Voivodeship, 32-500

  • Polsko-Amerykańskie Kliniki Serca ( Site 2145)

    Dąbrowa Górnicza, Silesian Voivodeship, 41-300

  • Poradnia Kardiologiczna KOS-Zawal ( Site 2104)

    Elblag, Warmian-Masurian Voivodeship, 82-300

  • Uniwersyteckie Centrum Kliniczne ( Site 2148)

    Gdansk, Pomeranian Voivodeship, 80-214

  • Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman ( Site 2112)

    Gdynia, Pomeranian Voivodeship, 81-157

  • Gabinet Kardiologiczno Internistyczny ( Site 2111)

    Gdynia, Pomeranian Voivodeship, 81-472

  • AMEDS CLINICAL RESEARCH ( Site 2166)

    Grodzisk Mazowiecki, Masovian Voivodeship, 05-825

  • SPZOZ im. Jana Pawła II w Grodzisku Mazowieckim ( Site 2155)

    Grodzisk Mazowiecki, Masovian Voivodeship, 05-825

  • Centrum Medyczne Pratia Katowice ( Site 2108)

    Katowice, Silesian Voivodeship, 40-081

  • Clinical Medical Research ( Site 2102)

    Katowice, Silesian Voivodeship, 40-156

  • Maopolskie Centrum Kliniczne ( Site 2113)

    Krakow, Lesser Poland Voivodeship, 30-149

  • Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 2118)

    Legnica, Lower Silesian Voivodeship, 59-220

  • SOMED CR ( Site 2160)

    Lodz, Łódź Voivodeship, 90-368

  • Instytut Centrum Zdrowia Matki Polki ( Site 2165)

    Lodz, Łódź Voivodeship, 93-338

  • NZOZ Twoja Przychodnia ( Site 2105)

    Lublin, Lublin Voivodeship, 20-857

  • Solumed Centrum Medyczne ( Site 2123)

    Poznan, Greater Poland Voivodeship, 60-529

  • Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k ( Site 2150)

    Poznan, Greater Poland Voivodeship, 61-731

  • Centrum Medyczne Medyk ( Site 2101)

    Rzeszów, Podkarpackie Voivodeship, 35-055

  • Velocity Skierniewice Sp. z o. o. ( Site 2114)

    Skierniewice, Łódź Voivodeship, 96-100

  • NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus ( Site 2130)

    Sopot, Pomeranian Voivodeship, 81-717

  • Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka ( Site 2119)

    Tarnów, Lesser Poland Voivodeship, 33-100

  • Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site 2162)

    Tarnów, Lesser Poland Voivodeship, 33-100

  • MICS Centrum Medyczne Torun ( Site 2159)

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100

  • Polsko-Amerykańskie Kliniki Serca ( Site 2142)

    Tychy, Silesian Voivodeship, 43-100

  • Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ ( Site 2139)

    Warsaw, Masovian Voivodeship, 04-073

  • Narodowy Inst. Kardiologii Stefana kardynala Wyszynskiego-Inst. Badawczy.Centr.Wsparcia Badan Klinic ( Site 2132)

    Warsaw, Masovian Voivodeship, 04-628

  • Indywidualna Specjalistyczna Praktyka Lekarska dr n.med. Andrzej Tomasik ( Site 2146)

    Zabrze, Silesian Voivodeship, 41-800

  • Polsko Amerykanskie Kliniki Serca - Zgierskie ( Site 2144)

    Zgierz, Łódź Voivodeship, 95-100

Other trials in Poland

Germany30 sites

  • Klinikum am Plattenwald ( Site 1590)

    Bad Friedrichshall, Baden-Wurttemberg, 74177

  • Kerckhoff-Klinik ( Site 1599)

    Bad Nauheim, Hesse, 61231

  • Praxis Rankestrasse ( Site 1548)

    Berlin, 10789

  • Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 1568)

    Berlin, 12203

  • DRK Kliniken Berlin - Köpenick ( Site 1580)

    Berlin, 12559

  • Synexus Berlin Clinical Research Centre ( Site 1585)

    Berlin, 12627

  • Jüdisches Krankenhaus Berlin ( Site 1595)

    Berlin, 13347

  • Klinikum Bielefeld Mitte ( Site 1561)

    Bielefeld, North Rhine-Westphalia, 33604

  • Zentrum fur klinische Forschung - Köln ( Site 1573)

    Cologne, North Rhine-Westphalia, 51069

  • St.-Johannes-Hospital Dortmund-Clinic of Internal medicine I ( Site 1567)

    Dortmund, North Rhine-Westphalia, 44137

  • Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden Neustadt GbR ( Site 1597)

    Dresden, Saxony, 01099

  • Universitaetsklinikum Carl Gustav Carus Dresden-Universitätsstudienzentrum für Stoffwechselerkranku ( Site 1549)

    Dresden, Saxony, 01307

  • Die Bocholder Hausärzte ( Site 1587)

    Essen, North Rhine-Westphalia, 45355

  • Klinisches Forschungszentrum Dr. Hagemann am Hausarztzentrum am Germaniaplatz ( Site 1554)

    Essen, North Rhine-Westphalia, 45355

  • Unterfrintroper Hausarztzentrum Klinische Forschung ( Site 1550)

    Essen, North Rhine-Westphalia, 45359

  • Synexus Clinical Research GmbH Synexus Frankfurt Clinical Research Centre ( Site 1592)

    Frankfurt am Main, Hesse, 60313

  • ClinPhenomics CVC GmbH ( Site 1593)

    Frankfurt am Main, Hesse, 60596

  • Universitaetsklinikum Hamburg-Eppendorf ( Site 1556)

    Hamburg, 20246

  • Cardiologicum Hamburg ( Site 1596)

    Hamburg, 22041

  • Siteworks GmbH ( Site 1552)

    Hanover, Lower Saxony, 30449

  • Siteworks GmbH - Heidelberg ( Site 1546)

    Heidelberg, Baden-Wurttemberg, 69115

  • Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels ( Site 1574)

    Hohenmölsen, Saxony-Anhalt, 06679

  • Kardiopraxis Schirmer Kaiserslautern ( Site 1576)

    Kaiserslautern, Rhineland-Palatinate, 67655

  • Synexus Leipzig Clinical Research Centre ( Site 1591)

    Leipzig, Saxony, 04103

  • ze:ro ARZTPRAXEN-Ze:ro Praxen ( Site 1583)

    Mannheim, Baden-Wurttemberg, 68165

  • Kardiologische Gemeinschaftspraxis ( Site 1564)

    Nuremberg, Bavaria, 90402

  • Studienzentrum Brinkum - Torsten Drescher & Dr. Lars Pohlmeier ( Site 1557)

    Stuhr, Lower Saxony, 28816

  • Siteworks GmbH - Völklingen ( Site 1553)

    Völklingen, Saarland, 66333

  • Gemeinschaftspraxis Dr. med. Josef und Wilma Großkopf ( Site 1547)

    Wallerfing, Bavaria, 94574

  • Forschungszentrum Ruhr ( Site 1586)

    Witten, North Rhine-Westphalia, 58455

Other trials in Germany

Mexico30 sites

  • Centro de Atención e Investigación Clínica ( Site 1010)

    Aguascalientes, 20129

  • Centro de Investigación Cardiometabólica de Aguascalientes ( Site 1034)

    Aguascalientes, 20230

  • Fundación Cardiovascular de Aguascalientes A.C. ( Site 1020)

    Aguascalientes, 20230

  • ICARO Investigaciones en Medicina ( Site 1005)

    Chihuahua City, 31000

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. ( Site 1006)

    Ciudad Madero, Tamaulipas, 89440

  • Centro de Investigación y Gastroenterología ( Site 1002)

    Cuauhtémoc, 06700

  • CHRISTUS Centro de Excelencia en Investigación (Norte) ( Site 1032)

    General Escobedo, Nuevo León, 66055

  • Instituto Jalisciense de Investigacion en Diabetes y Obesidad-Endocrinology ( Site 1007)

    Guadalajara, Jalisco, 04460

  • Unidad de Investigaci�n Cl�nica Cardiometabolica de Occident-Unidad de Investigación Clínica Cardio ( Site 1015)

    Guadalajara, Jalisco, 44150

  • Cardiocent de Guadalajara S.C.-cardiocent de guadalajara SC ( Site 1001)

    Guadalajara, Jalisco, 44160

  • Centro de Investigación Médico Biológica y Terapia Avanzada ( Site 1021)

    Guadalajara, Jalisco, 44650

  • Bio Investigación AMARC, S.C. ( Site 1013)

    Gustavo Adolfo Madero, Mexico City, 07800

  • Morales Vargas Centro de Investigacion ( Site 1029)

    León, Guanajuato, 37000

  • Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 1017)

    Mérida, Yucatán, 97130

  • Instituto Nacional de Cardiologia Ignacio Chavez-Endocrinology ( Site 1018)

    México, 14080

  • HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA-Farmacologia Clinica ( Site 1033)

    Mexico City, Mexico City, 06720

  • Centro de Imagen y Tecnología en Intervención Cardiovascular-Research ( Site 1041)

    Mexico City, Mexico City, 10400

  • Clínica Integral del Paciente Diabético y Obeso ( Site 1016)

    Mexico City, Mexico City, 11850

  • Medica Sur-Clinica de Enfermedades Digestivas y Obesidad ( Site 1024)

    Mexico City, Mexico City, 14050

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 1012)

    Mexico City, Mexico City, 14080

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Endocrinologia ( Site 1025)

    Monterrey, Nuevo León, 64460

  • Unidad biomedica avanzada monterrey-Clinical Trials ( Site 1000)

    Monterrey, Nuevo León, 64460

  • Centro de investigación y control metabólico ( Site 1003)

    Monterrey, Nuevo León, 66465

  • Oaxaca Site Management Organization S.C. ( Site 1004)

    Oaxaca City, 68000

  • Centro de Investigacion Clinica de Oaxaca ( Site 1011)

    Oaxaca City, 68020

  • Grupo Ollin Care ( Site 1023)

    Pachuca, Hidalgo, 42000

  • Centro de Investigacion Cardiovascular y Metabólica ( Site 1027)

    Tijuana, Estado de Baja California, 22500

  • Instituto Veracruzano en Investigación Clínica S.C. ( Site 1035)

    Veracruz, 91851

  • Arké SMO S.A de C.V ( Site 1026)

    Veracruz, 91900

  • Centro de Investigacion Medica de Occidente, S.C.-Departamento de Centro de Investigacion Medica d ( Site 1022)

    Zapopan, Jalisco, 44260

Other trials in Mexico

South Africa24 sites

  • Tiervlei Trial Centre-Clinical ( Site 2205)

    Bellville, Cape Town, Western Cape, 7530

  • IATROS INTERNATIONAL ( Site 2206)

    Bloemfontein, Free State, 9301

  • Helderberg Research Institute ( Site 2231)

    Cape Town, Western Cape, 7130

  • TREAD Research ( Site 2212)

    Cape Town, Western Cape, 7500

  • Enhancing Care Foundation-ECF research pharmacy ( Site 2213)

    Durban, KwaZulu-Natal, 4052

  • Private Practice - Dr. Neyaseelan Gounden ( Site 2207)

    Durban, KwaZulu-Natal, 4093

  • Excellentis Clinical Trial Consultants ( Site 2221)

    George, Western Cape, 6529

  • TASK Eden ( Site 2227)

    George, Western Cape, 6529

  • Lenasia Clinical Trial Centre - Johannesburg ( Site 2266)

    Johannesburg, Gauteng, 1827

  • Bara Cardiology Research ( Site 2258)

    Johannesburg, Gauteng, 2013

  • Helen Joseph Hospital-Clinical HIV Research Unit ( Site 2230)

    Johannesburg, Gauteng, 2092

  • Futurex Clinical. Dr Soraya Cassimjee INC ( Site 2269)

    Johannesburg, Gauteng, 2192

  • Netcare Sunninghill Hospital ( Site 2257)

    Johannesburg, Gauteng, 2196

  • Midrand Medical Centre ( Site 2202)

    Midrand, Gauteng, 1685

  • Zinakekele Medicall Centre ( Site 2225)

    Moloto, Gauteng, 1029

  • Be Part Yoluntu Centre ( Site 2209)

    Paarl, Western Cape, 7626

  • Paarl Research Centre ( Site 2214)

    Paarl, Western Cape, 7646

  • Tsitsikamma Clinical Research Initiative (TCRI) ( Site 2226)

    Plettenberg Bay, Western Cape, 6600

  • Phoenix Pharma ( Site 2204)

    Port Elizabeth, Eastern Cape, 6001

  • Clinical Trial Systems ( Site 2210)

    Pretoria, Gauteng, 0186

  • Sefako Makgatho Health Sciences University ( Site 2268)

    Pretoria, Gauteng, 0204

  • Jongaie Research ( Site 2211)

    Pretoria West, Gauteng, 0183

  • Wits Clinical Research ( Site 2220)

    Soweto, Gauteng, 2013

  • Clinical Projects Research ( Site 2265)

    Worcester, Western Cape, 6850

Other trials in South Africa

Spain23 sites

  • Hospital Universitario Fundacion ALcorcon ( Site 2353)

    Alcorcón, Madrid, Comunidad de, 28922

  • Hospital Universitari Vall d'Hebron ( Site 2342)

    Barcelona, Catalonia, 08035

  • Corporació de Salut del Maresme i la Selva ( Site 2365)

    Calella, Barcelona, 08370

  • Vithas Hospital Sevilla-Unidad de Salud Metabólica. Diabetes y Obesidad ( Site 2349)

    Castilleja de la Cuesta, Sevilla, 41950

  • EAP Osona Sud - Alt Congost S.L.P ( Site 2311)

    Centelles, Catalonia, 08540

  • Hospital Universitario Reina Sofia-Medicina Interna ( Site 2362)

    Córdoba, Andalusia, 14004

  • Hospital Clínico Universitario Virgen de la Arrixaca-CARDIOLOGÍA ( Site 2328)

    El Palmar, Murcia, Murcia, Region de, 30120

  • Hospital Universitari de Bellvitge-Unitat de Lipids i Risc Vascular ( Site 2327)

    L'Hospitalet de Llobregat, Catalonia, 08907

  • Complejo Asistencial Universitario de León - Hospital de León ( Site 2339)

    León, Leon, 24071

  • Hospital Universitario Ramón y Cajal ( Site 2337)

    Madrid, Madrid, Comunidad de, 28034

  • Hospital Universitario La Paz ( Site 2333)

    Madrid, Madrid, Comunidad de, 28046

  • Hospital La Luz ( Site 2366)

    Madrid, 28003

  • Hospital La Princesa ( Site 2334)

    Madrid, 28006

  • Hospital Clinico San Carlos-Cardiology ( Site 2325)

    Madrid, 28040

  • HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 2348)

    Majadahonda, Madrid, Comunidad de, 28222

  • Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2323)

    Málaga, Andalusia, 29010

  • HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-Endocrinologia y Nutrición ( Site 2344)

    Pozuelo de Alarcón, Madrid, 28223

  • CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 2320)

    Santiago de Compostela, La Coruna, 15706

  • Hospital Universitario Virgen de Valme-Internal Medicine ( Site 2336)

    Seville, Andalusia, 41014

  • Hospital Universitari Joan XXIII de Tarragona ( Site 2350)

    Tarragona, 43005

  • Hospital Universitario de Torrevieja ( Site 2351)

    Torrevieja, Alicante, 03186

  • Hospital Universitari i Politecnic La Fe ( Site 2340)

    Valencia, Valencia, 46026

  • HOSPITAL CLINICO DE VALENCIA-CARDIOLOGY ( Site 2321)

    Valencia, Valenciana, Comunitat, 46010

Other trials in Spain

Argentina21 sites

  • CIPREC-CIPREC Sede Arenales ( Site 0624)

    Buenos Aires, Buenos Aires F.D., C1061AAS

  • Fundación favaloro para la Docencia e Investigación Médica ( Site 0606)

    Buenos Aires, Buenos Aires F.D., C1093AAS

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0604)

    Buenos Aires, Buenos Aires F.D., C1425AGC

  • Fundación Respirar ( Site 0610)

    Buenos Aires, Buenos Aires F.D., C1426ABP

  • Sanatorio Finochietto ( Site 0626)

    Buenos Aires, C1187AAN

  • CEDIC ( Site 0612)

    CABA, Buenos Aires, C1060ABN

  • CEMEDIC ( Site 0609)

    CABA, Buenos Aires, C1407GTL

  • Centro de Investigaciones Metabólicas (CINME) ( Site 0620)

    CABA, C1056ABI

  • Instituto Médico DAMIC ( Site 0603)

    Córdoba, Córdoba Province, 5003DCE

  • Instituto de Cardiología "Juana F. Cabral"-Cardiología ( Site 0608)

    Corrientes, W3400AMZ

  • Framingham Centro Médico ( Site 0625)

    La Plata, Buenos Aires, B1902COS

  • CIMeL ( Site 0613)

    Lanus, Buenos Aires, B1824KAJ

  • Instituto de Investigaciones Clínicas Mar del Plata ( Site 0605)

    Mar del Plata, Buenos Aires, B7600FZO

  • DIM Clínica Privada ( Site 0627)

    Ramos Mejía, Buenos Aires, B1704ETD

  • Instituto de Investigaciones Clinicas Rosario ( Site 0602)

    Rosario, Santa Fe Province, S2000CVD

  • Fundacion Estudios Clinicos ( Site 0619)

    Rosario, Santa Fe Province, S2000DEJ

  • Laboratorio de Hemostasia y Trombosis ( Site 0623)

    Rosario, Santa Fe Province, S2000DTB

  • Go Centro Medico San Nicolás ( Site 0621)

    San Nicolás de los Arroyos, Buenos Aires, 2900

  • Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0615)

    Santa Fe, Santa Fe Province, S3000BPJ

  • Centro de Investigaciones Clinicas del Litoral ( Site 0607)

    Santa Fe, 3000

  • Instituto de Investigaciones Clinicas Zarate ( Site 0600)

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

Brazil18 sites

  • Centro de Pesquisa Clinica do Coracao ( Site 0713)

    Aracaju, Sergipe, 49055-530

  • Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0725)

    Bragança Paulista, São Paulo, 12916-542

  • Centro de Pesquisa Clinica do Brasil ( Site 0719)

    Brasília, Federal District, 71625-175

  • Hospital Angelina Caron ( Site 0702)

    Campina Grande do Sul, Paraná, 83430-000

  • Instituto de Pesquisa clinica de Campinas ( Site 0706)

    Campinas, São Paulo, 13060-080

  • Hospital do Rocio ( Site 0721)

    Campo Largo, Paraná, 83606-177

  • Hospital Universitário ( Site 0723)

    Canoas, Rio Grande do Sul

  • Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas ( Site 0728)

    Fortaleza, Ceará, 60430-350

  • Universidade Federal de Goias ( Site 0717)

    Goiânia, Goiás, 74605-020

  • Instituto de Cardiologia do Rio Grande do Sul ( Site 0704)

    Porto Alegre, Rio Grande do Sul, 90620001

  • Hospital Mae de Deus ( Site 0716)

    Porto Alegre, Rio Grande do Sul, 90880-480

  • Hospital Nossa Senhora da Conceição-FZ PESQUISA E SERVIÇOS EM CARDIOLOGIA CLÍNICA LTDA ( Site 0712)

    Porto Alegre, Rio Grande do Sul, 91350-280

  • IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 0715)

    Rio de Janeiro, 20241-180

  • Hospital e Maternidade Christóvão da Gama (HMCG) ( Site 0724)

    Santo André, São Paulo, 09020-270

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0707)

    São José do Rio Preto, São Paulo, 15090000

  • Instituto Dante Pazzanese de Cardiology-Fundação Adib Jatene ( Site 0708)

    São Paulo, São Paulo, 04012-909

  • CEPIC - Centro Paulista de Investigação Clínica ( Site 0710)

    São Paulo, São Paulo, 04266-010

  • Integral Pesquisa e Ensino ( Site 0709)

    Votuporanga, São Paulo, 15500-269

Other trials in Brazil

Colombia18 sites

  • Ciensalud Ips S A S ( Site 0903)

    Barranquilla, Atlántico, 08001

  • Clinica de la Costa S.A.S. ( Site 0902)

    Barranquilla, Atlántico, 080020

  • IPS Centro Científico Asistencial S.A.S ( Site 0900)

    Barranquilla, Atlántico, 080020

  • Sociedad de Cirugía de Bogotá - Hospital de San Jose ( Site 0920)

    Bogota, Cundinamarca, 1100100

  • Fundacion Santa Fe de Bogota ( Site 0916)

    Bogotá, Cundinamarca, 110111

  • Solano & Terront Servicios Medicos - UNIENDO ( Site 0915)

    Bogotá, Cundinamarca, 110221

  • Salud SURA Calle 100 ( Site 0918)

    Bogotá, Cundinamarca, 110231

  • Fundación Valle del Lili ( Site 0904)

    Cali, Valle del Cauca Department, 760032

  • Centro de Investigaciones Clinicas SAS ( Site 0912)

    Cali, Valle del Cauca Department, 760036

  • Mediservis del Tolima IPS S.A.S ( Site 0914)

    Ibague, Tolima Department, 730006

  • IPS Médicos Internistas de Caldas ( Site 0905)

    Manizales, Caldas Department, 170004

  • Fundación Centro de Investigación Clínica CIC ( Site 0906)

    Medellín, Antioquia, 050021

  • Salud SURA Industriales ( Site 0917)

    Medellín, Antioquia, 50021

  • Rodrigo Botero S.A.S ( Site 0901)

    Medellín, Antioquia, 50030

  • IMAT S.A.S ( Site 0907)

    Montería, Departamento de Córdoba, 230002

  • Fundación Cardiovascular de Colombia ( Site 0911)

    Piedecuesta, Santander Department, 681017

  • Instituto Cardiovascular del Cesar S.A ( Site 0919)

    Valledupar, Cesar Department, 200001

  • Healthy Medical Center S.A.S ( Site 0913)

    Zipaquirá, Cundinamarca, 250252

Other trials in Colombia

Israel18 sites

  • Barzilai Medical Center ( Site 1713)

    Ashkelon, 7830604

  • Soroka Medical Center ( Site 1715)

    Beersheba, 8410101

  • Hillel Yaffe Medical Center ( Site 1705)

    Hadera, 3810101

  • Linn Medical Center ( Site 1711)

    Haifa, 3100000

  • Rambam Health Care Campus ( Site 1702)

    Haifa, 3109601

  • Rambam Health Care Campus ( Site 1718)

    Haifa, 3109601

  • Institute of Diabetes, Technology and Research - Clalit Health ( Site 1701)

    Herzliya, 4630945

  • Clalit health Services - Holon Medical Center ( Site 1721)

    Holon, 5840608

  • Shaare Zedek Medical Center ( Site 1710)

    Jerusalem, 9103102

  • Hadassah Medical Center ( Site 1706)

    Jerusalem, 9112001

  • Hadassah Medical Center ( Site 1709)

    Jerusalem, 9112001

  • Clalit Health Services - Majd Al-Krum Clinic ( Site 1722)

    Majd el Kurūm, 2019000

  • Galilee Medical Center ( Site 1723)

    Nahariya, 2210001

  • Rabin Medical Center ( Site 1720)

    Petah Tikva, 4941 492

  • Rabin Medical Center ( Site 1703)

    Petah Tikva, 4941492

  • Sheba Medical Center ( Site 1708)

    Ramat Gan, 5265601

  • Kaplan Medical Center ( Site 1724)

    Rehovot, 7661041

  • Clalit Health Services - Sakhnin Community Clinic-Research Unit ( Site 1700)

    Sakhnin, 3081000

Other trials in Israel

Hungary17 sites

  • Lausmed Egészségügyi Szolgáltató ( Site 1621)

    Baja, Bács-Kiskun county, 6500

  • DRC Gyógyszervizsgáló Központ ( Site 1609)

    Balatonfüred, Veszprém megye, 8230

  • Private Practice - Dr. Lakatos Ferenc ( Site 1618)

    Békéscsaba, Bekes County, 5600

  • Zuglói Egészségügyi Szolgálat ( Site 1613)

    Budapest, Zala County, 1148

  • Óbudai Egészségügyi Centrum ( Site 1622)

    Budapest, 1036

  • Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1605)

    Budapest, 1096

  • Semmelweis Egyetem-Városmajori Szív- és Érgyógyászati Klinika ( Site 1601)

    Budapest, 1122

  • Medoc Egészégközpont - Lehel ( Site 1615)

    Budapest, 1134

  • Cardiogeneral Egészségügyi Kft. ( Site 1610)

    Budapest, 1141

  • Belinus Orvosi és Számitástechnikai Bt ( Site 1608)

    Debrecen, Hajdú-Bihar

  • Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1607)

    Debrecen, 4032

  • Óbudai Egészségügyi Centrum - Kaposvár Site ( Site 1625)

    Kaposvár, Somogy County, 7400

  • Borbánya Praxis-Private practice ( Site 1606)

    Nyíregyháza, Borbánya, Szabolcs-Szatmár-Bereg, 4405

  • CoroMed ( Site 1612)

    Pécs, Pecs, 7623

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1617)

    Szeged, Csongrád megye, 6725

  • Fejér Megyei Szent György Egyetemi Oktató Kórház-2nd Department of Internal Medicine ( Site 1611)

    Székesfehérvár, Fejér, 8000

  • Óbudai Egészségügyi Centrum - Zalaegerszeg ( Site 1624)

    Zalaegerszeg, 8900

Other trials in Hungary

Italy17 sites

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 1817)

    Bergamo, Lombardy, 20127

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 1820)

    Brescia, Lombardy, 25123

  • Azienda Ospedaliero Universitaria di Ferrara ( Site 1816)

    Cona, Ferrara, 44124

  • ASST DI LECCO ( Site 1814)

    Lecco, 23900

  • Centro Cardiologico Monzino ( Site 1804)

    Milan, Milano, 20138

  • ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 1811)

    Milan, Milano, 20162

  • Policlinico di Monza centro diabetologia e malattie metaboliche ( Site 1806)

    Monza, Monza E Brianza, 20052

  • University of Naples Federico II ( Site 1805)

    Naples, 80131

  • A.O.U. Policlinico Paolo Giaccone ( Site 1815)

    Palermo, Sicily, 90129

  • Azienda Ospedaliero Universitaria di Parma ( Site 1813)

    Parma, 43126

  • Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 1802)

    Pavia, 27100

  • Fondazione Policlinico Universitario Campus Bio-Medico ( Site 1818)

    Rome, Lazio, 00128

  • Fondazione Policlinico Tor Vergata ( Site 1809)

    Rome, Lazio, 00133

  • AOU Policlinico Umberto I-Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardi ( Site 1808)

    Rome, Lazio, 00161

  • Policlinico Gemellli - UOC di cardiologia ( Site 1821)

    Rome, Lazio, 168

  • Ospedale Mauriziano ( Site 1812)

    Torino, 10128

  • Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1801)

    Turin, Piedmont, 10126

Other trials in Italy

Peru17 sites

  • Hogar Clínica San Juan de Dios ( Site 1115)

    Arequipa, Ariqipa, 05154

  • Hospital Alberto Sabogal Sologuren ( Site 1109)

    Bellavista, Qallaw, 07011

  • Policlínico Especializado en Neurología ( Site 1112)

    La Perla-Callao, Lima, 07011

  • Unidad de Investigacon de la Clinica Internacional ( Site 1116)

    Lima, 15001

  • Clínica Internacional - Sede San Borja ( Site 1111)

    Lima, 15036

  • Clínica Vesalio-Cardiology ( Site 1101)

    Lima, 15036

  • Clínica Javier Prado ( Site 1100)

    Lima, 15046

  • Hospital Militar Geriátrico ( Site 1114)

    Lima, 15064

  • CLINICA DELGADO ( Site 1117)

    Lima, 15074

  • Clínica El Golf-Cardiologia ( Site 1103)

    Lima, 15076

  • Clínica Providencia ( Site 1102)

    Lima, 15088

  • Hospital Cayetano Heredia-Servicio de cardiologia ( Site 1113)

    Lima, Lima 31

  • ASOCIACION CIVIL POR LA SALUD ( Site 1107)

    Miraflores, Muni Metro de Lima, 15048

  • Centro de Investigación Clínica Belén ( Site 1108)

    Piura, 20000

  • Instituto Médico Soy Diabetico ( Site 1106)

    Piura, 20009

  • Centro de investigacion Clínica Trujillo-Medical specialties ( Site 1104)

    Trujillo, La Libertad, 13001

  • Clínica San Antonio ( Site 1118)

    Trujillo, La Libertad, 13008

Other trials in Peru

Turkey (Türkiye)17 sites

  • Adana Sehir Egitim ve Arastirma Hastanesi ( Site 2511)

    Adana, 01370

  • Hacettepe Universite Hastaneleri ( Site 2500)

    Altindağ, Ankara, 06230

  • SBÜ GÜLHANE EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 2524)

    Ankara, 06010

  • Ankara Bilkent Şehir Hastanesi-cardiology ( Site 2501)

    Ankara, 06800

  • Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 2518)

    Antalya, 07100

  • Ege Universitesi Hastanesi-Cardilogy Department ( Site 2502)

    Bornova, İzmir, 35100

  • Çanakkale Onsekiz Mart Üniversitesi ( Site 2509)

    Çanakkale, 17000

  • I.E.U. Medical Point Hastanesi ( Site 2521)

    Cordaleo, İzmir, 35575

  • Trakya University ( Site 2523)

    Edirne, 22030

  • Eskisehir Osmangazi University-Cardiology ( Site 2510)

    Eskişehir, 26480

  • Istanbul University Cerrahpasa Medical School Internal Diseases Institute ( Site 2528)

    Istanbul, 34098

  • Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 2520)

    Istanbul, 34899

  • Kocaeli Üniversitesi-Cardiology ( Site 2516)

    Kocaeli, 41380

  • NECMETTIN ERBAKAN MERAM MEDICAL FAC.-cardiology ( Site 2513)

    Konya, 42080

  • İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 2525)

    Malatya, 44280

  • Erciyes Universitesi Tıp Fakultesi Hastaneleri-endocrine ( Site 2522)

    Melikgazi, Kayseri, 38280

  • Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi ( Site 2527)

    Samsun, 55200

Other trials in Turkey (Türkiye)

New Zealand16 sites

  • Waitemata District Health Board ( Site 2915)

    Auckland, 0622

  • New Zealand Clinical Research (Auckland) ( Site 2900)

    Auckland, 0624

  • Waitemata Clinical Research Ltd ( Site 2916)

    Auckland, 0626

  • Auckland City Hospital ( Site 2911)

    Auckland, 1023

  • New Zealand Clinical Research (Christchurch) ( Site 2901)

    Christchurch, Canterbury, 8011

  • Pacific Clinical Research Network - Forte ( Site 2903)

    Christchurch, Canterbury, 8013

  • Momentum Clinical Research Dunedin ( Site 2910)

    Dunedin, Otago, 9016

  • Lakeland Clinical Trials Wellington ( Site 2904)

    Ebdentown, Wellington Region, 5018

  • Momentum Clinical Research Hawke's Bay ( Site 2913)

    Hastings, Hawkes Bay, 4122

  • Momentum Clinical Research Lower Hutt ( Site 2914)

    Lower Hutt, Wellington Region, 5010

  • Lakeland Clinical Trials Waikato ( Site 2906)

    Nawton, Waikato Region, 3200

  • Pacific Clinical Research Network - Tasman ( Site 2905)

    Nelson, 7011

  • Momentum Clinical Research - Palmerston North ( Site 2909)

    Palmerston North, Manawatu-Wanganui, 4414

  • Pacific Clinical Research Network - Rotorua ( Site 2902)

    Rotorua, Bay of Plenty, 3010

  • Momentum Clinical Research - Tauranga ( Site 2907)

    Tauranga, Bay of Plenty, 3110

  • Momentum Clinical Research Kapiti ( Site 2912)

    Wellington, 5036

Other trials in New Zealand

Chile15 sites

  • Biocenter ( Site 0819)

    Concepción, Biobio, 4070196

  • Espacio Eme ( Site 0806)

    Ñuñoa, Region M. de Santiago, 7770086

  • Servicios Medicos Godoy ( Site 0810)

    Providencia, Region M. de Santiago, 7500710

  • Centro Respiratorio Integral - CENRESIN. ( Site 0820)

    Quillota, Valparaiso, 5501775

  • Enroll SpA ( Site 0803)

    Santiago, Region M. de Santiago, 7500587

  • FALP-UIDO ( Site 0815)

    Santiago, Region M. de Santiago, 7500921

  • CECIM ( Site 0811)

    Santiago, Region M. de Santiago, 8320000

  • Centro de Investigacion Clinicadela Universidad Catolica ( Site 0812)

    Santiago, Region M. de Santiago, 8330034

  • Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0800)

    Santiago, Region M. de Santiago, 8380420

  • Clínica Ensenada ( Site 0801)

    Santiago, Region M. de Santiago, 8380465

  • Centro de Investigación del Maule ( Site 0816)

    Talca, Maule Region, 3460000

  • Centro de Investigación Clinica Del Sur ( Site 0821)

    Temuco, Araucania, 4781156

  • Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0805)

    Temuco, Araucania, 4813299

  • Clinical Research Chile SpA ( Site 0804)

    Valdivia, Los Ríos Region, 5110683

  • ONCOCENTRO APYS ( Site 0808)

    Viña del Mar, Valparaiso, 2520598

Other trials in Chile

France15 sites

  • CHRU Troussau-CARDIOLOGY ( Site 1402)

    Chambray-lès-Tours, Centre-Val de Loire, 37170

  • Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1409)

    Dijon, Cote-d Or, 21079

  • Centre Hospitalier Universitaire de Grenoble-Cardiology ( Site 1421)

    Grenoble, Auvergne-Rhône-Alpes, 38700

  • Centre Hospitalier Louis Pasteur ( Site 1405)

    Le Coudray, Eure-et-Loir, 28630

  • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1413)

    Limoges, Haute-Vienne, 87042

  • Clinique du Pont de Chaume ( Site 1407)

    Montauban, Tarn-et-Garonne, 82017

  • Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau ( Site 1401)

    Nîmes, Gard, 30029

  • CENTRE HOSPITALIER REGIONAL D'ORLEANS-Service de Cardiologie ( Site 1416)

    Orléans, Centre-Val de Loire, 45067

  • Pitie Salpetriere University Hospital ( Site 1414)

    Paris, Orne, 75013

  • Centre Hospitalier de Pau ( Site 1408)

    Pau, Pyrenees-Atlantiques, 64046

  • Centre Hospitalier Universitaire de Poitiers ( Site 1417)

    Poitiers, Vienne, 86021

  • Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 1418)

    Reims, Marne, 51092

  • Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 1404)

    Rennes, Ille-et-Vilaine, 35000

  • Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord ( Site 1400)

    Saint Priest En Jarez, Pays de la Loire Region, 42270

  • Polyclinique Vauban ( Site 1406)

    Valenciennes, Nord, 59300

Other trials in France

United Kingdom12 sites

  • West Walk Surgery ( Site 2602)

    Bristol, Bristol, City of, BS37 4AX

  • Velocity Clinical Research Romford ( Site 2615)

    Bristol, Bristol, City of, BS8 2RA

  • Golden Jubilee National Hospital ( Site 2613)

    Clydebank, Glasgow City, G81 4DY

  • Lakeside Surgery ( Site 2601)

    Corby, Northamptonshire, NN17 2UR

  • Royal Devon & Exeter Hospital-Patient Recruitment Centre: Exeter ( Site 2605)

    Exeter, Devon, EX2 5DW

  • Velocity Clinical Research, Leicester ( Site 2614)

    Leicester, LE1 6NB

  • Barts Health NHS Trust-William Harvey Clinical Research Centre ( Site 2603)

    London, England, EC1M 6BQ

  • Manchester Royal Infirmary ( Site 2612)

    Manchester, M13 9WL

  • NIHR Commercial Recruitment Delivery Centre: Newcastle ( Site 2606)

    Newcastle upon Tyne, England, NE1 4LP

  • Velocity Clinical Research Romford ( Site 2618)

    Romford, London, City of, RM1 3PJ

  • Northern General Hospital ( Site 2611)

    Sheffield, S5 7AU

  • Walsall Manor Hospital ( Site 2600)

    Walsall, Devon, WS2 9PS

Other trials in United Kingdom

Denmark11 sites

  • Aarhus Universitetshospital, Skejby ( Site 1201)

    Aarhus, Central Jutland, 8200

  • Herlev and Gentofte Hospital-Department of Cardiology ( Site 1210)

    Copenhagen, Capital Region, 2730

  • Sydvestjysk Sygehus Esbjerg ( Site 1206)

    Esbjerg, Region Syddanmark, 6700

  • Sanos Clinic - Nordjylland ( Site 1203)

    Gandrup, North Denmark, 9362

  • Sanos Clinic-Sanos Clinic ( Site 1204)

    Herlev, Capital Region, 2730

  • Regionshospitalet Gødstrup ( Site 1207)

    Herning, Central Jutland, 7400

  • Sygehus Vendsyssel Hjoerring ( Site 1209)

    Hjørring, North Denmark, 9800

  • Roskilde Sygehus ( Site 1212)

    Roskilde, Region Sjælland, 4000

  • Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1205)

    Slagelse, Region Sjælland, 4200

  • Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1200)

    Svendborg, Region Syddanmark, 5700

  • Sanos Clinic - Syddanmark ( Site 1202)

    Vejle, Region Syddanmark, 7100

Other trials in Denmark

Canada10 sites

  • Cambridge Cardiac Care Centre ( Site 0508)

    Cambridge, Ontario, N1R 6V6

  • Ecogene-21 ( Site 0510)

    Chicoutimi, Quebec, G7H 7K9

  • OCT Research ULC ( Site 0512)

    Kelowna, British Columbia, V1Y 1Z9

  • Institut de Cardiologie de Montreal ( Site 0506)

    Montreal, Quebec, H1T 1C8

  • North York Diagnostic and Cardiac Centre ( Site 0514)

    North York, Ontario, M6B 3H7

  • Oakville Cardiovascular Research LP ( Site 0507)

    Oakville, Ontario, L6K 3W7

  • IUCPQ ( Site 0515)

    Québec, Quebec, G1V 4G5

  • Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur. ( Site 0509)

    Terrebonne, Quebec, J6V 2H2

  • Corcare ( Site 0511)

    Toronto, Ontario, M1B 5N1

  • Diex Recherche Trois-Rivieres ( Site 0505)

    Trois-Rivières, Quebec, G9A 4P3

Other trials in Canada

South Korea10 sites

  • Dong-A University Hospital ( Site 3013)

    Busan, Pusan-Kwangyokshi, 49201

  • Keimyung University Dongsan Hospital CRC room 1 ( Site 3003)

    Daegu, Taegu-Kwangyokshi, 42601

  • Seoul National University Bundang Hospital ( Site 3005)

    Seongnam, Kyonggi-do, 13620

  • Seoul National University Hospital ( Site 3001)

    Seoul, 03080

  • Kangbuk Samsung Hospital ( Site 3009)

    Seoul, 03181

  • Severance Hospital, Yonsei University Health System ( Site 3002)

    Seoul, 03722

  • Asan Medical Center ( Site 3004)

    Seoul, 05505

  • Samsung Medical Center-cardiology ( Site 3000)

    Seoul, 06351

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 3007)

    Seoul, 06591

  • Ajou University Hospital ( Site 3006)

    Suwon, Kyonggi-do, 16499

Other trials in South Korea

Taiwan10 sites

  • Changhua Christian Hospital ( Site 3101)

    Changhua, 50006

  • Kaohsiung Medical University Hospital ( Site 3109)

    Kaohsiung City, 807

  • Chang Gung Memorial Hospital at Kaohsiung ( Site 3102)

    Kaohsiung City, 83301

  • Mackay Memorial Hospital -Tamsui Branch ( Site 3108)

    New Taipei City, New Taipei, 251

  • China Medical University Hospital ( Site 3103)

    Taichung, 404332

  • Chi Mei Medical Center-Cardiology ( Site 3104)

    Tainan, Tainan, 71004

  • National Taiwan University Hospital ( Site 3100)

    Taipei, 10002

  • Taipei Medical University Hospital-Cardiology ( Site 3107)

    Taipei, 110

  • Taipei Veterans General Hospital ( Site 3106)

    Taipei, 112

  • Tri-Service General Hospital ( Site 3110)

    Taipei, 114202

Other trials in Taiwan

Norway9 sites

  • Ålesund sjukehus ( Site 2029)

    Ålesund, Møre og Romsdal, 6017

  • Haukeland Universitetssjukehus ( Site 2023)

    Bergen, Hordaland, 5021

  • Nordlandssykehuset ( Site 2021)

    Bodø, Nordland, 8005

  • Sykehuset Innlandet HF Lillehammer-Medisinsk avdeling ( Site 2030)

    Lillehammer, Oppland, 2629

  • Akershus Universitetssykehus-Hjertemedisinsk Avdeling ( Site 2028)

    Lorenskog, Akershus, 1478

  • Oslo Universitetssykehus Aker-Lipidklinikken ( Site 2020)

    Oslo, 0316

  • Colosseumsklinikken AS ( Site 2024)

    Oslo, 0369

  • Oslo Universitetssykehus Rikshospitalet-Kardiologisk avdeling ( Site 2025)

    Oslo, 0372

  • Oslo Universitetssykehus Ullevål ( Site 2031)

    Oslo, 0450

Other trials in Norway

Australia7 sites

  • Paratus Clinical Research Western Sydney ( Site 2805)

    Blacktown, New South Wales, 2148

  • The Prince Charles Hospital ( Site 2810)

    Brisbane, Queensland, 4032

  • Paratus Clinical Research Canberra ( Site 2804)

    Bruce, Australian Capital Territory, 2617

  • Royal Prince Alfred Hospital ( Site 2808)

    Camperdown, New South Wales, 2050

  • Victorian Heart Hospital-Monash Cardiovascular Research Centre (MCRC) ( Site 2803)

    Clayton, Victoria, 3168

  • Baker IDI Heart & Diabetes Institute ( Site 2809)

    Hoppers Crossing, Victoria, 3029

  • Paratus Clinical Research Central Coast ( Site 2806)

    Kanwal, New South Wales, 2259

Other trials in Australia

Hong Kong5 sites

  • Queen Mary Hospital-Medicine - Cardiology ( Site 3303)

    Hksar

  • Queen Mary Hospital-Medical ( Site 3300)

    Pok Fu Lam

  • Prince of Wales Hospital ( Site 3301)

    Shatin

  • Prince of Wales Hospital ( Site 3304)

    Shatin

  • Our Lady of Maryknoll Hospital-Department of Medicine and Geriatrics ( Site 3305)

    Wong Tai Sin, 999077

Other trials in Hong Kong

Puerto Rico4 sites

  • Clinical Research Investigator Group ( Site 3701)

    Bayamón, 00960

  • Investigadores del Este LLC ( Site 3700)

    Humacao, 00791

  • Ponce Medical School Foundation Inc. ( Site 3702)

    Ponce, 00716

  • Latin Clinical Trial Center ( Site 3704)

    San Juan, 00909

Other trials in Puerto Rico

About this study

Official title: Phase 3 Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-0616 in Reducing Major Adverse Cardiovascular Events in Participants at High Cardiovascular Risk

This is a phase 3, randomized, placebo-controlled study of the efficacy and safety of enlicitide decanoate, an oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, in participants with high cardiovascular risk. The primary objective is to evaluate the efficacy of enlicitide decanoate compared with placebo in increasing the time to the first occurrence of major adverse cardiovascular events (MACE) including coronary heart disease (CHD) death, ischemic stroke, myocardial infarction (MI), acute limb ischemia or major amputation, or urgent arterial revascularization.

Being tested
Enlicitide Decanoate, Placebo
Medical subject headings
Arteriosclerosis, Hypercholesterolemia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Enlicitide DecanoateDrug

    Also called MK-0616

    Enlicitide Decanoate 20 mg tablet taken by mouth.

  • PlaceboDrug

    Placebo tablet matched to enlicitide decanoate taken by mouth.

Study groups in NCT06008756
Study groupRoleWhat they receive
Blinded Portion: Enlicitide DecanoateExperimentalParticipants receive enlicitide decanoate 20 mg once daily.
Receives: Drug: Enlicitide Decanoate
Blinded Portion: PlaceboPlacebo comparatorParticipants receive placebo once daily.
Receives: Drug: Placebo
Open-Label Extension: Enlicitide DecanoateExperimentalParticipants who complete the blinded portion may enroll in this open-label extension arm. Participants in the extension arm receive enlicitide decanoate once daily up to 2 years.
Receives: Drug: Enlicitide Decanoate

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Blinded Period: Time to First Occurrence of Coronary Heart Disease (CHD) Death-Based Major Adverse Cardiovascular Events (MACE)-Plus

    Time to the first occurrence of CHD death-based MACE-plus, which is defined as any of the following: coronary heart disease death, myocardial infarction (MI), ischemic stroke (fatal and nonfatal), acute limb ischemia or major amputation, or urgent arterial revascularization (coronary, cerebrovascular, or peripheral).

    Measured: From date of randomization until the date of first occurrence of CHD death-based MACE-plus, assessed up to approximately 6 years

Secondary outcomes (17)

  1. Blinded Period: Time to First Occurrence of 3-point MACE

    Time to the first occurrence of 3-point MACE (defined as cardiovascular death, MI, or ischemic stroke).

    Measured: From date of randomization until the date of first occurrence of 3-point MACE, assessed up to approximately 6 years

  2. Blinded Period: Time to First Occurrence of Cardiovascular (CV) Death-Based MACE Plus

    Time to the first occurrence of CV death-based MACE plus, defined as any of the following: cardiovascular death, MI, ischemic stroke, acute limb ischemia or major amputation, or urgent arterial revascularization (coronary, cerebrovascular, or peripheral).

    Measured: From date of randomization until the date of first occurrence of CV death-based MACE plus, assessed up to approximately 6 years

  3. Blinded Period: Time to First Occurrence of CHD Death or MI

    Time to the first occurrence of CHD death or MI.

    Measured: From date of randomization until the date of first occurrence of CHD death or MI, assessed up to approximately 6 years

  4. Blinded Period: Time to CV Death

    Time to cardiovascular death.

    Measured: From date of randomization until the date of CV death, assessed up to approximately 6 years

  5. Blinded Period: Time to All-Cause Death

    Time to all-cause death.

    Measured: From date of randomization until the date of death, assessed up to approximately 6 years

  6. Blinded Period: Time to CHD Death

    Time to CHD death.

    Measured: From date of randomization until the date of CHD death, assessed up to approximately 6 years

  7. Blinded Period: Time to First Event of MI

    Time to the first occurrence of MI.

    Measured: From date of randomization until the date of MI, assessed up to approximately 6 years

  8. Blinded Period: Time to First Event of Ischemic Stroke

    Time to the first occurrence of ischemic stroke.

    Measured: From date of randomization until the date of first occurrence of ischemic stroke, assessed up to approximately 6 years

  9. Blinded Period: Time to First Event of Acute Limb Ischemia or Major Amputation

    Time to the first occurrence of acute limb ischemia or major amputation.

    Measured: From date of randomization until the date of first occurrence of acute limb ischemia or major amputation, assessed up to approximately 6 years

  10. Blinded Period: Time to First Event of Urgent Arterial Revascularization

    Time to the first occurrence of urgent arterial revascularization (coronary, cerebrovascular, or peripheral).

    Measured: From date of randomization until the date of urgent arterial revascularization, assessed up to approximately 6 years

  11. Blinded Period: Percent Change from Baseline in Low-Density Lipoprotein Cholesterol (LDL-C)

    The percent change from baseline in LDL-C.

    Measured: Baseline and Week 52

  12. Blinded Period: Percent Change from Baseline in Apolipoprotein B

    The percent change from baseline in apolipoprotein B.

    Measured: Baseline and Week 52

  13. Blinded Period: Percent Change from Baseline in Non-High-Density Lipoprotein Cholesterol (non-HDL-C) cholesterol

    The percent change from baseline in Non-HDL-C.

    Measured: Baseline and Week 52

  14. Blinded Period: Percent Change from Baseline in Lipoprotein (a)

    The percent change from baseline in lipoprotein (a).

    Measured: Baseline and Week 52

  15. Blinded Period: Number of Participants with an Adverse Event (AE)

    An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. The number of participants with AE(s) in each arm will be reported.

    Measured: Up to approximately 6 years

  16. Blinded Period: Number of Participants Discontinuing from Study Therapy Due to AE

    An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. The number of participants discontinuing due to AE(s) in each arm will be reported.

    Measured: Up to approximately 6 years

  17. Open-Label Extension (OLE): Time to First Occurrence of CHD Death-Based MACE Plus

    Time to the first occurrence of CHD death-based MACE-plus, which is defined as any of the following: coronary heart disease death, MI, ischemic stroke (fatal and nonfatal), acute limb ischemia or major amputation, or urgent arterial revascularization (coronary, cerebrovascular, or peripheral).

    Measured: From date of randomization until the date of first occurrence of CHD death-based MACE plus, assessed up to approximately 8 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted24 Aug 2023
  2. Study start9 Oct 2023
  3. Primary completion29 Nov 2029 (estimated)
  4. Study completion29 Nov 2031 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
There are two parts of the study. The blinded period is randomized parallel treatment groups. Participants who complete the blinded period are then eligible to enroll in an open label extension (OLE) (single group).
Masking
Triple blind
Who is masked
Participant, Investigator, Outcomes assessor
Enrolment
14,550 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06008756
Sponsor's protocol ID
0616-015
Other IDs
jRCT2071230064, 2022-502781-24-00, U1111-1285-4245
Status last verified
Apr 2026
First submitted
17 Aug 2023
Last updated
23 Apr 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Enlicitide Decanoate in people with Arteriosclerosis and Hypercholesterolaemia, run by Merck Sharp & Dohme LLC at 669 sites in 29 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 23 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 669 sites in United States, China, Japan, Netherlands, Poland and 24 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Blinded Period: Time to First Occurrence of Coronary Heart Disease (CHD) Death-Based Major Adverse Cardiovascular Events (MACE)-Plus (time frame: From date of randomization until the date of first occurrence of CHD death-based MACE-plus, assessed up to approximately 6 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06008756.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Apr 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in